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Zhou Group

Keywords

Nucleic Acids Chemistry, Protein Chemistry, Nucleic Acid - Protein Interaction

Countries

China

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Employment (2)

Nankai University: Tianjin, Tianjin, CN

2014-07 to present | Professor
Employment
Source: Self-asserted source
Chuanzheng Zhou

Johns Hopkins University: Baltimore, MD, US

2010-10 to 2014-06 | Postdoc (Chemistry)
Employment
Source: Self-asserted source
Chuanzheng Zhou

Education and qualifications (3)

Uppsala Universitet: Uppsala, SE

2004-10 to 2010-09 | Ph. D. (Bioorganic Chemistry)
Education
Source: Self-asserted source
Chuanzheng Zhou

Nankai University: Tianjin, Tianjin, CN

2001-09 to 2004-06 | M. Sc.
Education
Source: Self-asserted source
Chuanzheng Zhou

Nankai University: Tianjin, Tianjin, CN

1997-09 to 2001-06 | B. Sc. (Chemistry)
Education
Source: Self-asserted source
Chuanzheng Zhou

Works (40)

Structural basis for human OGG1 processing 8-oxodGuo within nucleosome core particles

Nature Communications
2024-10-31 | Journal article
DOI: 10.1038/s41467-024-53811-3
Contributors: Mengtian Ren; Fabian Gut; Yilan Fan; Jingke Ma; Xiajing Shan; Aysenur Yikilmazsoy; Mariia Likhodeeva; Karl-Peter Hopfner; Chuanzheng Zhou
Source: check_circle
Crossref

Peptide Stapling by Crosslinking Two Amines with α‐Ketoaldehydes through Diverse Modified Glyoxal‐Lysine Dimer Linkers

Angewandte Chemie
2024-04-15 | Journal article
DOI: 10.1002/ange.202318893
Contributors: Pan Guo; Xin Chu; Chengjin Wu; Tianjiao Qiao; Wenli Guan; Chuanzheng Zhou; Tao Wang; Changlin Tian; Gang He; Gong Chen
Source: check_circle
Crossref

Peptide Stapling by Crosslinking Two Amines with α‐Ketoaldehydes through Diverse Modified Glyoxal‐Lysine Dimer Linkers

Angewandte Chemie International Edition
2024-04-15 | Journal article
DOI: 10.1002/anie.202318893
Contributors: Pan Guo; Xin Chu; Chengjin Wu; Tianjiao Qiao; Wenli Guan; Chuanzheng Zhou; Tao Wang; Changlin Tian; Gang He; Gong Chen
Source: check_circle
Crossref

In-situ synthesis of quantum dots in the nucleus of live cells

National Science Review
2024-02-01 | Journal article
DOI: 10.1093/nsr/nwae021
Contributors: Yusi Hu; Zhi-Gang Wang; Haohao Fu; Chuanzheng Zhou; Wensheng Cai; Xueguang Shao; Shu-Lin Liu; Dai-Wen Pang
Source: check_circle
Crossref

Photo-caged 2-butene-1,4-dial as an efficient, target-specific photo-crosslinker for covalent trapping of DNA-binding proteins

Chemical Science
2023 | Journal article
DOI: 10.1039/D3SC03719C
Contributors: Jiahui Li; Zenghui Cui; Chaochao Fan; Yifei Zhou; Mengtian Ren; Chuanzheng Zhou
Source: check_circle
Crossref

Suppression of alpha-carbon racemization in peptide synthesis based on a thiol-labile amino protecting group

Nature Communications
2023-09-01 | Journal article
DOI: 10.1038/s41467-023-41115-x
Contributors: Yifei Zhou; Hongjun Li; Yi Huang; Jiahui Li; Guiyu Deng; Gong Chen; Zhen Xi; Chuanzheng Zhou
Source: check_circle
Crossref

Participation of Histones in DNA Damage and Repair within Nucleosome Core Particles: Mechanism and Applications

Accounts of Chemical Research
2022-04-05 | Journal article
DOI: 10.1021/acs.accounts.2c00041
Contributors: Mengtian Ren; Marc M. Greenberg; Chuanzheng Zhou
Source: check_circle
Crossref

2′,3′‐Cyclic GMP‐AMP Dinucleotides for STING‐Mediated Immune Modulation: Principles, Immunotherapeutic Potential, and Synthesis

ChemMedChem
2022-01-19 | Journal article
DOI: 10.1002/cmdc.202100671
Contributors: Mengdi Shang; Kuan Lu; Wenli Guan; Shujie Cao; Mengtian Ren; Chuanzheng Zhou
Source: check_circle
Crossref

Nucleosomes enter cells by clathrin- and caveolin-dependent endocytosis

Nucleic Acids Research
2021-12-02 | Journal article
DOI: 10.1093/nar/gkab1121
Contributors: Huawei Wang; Xiajing Shan; Mengtian Ren; Mengdi Shang; Chuanzheng Zhou
Source: check_circle
Crossref

C4’‐Fluorinated Oligodeoxynucleotides: Synthesis, Stability, Structural Studies

Chemistry – A European Journal
2021-09-28 | Journal article
DOI: 10.1002/chem.202102561
Part of ISSN: 0947-6539
Part of ISSN: 1521-3765
Source: Self-asserted source
Chuanzheng Zhou

Designing in vivo active DNAzymes

Nature Chemistry
2021-04-30 | Journal article
DOI: 10.1038/s41557-021-00669-3
Contributors: Yifei Zhou; Chuanzheng Zhou
Source: check_circle
Crossref

Histones participate in base excision repair of 8-oxodGuo by transiently cross-linking with active repair intermediates in nucleosome core particles

Nucleic Acids Research
2021-01-11 | Journal article
DOI: 10.1093/nar/gkaa1153
Contributors: Mengtian Ren; Mengdi Shang; Huawei Wang; Zhen Xi; Chuanzheng Zhou
Source: check_circle
Crossref

Cellular uptake of extracellular nucleosomes induces innate immune responses by binding and activating cGMP-AMP synthase (cGAS)

Scientific Reports
2020-12 | Journal article
DOI: 10.1038/s41598-020-72393-w
Part of ISSN: 2045-2322
Source: Self-asserted source
Chuanzheng Zhou

4′-Fluorinated RNA: Synthesis, Structure, and Applications as a Sensitive 19F NMR Probe of RNA Structure and Function

Journal of the American Chemical Society
2020-03-11 | Journal article
DOI: 10.1021/jacs.9b13207
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Source: Self-asserted source
Chuanzheng Zhou

Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome

Proceedings of the National Academy of Sciences
2020-02-25 | Journal article
DOI: 10.1073/pnas.1911998117
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Chuanzheng Zhou

Cysteine-specific protein multi-functionalization and disulfide bridging using 3-bromo-5-methylene pyrrolones

Nature Communications
2020-02-21 | Journal article
DOI: 10.1038/s41467-020-14757-4
Contributors: Yingqian Zhang; Chuanlong Zang; Guoce An; Mengdi Shang; Zenghui Cui; Gong Chen; Zhen Xi; Chuanzheng Zhou
Source: check_circle
Crossref

A light-responsive, self-immolative linker for controlled drug delivery via peptide- and protein-drug conjugates

Chemical Science
2019 | Journal article
DOI: 10.1039/C9SC03016F
Contributors: Chuanlong Zang; Huawei Wang; Tiantian Li; Yingqian Zhang; Jiahui Li; Mengdi Shang; Juanjuan Du; Zhen Xi; Chuanzheng Zhou
Source: check_circle
Crossref

Nitrogen Mustard Induces Formation of DNA–Histone Cross-Links in Nucleosome Core Particles

Chemical Research in Toxicology
2019-12-16 | Journal article
DOI: 10.1021/acs.chemrestox.9b00354
Contributors: Mengdi Shang; Mengtian Ren; Chuanzheng Zhou
Source: check_circle
Crossref

Formation and biological consequences of 5-Formylcytosine in genomic DNA

DNA Repair
2019-09 | Journal article
DOI: 10.1016/j.dnarep.2019.102649
Part of ISSN: 1568-7864
Source: Self-asserted source
Chuanzheng Zhou

DNA damage in nucleosomes

Science China Chemistry
2019-05 | Journal article
DOI: 10.1007/s11426-018-9421-5
Part of ISSN: 1674-7291
Part of ISSN: 1869-1870
Source: Self-asserted source
Chuanzheng Zhou

4'-C-Trifluoromethyl modified oligodeoxynucleotides: synthesis, biochemical studies, and cellular uptake properties.

Organic & biomolecular chemistry
2019-05-21 | Journal article
DOI: 10.1039/c9ob00765b
PMID: 31112186
Source: Self-asserted source
Chuanzheng Zhou

Transesterification Reaction and the Repair of Embedded Ribonucleotides in DNA Are Suppressed upon the Assembly of DNA into Nucleosome Core Particles

Chemical Research in Toxicology
2019-05-20 | Journal article
DOI: 10.1021/acs.chemrestox.9b00059
Contributors: Mengtian Ren; Yiran Cheng; Qian Duan; Chuanzheng Zhou
Source: check_circle
Crossref

Oxidation of 8-Oxo-7,8-dihydro-2′-deoxyguanosine Leads to Substantial DNA-Histone Cross-Links within Nucleosome Core Particles

Chemical Research in Toxicology
2018-12-17 | Journal article
DOI: 10.1021/acs.chemrestox.8b00244
Contributors: Jing Bai; Yingqian Zhang; Zhen Xi; Marc M. Greenberg; Chuanzheng Zhou
Source: check_circle
Crossref

Effect of Ribose Conformation on RNA Cleavage via Internal Transesterification.

Journal of the American Chemical Society
2018-09-14 | Journal article
DOI: 10.1021/jacs.8b06313
PMID: 30207719
Source: Self-asserted source
Chuanzheng Zhou

Synthesis and biological applications of fluoro-modified nucleic acids

Organic & Biomolecular Chemistry
2017 | Journal article
DOI: 10.1039/C7OB02094E
Contributors: Fengmin Guo; Qiang Li; Chuanzheng Zhou
Source: check_circle
Crossref

Thiol Specific and Tracelessly Removable Bioconjugation via Michael Addition to 5-Methylene Pyrrolones

Journal of the American Chemical Society
2017 | Journal article
DOI: 10.1021/jacs.7b00670
ARXIV:

http://dx.doi.org/10.1021/jacs.7b00670

Source: Self-asserted source
Chuanzheng Zhou
grade
Preferred source (of 2)‎

5-Formylcytosine Yields DNA–Protein Cross-Links in Nucleosome Core Particles

Journal of the American Chemical Society
2017-08-09 | Journal article
DOI: 10.1021/jacs.7b05495
Contributors: Fengchao Li; Yingqian Zhang; Jing Bai; Marc M. Greenberg; Zhen Xi; Chuanzheng Zhou
Source: check_circle
Crossref

Probing Interactions between Lysine Residues in Histone Tails and Nucleosomal DNA via Product and Kinetic Analysis

ACS Chemical Biology
2015 | Journal article
DOI: 10.1021/cb500737y
ARXIV:

http://dx.doi.org/10.1021/cb500737y

Source: Self-asserted source
Chuanzheng Zhou

DNA Damage by Histone Radicals in Nucleosome Core Particles

Journal of the American Chemical Society
2014 | Journal article
DOI: 10.1021/ja501285s
ARXIV:

http://dx.doi.org/10.1021/ja501285s

Source: Self-asserted source
Chuanzheng Zhou

Histone Modification via Rapid Cleavage of C4′-Oxidized Abasic Sites in Nucleosome Core Particles

Journal of the American Chemical Society
2013 | Journal article
DOI: 10.1021/ja400915w
ARXIV:

http://dx.doi.org/10.1021/ja400915w

Source: Self-asserted source
Chuanzheng Zhou

Nucleosome Core Particle-Catalyzed Strand Scission at Abasic Sites

Biochemistry
2013 | Journal article
DOI: 10.1021/bi3010076
ARXIV:

http://dx.doi.org/10.1021/bi3010076

Source: Self-asserted source
Chuanzheng Zhou

Histone-Catalyzed Cleavage of Nucleosomal DNA Containing 2-Deoxyribonolactone

Journal of the American Chemical Society
2012 | Journal article
DOI: 10.1021/ja302993h
ARXIV:

http://dx.doi.org/10.1021/ja302993h

Source: Self-asserted source
Chuanzheng Zhou

Intramolecular Free-Radical Cyclization Reactions on Pentose Sugars for the Synthesis of Carba-LNA and Carba-ENA and the Application of Their Modified Oligonucleotides as Potential RNA Targeted Therapeutics

Chemical Reviews
2012 | Journal article
DOI: 10.1021/cr100306q
ARXIV:

http://dx.doi.org/10.1021/cr100306q

Source: Self-asserted source
Chuanzheng Zhou

Mechanistic Studies on Histone Catalyzed Cleavage of Apyrimidinic/Apurinic Sites in Nucleosome Core Particles

Journal of the American Chemical Society
2012 | Journal article
DOI: 10.1021/ja306858m
ARXIV:

http://dx.doi.org/10.1021/ja306858m

Source: Self-asserted source
Chuanzheng Zhou

Carba-LNA-5MeC/A/G/T Modified Oligos Show Nucleobase-Specific Modulation of 3′-Exonuclease Activity, Thermodynamic Stability, RNA Selectivity, and RNase H Elicitation: Synthesis and Biochemistry

The Journal of Organic Chemistry
2011 | Journal article
DOI: 10.1021/jo200073q
ARXIV:

http://dx.doi.org/10.1021/jo200073q

Source: Self-asserted source
Chuanzheng Zhou
grade
Preferred source (of 2)‎

Synthesis of 2′,4′-Propylene-Bridged (Carba-ENA) Thymidine and Its Analogues: The Engineering of Electrostatic and Steric Effects at the Bottom of the Minor Groove for Nuclease and Thermodynamic Stabilities and Elicitation of RNase H

The Journal of Organic Chemistry
2010 | Journal article
DOI: 10.1021/jo101207d
ARXIV:

http://dx.doi.org/10.1021/jo101207d

Source: Self-asserted source
Chuanzheng Zhou

Why Carba-LNA-Modified Oligonucleotides Show Considerably Improved 3′-Exonuclease Stability Compared to That of the LNA Modified or the Native Counterparts: A Michaelis−Menten Kinetic Analysis

The Journal of Organic Chemistry
2010 | Journal article
DOI: 10.1021/jo100170g
ARXIV:

http://dx.doi.org/10.1021/jo100170g

Source: Self-asserted source
Chuanzheng Zhou

Double Sugar and Phosphate Backbone-Constrained Nucleotides: Synthesis, Structure, Stability, and Their Incorporation into Oligodeoxynucleotides

The Journal of Organic Chemistry
2009 | Journal article
DOI: 10.1021/jo900391n
ARXIV:

http://dx.doi.org/10.1021/jo900391n

Source: Self-asserted source
Chuanzheng Zhou

Fine Tuning of Electrostatics around the Internucleotidic Phosphate through Incorporation of Modified 2′,4′-Carbocyclic-LNAs and -ENAs Leads to Significant Modulation of Antisense Properties

The Journal of Organic Chemistry
2009 | Journal article
DOI: 10.1021/jo8016742
ARXIV:

http://dx.doi.org/10.1021/jo8016742

Source: Self-asserted source
Chuanzheng Zhou

Modulation of Pyrene Fluorescence in DNA Probes Depends upon the Nature of the Conformationally Restricted Nucleotide

The Journal of Organic Chemistry
2008 | Journal article
DOI: 10.1021/jo702747w
ARXIV:

http://dx.doi.org/10.1021/jo702747w

Source: Self-asserted source
Chuanzheng Zhou

Peer review (38 reviews for 15 publications/grants)

Review activity for ACS central science. (2)
Review activity for ACS chemical biology. (1)
Review activity for ACS combinatorial science. (1)
Review activity for Angewandte Chemie. (1)
Review activity for Bioconjugate chemistry. (3)
Review activity for Cell. (1)
Review activity for Cellular and molecular life sciences (1)
Review activity for ChemBioChem. (3)
Review activity for Chemical research in toxicology. (12)
Review activity for Chemistry. (1)
Review activity for Journal of medicinal chemistry. (2)
Review activity for Journal of organic chemistry. (3)
Review activity for Journal of the American Chemical Society. (5)
Review activity for Organic letters. (1)
Review activity for Tetrahedron. (1)
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