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Emails & domains

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Verified email domains

Other IDs

Loop profile: 954683
Scopus Author ID: 57190523114

Keywords

Neurology, Neuroimaging, Neuro-critical care, Stem cells, monoamines, Cerebellum

Countries

United States

Activities

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Employment (4)

Yale University School of Medicine: New Haven, Connecticut, US

2023-11-01 to present | Professor (Neurology)
Employment
Source: Self-asserted source
Sayed Ausim Azizi

Global Neuroscience Institute: Chester, Pennsylvania, US

2019-08-01 to 2033-10-31 | Director (Neurology)
Employment
Source: Self-asserted source
Sayed Ausim Azizi

Lewis Katz School of Medicine at Temple University: Philadelphia, PA, US

2001-10-10 to 2019-07-31 | Chairperson, professor (Neurology)
Employment
Source: Self-asserted source
Sayed Ausim Azizi

Drexel University College of Medicine: Philadelphia, PA, US

1995-07-01 to 2001-10-01 | Associate professor (Neurology)
Employment
Source: Self-asserted source
Sayed Ausim Azizi

Education and qualifications (3)

Yale University School of Medicine: New Haven, CT, US

1991-07-01 to 1994-06-15 (Neurology)
Education
Source: Self-asserted source
Sayed Ausim Azizi

Yale New Haven Hospital: New Haven, Connecticut, US

1990-06-15 to 1991-05-31 (Meidicine)
Education
Source: Self-asserted source
Sayed Ausim Azizi

University of Texas Southwestern Medical Center: Dallas, TX, US

1981-07-01 to 1990-05-31 | MD, PhD
Education
Source: Self-asserted source
Sayed Ausim Azizi

Professional activities (7)

American Association For The Advancement of Science: Washington D.C., District of Columbia, US

2002 to present
Membership
Source: Self-asserted source
Sayed Ausim Azizi

American Neurological Association: Mount Laurel, NJ, US

2000 to present | Fellow
Membership
Source: Self-asserted source
Sayed Ausim Azizi

American Academy of Neurology: Minneapolis, MN, US

1998 to present | Active
Membership
Source: Self-asserted source
Sayed Ausim Azizi

Society for Neuroscience: Washington, DC, US

1990 to present
Membership
Source: Self-asserted source
Sayed Ausim Azizi

Thomas Jefferson University: Philadelphia, Pennsylvania, US

2019-06-06 | Alper's Lecture and visiting Professor (Neurology)
Distinction
Source: Self-asserted source
Sayed Ausim Azizi

University of Pennsylvania: Philadelphia, PA, US

2015-09-01 | Visiting Professor (Neurology)
Distinction
Source: Self-asserted source
Sayed Ausim Azizi

Mayo Clinic: Rochester, Minnesota, US

2004-04-01 to 2004-04-07 | Visiting Professor (Neurology)
Invited position
Source: Self-asserted source
Sayed Ausim Azizi

Works (47)

A role for the prefrontal cortex in reward, punishment, and animal behavior: An anatomical/functional framework

Neuroscience Letters
2023-06 | Journal article
DOI: 10.1016/j.neulet.2023.137296
Contributors: Sayed Ausim Azizi
Source: check_circle
Crossref

Monoamines: Dopamine, Norepinephrine, and Serotonin, Beyond Modulation, “Switches” That Alter the State of Target Networks

The Neuroscientist
2022-04 | Journal article
DOI: 10.1177/1073858420974336
Contributors: Sayed Ausim Azizi
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Role of the cerebellum in the phenotype of neurodegenerative diseases: Mitigate or exacerbate?

Neuroscience letters
2021-07-08 | Journal article
DOI: 10.1016/j.neulet.2021.136105
PMID: 34246702
Contributors: Azizi SA
Source: Self-asserted source
Sayed Ausim Azizi

Neurological injuries in COVID-19 patients: direct viral invasion or a bystander injury after infection of epithelial/endothelial cells

Journal of NeuroVirology
2020-10 | Journal article
DOI: 10.1007/s13365-020-00903-7
Contributors: Sayed Ausim Azizi; Saara-Anne Azizi
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Synucleinopathies in neurodegenerative diseases: Accomplices, an inside job and selective vulnerability

Neuroscience Letters
2018 | Journal article
DOI: 10.1016/j.neulet.2017.12.003
EID:

2-s2.0-85037742110

Part of ISSN: 18727972 03043940
Contributors: Azizi, S.A.; Azizi, S.-A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Intracerebral hemorrhage with intraventricular extension and no hydrocephalus may not increase mortality or severe disability

Journal of Clinical Neuroscience
2016 | Journal article
DOI: 10.1016/j.jocn.2015.11.028
EID:

2-s2.0-84960172552

Part of ISSN: 15322653 09675868
Contributors: Mahta, A.; Katz, P.M.; Kamel, H.; Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

" I think therefore I am" : New prospects for neural prostheses

Neuroscience Letters
2013 | Journal article
DOI: 10.1016/j.neulet.2012.12.015
EID:

2-s2.0-84875114407

Part of ISSN: 03043940 18727972
Contributors: Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Erratum: Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders (Journal of Biological Chemistry (2011) 286 (34976-34985) DOI:10.1074/jbc.A111.241547)

Journal of Biological Chemistry
2013 | Journal article
DOI: 10.1074/jbc.A111.241547
EID:

2-s2.0-84875431557

Part of ISSN: 00219258 1083351X
Contributors: Mukerjee, R.; Chang, J.R.; Del Valle, L.; Bagashev, A.; Gayed, M.M.; Lyde, R.B.; Hawkins, B.J.; Brailoiu, E.; Cohen, E.; Power, C. et al.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Erratum: Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders (The Journal of Biological Chemistry (2011) 286 (34976-34985))

Journal of Biological Chemistry
2013 | Journal article
DOI: 10.1074/jbc.A113.241547
EID:

2-s2.0-84884799349

Part of ISSN: 00219258 1083351X
Contributors: Mukerjee, R.; Chang, J.R.; Del Valle, L.; Bagashev, A.; Gayed, M.M.; Lyde, R.B.; Hawkins, B.J.; Brailoiu, E.; Cohen, E.; Power, C. et al.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Neural Crest Cells Isolated from the Bone Marrow of Transgenic Mice Express JCV T-Antigen

PLoS ONE
2013 | Journal article
DOI: 10.1371/journal.pone.0065947
EID:

2-s2.0-84879255568

Part of ISSN: 19326203
Contributors: Gordon, J.; Sariyer, I.K.; De La Fuente-Granada, M.; Augelli, B.J.; Otte, J.; Azizi, S.A.; Amini, S.; Khalili, K.; Krynska, B.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Erratum: Multifocal CNS infiltration of chronic lymphocytic leukemia in the form of small-cell solid metastatic lesions (Journal of Neuro-Oncology DOI: 10.1007/s11060-012-0869-5)

Journal of Neuro-Oncology
2012 | Journal article
DOI: 10.1007/s11060-012-0899-z
EID:

2-s2.0-84865404823

Part of ISSN: 0167594X 15737373
Contributors: Imitola, J.; Pitt, K.; Peoples, J.F.; Krynska, B.; Sheikh, H.; Kesari, S.; Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Multifocal CNS infiltration of chronic lymphocytic leukemia in the form of small-cell solid metastatic lesions

Journal of Neuro-Oncology
2012 | Journal article
DOI: 10.1007/s11060-012-0869-5
EID:

2-s2.0-84864279858

Part of ISSN: 15737373 0167594X
Contributors: Imitola, J.; Pitt, K.; Peoples, J.L.; Krynska, B.; Sheikh, H.; Kesari, S.; Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Deregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders

Journal of Biological Chemistry
2011 | Journal article
DOI: 10.1074/jbc.M111.241547
EID:

2-s2.0-80053431211

Part of ISSN: 00219258 1083351X
Contributors: Mukerjee, R.; Chang, J.R.; Del Valle, L.; Bagashev, A.; Gayed, M.M.; Lyde, R.B.; Hawkins, B.J.; Brailoiu, E.; Cohen, E.; Power, C. et al.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics

Cancer Biology and Therapy
2010 | Journal article
DOI: 10.4161/cbt.9.4.10653
EID:

2-s2.0-77953549238

Part of ISSN: 15558576 15384047
Contributors: Del Valle, L.; Piña-Oviedo, S.; Perez-Liz, G.; Augelli, B.J.; Azizi, S.A.; Khalili, K.; Gordon, J.; Krynska, B.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Parkinson's Disease

Encyclopedia of Behavioral Neuroscience
2010 | Book chapter
Part of DOI: 10.1016/B978-0-08-045396-5.00035-X
EID:

2-s2.0-85069200052
Contributors: Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

A population of human brain cells expressing phenotypic markers of more than one lineage can be induced in vitro to differentiate into mesenchymal cells

Experimental Cell Research
2009 | Journal article
DOI: 10.1016/j.yexcr.2008.11.004
EID:

2-s2.0-58249140680

Part of ISSN: 10902422 00144827
Contributors: Rieske, P.; Augelli, B.J.; Stawski, R.; Gaughan, J.; Azizi, S.A.; Krynska, B.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Brain to music to brain!

Neuroscience Letters
2009 | Journal article
DOI: 10.1016/j.neulet.2009.04.038
EID:

2-s2.0-65749116611

Part of ISSN: 03043940
Contributors: Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Successful elimination of non-neural cells and unachievable elimination of glial cells by means of commonly used cell culture manipulations during differentiation of GFAP and SOX2 positive neural progenitors (NHA) to neuronal cells

BMC Biotechnology
2008 | Journal article
DOI: 10.1186/1472-6750-8-56
EID:

2-s2.0-48249146508

Part of ISSN: 14726750
Contributors: Witusik, M.; Piaskowski, S.; Hulas-Bigoszewska, K.; Zakrzewska, M.; Gresner, S.M.; Azizi, S.A.; Krynska, B.; Liberski, P.P.; Rieske, P.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Teaching NeuroImage: Acute spastic monoplegia secondary to spinal epidural venous engorgement in pregnancy

Neurology
2008 | Journal article
DOI: 10.1212/01.wnl.0000316310.85132.b3
EID:

2-s2.0-48249123486

Part of ISSN: 1526632X 00283878
Contributors: Franco, M.J.; Vendrame, M.; Haneef, Z.; Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

A population of human brain parenchymal cells express markers of glial, neuronal and early neural cells and differentiate into cells of neuronal and glial lineages

European Journal of Neuroscience
2007 | Journal article
DOI: 10.1111/j.1460-9568.2006.05254.x
EID:

2-s2.0-33846221436

Part of ISSN: 0953816X 14609568
Contributors: Rieske, P.; Azizi, S.A.; Augelli, B.; Gaughan, J.; Krynska, B.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Exercise: A workout for neuroregeneration

Neuroscience Letters
2007 | Journal article
DOI: 10.1016/j.neulet.2007.03.057
EID:

2-s2.0-34247602940

Part of ISSN: 03043940
Contributors: Azizi, S.A.; Vendrame, M.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Neuronal and astrocytic cells, obtained after differentiation of human neural GFAP-positive progenitors, present heterogeneous expression of PrP<sup>c</sup>

Brain Research
2007 | Journal article
DOI: 10.1016/j.brainres.2007.10.039
EID:

2-s2.0-37649018081

Part of ISSN: 00068993
Contributors: Witusik, M.; Gresner, S.M.; Hulas-Bigoszewska, K.; Krynska, B.; Azizi, S.A.; Liberski, P.P.; Brown, P.; Rieske, P.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Pyramidal and extrapyramidal dysfunction as a sequela of hypoxic injury: Case report

BMC Neurology
2007 | Journal article
DOI: 10.1186/1471-2377-7-18
EID:

2-s2.0-34547465637

Part of ISSN: 14712377
Contributors: Vendrame, M.; Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

The spectrum of neuromyelitis optica: A case of NMO with extensive brain stem involvement

Neurological Research
2007 | Journal article
DOI: 10.1179/016164106X115071
EID:

2-s2.0-33846627729

Part of ISSN: 01616412
Contributors: Vendrame, M.; Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Botulinum toxin: More than meets the naked eye!

Neuroscience Letters
2005 | Journal article
DOI: 10.1016/j.neulet.2005.04.008
EID:

2-s2.0-19344378308

Part of ISSN: 03043940
Contributors: Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Ethmoid abscess with findings simulating Weber syndrome

Neurology
2005 | Journal article
DOI: 10.1212/01.wn1.0000161487.06549.b7
EID:

2-s2.0-16844385094

Part of ISSN: 00283878
Contributors: Luo, J.J.; Jacobson, M.; Kamal, A.K.; Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Human fibroblast-derived cell lines have characteristics of embryonic stem cells and cells of neuro-ectodermal origin

Differentiation
2005 | Journal article
DOI: 10.1111/j.1432-0436.2005.00050.x
EID:

2-s2.0-33644876842

Part of ISSN: 14320436 03014681
Contributors: Rieske, P.; Krynska, B.; Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Rat marrow stromal cells rapidly transduced with a self-inactivating retrovirus synthesize L-DOPA in vitro

Gene Therapy
2001 | Journal article
DOI: 10.1038/sj.gt.3301517
EID:

2-s2.0-0034886787

Part of ISSN: 09697128
Contributors: Schwarz, E.J.; Reger, R.L.; Alexander, G.M.; Class, R.; Azizi, S.A.; Prockop, D.J.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Exploiting nonneural cells to rebuild the nervous system: From bone marrow to brain

Neuroscientist
2000 | Journal article
DOI: 10.1177/107385840000600509
EID:

2-s2.0-0033810744

Part of ISSN: 10738584
Contributors: Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Potential use of marrow stromal cells as therapeutic vectors for diseases of the central nervous system

Progress in Brain Research
2000 | Book
DOI: 10.1016/S0079-6123(00)28026-6
EID:

2-s2.0-0034589367

Part of ISSN: 00796123
Contributors: Prockop, D.J.; Azizi, S.A.; Phinney, D.G.; Kopen, G.C.; Schwarz, E.J.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Potential use of stem cells from bone marrow to repair the extracellular matrix and the central nervous system

Biochemical Society Transactions
2000 | Journal article
DOI: 10.1042/bst0280341
EID:

2-s2.0-0033850535

Part of ISSN: 03005127
Contributors: Prockop, D.J.; Azizi, S.A.; Colter, D.; DiGirolamo, C.; Kopen, G.; Phinney, D.G.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Multipotential marrow stromal cells transduced to produce L-DOPA: Engraftment in a rat model of Parkinson disease

Human Gene Therapy
1999 | Journal article
DOI: 10.1089/10430349950016870
EID:

2-s2.0-0033544028

Part of ISSN: 10430342
Contributors: Schwarz, E.J.; Alexander, G.M.; Prockop, D.J.; Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Engraftment and migration of human bone marrow stromal cells implanted in the brains of albino rats - Similarities to astrocyte grafts

Proceedings of the National Academy of Sciences of the United States of America
1998 | Journal article
DOI: 10.1073/pnas.95.7.3908
EID:

2-s2.0-0032584132

Part of ISSN: 00278424
Contributors: Azizi, S.A.; Stokes, D.; Augelli, B.J.; DiGirolamo, C.; Prockop, D.J.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Adenovirus mediated gene transfer to astrocytes from adult rats: Vehicles for ex vivo gene therapy

Journal of NeuroVirology
1997 | Journal article
EID:

2-s2.0-0031006783

Part of ISSN: 13550284
Contributors: Azizi, S.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Human immunodeficiency virus—associated motor axonal polyradiculoneuropathy

Archives of Neurology
1993 | Journal article
DOI: 10.1001/archneur.1993.00540120031009
EID:

2-s2.0-0027135236

Part of ISSN: 15383687 00039942
Contributors: Goldstein, J.M.; Azizi, S.A.; Booss, J.; Vollmer, T.L.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Interactions of visual and auditory mossy fiber inputs in the paraflocculus of the rat: a gating action of multimodal inputs

Brain Research
1990 | Journal article
DOI: 10.1016/0006-8993(90)91347-J
EID:

2-s2.0-0025185515

Part of ISSN: 00068993
Contributors: Azizi, S.A.; Woodward, D.J.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Survey of noncortical afferent projections to the basilar pontine nuclei: A retrograde tracing study in the rat

Journal of Comparative Neurology
1989 | Journal article
DOI: 10.1002/cne.902820411
EID:

2-s2.0-0024547017

Part of ISSN: 10969861 00219967
Contributors: Mihailoff, G.A.; Kosinski, R.J.; Azizi, S.A.; Border, B.G.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Convergence of cortico- and cuneopontine projections onto components of the pontocerebellar system in the rat: an anatomical and electrophysiological study

Experimental Brain Research
1988 | Journal article
DOI: 10.1007/BF00248746
EID:

2-s2.0-0023811454

Part of ISSN: 00144819 14321106
Contributors: Kosinski, R.J.; Azizi, S.A.; Mihailoff, G.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Electrophysiological actions of norepinephrine in rat lateral hypothalamus. II. An in vitro study of the effects of iontophoretically applied norepinephrine on LH neuronal responses to γ-aminobutyric acid (GABA)

Brain Research
1988 | Journal article
DOI: 10.1016/0006-8993(88)91299-1
EID:

2-s2.0-0023930286

Part of ISSN: 00068993
Contributors: Cheng, J.-T.; Sessler, F.M.; Azizi, S.A.; Chapin, J.K.; Waterhouse, B.D.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

New evidence for a gating action of norepinephrine in central neuronal circuits of mammalian brain

Brain Research Bulletin
1988 | Journal article
DOI: 10.1016/0361-9230(88)90154-2
EID:

2-s2.0-0024157855

Part of ISSN: 03619230
Contributors: Waterhouse, B.D.; Sessler, F.M.; Jung-Tung, C.; Woodward, D.J.; Azizi, S.A.; Moises, H.C.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Inferior olivary nuclear complex of the rat: Morphology and comments on the principles of organization within the olivocerebellar system

Journal of Comparative Neurology
1987 | Journal article
DOI: 10.1002/cne.902630402
EID:

2-s2.0-0023233124

Part of ISSN: 10969861 00219967
Contributors: Azizi, S.A.; Woodward, D.J.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Certain basilar pontine afferent systems are GABA-ergic: Combined HRP and immunocytochemical studies in the rat

Brain Research Bulletin
1986 | Journal article
DOI: 10.1016/0361-9230(86)90113-9
EID:

2-s2.0-0022494530

Part of ISSN: 03619230
Contributors: Border, B.G.; Kosinski, R.J.; Azizi, S.A.; Mihailoff, G.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Origin and ultrastructural identification of dorsal column nuclear synaptic terminals in the basilar pontine gray of rats

Journal of Comparative Neurology
1986 | Journal article
DOI: 10.1002/cne.902530108
EID:

2-s2.0-0022973426

Part of ISSN: 10969861 00219967
Contributors: Kosinski, R.J.; Azizi, S.A.; Border, B.G.; Mihailoff, B.G.A.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

The auditory corticopontocerebellar projection in the rat: inputs to the paraflocculus and midvermis. An anatomical and physiological study

Experimental Brain Research
1985 | Journal article
DOI: 10.1007/BF00237663
EID:

2-s2.0-0022263523

Part of ISSN: 00144819 14321106
Contributors: Azizi, S.A.; Burne, R.A.; Woodward, D.J.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

The pontocerebellar system in the rat: An HRP study. I. Posterior vermis

Journal of Comparative Neurology
1981 | Journal article
DOI: 10.1002/cne.901970402
EID:

2-s2.0-0019430215

Part of ISSN: 10969861 00219967
Contributors: Azizi, S.A.; Mihailoff, G.A.; Burne, R.A.; Woodward, D.J.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

The pontocerebellar system in the rat: An HRP study. II. Hemispheral components

Journal of Comparative Neurology
1981 | Journal article
DOI: 10.1002/cne.901970403
EID:

2-s2.0-0019449090

Part of ISSN: 10969861 00219967
Contributors: Mihailoff, G.A.; Burne, R.A.; Azizi, S.A.; Norell, G.; Woodward, D.J.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

The tectopontine projection in the rat with comments on visual pathways to the basilar pons

Journal of Comparative Neurology
1981 | Journal article
DOI: 10.1002/cne.902020212
EID:

2-s2.0-0019443620

Part of ISSN: 10969861 00219967
Contributors: Burne, R.A.; Azizi, S.A.; Mihailoff, G.A.; Woodward, D.J.
Source: Self-asserted source
Sayed Ausim Azizi via Scopus - Elsevier

Peer review (12 reviews for 2 publications/grants)

Review activity for Journal of neurovirology. (11)
Review activity for Neuroscience letters. (1)
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