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Biography

Christopher S. Colwell is a Neuroscientist who has served on the UCLA School of Medicine faculty since he joined the Department of Psychiatry and Biobehavioral Sciences in 1997. He is presently head of the Laboratory of Circadian and Sleep Medicine in the Semel Institute. Colwell is the author of over 100 basic science studies on our body’s clock. He recently edited the book entitled "Circadian Medicine." His group is presently examining whether behavioral interventions including scheduled exercise, food availability, lighting regimes and diet can delay the onset of age and disease related decline in the sleep/wake cycle. The results of these experiments should provide insights into how to minimize the impact of disease-related changes in the circadian timing system on human health and safety.

Activities

Employment (1)

University of California Los Angeles: Los Angeles, CA, US

1997-09-01 to present | Professor (Psychiatry)
Employment
Source: Self-asserted source
Christopher Colwell

Education and qualifications (2)

University of Virginia: Charlottesville, VA, US

1987-01-01 to 1991-05-25 | PhD (Biology)
Education
Source: Self-asserted source
Christopher Colwell

Vanderbilt University: Nashville, TN, US

1981-09-01 to 1985-05-31 | BS (Neuroscience)
Education
Source: Self-asserted source
Christopher Colwell

Works (50 of 159)

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Page 1 of 4

Contributors

2024 | Book chapter
Contributors: Jeffrey S. Aaronson; Juliana Abramovich; Neil Aronin; Monica Bañez-Coronel; Gillian P. Bates; Michael Brodsky; Richard Z. Chen; John Douglas Cleary; Christopher S. Colwell; Ileana M. Cristea et al.
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The promise of an underappreciated therapeutic target: Sleep and circadian rhythm dysfunction in Huntington's disease

2024 | Book chapter
Contributors: Christopher S. Colwell; Weiyi Tan; A. Jennifer Morton
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Newly defined neural population in lateral amygdala is responsible for circadian rhythms in anxiety and touch sensitivity

Neuron
2024-11 | Journal article
Contributors: Christopher S. Colwell
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Scheduled feeding improves behavioral outcomes and reduces inflammation in a mouse model of Fragile X syndrome

2024-09-16 | Preprint
Contributors: Huei Bin Wang; Natalie E. Smale; Sarah H. Brown; Sophia Anne Marie Villanueva; David Zhou; Aly Mulji; Kyle Nguyen-Ngo; John R. Harvey; Cristina A. Ghiani; Christopher S. Colwell
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Relative importance of intensity and spectrum of artificial light at night in disrupting behavior of a nocturnal rodent

Journal of Experimental Biology
2024-07-15 | Journal article
Contributors: Travis Longcore; Sophia Anne Marie B. Villanueva; Kyle Nguyen-Ngo; Cristina A. Ghiani; Benjamin Harrison; Christopher S. Colwell
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Scheduled feeding improves sleep in a mouse model of Huntington’s disease

2024-05-07 | Preprint
Contributors: Emily Chiem; Kevin Zhao; Derek Dell’Angelica; Cristina A. Ghiani; Ketema N. Paul; Christopher S. Colwell
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Sex differences in sleep architecture in a mouse model of Huntington's disease

Journal of Neuroscience Research
2024-01 | Journal article
Contributors: Emily Chiem; Kevin Zhao; Gemma Stark; Cristina A. Ghiani; Christopher S. Colwell; Ketema N. Paul
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Sleep disorders, sleep medication use, and predictors of sleep disturbance in children with persistent tic disorders

Children's Health Care
2024-01-02 | Journal article
Contributors: Valerie S. Swisher; Maya S. Tooker; Christine Qu; Helen J. Burgess; Meredith E. Coles; Shannon M. Bennett; John Piacentini; Christopher S. Colwell; Emily J. Ricketts
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Crossref

Motor Activity-Induced White Matter Repair in White Matter Stroke

The Journal of Neuroscience
2023-11-29 | Journal article
Contributors: Miguel A. Marin; Amy J. Gleichman; Xiaofei Wei; Daniel S. Whittaker; Istvan Mody; Christopher S. Colwell; S. Thomas Carmichael
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A Randomized, Double-Blind, Placebo Controlled Trial to Assess the Effectiveness and Safety of Melatonin and Three Formulations of Floraworks Proprietary TruCBNâ„¢ for Improving Sleep

2023-11-08 | Preprint
Contributors: Antonija Kolobaric; Jessica Saleska; Susan J Hewlings; Corey Bryant; Christopher S. Colwell; Christopher R. D’Adamo; Jeff Chen; Emily K Pauli
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Crossref

A Randomized, Double-Blind, Placebo-Controlled Decentralized Trial to Assess Sleep, Health Outcomes, and Overall Well-Being in Healthy Adults Reporting Disturbed Sleep, Taking a Melatonin-Free Supplement

Nutrients
2023-08-30 | Journal article
Contributors: Antonija Kolobaric; Susan J. Hewlings; Corey Bryant; Christopher S. Colwell; Christopher R. D’Adamo; Bernard Rosner; Jeff Chen; Emily K. Pauli
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A randomized, double-blind, placebo-controlled decentralized trial to assess sleep, health outcomes, and overall well-being in healthy adults reporting disturbed sleep, taking a melatonin-free supplement

2023-07-06 | Preprint
Contributors: Antonija Kolobaric; Susan J Hewlings; Corey Bryant; Chris Colwell; Chris D’Adamo; Bernard Rosner; Jeff Chen; Emily K Pauli
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Crossref

Sex Differences in Sleep Phenotypes in the BACHD Mouse Model of Huntington’s Disease

2023-04-28 | Preprint
Contributors: Emily Chiem; Kevin Zhao; Gemma Stark; Cristina A. Ghiani; Christopher S. Colwell; Ketema N. Paul
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Crossref

Circadian modulation by time-restricted feeding restores brain transcription and slows amyloid deposition in a mouse model of Alzheimer’s disease

2022-10-07 | Preprint
Contributors: Daniel S. Whittaker; Laila Akhmetova; Haylie Romero; David K. Welsh; Christopher S. Colwell; Paula Desplats
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Crossref

Electric lighting, adolescent sleep and circadian outcomes, and recommendations for improving light health

Sleep Medicine Reviews
2022-08 | Journal article
Contributors: Emily J. Ricketts; Daniel S. Joyce; Ariel J. Rissman; Helen J. Burgess; Christopher S. Colwell; Leon C. Lack; Michael Gradisar
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Crossref

Sleep and chronotype in adults with persistent tic disorders

Journal of Clinical Psychology
2022-07 | Journal article
Contributors: Emily J. Ricketts; Gabrielle E. Montalbano; Helen J. Burgess; Dana L. McMakin; Meredith E. Coles; John Piacentini; Christopher S. Colwell
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Crossref

Time-restricted feeding prevents deleterious metabolic effects of circadian disruption through epigenetic control of β cell function

Science Advances
2021-12-17 | Journal article
Contributors: Matthew R. Brown; Satish K. Sen; Amelia Mazzone; Tracy K. Her; Yuning Xiong; Jeong-Heon Lee; Naureen Javeed; Christopher S. Colwell; Kuntol Rakshit; Nathan K. LeBrasseur et al.
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Crossref

Defining circadian disruption in neurodegenerative disorders

Journal of Clinical Investigation
2021-10-01 | Journal article
Contributors: Christopher S. Colwell
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Crossref

Oestrogen inhibits salt-dependent hypertension by suppressing GABAergic excitation in magnocellular AVP neurons

Cardiovascular Research
2021-08-29 | Journal article
Contributors: Xiangyan Jin; Woong Bin Kim; Mi-Na Kim; Won Woo Jung; Hyung Kyung Kang; Eun-Hwa Hong; Yoon Sik Kim; Wan Joo Shim; Hee Chul Han; Christopher S Colwell et al.
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Crossref

Potential Circadian Rhythms in Oligodendrocytes? Working Together Through Time

Neurochemical Research
2020-03-25 | Journal article
Contributors: Christopher S. Colwell; Cristina A. Ghiani
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Crossref

Circadian dysfunction in the Q175 model of Huntington's disease: Network analysis

Journal of Neuroscience Research
2019-12 | Journal article
Contributors: Benjamin Smarr; Tamara Cutler; Dawn H. Loh; Takashi Kudo; Dika Kuljis; Lance Kriegsfeld; Cristina A. Ghiani; Christopher S. Colwell
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Michael S. Levine: Research pioneer of basal ganglia function and dysfunction. A small tribute on the occasion of his 75th birthday anniversary

Journal of Neuroscience Research
2019-12 | Journal article
Contributors: Carlos Cepeda; Christopher Scott Colwell
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Crossref

Pathophysiology in the suprachiasmatic nucleus in mouse models of Huntington’s disease

Journal of Neuroscience Research
2018-12 | Journal article
Contributors: Dika Kuljis; Takashi Kudo; Yu Tahara; Cristina A. Ghiani; Christopher S. Colwell
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Crossref

Circadian-based Treatment Strategy Effective in the BACHD Mouse Model of Huntington’s Disease

Journal of Biological Rhythms
2018-10 | Journal article
Contributors: Daniel S. Whittaker; Dawn H. Loh; Huei-Bin Wang; Yu Tahara; Dika Kuljis; Tamara Cutler; Cristina A. Ghiani; Shigenobu Shibata; Gene D. Block; Christopher S. Colwell
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Crossref

Time-Restricted Feeding Improves Circadian Dysfunction as well as Motor Symptoms in the Q175 Mouse Model of Huntington’s Disease

eneuro
2018-01 | Journal article
Contributors: Huei-Bin Wang; Dawn H. Loh; Daniel S. Whittaker; Tamara Cutler; David Howland; Christopher S. Colwell
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Crossref

Blue light therapy improves circadian dysfunction as well as motor symptoms in two mouse models of Huntington's disease

Neurobiology of Sleep and Circadian Rhythms
2017 | Journal article
EID:

2-s2.0-85016146494

Contributors: Wang, H.-B.; Whittaker, D.S.; Truong, D.; Mulji, A.K.; Ghiani, C.A.; Loh, D.H.; Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Corrigendum to "Sleep functioning in adults with trichotillomania (hair-pulling disorder), excoriation (skin-picking) disorder, and a non-affected comparison sample" [Journal of Obsessive-Compulsive and Related Disorders 13 (2017) 49-57]

Journal of Obsessive-Compulsive and Related Disorders
2017 | Journal article
EID:

2-s2.0-85036512142

Contributors: Ricketts, E.J.; Snorrason, I.; Rozenman, M.; Colwell, C.S.; McCracken, J.T.; Piacentini, J.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Development of diabetes does not alter behavioral and molecular circadian rhythms in a transgenic rat model of type 2 diabetes mellitus

American Journal of Physiology - Endocrinology and Metabolism
2017 | Journal article
EID:

2-s2.0-85027039007

Contributors: Qian, J.; Thomas, A.P.; Schroeder, A.M.; Rakshit, K.; Colwell, C.S.; Matveyenko, A.V.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Membrane currents, gene expression, and circadian clocks

Cold Spring Harbor Perspectives in Biology
2017 | Journal article
EID:

2-s2.0-85009142258

Contributors: Allen, C.N.; Nitabach, M.N.; Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Neurocardiovascular deficits in the Q175 mouse model of Huntington's disease

Physiological Reports
2017 | Journal article
EID:

2-s2.0-85020789924

Contributors: Cutler, T.S.; Park, S.; Loh, D.H.; Jordan, M.C.; Yokota, T.; Roos, K.P.; Ghiani, C.A.; Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier
grade
Preferred source (of 2)‎

Possible use of a H3R antagonist for the management of nonmotor symptoms in the Q175 mouse model of Huntington's disease

Pharmacology Research and Perspectives
2017 | Journal article
EID:

2-s2.0-85030237010

Contributors: Whittaker, D.S.; Wang, H.-B.; Loh, D.H.; Cachope, R.; Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier
grade
Preferred source (of 2)‎

Sleep functioning in adults with trichotillomania (hair-pulling disorder), excoriation (skin-picking) disorder, and a non-affected comparison sample

Journal of Obsessive-Compulsive and Related Disorders
2017 | Journal article
EID:

2-s2.0-85011271385

Contributors: Ricketts, E.J.; Snorrason, I.; Rozenman, M.; Colwell, C.S.; McCracken, J.T.; Piacentini, J.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Titanium biomaterials with complex surfaces induced aberrant peripheral circadian rhythms in bone marrow mesenchymal stromal cells

PLoS ONE
2017 | Journal article
EID:

2-s2.0-85027564470

Contributors: Hassan, N.; McCarville, K.; Morinaga, K.; Mengatto, C.M.; Langfelder, P.; Hokugo, A.; Tahara, Y.; Colwell, C.S.; Nishimura, I.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Cardiac Dysfunction in the BACHD Mouse Model of Huntington's Disease

PloS one
2016 | Journal article
EID:

2-s2.0-84991723831

Contributors: Schroeder, A.M.; Wang, H.B.; Park, S.; Jordan, M.C.; Gao, F.; Coppola, G.; Fishbein, M.C.; Roos, K.P.; Ghiani, C.A.; Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Circadian Rhythms: Does Burning the Midnight Oil Leave You Weak?

Current Biology
2016 | Journal article
EID:

2-s2.0-84992597923

Contributors: Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Histamine 1 receptor-G<inf>βγ</inf>-cAMP/PKA-CFTR pathway mediates the histamine-induced resetting of the suprachiasmatic circadian clock

Molecular Brain
2016 | Journal article
EID:

2-s2.0-84969524196

Contributors: Kim, Y.S.; Kim, Y.-B.; Kim, W.B.; Lee, S.W.; Oh, S.B.; Han, H.-C.; Lee, C.J.; Colwell, C.S.; Kim, Y.I.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Sex differences in circadian dysfunction in the BACHD mouse model of Huntington's disease

PLoS ONE
2016 | Journal article
EID:

2-s2.0-84960473751

Contributors: Kuljis, D.A.; Gad, L.; Loh, D.H.; Kaswan, Z.M.; Hitchcock, O.N.; Ghiani, C.A.; Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Can we Fix a Broken Clock?

Circadian Medicine
2015 | Book
EID:

2-s2.0-85018815905

Contributors: Schroeder, A.M.; Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Circadian disruption and diet-induced obesity synergize to promote development of β-cell failure and diabetes in male rats

Endocrinology
2015 | Journal article
EID:

2-s2.0-84948144133

Contributors: Qian, J.; Yeh, B.; Rakshit, K.; Colwell, C.S.; Matveyenko, A.V.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Circadian dysfunction in huntington’s disease

Mechanisms of Circadian Systems in Animals and Their Clinical Relevance
2015 | Book
EID:

2-s2.0-84944598566

Contributors: Kuljis, D.; Schroeder, A.M.; Kudo, T.; Loh, D.H.; Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Circadian Dysfunction in Parkinson's Disease

Circadian Medicine
2015 | Book
EID:

2-s2.0-85018857500

Contributors: Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Circadian rhythm disruption in a mouse model of Rett syndrome circadian disruption in RTT

Neurobiology of Disease
2015 | Journal article
EID:

2-s2.0-84925147674

Contributors: Li, Q.; Loh, D.H.; Kudo, T.; Truong, D.; Derakhshesh, M.; Kaswan, Z.M.; Ghiani, C.A.; Tsoa, R.; Cheng, Y.; Sun, Y.E. et al.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

GABAergic inhibition is weakened or converted into excitation in the oxytocin and vasopressin neurons of the lactating rat

Molecular Brain
2015 | Journal article
EID:

2-s2.0-84929845138

Contributors: Lee, S.W.; Kim, Y.-B.; Kim, J.S.; Kim, W.B.; Kim, Y.S.; Han, H.C.; Colwell, C.S.; Cho, Y.-W.; Kim, Y.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Histamine resets the circadian clock in the suprachiasmatic nucleus through the H1R-Ca<inf>V</inf>1.3-RyR pathway in the mouse

European Journal of Neuroscience
2015 | Journal article
EID:

2-s2.0-84942984677

Contributors: Kim, Y.S.; Kim, Y.-B.; Kim, W.B.; Yoon, B.-E.; Shen, F.-Y.; Lee, S.W.; Soong, T.-W.; Han, H.-C.; Colwell, C.S.; Lee, C.J. et al.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

How a Disrupted Clock may Cause a Decline in Learning and Memory

Circadian Medicine
2015 | Book
EID:

2-s2.0-85018857942

Contributors: Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Misaligned feeding impairs memories

eLife
2015 | Journal article
EID:

2-s2.0-84955249787

Contributors: Loh, D.H.; Jami, S.A.; Flores, R.E.; Truong, D.; Ghiani, C.A.; O'Dell, T.J.; Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Preface

Circadian Medicine
2015 | Book
EID:

2-s2.0-85018822890

Contributors: Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Reductions in synaptic proteins and selective alteration of prepulse inhibition in male C57BL/6 mice after postnatal administration of a VIP receptor (VIPR2) agonist

Psychopharmacology
2015 | Journal article
EID:

2-s2.0-84929340167

Contributors: Ago, Y.; Condro, M.C.; Tan, Y.-V.; Ghiani, C.A.; Colwell, C.S.; Cushman, J.D.; Fanselow, M.S.; Hashimoto, H.; Waschek, J.A.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Role of vasoactive intestinal peptide in the light input to the circadian system

European Journal of Neuroscience
2015 | Journal article
EID:

2-s2.0-84937253113

Contributors: Vosko, A.; van Diepen, H.C.; Kuljis, D.; Chiu, A.M.; Heyer, D.; Terra, H.; Carpenter, E.; Michel, S.; Meijer, J.H.; Colwell, C.S.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier

Sex differences in diurnal rhythms of food intake in mice caused by gonadal hormones and complement of sex chromosomes

Hormones and Behavior
2015 | Journal article
EID:

2-s2.0-84938696205

Contributors: Chen, X.; Wang, L.; Loh, D.H.; Colwell, C.S.; Taché, Y.; Reue, K.; Arnold, A.P.
Source: Self-asserted source
Christopher Colwell via Scopus - Elsevier
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Peer review (21 reviews for 16 publications/grants)

Review activity for BMJ mental health. (1)
Review activity for Communications biology. (1)
Review activity for EMBO journal. (1)
Review activity for F1000Research. (1)
Review activity for Nature communications (4)
Review activity for Nature neuroscience. (1)
Review activity for Nature reviews. (1)
Review activity for Neurobiology of stress. (1)
Review activity for Neuron. (2)
Review activity for Neuropsychopharmacology. (1)
Review activity for Neurotherapeutics. (1)
Review activity for npj aging and mechanisms of disease. (1)
Review activity for Peptides. (2)
Review activity for PLoS biology. (1)
Review activity for Stem cell reports. (1)
Review activity for Wellcome open research. (1)