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Scopus Author ID: 22734209500
ResearcherID: L-6921-2015
Loop profile: 269245

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University of Oxford: Oxford, Oxfordshire, GB

(Structural Genomics Consortium; Target Discovery Institute)
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ORCID Integration at the University of Oxford

Works (50 of 66)

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Drug repurposing in amyotrophic lateral sclerosis (ALS)

Expert Opinion on Drug Discovery
2025-04-03 | Journal article
DOI: 10.1080/17460441.2025.2474661
Contributors: Emily Carroll; Jakub Scaber; Kilian V. M. Huber; Paul E. Brennan; Alexander G. Thompson; Martin R. Turner; Kevin Talbot
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Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence

2025-03-26 | Preprint
DOI: 10.1101/2025.03.25.645228
Contributors: Jinsen Lu; Srinivasa Rao Rao; Helen Knowles; Haoqun Zhan; Beatriz Gamez; Eleanor Platt; Lucy R. Frost; Tiffany-Jayne Allen; Gayle Marshall; Kilian V.M. Huber et al.
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Pharmacological targeting of BMAL1 modulates circadian and immune pathways

Nature Chemical Biology
2025-03-25 | Journal article
DOI: 10.1038/s41589-025-01863-x
Contributors: Hua Pu; Laura C. Bailey; Ludwig G. Bauer; Maria Voronkov; Matthew Baxter; Kilian V. M. Huber; Sepideh Khorasanizadeh; David Ray; Fraydoon Rastinejad
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Paralogue-Selective Degradation of the Lysine Acetyltransferase EP300

JACS Au
2024-08-26 | Journal article
DOI: 10.1021/jacsau.4c00442
Contributors: Xuemin Chen; McKenna C. Crawford; Ying Xiong; Anver Basha Shaik; Kiall F. Suazo; Ludwig G. Bauer; Manini S. Penikalapati; Joycelyn H. Williams; Kilian V. M. Huber; Thorkell Andressen et al.
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Open resources for chemical probes and their implications for future drug discovery

Expert Opinion on Drug Discovery
2023-05-04 | Journal article
DOI: 10.1080/17460441.2023.2199979
Contributors: Esra Balıkçı; Anne-Sophie M. C. Marques; Jesper S. Hansen; Kilian V. M. Huber
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Covalent fragment-based ligand screening approaches for identification of novel ubiquitin proteasome system modulators

Biological Chemistry
2022-03-28 | Journal article
DOI: 10.1515/hsz-2021-0396
Contributors: Elisabeth M. Rothweiler; Paul E. Brennan; Kilian V. M. Huber
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A chemical biology toolbox to investigate in-cell target engagement and specificity of PRMT5-inhibitors

2022-01-22 | Preprint
DOI: 10.1101/2022.01.20.477145
Contributors: Elisabeth M. Rothweiler; Jakub Stefaniak; Jennifer A. Ward; Catherine Rogers; Esra Balikci; Kilian V. M. Huber
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Chemoproteomic Profiling of Covalent XPO1 Inhibitors to Assess Target Engagement and Selectivity

ChemBioChem
2021-06-15 | Journal article
DOI: 10.1002/cbic.202100038
Contributors: Jeffrey G. Martin; Jennifer A. Ward; Felix Feyertag; Lu Zhang; Shalise Couvertier; Kevin Guckian; Kilian V. M. Huber; Douglas S. Johnson
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Fragment Screening Reveals Starting Points for Rational Design of Galactokinase 1 Inhibitors to Treat Classic Galactosemia

ACS Chemical Biology
2021-04-16 | Journal article
DOI: 10.1021/acschembio.0c00498
Contributors: Sabrina R. Mackinnon; Tobias Krojer; William R. Foster; Laura Diaz-Saez; Manshu Tang; Kilian V. M. Huber; Frank von Delft; Kent Lai; Paul E. Brennan; Gustavo Arruda Bezerra et al.
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TP-MAP - an Integrated Software Package for the Analysis of 1D and 2D Thermal Profiling Data

2021-02-23 | Preprint
DOI: 10.1101/2021.02.22.432361
Contributors: Felix Feyertag; Kilian V.M. Huber
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Importance of Quantifying Drug-Target Engagement in Cells

ACS Medicinal Chemistry Letters
2020-04-09 | Journal article
DOI: 10.1021/acsmedchemlett.9b00570
Contributors: Jakub Stefaniak; Kilian V. M. Huber
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Re-Evaluating the Mechanism of Action of α,β-Unsaturated Carbonyl DUB Inhibitors b-AP15 and VLX1570: A Paradigmatic Example of Unspecific Protein Cross-linking with Michael Acceptor Motif-Containing Drugs

Journal of Medicinal Chemistry
2020-04-09 | Journal article
DOI: 10.1021/acs.jmedchem.0c00144
Contributors: Jennifer A. Ward; Adan Pinto-Fernandez; Loïc Cornelissen; Sarah Bonham; Laura Díaz-Sáez; Olivier Riant; Kilian V. M. Huber; Benedikt M. Kessler; Olivier Feron; Edward W. Tate
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A chemical biology toolbox to study protein methyltransferases and epigenetic signaling

Nature Communications
2019 | Journal article
DOI: 10.1038/s41467-018-07905-4
EID:

2-s2.0-85059495359
Contributors: Scheer, S.; Ackloo, S.; Medina, T.S.; Schapira, M.; Li, F.; Ward, J.A.; Lewis, A.M.; Northrop, J.P.; Richardson, P.L.; Kaniskan, H.Ü. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Design, Synthesis and Characterization of Covalent KDM5 Inhibitors

Angewandte Chemie - International Edition
2019 | Journal article
DOI: 10.1002/anie.201810179
EID:

2-s2.0-85058138887
Contributors: Vazquez-Rodriguez, S.; Wright, M.; Rogers, C.M.; Cribbs, A.P.; Velupillai, S.; Philpott, M.; Lee, H.; Dunford, J.E.; Huber, K.V.M.; Robers, M.B. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Regulation of influenza A virus mRNA splicing by CLK1

Antiviral Research
2019-08 | Journal article
DOI: 10.1016/j.antiviral.2019.06.003
Contributors: Anita Artarini; Michael Meyer; Yu Jin Shin; Kilian Huber; Nikolaus Hilz; Franz Bracher; Daniel Eros; Laszlo Orfi; Gyorgy Keri; Sigrid Goedert et al.
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Alterations on growth and cell organization of Giardia intestinalis trophozoites after treatment with KH-TFMDI, a novel class III histone deacetylase inhibitor

International Journal of Medical Microbiology
2019-03 | Journal article
DOI: 10.1016/j.ijmm.2019.01.002
Contributors: Ana Paula R. Gadelha; Bárbara Bravim; Juliana Vidal; Lissa Catherine Reignault; Bruno Cosme; Kilian Huber; Franz Bracher; Wanderley de Souza
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Creation of a Novel Class of Potent and Selective MutT Homologue 1 (MTH1) Inhibitors Using Fragment-Based Screening and Structure-Based Drug Design

Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1021/acs.jmedchem.7b01884
EID:

2-s2.0-85044242612
Contributors: Rahm, F.; Viklund, J.; Trésaugues, L.; Ellermann, M.; Giese, A.; Ericsson, U.; Forsblom, R.; Ginman, T.; Günther, J.; Hallberg, K. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Discovery of an MLLT1/3 YEATS Domain Chemical Probe

Angewandte Chemie - International Edition
2018 | Journal article
DOI: 10.1002/anie.201810617
EID:

2-s2.0-85056738071
Contributors: Moustakim, M.; Christott, T.; Monteiro, O.P.; Bennett, J.; Giroud, C.; Ward, J.; Rogers, C.M.; Smith, P.; Panagakou, I.; Díaz-Sáez, L. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Quantitative, Wide-Spectrum Kinase Profiling in Live Cells for Assessing the Effect of Cellular ATP on Target Engagement

Cell Chemical Biology
2018 | Journal article
DOI: 10.1016/j.chembiol.2017.10.010
EID:

2-s2.0-85034627489
Contributors: Vasta, J.D.; Corona, C.R.; Wilkinson, J.; Zimprich, C.A.; Hartnett, J.R.; Ingold, M.R.; Zimmerman, K.; Machleidt, T.; Kirkland, T.A.; Huwiler, K.G. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling

EMBO Journal
2018 | Journal article
DOI: 10.15252/embj.201899372
EID:

2-s2.0-85050409574
Contributors: Hrdinka, M.; Schlicher, L.; Dai, B.; Pinkas, D.M.; Bufton, J.C.; Picaud, S.; Ward, J.A.; Rogers, C.; Suebsuwong, C.; Nikhar, S. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Chemical Instability and Promiscuity of Arylmethylidenepyrazolinone-Based MDMX Inhibitors

ACS Chemical Biology
2018-10-19 | Journal article
DOI: 10.1021/acschembio.8b00665
Contributors: Jakub Stefaniak; Andrew M. Lewis; Daniel Conole; Sébastien R. G. Galan; Carole J. R. Bataille; Graham M. Wynne; M. Paola Castaldi; Thomas Lundbäck; Angela J. Russell; Kilian V. M. Huber
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Artemisinins Target GABA<inf>A</inf> Receptor Signaling and Impair α Cell Identity

Cell
2017 | Journal article
DOI: 10.1016/j.cell.2016.11.010
EID:

2-s2.0-85007346465
Contributors: Li, J.; Casteels, T.; Huber, K.V.M.; Lardeau, C.-H.; Klughammer, J.; Farlik, M.; Sdelci, S.; Májek, P.; Pauler, F.M.; Penz, T. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Benzoisoquinolinediones as Potent and Selective Inhibitors of BRPF2 and TAF1/TAF1L Bromodomains

Journal of Medicinal Chemistry
2017 | Journal article
DOI: 10.1021/acs.jmedchem.7b00306
EID:

2-s2.0-85019069491
Contributors: Bouché, L.; Christ, C.D.; Siegel, S.; Fernández-Montalván, A.E.; Holton, S.J.; Fedorov, O.; Ter Laak, A.; Sugawara, T.; Stöckigt, D.; Tallant, C. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Discovery of a PCAF Bromodomain Chemical Probe

Angewandte Chemie - International Edition
2017 | Journal article
DOI: 10.1002/anie.201610816
EID:

2-s2.0-85007227808
Contributors: Moustakim, M.; Clark, P.G.K.; Trulli, L.; Fuentes de Arriba, A.L.; Ehebauer, M.T.; Chaikuad, A.; Murphy, E.J.; Mendez-Johnson, J.; Daniels, D.; Hou, C.-F.D. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and Unusual Mode of Action

ACS Chemical Biology
2017 | Journal article
DOI: 10.1021/acschembio.7b00708
EID:

2-s2.0-85034625758
Contributors: Fernández-Montalván, A.E.; Berger, M.; Kuropka, B.; Koo, S.J.; Badock, V.; Weiske, J.; Puetter, V.; Holton, S.J.; Stöckigt, D.; Ter Laak, A. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

KH-TFMDI, a novel sirtuin inhibitor, alters the cytoskeleton and mitochondrial metabolism promoting cell death in Leishmania amazonensis

Apoptosis
2017 | Journal article
DOI: 10.1007/s10495-017-1397-8
EID:

2-s2.0-85021935495
Contributors: Verçoza, B.R.F.; Godinho, J.L.P.; de Macedo-Silva, S.T.; Huber, K.; Bracher, F.; de Souza, W.; Rodrigues, J.C.F.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Thiazolidine derivatives as potent and selective inhibitors of the PIM kinase family

Bioorganic and Medicinal Chemistry
2017 | Journal article
DOI: 10.1016/j.bmc.2017.02.056
EID:

2-s2.0-85015876936
Contributors: Bataille, C.J.R.; Brennan, M.B.; Byrne, S.; Davies, S.G.; Durbin, M.; Fedorov, O.; Huber, K.V.M.; Jones, A.M.; Knapp, S.; Liu, G. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Nilotinib-induced vasculopathy: identification of vascular endothelial cells as a primary target site

Leukemia
2017-11 | Journal article
DOI: 10.1038/leu.2017.245
Contributors: E Hadzijusufovic; K Albrecht-Schgoer; K Huber; G Hoermann; F Grebien; G Eisenwort; W Schgoer; S Herndlhofer; C Kaun; M Theurl et al.
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Global survey of the immunomodulatory potential of common drugs

Nature Chemical Biology
2017-06 | Journal article
DOI: 10.1038/nchembio.2360
Contributors: Gregory I Vladimer; Berend Snijder; Nikolaus Krall; Johannes W Bigenzahn; Kilian V M Huber; Charles-Hugues Lardeau; Kumar Sanjiv; Anna Ringler; Ulrika Warpman Berglund; Monika Sabler et al.
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Lapatinib potentiates cytotoxicity of  YM155 in neuroblastoma via inhibition of the ABCB1 efflux transporter

Scientific Reports
2017-06-08 | Journal article
DOI: 10.1038/s41598-017-03129-6
Contributors: Branka Radic-Sarikas; Melinda Halasz; Kilian V. M. Huber; Georg E. Winter; Kalliopi P. Tsafou; Theodore Papamarkou; Søren Brunak; Walter Kolch; Giulio Superti-Furga
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Crossref

Shining a light

Nature Chemical Biology
2017-02-19 | Journal article
DOI: 10.1038/nchembio.2295
Contributors: Kilian V M Huber
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Crossref

Combinatorial drug screening identifies Ewing sarcoma-specific sensitivities

Molecular Cancer Therapeutics
2016 | Journal article
DOI: 10.1158/1535-7163.MCT-16-0235
ARXIV:

http://mct.aacrjournals.org/content/early/2016/11/15/1535-7163.MCT-16-0235.full.pdf
Source: Self-asserted source
Kilian Huber

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

Nature Chemical Biology
2016 | Journal article
DOI: 10.1038/nchembio.2080
EID:

2-s2.0-84966666626
Contributors: Sdelci, S.; Lardeau, C.-H.; Tallant, C.; Klepsch, F.; Klaiber, B.; Bennett, J.; Rathert, P.; Schuster, M.; Penz, T.; Fedorov, O. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Profiling of small molecules by chemical proteomics

Methods in Molecular Biology
2016 | Book
DOI: 10.1007/978-1-4939-3341-9_15
EID:

2-s2.0-84951856514
Contributors: Huber, K.V.M.; Superti-Furga, G.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions

Nature Immunology
2016-12-31 | Journal article
DOI: 10.1038/ni.3590
Contributors: Rui Martins; Julia Maier; Anna-Dorothea Gorki; Kilian V M Huber; Omar Sharif; Philipp Starkl; Simona Saluzzo; Federica Quattrone; Riem Gawish; Karin Lakovits et al.
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A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis

Cell Death & Disease
2015 | Journal article
DOI: 10.1038/cddis.2015.130
WOSUID:

WOS:000357513200032
Contributors: Fauster, A.; Rebsamen, M.; Huber, K. V. M.; Bigenzahn, J. W.; Stukalov, A.; Lardeau, C-H; Scorzoni, S.; Bruckner, M.; Gridling, M.; Parapatics, K. et al.
Source: Self-asserted source
Kilian Huber via ResearcherID

Erratum: Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia (Nature Chemical Biology (2015) 11: 571-578)

Nature Chemical Biology
2015 | Journal article
DOI: 10.1038/nchembio1015-815b
EID:

2-s2.0-84942017531
Contributors: Grebien, F.; Vedadi, M.; Getlik, M.; Giambruno, R.; Grover, A.; Avellino, R.; Skucha, A.; Vittori, S.; Kuznetsova, E.; Smil, D. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Erratum: The promise and peril of chemical probes (Nature Chemical Biology (2015) 11 (536-541))

Nature Chemical Biology
2015 | Journal article
DOI: 10.1038/nchembio1115-887c
EID:

2-s2.0-84945286266
Contributors: Arrowsmith, C.H.; Audia, J.E.; Austin, C.; Baell, J.; Bennett, J.; Blagg, J.; Bountra, C.; Brennan, P.E.; Brown, P.J.; Bunnage, M.E. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

Pharmacological targeting of the Wdr5-MLL interaction in C/EBPα N-terminal leukemia

Nature Chemical Biology
2015 | Journal article
DOI: 10.1038/nchembio.1859
EID:

2-s2.0-84937412774
Contributors: Grebien, F.; Vedadi, M.; Getlik, M.; Giambruno, R.; Grover, A.; Avellino, R.; Skucha, A.; Vittori, S.; Kuznetsova, E.; Smil, D. et al.
Source: Self-asserted source
Kilian Huber via Scopus - Elsevier

SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1

Nature
2015 | Journal article
DOI: 10.1038/nature14107
WOSUID:

WOS:000351602800057
Contributors: Rebsamen, Manuele; Pochini, Lorena; Stasyk, Taras; de Araujo, Mariana E. G.; Galluccio, Michele; Kandasamy, Richard K.; Snijder, Berend; Fauster, Astrid; Rudashevskaya, Elena L.; Bruckner, Manuela et al.
Source: Self-asserted source
Kilian Huber via ResearcherID

Target profiling of an antimetastatic RAPTA agent by chemical proteomics: relevance to the mode of action

Chemical Science
2015 | Journal article
DOI: 10.1039/c4sc03905j
WOSUID:

WOS:000351412800040
Contributors: Babak, Maria V.; Meier, Samuel M.; Huber, Kilian V. M.; Reynisson, Johannes; Legin, Anton A.; Jakupec, Michael A.; Roller, Alexander; Stukalov, Alexey; Gridling, Manuela; Bennett, Keiryn L. et al.
Source: Self-asserted source
Kilian Huber via ResearcherID

The promise and peril of chemical probes

Nature Chemical Biology
2015 | Journal article
DOI: 10.1038/nchembio.1867
WOSUID:

WOS:000358255300003
Contributors: Arrowsmith, Cheryl H.; Audia, James E.; Austin, Christopher; Baell, Jonathan; Bennett, Jonathan; Blagg, Julian; Bountra, Chas; Brennan, Paul E.; Brown, Peter J.; Bunnage, Mark E. et al.
Source: Self-asserted source
Kilian Huber via ResearcherID

Proteome-wide drug and metabolite interaction mapping by thermal-stability profiling

Nature Methods
2015-11-21 | Journal article
DOI: 10.1038/nmeth.3590
Contributors: Kilian V M Huber; Karin M Olek; André C Müller; Chris Soon Heng Tan; Keiryn L Bennett; Jacques Colinge; Giulio Superti-Furga
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Building and exploring an integrated human kinase network: Global organization and medical entry points

Journal of Proteomics
2014 | Journal article
DOI: 10.1016/j.jprot.2014.03.028
WOSUID:

WOS:000340322600015
Contributors: Colinge, Jacques; Cesar-Razquin, Adrian; Huber, Kilian; Breitwieser, Florian P.; Majek, Peter; Superti-Furga, Giulio
Source: Self-asserted source
Kilian Huber via ResearcherID

Evaluating the Promiscuous Nature of Tyrosine Kinase Inhibitors Assessed in A431 Epidermoid Carcinoma Cells by Both Chemical- and Phosphoproteomics

Acs Chemical Biology
2014 | Journal article
DOI: 10.1021/cb500116c
WOSUID:

WOS:000339366600014
Contributors: Giansanti, Piero; Preisinger, Christian; Huber, Kilian V. M.; Gridling, Manuela; Superti-Furga, Giulio; Bennett, Keiryn L.; Heck, Albert J. R.
Source: Self-asserted source
Kilian Huber via ResearcherID

Inhibition of NAD(+)-dependent histone deacetylases (sirtuins) causes growth arrest and activates both apoptosis and autophagy in the pathogenic protozoan Trypanosoma cruzi

Parasitology
2014 | Journal article
DOI: 10.1017/S0031182013001704
WOSUID:

WOS:000333966400009
Contributors: Veiga-Santos, Phercyles; Reignault, Lissa Catherine; Huber, Kilian; Bracher, Franz; De Souza, Wanderley; Ulisses De Carvalho, Tecia Maria
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Kilian Huber via ResearcherID

Inhibition of the SR Protein-Phosphorylating CLK Kinases of Plasmodium falciparum Impairs Blood Stage Replication and Malaria Transmission

Plos One
2014 | Journal article
DOI: 10.1371/journal.pone.0105732
WOSUID:

WOS:000341271500012
Contributors: Kern, Selina; Agarwal, Shruti; Huber, Kilian; Gehring, Andre P.; Stroedke, Benjamin; Wirth, Christine C.; Bruegl, Thomas; Abodo, Liliane Onambele; Dandekar, Thomas; Doerig, Christian et al.
Source: Self-asserted source
Kilian Huber via ResearcherID

Nilotinib exerts proatherogenic and growth-inhibitory effects on endothelial cells: a potential mechanism underlying drug-related vasculopathy in Ph plus CML

Oncology Research and Treatment
2014 | Journal article
WOSUID:

WOS:000343816900739
Contributors: Hadzijusufovic, E.; Albrecht-Schgoer, K.; Huber, K.; Grebien, F.; Eisenwort, G.; Schgoer, W.; Ghanim, V; Sadovnik, I; Kaun, C.; Herndlhofer, S. et al.
Source: Self-asserted source
Kilian Huber via ResearcherID

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

Nature
2014 | Journal article
DOI: 10.1038/nature13194
WOSUID:

WOS:000333979900039
Contributors: Huber, Kilian V. M.; Salah, Eidarus; Radic, Branka; Gridling, Manuela; Elkins, Jonathan M.; Stukalov, Alexey; Jemth, Ann-Sofie; Gokturk, Camilla; Sanjiv, Kumar; Stromberg, Kia et al.
Source: Self-asserted source
Kilian Huber via ResearcherID

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

Nature Chemical Biology
2014 | Journal article
DOI: 10.1038/NCHEMBIO.1590
WOSUID:

WOS:000341126800014
Contributors: Winter, Georg E.; Radic, Branka; Mayor-Ruiz, Cristina; Blomen, Vincent A.; Trefzer, Claudia; Kandasamy, Richard K.; Huber, Kilian V. M.; Gridling, Manuela; Chen, Doris; Klampfl, Thorsten et al.
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Kilian Huber via ResearcherID
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Peer review (13 reviews for 7 publications/grants)

Review activity for ACS central science. (2)
Review activity for ACS chemical biology. (2)
Review activity for ACS medicinal chemistry letters. (1)
Review activity for Angewandte Chemie. (2)
Review activity for Current opinion in structural biology. (1)
Review activity for Journal of medicinal chemistry. (4)
Review activity for Nature chemical biology. (1)
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