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Chang Gung University profile page

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ResearcherID: LCD-7687-2024
Scopus Author ID: 8222812000

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Taiwan

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Employment (5)

Chang Gung University: Taoyuan, TW

2024-08-01 to present | Associate Professor (Biochemistry)
Employment
Source: Self-asserted source
Ling-Yu Wang

Chang Gung University: Taoyuan, Taoyuan, TW

2019-02-01 to 2024-07-31 | Assistant Professor (Biochemistry)
Employment
Source: Self-asserted source
Ling-Yu Wang

Industrial Technology Research Institute: Hsinchu, TW

2017-08 to 2019-01 | Researcher (Biomedical Technology and Device Research)
Employment
Source: Self-asserted source
Ling-Yu Wang

UC Davis Health System: Sacramento, California, US

2013-06 to 2017-06 | Assistant Project Scientist (Biochemistry and Molecular Medicine)
Employment
Source: Self-asserted source
Ling-Yu Wang

UC Davis Health System: Sacramento, California, US

2012-04 to 2013-03 | Staff Research Associate (Cancer Center)
Employment
Source: Self-asserted source
Ling-Yu Wang

Education and qualifications (2)

University of California Davis: Davis, CA, US

Ph.D. (Microbiology)
Education
Source: Self-asserted source
Ling-Yu Wang

National Taiwan Normal University: Taipei, TW

B.S. (Biology)
Education
Source: Self-asserted source
Ling-Yu Wang

Works (25)

PROTACs as Therapeutic Modalities for Drug Discovery in Castration-Resistant Prostate Cancer

Annual review of pharmacology and toxicology
2025-01-23 | Journal article | Author
DOI: 10.1146/annurev-pharmtox-030624-110238
SOURCE-WORK-ID:

9a47d71b-c6e6-452c-8317-7f073ab89ebe

PMID: 39116434
EID:

2-s2.0-85216715921

PMID: 39116434
Contributors: Ling-Yu Wang; Chiu Lien Hung; Tsan Chun Wang; Hung Chih Hsu; Hsing Jien Kung; Kwang-Huei Lin
Source: check_circle
Chang Gung University
grade
Preferred source (of 2)‎

Selective p300 degradation via peptide PROTAC: a new therapeutic strategy for advanced prostate cancers

eBioMedicine
2024-08 | Journal article
DOI: 10.1016/j.ebiom.2024.105245
Contributors: Ling-Yu Wang
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

BPR3P0128, a non-nucleoside RNA-dependent RNA polymerase inhibitor, inhibits SARS-CoV-2 variants of concern and exerts synergistic antiviral activity in combination with remdesivir

Antimicrobial Agents and Chemotherapy
2024-04-03 | Journal article | Author
DOI: 10.1128/aac.00956-23
SOURCE-WORK-ID:

310d930b-d0d5-4f2a-ad38-ac4cd2ede265

EID:

2-s2.0-85189762889

PMID: 38446062
Contributors: Wen Fang Tang; Yu Hsiu Chang; Cheng Chin Lin; Jia Rong Jheng; Chung Fan Hsieh; Yuan Fan Chin; Tein Yao Chang; Jin Ching Lee; Po Huang Liang; Chia Yi Lin et al.
Source: check_circle
Chang Gung University

<i>Clostridium</i><i> scindens</i> metabolites trigger prostate cancer progression through androgen receptor signaling

Journal of Microbiology, Immunology and Infection
2023 | Journal article
DOI: 10.1016/J.JMII.2022.12.009
WOSUID: WOS:000994421300001
Contributors: Bui, Ngoc-Niem; Li, Chen-Yi; Wang, Ling-Yu; Chen, Yu-An; Kao, Wei-Hsiang; Chou, Li-Fang; Hsieh, Jer-Tsong; Lin, Ho; Lai, Chih-Ho
Source: check_circle
Web of Science Researcher Profile Sync
grade
Preferred source (of 3)‎

SARS-CoV-2 pandemics

Biomedical Journal
2023-04 | Journal article | Author
DOI: 10.1016/j.bj.2023.02.007
SOURCE-WORK-ID:

eabd6e6d-052f-4ac2-a39d-f0d97f862fbf

EID:

2-s2.0-85151884343

PMID: 36849044
Contributors: Wen Fang Tang; Anh Tu Tran; Ling-Yu Wang; Jim-Tong Horng
Source: check_circle
Chang Gung University

Targeting androgen receptor and the variants by an orally bioavailable Proteolysis Targeting Chimeras compound in castration resistant prostate cancer

eBioMedicine
2023-04 | Journal article | Author
DOI: 10.1016/j.ebiom.2023.104500
Part of ISSN: 2352-3964
Contributors: Chiu-Lien Hung; Hao-Hsuan Liu; Chih-Wei Fu; Hsun-Hao Yeh; Tsan-Lin Hu; Zong-Keng Kuo; Yu-Chin Lin; Mei-Ru Jhang; Chrong-Shiong Hwang; Hung-Chih Hsu et al.
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 3)‎

Abstract LB133: An orally bioavailable degrader targeting androgen receptor and the splice variant in castration resistant prostate cancer

Cancer Research
2023-04-14 | Conference poster
DOI: 10.1158/1538-7445.am2023-lb133
Part of ISSN: 1538-7445
Contributors: Chiu-Lien Hung; Ling-Yu Wang; Chih-Wei Fu; Hung-Chih Hsu; Hsin-Jien Kung
Source: Self-asserted source
Ling-Yu Wang

Evaluation and Application of Drug Resistance by Biomarkers in the Clinical Treatment of Liver Cancer

Cells
2023-03-10 | Review
DOI: 10.3390/cells12060869
Part of ISSN: 2073-4409
Contributors: Po-Shuan Huang; Ling-Yu Wang; Yi-Wen Wang; Ming-Ming Tsai; Tzu-Kang Lin; Chia-Jung Liao; Chau-Ting Yeh; Kwang-Huei Lin
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Natural product myricetin is a pan-KDM4 inhibitor which with poly lactic-co-glycolic acid formulation effectively targets castration-resistant prostate cancer

Journal of Biomedical Science
2022-05-09 | Journal article
DOI: 10.1186/s12929-022-00812-3
Part of ISSN: 1423-0127
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

KDM8/JMJD5 as a dual coactivator of AR and PKM2 integrates AR/EZH2 network and tumor metabolism in CRPC.

Oncogene
2018-08-02 | Journal article
DOI: 10.1038/s41388-018-0414-x
PMID: 30072740
PMC: PMC6755995
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression.

Nature communications
2017-06-22 | Journal article
DOI: 10.1038/ncomms15874
PMID: 28639619
PMC: PMC5489688
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy.

Cell death and differentiation
2016-09-09 | Journal article
DOI: 10.1038/cdd.2016.92
PMID: 27612013
PMC: PMC5071577
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

KDM4A Coactivates E2F1 to Regulate the PDK-Dependent Metabolic Switch between Mitochondrial Oxidation and Glycolysis.

Cell reports
2016-09-01 | Journal article
DOI: 10.1016/j.celrep.2016.08.018
PMID: 27626669
PMC: PMC5024724
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Tyrosine kinome profiling: oncogenic mutations and therapeutic targeting in cancer

Molecular Oncology:Causes of Cancer and Targets for Treatmen
2015 | Book chapter | Author
SOURCE-WORK-ID:

e48f7465-1cd3-4b16-820f-cb5fcf60281f

Part of ISBN: 9781139046947
Contributors: Paramita Ghosh; Yun Qiu; Ling-Yu Wang; Hsing Jien Kung
Source: check_circle
Chang Gung University

Non-Coding RNAs in Castration-Resistant Prostate Cancer: Regulation of Androgen Receptor Signaling and Cancer Metabolism.

International journal of molecular sciences
2015-12-04 | Journal article
DOI: 10.3390/ijms161226138
PMID: 26690121
PMC: PMC4691085
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Tyrosine kinome proiling

Molecular Oncology
2015-01-01 | Book chapter | Author
DOI: 10.1017/CBO9781139046947.009
SOURCE-WORK-ID:

e5fdb047-109b-4f6e-950c-e9eb2b8eb0a7

EID:

2-s2.0-84954153477

Part of ISBN: 9781139046947
Part of ISBN: 9780521876629
Contributors: Paramita Ghosh; Yun Qiu; Ling-Yu Wang; Hsing Jien Kung
Source: check_circle
Chang Gung University

A long noncoding RNA connects c-Myc to tumor metabolism.

Proceedings of the National Academy of Sciences of the United States of America
2014-12-15 | Journal article
DOI: 10.1073/pnas.1415669112
PMID: 25512540
PMC: PMC4284533
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

KDM4B as a target for prostate cancer: structural analysis and selective inhibition by a novel inhibitor.

Journal of medicinal chemistry
2014-07-09 | Journal article
DOI: 10.1021/jm500249n
PMID: 24971742
PMC: PMC4216216
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Histone Demethylases in Prostate Cancer

2013 | Book chapter
DOI: 10.1007/978-1-4614-8039-6_15
SOURCE-WORK-ID: BASE:1ae4965f14093e53e28403c776a9b63113913fcad2178a82298170bf20c9da05
Contributors: Wang, Ling-Yu; Guo, Wenchang; Kim, Kevin; Pochampalli, Mamata; Hung, Chiu-Lien; Izumiya, Yoshihiro; Kung, Hsing-Jien
Source: Self-asserted source
Ling-Yu Wang via BASE - Bielefeld Academic Search Engine
grade
Preferred source (of 2)‎

Male germ cell-associated kinase is overexpressed in prostate cancer cells and causes mitotic defects via deregulation of APC/CCDH1.

Oncogene
2011-10-10 | Journal article
DOI: 10.1038/onc.2011.464
PMID: 21986944
PMC: PMC3566783
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Autophagy Blockade Sensitizes Prostate Cancer Cells towards Src Family Kinase Inhibitors.

Genes & cancer
2010-01-01 | Journal article
DOI: 10.1177/1947601909358324
PMID: 20811583
PMC: PMC2930266
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Inappropriate activation of androgen receptor by relaxin via beta-catenin pathway.

Oncogene
2007-07-23 | Journal article
DOI: 10.1038/sj.onc.1210671
PMID: 17653089
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein.

FEBS letters
2006-03-30 | Journal article
DOI: 10.1016/j.febslet.2006.03.065
PMID: 16603158
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Response of fission yeast to toxic cations involves cooperative action of the stress-activated protein kinase Spc1/Sty1 and the Hal4 protein kinase.

Molecular and cellular biology
2005-05-01 | Journal article
DOI: 10.1128/mcb.25.10.3945-3955.2005
PMID: 15870269
PMC: PMC1087739
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Effect of interleukin (IL)-12 and IL-15 on apoptosis and proliferation of umbilical cord blood mononuclear cells.

Bone marrow transplantation
2001-09-01 | Journal article
DOI: 10.1038/sj.bmt.1703182
PMID: 11593316
Source: Self-asserted source
Ling-Yu Wang
grade
Preferred source (of 2)‎

Peer review (9 reviews for 5 publications/grants)

Review activity for Biomedicine & pharmacotherapy. (1)
Review activity for Drug resistance updates. (1)
Review activity for EBioMedicine. (3)
Review activity for Nature communications (2)
Review activity for RSC medicinal chemistry. (2)
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