Yuxian Shen (0000-0002-0916-0743)

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Biography

沈玉先，博士，二级教授，博士生导师，享受国务院特殊津贴，教育部“新世纪优秀人才支持计划”入选者，省领军人才团队带头人、省“115”产业创新团队带头人、省高校优秀科研团队带头人，省学术技术带头人、省创新争先奖获得者，省教书育人楷模，省先进工作者、全国妇女十二大代表等。现任安徽医科大学基础医学院院长、生物药物研究所所长。

一、教育背景

1984.09-1989.06 安徽医科大学医学系本科/学士
1989.09-1992.06 安徽医科大学药理学专业研究生/硕士
1997.09-2000.06 安徽医科大学药理学专业研究生/博士

二、工作经历
1992.07-1995.06 安徽医科大学临床药理研究所助教
1995.07-1999.10 安徽医科大学临床药理研究所讲师
1999.11-2003.10 安徽医科大学临床药理研究所副教授
2003.02-2004.08 美国马利兰大学生物技术研究所博士后研究
2005.05-2008.12 中国科学技术大学生命科学院博士后研究
2003.11-2007.05 安徽医科大学临床药理研究所教授
2007.06-2010.06 省部共建教育部重点实验室教授

2009.01-2010.12 安徽医科大学护理学院副院长
2010.07-2012.05 安徽医科大学基础医学院教授，常务副院长
2012.06-至今安徽医科大学基础医学院教授，院长

三、研究方向
1.内质网应激与疾病
2.功能蛋白与药物作用靶点
3.蛋白转录后修饰与蛋白降解

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Anhui Medical University: Hefei, Anhui, CN

1992-07-01 to present | Dean (School of Basic Medical Sciences)

Employment

Yuxian Shen

https://orcid.org/0000-0002-0916-0743

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Biography

Activities

Employment (1)

Anhui Medical University: Hefei, Anhui, CN

Education and qualifications (3)

安徽医科大学: 合肥, 安徽省, CN

安徽医科大学: 合肥, 安徽省, CN

安徽医科大学: 合肥, 安徽省, CN

Works (50 of 91)

E3 Ubiquitin Ligase Ring Finger Protein 2 Alleviates Cerebral Ischemia–Reperfusion Injury by Stabilizing Mesencephalic Astrocyte‐Derived Neurotrophic Factor Through Monoubiquitination

MAGED4B Promotes Glioma Progression via Inactivation of the TNF-α-induced Apoptotic Pathway by Down-regulating TRIM27 Expression

PRDX6 Promotes Fatty Acid Oxidation via PLA2-Dependent PPARα Activation in Rats Fed High-Fat Diet

Dynamic tracking of p21 mRNA in living cells by sticky-flares for the visual evaluation of the tumor treatment effect

PRDX6 knockout restrains the malignant progression of intrahepatic cholangiocarcinoma

The momentous role of N6‐methyladenosine in lung cancer

Mono-macrophage-Derived MANF Protects Against Lipopolysaccharide-Induced Acute Kidney Injury via Inhibiting Inflammation and Renal M1 Macrophages

Folic acid modified Fe3O4 nanoclusters by a one-step ultrasonic technique for drug delivery and MR imaging

<p>Advances in Exosome-Based Drug Delivery and Tumor Targeting: From Tissue Distribution to Intracellular Fate</p>

Facile synthesis of multifunctional nanocomposites with good compatibility for efficient dual-mode T1 and T2 magnetic resonance imaging and gene delivery

Xanthatin induces glioma cell apoptosis and inhibits tumor growth via activating endoplasmic reticulum stress-dependent CHOP pathway.

BAF45D Downregulation in Spinal Cord Ependymal Cells Following Spinal Cord Injury in Adult Rats and Its Potential Role in the Development of Neuronal Lesions.

pH-Responsive polyelectrolyte coated gadolinium oxide-doped mesoporous silica nanoparticles (Gd2O3@MSNs) for synergistic drug delivery and magnetic resonance imaging enhancement.

MANF inhibits liver cancer via SUMOylation-related suppression of NF-κB/Snail signaling pathway and epithelial-mesenchymal transition.

The oncogenic impact of RNF2 on cell proliferation, invasion and migration through EMT on mammary carcinoma.

MANF regulates splenic macrophage differentiation in mice.

Microglial proliferation and monocyte infiltration contribute to microgliosis following status epilepticus.

Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress.

Dexmedetomidine Promotes SH-SY5Y Cell Resistance Against Impairment of Iron Overload by Inhibiting NF-κB Pathways.

Xanthatin induces apoptosis by activating endoplasmic reticulum stress in hepatoma cells.

Activator protein‑1 is a novel regulator of mesencephalic astrocyte‑derived neurotrophic factor transcription.

The antitumour growth and antiangiogenesis effects of xanthatin in murine glioma dynamically evaluated by dynamic contrast-enhanced magnetic resonance imaging.

Mitochondrial oxidation of the carbohydrate fuel is required for neural precursor/stem cell function and postnatal cerebellar development.

Mesencephalic Astrocyte-Derived Neurotrophic Factor Prevents Traumatic Brain Injury in Rats by Inhibiting Inflammatory Activation and Protecting the Blood-Brain Barrier.

XBP1 activation enhances MANF expression via binding to endoplasmic reticulum stress response elements within MANF promoter region in hepatitis B.

The BAF45D Protein Is Preferentially Expressed in Adult Neurogenic Zones and in Neurons and May Be Required for Retinoid Acid Induced PAX6 Expression.

1α,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells.

Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response.

Roles of SAMHD1 in antiviral defense, autoimmunity and cancer.

Lactoferrin modified graphene oxide iron oxide nanocomposite for glioma-targeted drug delivery.

Ubiquitin ligase SYVN1/HRD1 facilitates degradation of the SERPINA1 Z variant/α-1-antitrypsin Z variant via SQSTM1/p62-dependent selective autophagy.

MRI Dynamically Evaluates the Therapeutic Effect of Recombinant Human MANF on Ischemia/Reperfusion Injury in Rats.

Rifampicin-induced injury in L02 cells is alleviated by 4-PBA via inhibition of the PERK-ATF4-CHOP pathway.

Small ubiquitin-related modifier 1 is involved in hepatocellular carcinoma progression via mediating p65 nuclear translocation.

Small differences make a big impact: Structural insights into the differential function of the 2 Atg8 homologs in C. elegans.

Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.

Data in support of DPF2 regulates OCT4 protein level and nuclear distribution.

Small ubiquitin-related modifier 2/3 interacts with p65 and stabilizes it in the cytoplasm in HBV-associated hepatocellular carcinoma.

ER stress-inducible protein MANF selectively expresses in human spleen.

DPF2 regulates OCT4 protein level and nuclear distribution.

Interferon-stimulated gene factor 3 complex is required for the induction of sterile α motif and HD domain-containing protein 1 expression by interferon-α in SMMC-7721 cells.

Mesencephalic astrocyte-derived neurotrophic factor is involved in inflammation by negatively regulating the NF-κB pathway.

Identification of MANF as a protein interacting with RTN1-C.

Deficiency of IRE1 and PERK signal pathways in systemic lupus erythematosus.

Circulating endothelial progenitor cells are involved in VEGFR-2-related endothelial differentiation in glioma.

Inhibition of Hepatitis B virus replication by SAMHD1.

Mesencephalic astrocyte-derived neurotrophic factor prevents neuron loss via inhibiting ischemia-induced apoptosis.

Endoplasmic reticulum stress is involved in the neuroprotective effect of propofol.

Toxoplasma gondii virulence factor ROP18 inhibits the host NF-κB pathway by promoting p65 degradation.

Activated macrophage-like synoviocytes are resistant to endoplasmic reticulum stress-induced apoptosis in antigen-induced arthritis.

Peer review (4 reviews for 2 publications/grants)