Personal information

Websites & social links

http://www.biochemistry1.hhu.de

Other IDs

Loop profile: 469083

Keywords

ABC transporters, Membrane transport, Structural biology

Countries

Germany

Activities

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Employment (3)

Heinrich-Heine-Universitat Düsseldorf: Dusseldorf, Nordrhein-Westfalen, DE

2008-04 to present | Full Professor (Institute of Biochemistry)
Employment
Source: Self-asserted source
Lutz Schmitt

Heinrich-Heine-Universitat Düsseldorf: Dusseldorf, Nordrhein-Westfalen, DE

2004-12 to 2008-03 | Associate Professor (Institute of Biochemistry)
Employment
Source: Self-asserted source
Lutz Schmitt

Stanford University: Stanford, CA, US

1996-08 to 1999-05 | Postdoc (Department of Chemistry)
Employment
Source: Self-asserted source
Lutz Schmitt

Education and qualifications (2)

Technical University Munich: Munich, DE

1992-05-01 to 1996-03-08 | PhD (Institute of Biophysics)
Education
Source: Self-asserted source
Lutz Schmitt

Albert-Ludwigs-Universität Freiburg: Freiburg im Breisgau, Baden-Württemberg, DE

1986-10 to 1992-03 | Diploma (Department of Chemistry)
Education
Source: Self-asserted source
Lutz Schmitt

Works (30)

Acylation of the RTX Toxin MbxA stimulates host membrane disruption through a specific interaction with cholesterol

2025-02-22 | Preprint
DOI: 10.1101/2025.02.19.639210
Contributors: Feby Mariam Chacko; Sarah Michelle Ganz; Anne Pfitzer-Bilsing; Sebastian Hänsch; Philipp Westhoff; Stefanie Weidtkamp-Peters; Sander H. J. Smits; Marten Exterkate; Lutz Schmitt
Source: check_circle
Crossref

An in vitro set‐up to study Pdr5‐mediated substrate translocation

Protein Science
2024-10 | Journal article
DOI: 10.1002/pro.5181
Contributors: Stefanie L. Gala Marti; Manuel Wagner; Lea‐Marie Nentwig; Sander H. J. Smits; Lutz Schmitt
Source: check_circle
Crossref

Probing macromolecular crowding at the lipid membrane interface with genetically‐encoded sensors

Protein Science
2023-11 | Journal article
DOI: 10.1002/pro.4797
Contributors: Maryna Löwe; Sebastian Hänsch; Eymen Hachani; Lutz Schmitt; Stefanie Weidtkamp‐Peters; Alexej Kedrov
Source: check_circle
Crossref

A step forward to the optimized HlyA type 1 secretion system through directed evolution

Applied Microbiology and Biotechnology
2023-08 | Journal article
DOI: 10.1007/s00253-023-12653-7
Contributors: Zohreh N. Pourhassan; Haiyang Cui; Neele Muckhoff; Mehdi D. Davari; Sander H. J. Smits; Ulrich Schwaneberg; Lutz Schmitt
Source: check_circle
Crossref

Interaction of RTX toxins with the host cell plasma membrane

Biological Chemistry
2023-06-27 | Journal article
DOI: 10.1515/hsz-2022-0336
Contributors: Feby M. Chacko; Lutz Schmitt
Source: check_circle
Crossref

Waste or die: The price to pay to stay alive

Trends in Microbiology
2023-03 | Journal article
DOI: 10.1016/j.tim.2022.09.005
Contributors: Cédric Orelle; Lutz Schmitt; Jean-Michel Jault
Source: check_circle
Crossref

Flipping and other astonishing transporter dance moves in fungal drug resistance

BioEssays
2022-07 | Journal article
DOI: 10.1002/bies.202200035
Contributors: Stefanie L. Raschka; Andrzej Harris; Ben F. Luisi; Lutz Schmitt
Source: check_circle
Crossref

A MademoiseLLE domain binding platform links the key RNA transporter to endosomes

PLOS Genetics
2022-06-21 | Journal article
DOI: 10.1371/journal.pgen.1010269
Contributors: Senthil-Kumar Devan; Aaron P. Mitchell; Stephan Schott-Verdugo; Kira Müntjes; Lilli Bismar; Jens Reiners; Eymen Hachani; Lutz Schmitt; Astrid Höppner; Sander HJ Smits et al.
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Crossref

Optimized Hemolysin Type 1 Secretion System in Escherichia coli by Directed Evolution of the Hly Enhancer Fragment and Including a Terminator Region

ChemBioChem
2022-03-18 | Journal article
DOI: 10.1002/cbic.202100702
Contributors: Zohreh Pourhassan N.; Haiyang Cui; Sakshi Khosa; Mehdi D. Davari; Karl‐Erich Jaeger; Sander H. J. Smits; Ulrich Schwaneberg; Lutz Schmitt
Source: check_circle
Crossref

The periplasmic chaperone Skp prevents misfolding of the secretory lipase A from Pseudomonas aeruginosa

2022-03-01 | Preprint
DOI: 10.1101/2022.03.01.482502
Contributors: Athanasios Papadopoulos; Max Busch; Jens Reiners; Eymen Hachani; Miriam Bäumers; Lutz Schmitt; Karl-Erich Jaeger; Filip Kovacic; Sander H.J. Smits; Alexej Kedrov
Source: check_circle
Crossref

Quantification and Surface Localization of the Hemolysin A Type I Secretion System at the Endogenous Level and under Conditions of Overexpression

Applied and Environmental Microbiology
2022-02-08 | Journal article
DOI: 10.1128/aem.01896-21
Contributors: Tobias Beer; Sebastian Hänsch; Klaus Pfeffer; Sander H. J. Smits; Stefanie Weidtkamp-Peters; Lutz Schmitt; Christopher A. Elkins
Source: check_circle
Crossref

Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

Nature Communications
2021-09-06 | Journal article
DOI: 10.1038/s41467-021-25574-8
Contributors: Andrzej Harris; Manuel Wagner; Dijun Du; Stefanie Raschka; Lea-Marie Nentwig; Holger Gohlke; Sander H. J. Smits; Ben F. Luisi; Lutz Schmitt
Source: check_circle
Crossref

The many facets of bile acids in the physiology and pathophysiology of the human liver

Biological Chemistry
2021-08-26 | Journal article
DOI: 10.1515/hsz-2021-0156
Contributors: Christoph G.W. Gertzen; Holger Gohlke; Dieter Häussinger; Diran Herebian; Verena Keitel; Ralf Kubitz; Ertan Mayatepek; Lutz Schmitt
Source: check_circle
Crossref

Importance of the leader peptide sequence on the lanthipeptide secretion level

The FEBS Journal
2021-07 | Journal article
DOI: 10.1111/febs.15724
Contributors: Marcel Lagedroste; Sander H.J. Smits; Lutz Schmitt
Source: check_circle
Crossref

A new twist in ABC transporter mediated multidrug resistance – Pdr5 is a drug/proton co-transporter

2021-05-26 | Other
DOI: 10.1101/2021.05.26.445758
Contributors: Manuel Wagner; Daniel Blum; Stefanie L. Raschka; Christoph G. W. Gertzen; Sander H. J. Smits; Richard Wagner; Lutz Schmitt
Source: check_circle
Crossref

Structure and Function of Hepatobiliary ATP Binding Cassette Transporters

Chemical Reviews
2021-05-12 | Journal article
DOI: 10.1021/acs.chemrev.0c00659
Contributors: Tim Kroll; Martin Prescher; Sander H. J. Smits; Lutz Schmitt
Source: check_circle
Crossref

Structure and efflux mechanism of the yeast pleiotropic drug resistance transporter Pdr5

2021-02-09 | Preprint
DOI: 10.1101/2021.02.09.430491
Contributors: Andrzej Harris; Manuel Wagner; Dijun Du; Stefanie Raschka; Holger Gohlke; Sander H. J. Smits; Ben F. Luisi; Lutz Schmitt
Source: check_circle
Crossref

The ABC transporter G subfamily in Arabidopsis thaliana

Journal of Experimental Botany
2021-01-20 | Journal article
DOI: 10.1093/jxb/eraa260
Contributors: Katharina Gräfe; Lutz Schmitt; Andreas Weber
Source: check_circle
Crossref

Self‐immunity to antibacterial peptides by ABC transporters

FEBS Letters
2020-12 | Journal article
DOI: 10.1002/1873-3468.13953
Contributors: Sander H.J. Smits; Lutz Schmitt; Konstantinos Beis
Source: check_circle
Crossref

The role of the degenerate nucleotide binding site in type I ABC exporters

FEBS Letters
2020-12 | Journal article
DOI: 10.1002/1873-3468.13997
Contributors: Thomas Stockner; Ralph Gradisch; Lutz Schmitt
Source: check_circle
Crossref

Stimulation of ABCB4/MDR3 ATPase activity requires an intact phosphatidylcholine lipid

Journal of Lipid Research
2020-12-11 | Journal article
DOI: 10.1194/jlr.RA120000889
Contributors: Martin Prescher; Sander H.J. Smits; Lutz Schmitt
Source: check_circle
Crossref

A bifunctional dermaseptin–thanatin dipeptide functionalizes the crop surface for sustainable pest management

Green Chemistry
2019 | Journal article
DOI: 10.1039/C9GC00457B
Contributors: Patrick Schwinges; Shyam Pariyar; Felix Jakob; Mehran Rahimi; Lina Apitius; Mauricio Hunsche; Lutz Schmitt; Georg Noga; Caspar Langenbach; Ulrich Schwaneberg et al.
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Crossref

Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail

Biochemical Journal
2019-11-15 | Journal article
DOI: 10.1042/BCJ20190364
Contributors: Larissa Legewie; Jennifer Loschwitz; Nora Steffens; Martin Prescher; Xue Wang; Sander H. J. Smits; Lutz Schmitt; Birgit Strodel; Daniel Degrandi; Klaus Pfeffer
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Crossref

Mechanism of the secretion of the lanthipeptide nisin

2019-11-12 | Other
DOI: 10.1101/839423
Contributors: Marcel Lagedroste; Jens Reiners; Sander H.J. Smits; Lutz Schmitt
Source: check_circle
Crossref

An A666G mutation in transmembrane helix 5 of the yeast multidrug transporter Pdr5 increases drug efflux by enhancing cooperativity between transport sites

Molecular Microbiology
2019-10 | Journal article
DOI: 10.1111/mmi.14351
Contributors: Nidhi Arya; Hadiar Rahman; Andrew Rudrow; Manuel Wagner; Lutz Schmitt; Suresh V. Ambudkar; John Golin
Source: check_circle
Crossref

ABCG1 contributes to suberin formation in Arabidopsis thaliana roots

Scientific Reports
2019-08-06 | Journal article
DOI: 10.1038/s41598-019-47916-9
Contributors: Kalpana Shanmugarajah; Nicole Linka; Katharina Gräfe; Sander H. J. Smits; Andreas P. M. Weber; Jürgen Zeier; Lutz Schmitt
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Crossref

In vitro NTPase activity of highly purified Pdr5, a major yeast ABC multidrug transporter

Scientific Reports
2019-05-23 | Journal article
DOI: 10.1038/s41598-019-44327-8
Contributors: Manuel Wagner; Sander H. J. Smits; Lutz Schmitt
Source: check_circle
Crossref

Cloning and expression of selected ABC transporters from the Arabidopsis thaliana ABCG family in Pichia pastoris

PLOS ONE
2019-01-18 | Journal article
DOI: 10.1371/journal.pone.0211156
Contributors: Katharina Gräfe; Hendrik W. van Veen; Kalpana Shanmugarajah; Thomas Zobel; Stefanie Weidtkamp-Peters; Diana Kleinschrodt; Sander H. J. Smits; Lutz Schmitt
Source: check_circle
Crossref

Substrate Specificity of the Secreted Nisin Leader Peptidase NisP

Biochemistry
2017-08-01 | Journal article
DOI: 10.1021/acs.biochem.7b00524
Contributors: Marcel Lagedroste; Sander H. J. Smits; Lutz Schmitt
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Crossref

Synthesis and cytotoxic activities of goniothalamins and derivatives

Bioorganic & Medicinal Chemistry
2017-02 | Journal article
DOI: 10.1016/j.bmc.2017.02.004
Contributors: Anja Weber; Katja Döhl; Julia Sachs; Anja C.M. Nordschild; Dennis Schröder; Andrea Kulik; Thomas Fischer; Lutz Schmitt; Nicole Teusch; Jörg Pietruszka
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Crossref

Peer review (10 reviews for 4 publications/grants)

Review activity for ACS synthetic biology. (3)
Review activity for Angewandte Chemie. (1)
Review activity for Biochemistry. (5)
Review activity for Journal of bioenergetics and biomembranes. (1)
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