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Employment (2)

Benaroya Research Institute at Virginia Mason: Seattle, WA, US

2024-04-01 to present | Research assistant member (Center of Fundamental Immunology)
Employment
Source: Self-asserted source
Kazushige Obata-Ninomiya

Benaroya Research Institute: Seattle, US

2018-03-31 to 2024-03-31 | Staff scientist (Ziegler Lab)
Employment
Source: Self-asserted source
Kazushige Obata-Ninomiya

Education and qualifications (3)

Tokyo Medical and Dental University: Tokyo, JP

2006-04-01 to 2009-03-31 | PhD (Department of Immunology)
Education
Source: Self-asserted source
Kazushige Obata-Ninomiya

Tokyo Medical and Dental University: Tokyo, JP

2004-04-01 to 2006-03-31 | M.S. (Department of Immunology)
Education
Source: Self-asserted source
Kazushige Obata-Ninomiya

Hoshi University: Tokyo, JP

2000-04-01 to 2004-03-31 | BPharm, Pharmacist (Department of Microbiology)
Education
Source: Self-asserted source
Kazushige Obata-Ninomiya

Funding (4)

Development of treatment for colorectal cancer targeting on TSLPR+ST2+Treg

2023-09 to 2025-06 | Grant
Washington Research Foundation (Seattle, Washington, US)
Source: Self-asserted source
Kazushige Obata-Ninomiya

Identification of novel targets in a unique subset of Tregs for therapies for colorectal cancer

2023-07 to 2025-06 | Grant
Andy Hill CARE Fund (WA, WA, US)
Source: Self-asserted source
Kazushige Obata-Ninomiya

好塩基球の生体内における機能解析

2010-01-01 to 2012-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.5751816
GRANT_NUMBER: 10J05115
Source: Self-asserted source
Kazushige Obata-Ninomiya via DimensionsWizard

好塩基球の生体内における機能解析

2008-01-01 to 2009-12-31 | Grant
Japan Society for the Promotion of Science (Tokyo, JP)
URL: https://app.dimensions.ai/details/grant/grant.5704021
GRANT_NUMBER: 08J05108
Source: Self-asserted source
Kazushige Obata-Ninomiya via DimensionsWizard

Works (36)

SKI Regulates Medullary Thymic Epithelial Cell Differentiation to Control Peripheral T Cell Responses in Mice

The Journal of Immunology
2024-07-01 | Journal article
DOI: 10.4049/jimmunol.2300262
Contributors: Honyin Chiu; Kristin N Weinstein; Sabine Spath; Alex Hu; Stephanie Varela; Kazushige Obata-Ninomiya; Steven F Ziegler
Source: check_circle
Crossref

From the bench to the clinic: basophils and type 2 epithelial cytokines of thymic stromal lymphopoietin and IL‐33

Clinical & Translational Immunology
2024-01 | Journal article
DOI: 10.1002/cti2.70020
Contributors: Kazushige Obata‐Ninomiya; Tharmalingam Jayaraman; Steven F Ziegler
Source: check_circle
Crossref

Regulatory T cells suppress CD4+ effector T cell activation by controlling protein synthesis

Journal of Experimental Medicine
2023-03-06 | Journal article
DOI: 10.1084/jem.20221676
Contributors: Lomon So; Kazushige Obata-Ninomiya; Alex Hu; Virginia S. Muir; Ayako Takamori; Jing Song; Jane H. Buckner; Ram Savan; Steven F. Ziegler
Source: check_circle
Crossref

CBLB Deficiency in Human CD4+ T Cells Results in Resistance to T Regulatory Suppression through Multiple Mechanisms

The Journal of Immunology
2022-10-01 | Journal article
DOI: 10.4049/jimmunol.2200219
Contributors: Jing Song; Warren Anderson; Alex Hu; Kazushige Obata-Ninomiya; Steven F Ziegler; David J Rawlings; Jane H Buckner
Source: check_circle
Crossref

Emerging role for thymic stromal lymphopoietin–responsive regulatory T cells in colorectal cancer progression in humans and mice

Science Translational Medicine
2022-05-18 | Journal article
DOI: 10.1126/scitranslmed.abl6960
Contributors: Kazushige Obata-Ninomiya; Steven de Jesus Carrion; Alex Hu; Steven F. Ziegler
Source: check_circle
Crossref

Basophils and Eosinophils in Nematode Infections

Frontiers in Immunology
2020-11-27 | Journal article
DOI: 10.3389/fimmu.2020.583824
Part of ISSN: 1664-3224
Source: Self-asserted source
Kazushige Obata-Ninomiya

Epithelial cell–derived cytokines: more than just signaling the alarm

Journal of Clinical Investigation
2019-04-01 | Journal article
DOI: 10.1172/jci124606
Part of ISSN: 0021-9738
Contributors: Florence Roan; Kazushige Obata-Ninomiya; Steven F. Ziegler
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search
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Preferred source (of 2)‎

Ezh2 controls development of natural killer T cells that cause spontaneous asthma-like pathology

Journal of Allergy and Clinical Immunology
2019-03 | Journal article
DOI: 10.1016/j.jaci.2019.02.024
Part of ISSN: 0091-6749
Contributors: Damon Tumes; Kiyoshi Hirahara; Magdalene Papadopoulos; Kenta Shinoda; Atsushi Onodera; Jin Kumagai; Kwok Ho Yip; Harshita Pant; Kota Kokubo; Kiuchi Masahiro et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

ACC1 determines memory potential of individual CD4+ T cells by regulating de novo fatty acid biosynthesis

Nature Metabolism
2019-01 | Journal article
DOI: 10.1038/s42255-018-0025-4
Part of ISSN: 2522-5812
Contributors: Yusuke Endo; Atsushi Onodera; Kazushige Obata-Ninomiya; Ryo Koyama-Nasu; Hikari K. Asou; Toshihiro Ito; Takeshi Yamamoto; Toshio Kanno; Takahiro Nakajima; Kenji Ishiwata et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

CXCR6+ST2+ memory T helper 2 cells induced the expression of major basic protein in eosinophils to reduce the fecundity of helminth

Proceedings of the National Academy of Sciences
2018-10-01 | Journal article
DOI: 10.1073/pnas.1714731115
Part of ISSN: 0027-8424
Contributors: Kazushige Obata-Ninomiya; Kenji Ishiwata; Hisanobu Nakano; Yusuke Endo; Tomomi Ichikawa; Atsushi Onodera; Kiyoshi Hirahara; Yoshitaka Okamoto; Hirotaka Kanuka; Toshinori Nakayama
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

IL-33/ST2 contributes to severe symptoms in Plasmodium chabaudi -infected BALB/c mice

Parasitology International
2018-02 | Journal article
DOI: 10.1016/j.parint.2017.03.008
Part of ISSN: 1383-5769
Contributors: Takenori Seki; Kazushige Obata-Ninomiya; Rieko Shimogawara-Furushima; Toshio Arai; Nobuaki Akao; Tomoaki Hoshino; Nobuo Ohta
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

Basophils Trigger Fibroblast Activation in Cardiac Allograft Fibrosis Development.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
2016-03 | Journal article
DOI: 10.1111/ajt.13764
PMID: 26932231
Contributors: Schiechl G; Hermann FJ; Rodriguez Gomez M; Kutzi S; Schmidbauer K; Talke Y; Neumayer S; Goebel N; Renner K; Brühl H et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

The Ectoenzyme E-NPP3 Negatively Regulates ATP-Dependent Chronic Allergic Responses by Basophils and Mast Cells

Immunity
2015-02 | Journal article
DOI: 10.1016/j.immuni.2015.01.015
Part of ISSN: 1074-7613
Contributors: Shih Han Tsai; Makoto Kinoshita; Takashi Kusu; Hisako Kayama; Ryu Okumura; Kayo Ikeda; Yosuke Shimada; Akira Takeda; Soichiro Yoshikawa; Kazushige Obata-Ninomiya et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway

Immunity
2015-02 | Journal article
DOI: 10.1016/j.immuni.2015.01.016
Part of ISSN: 1074-7613
Contributors: Yusuke Endo; Kiyoshi Hirahara; Tomohisa Iinuma; Kenta Shinoda; Damon J. Tumes; Hikari K. Asou; Nao Matsugae; Kazushige Obata-Ninomiya; Heizaburo Yamamoto; Shinichiro Motohashi et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

NADPH oxidase-independent formation of extracellular DNA traps by basophils

American Association of Immunologists
2014 | Other
DOI: 10.7892/boris.54047
Contributors: Ruslan Hlushchuk; Hajime Karasuyama; Morshed, Md. Mahbubul; Dagmar Simon; Shida Yousefi; Alexander Eggel; Valentin Djonov; Hans-Uwe Simon; Andrew F. Walls; Thomas Kaufmann et al.
Source: check_circle
DataCite

Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.

Proceedings of the National Academy of Sciences of the United States of America
2014-08 | Journal article
DOI: 10.1073/pnas.1321245111
PMID: 25136117
PMC: PMC4156753
Contributors: Watanabe Y; Onodera A; Kanai U; Ichikawa T; Obata-Ninomiya K; Wada T; Kiuchi M; Iwamura C; Tumes DJ; Shinoda K et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

NADPH Oxidase-Independent Formation of Extracellular DNA Traps by Basophils

The Journal of Immunology
2014-04 | Journal article
DOI: 10.4049/jimmunol.1303418
Part of ISSN: 0022-1767
Contributors: M. Morshed; R. Hlushchuk; D. Simon; A. F. Walls; K. Obata-Ninomiya; H. Karasuyama; V. Djonov; A. Eggel; T. Kaufmann; H.-U. Simon et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

Basophil depletion downregulates Schistosoma mansoni egg-induced granuloma formation

Parasitology International
2013 | Journal article
DOI: 10.1016/j.parint.2013.07.003
Part of ISSN: 1383-5769
Contributors: William K. Anyan; Takenori Seki; Takashi Kumagai; Kazushige Obata-Ninomiya; Rieko Furushima-Shimogawara; Bethel Kwansa-Bentum; Nobuaki Akao; Kwabena M. Bosompem; Daniel A. Boakye; Michael D. Wilson et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

Comparative studies of serum-free media and detection techniques for <i>in vitro</i> drug sensitivity assessment of <i>Plasmodium falciparum</i>

Open Journal of Clinical Diagnostics
2013 | Journal article
DOI: 10.4236/ojcd.2013.33020
Part of ISSN: 2162-5816
Contributors: Bethel Kwansa-Bentum; Shinji Izumiyama; Kei Kitamura; Kazushige Obata-Ninomiya; Nobuo Ohta; Hiroko Asahi
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

GATA-1 regulates the generation and function of basophils

Proceedings of the National Academy of Sciences
2013-10 | Journal article
DOI: 10.1073/pnas.1311668110
Part of ISSN: 0027-8424
Contributors: Y. Nei; K. Obata-Ninomiya; H. Tsutsui; K. Ishiwata; M. Miyasaka; K. Matsumoto; S. Nakae; H. Kanuka; N. Inase; H. Karasuyama
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

The skin is an important bulwark of acquired immunity against intestinal helminths

The Journal of Experimental Medicine
2013-10 | Journal article
DOI: 10.1084/jem.20130761
Part of ISSN: 0022-1007
Contributors: Kazushige Obata-Ninomiya; Kenji Ishiwata; Hidemitsu Tsutsui; Yuichiro Nei; Soichiro Yoshikawa; Yohei Kawano; Yoshiyuki Minegishi; Nobuo Ohta; Naohiro Watanabe; Hirotaka Kanuka et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Crossref Metadata Search

Thymic stromal lymphopoietin-elicited basophil responses promote eosinophilic esophagitis.

Nature medicine
2013-07 | Journal article
DOI: 10.1038/nm.3281
PMID: 23872715
PMC: PMC3951204
Contributors: Noti M; Wojno ED; Kim BS; Siracusa MC; Giacomin PR; Nair MG; Benitez AJ; Ruymann KR; Muir AB; Hill DA et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction.

Journal of dermatological science
2012-06 | Journal article
DOI: 10.1016/j.jdermsci.2012.06.005
PMID: 22784785
Contributors: Jin G; Matsushita T; Hamaguchi Y; Le Huu D; Ishii T; Hasegawa M; Obata K; Karasuyama H; Takehara K; Fujimoto M
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Basophil-derived mouse mast cell protease 11 induces microvascular leakage and tissue edema in a mast cell-independent manner.

Biochemical and biophysical research communications
2011-11 | Journal article
DOI: 10.1016/j.bbrc.2011.10.150
PMID: 22086176
Contributors: Yamagishi H; Mochizuki Y; Hamakubo T; Obata K; Ugajin T; Sato S; Kawano Y; Minegishi Y; Karasuyama H
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Nonredundant roles of basophils in immunity.

Annual review of immunology
2011-01 | Journal article
DOI: 10.1146/annurev-immunol-031210-101257
PMID: 21166539
Contributors: Karasuyama H; Mukai K; Obata K; Tsujimura Y; Wada T
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Emerging roles of basophils in protective immunity against parasites.

Trends in immunology
2010-12 | Journal article
DOI: 10.1016/j.it.2010.11.006
PMID: 21168364
Contributors: Karasuyama H; Wada T; Yoshikawa S; Obata K
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

IgG-mediated systemic anaphylaxis to protein antigen can be induced even under conditions of limited amounts of antibody and antigen.

Biochemical and biophysical research communications
2010-10 | Journal article
DOI: 10.1016/j.bbrc.2010.10.098
PMID: 21029722
Contributors: Ishikawa R; Tsujimura Y; Obata K; Kawano Y; Minegishi Y; Karasuyama H
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Selective ablation of basophils in mice reveals their nonredundant role in acquired immunity against ticks.

The Journal of clinical investigation
2010-07 | Journal article
DOI: 10.1172/JCI42680
PMID: 20664169
PMC: PMC2912199
Contributors: Wada T; Ishiwata K; Koseki H; Ishikura T; Ugajin T; Ohnuma N; Obata K; Ishikawa R; Yoshikawa S; Mukai K et al.
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Role for basophils in systemic anaphylaxis.

Chemical immunology and allergy
2010-06 | Journal article
DOI: 10.1159/000315939
PMID: 20519883
Contributors: Karasuyama H; Tsujimura Y; Obata K; Mukai K
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Basophils preferentially express mouse Mast Cell Protease 11 among the mast cell tryptase family in contrast to mast cells.

Journal of leukocyte biology
2009-12 | Journal article
DOI: 10.1189/jlb.0609400
PMID: 19703899
Contributors: Ugajin T; Kojima T; Mukai K; Obata K; Kawano Y; Minegishi Y; Eishi Y; Yokozeki H; Karasuyama H
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

[The roles for basophils in allergy].

Nihon rinsho. Japanese journal of clinical medicine
2009-11 | Journal article
PMID: 19899522
Contributors: Mukai K; Obata K; Tsujimura Y; Karasuyama H
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

New insights into the roles for basophils in acute and chronic allergy.

Allergology international : official journal of the Japanese Society of Allergology
2009-01 | Journal article
DOI: 10.2332/allergolint.08-rai-0059
PMID: 19153532
Contributors: Mukai K; Obata K; Tsujimura Y; Karasuyama H
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Newly discovered roles for basophils: a neglected minority gains new respect.

Nature reviews. Immunology
2009-01 | Journal article
DOI: 10.1038/nri2458
PMID: 19039320
Contributors: Karasuyama H; Mukai K; Tsujimura Y; Obata K
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Fc receptor gamma-chain, a constitutive component of the IL-3 receptor, is required for IL-3-induced IL-4 production in basophils.

Nature immunology
2008-12 | Journal article
DOI: 10.1038/ni.1686
PMID: 19098920
Contributors: Hida S; Yamasaki S; Sakamoto Y; Takamoto M; Obata K; Takai T; Karasuyama H; Sugane K; Saito T; Taki S
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Mast cells and basophils are selectively activated in vitro and in vivo through CD200R3 in an IgE-independent manner.

Journal of immunology (Baltimore, Md. : 1950)
2007-11 | Journal article
DOI: 10.4049/jimmunol.179.10.7093
PMID: 17982101
Contributors: Kojima T; Obata K; Mukai K; Sato S; Takai T; Minegishi Y; Karasuyama H
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central

Basophils are essential initiators of a novel type of chronic allergic inflammation.

Blood
2007-04 | Journal article
DOI: 10.1182/blood-2007-01-068718
PMID: 17409268
Contributors: Obata K; Mukai K; Tsujimura Y; Ishiwata K; Kawano Y; Minegishi Y; Watanabe N; Karasuyama H
Source: Self-asserted source
Kazushige Obata-Ninomiya via Europe PubMed Central
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