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Employment (6)

EMERGENCE THERAPEUTICS FRANCE: MARSEILLE, FR

2019-11-01 to present | CSO
Employment
Source: Self-asserted source
Xavier Preville

TALIX THERAPEUTICS FRANCE: PARIS, FR

2017-12-01 to 2019-10-14 | CSO
Employment
Source: Self-asserted source
Xavier Preville

AMONETA-DIAGNOSTICS: HUNINGUE, ALSACE, FR

2016-01 to 2017-11-30 | DIRECTOR (CELLULAR DIAGNOSTICS)
Employment
Source: Self-asserted source
Xavier Preville

Transgene: Illkirch-Graffenstaden, Alsace, FR

2008-07 to 2015-12 | Head of department (Onco-Immunology)
Employment
Source: Self-asserted source
Xavier Preville

BT PHARMA/GENTICEL: LABEGE, FR

2002-10 to 2008-06 | Chief Scientist
Employment
Source: Self-asserted source
Xavier Preville

INSERM U503/SANGSTAT: LYON, FR

1998-04 to 2001-03 | Post Doctorant
Employment
Source: Self-asserted source
Xavier Preville

Education and qualifications (2)

Université Claude Bernard Lyon 1 Faculté des Sciences et Technologies: Villeurbanne, FR

1994-10-01 to 1998-02-20 | PhD Cellular Biology
Education
Source: Self-asserted source
Xavier Preville

Université Claude Bernard Lyon 1 Faculté des Sciences et Technologies: Villeurbanne, FR

1993-09 to 1994-10 | Msc Differentiation, Genetics and Immunology
Education
Source: Self-asserted source
Xavier Preville

Works (39)

Fcγ receptor–mediated cross-linking codefines the immunostimulatory activity of anti-human CD96 antibodies

JCI Insight
2022-10-10 | Journal article
DOI: 10.1172/jci.insight.158444
Contributors: Anne Rogel; Fathima M. Ibrahim; Stephen M. Thirdborough; Florence Renart-Depontieu; Charles N. Birts; Sarah L. Buchan; Xavier Preville; Emma V. King; Aymen Al-Shamkhani
Source: check_circle
Crossref

Immunogenicity of oncolytic vaccinia viruses JX-GFP and TG6002 in a human melanoma in vitro model: studying immunogenic cell death, dendritic cell maturation and interaction with cytotoxic T lymphocytes.

OncoTargets and therapy
2017 | Journal article
DOI: 10.2147/ott.s126320
PMID: 28496337
PMC: PMC5422459
Source: Self-asserted source
Xavier Preville via Europe PubMed Central
grade
Preferred source (of 2)‎

Sequential administration of MVA-based vaccines and PD-1/PD-L1-blocking antibodies confers measurable benefits on tumor growth and survival: preclinical studies with MVA-βGal and MVA-MUC1 (TG4010) in a murine tumor model.

Human vaccines & immunotherapeutics
2017-09 | Journal article
DOI: 10.1080/21645515.2017.1373921
PMID: 28925793
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Viral based vaccine TG4010 induces broadening of specific immune response and improves outcome in advanced NSCLC.

Journal for immunotherapy of cancer
2017-09 | Journal article
DOI: 10.1186/s40425-017-0274-x
PMID: 28923084
PMC: PMC5604422
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Immune Checkpoint Blockade, Immunogenic Chemotherapy or IFN-α Blockade Boost the Local and Abscopal Effects of Oncolytic Virotherapy.

Cancer research
2017-08 | Journal article
DOI: 10.1158/0008-5472.can-16-2165
PMID: 28536278
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Typing of killer-cell immunoglobulin-like receptors and their cognate human leukocyte antigen class I ligands predicts survival of Chinese Han patients with metastatic non-small-cell lung cancer.

Molecular and clinical oncology
2017-02 | Journal article
DOI: 10.3892/mco.2016.1106
PMID: 28357111
PMC: PMC5351717
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Sequential administration of a MVA-based MUC1 cancer vaccine and the TLR9 ligand Litenimod (Li28) improves local immune defense against tumors.

Vaccine
2017-01 | Journal article
DOI: 10.1016/j.vaccine.2016.12.020
PMID: 28012777
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition.

Oncoimmunology
2016 | Journal article
DOI: 10.1080/2162402x.2016.1220467
PMID: 27853644
PMC: PMC5087307
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor microenvironment.

2016-02 | Journal article
PMID: 27057460
PMC: PMC4801465
Contributors: Fend L; Remy-Ziller C; Foloppe J; Kempf J; Cochin S; Barraud L; Accart N; Erbs P; Fournel S; Préville X
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Trial Watch-Oncolytic viruses and cancer therapy.

2016-02 | Journal article
PMID: 27057469
Contributors: Pol J; Buqué A; Aranda F; Bloy N; Cremer I; Eggermont A; Erbs P; Fucikova J; Galon J; Limacher JM et al.
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Shaping the tumor microenvironment with Modified Vaccinia Virus Ankara and TLR9 ligand.

2015-05 | Journal article
PMID: 26155396
PMC: PMC4485804
Contributors: Préville X; Rittner K; Fend L
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Intravenous injection of a modified vaccinia ankara virus induces intratumoral CD8+ lymphocyte infiltration favoring tumor control in an orthotopic tumor model upon combinatorial treatment with a TLR9 agonist.

2014 | Journal article
PMC: PMC4288698
Contributors: Fend L; Gatard-Scheikl T; Kintz J; Gantzer M; Schaedler E; Rittner K; Cochin S; Fournel S; Préville X
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Trial Watch:: Oncolytic viruses for cancer therapy.

2014 | Journal article
PMID: 25097804
PMC: PMC4091053
Contributors: Pol J; Bloy N; Obrist F; Eggermont A; Galon J; Cremer I; Erbs P; Limacher JM; Preville X; Zitvogel L et al.
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Intravenous injection of MVA virus targets CD8+ lymphocytes to tumors to control tumor growth upon combinatorial treatment with a TLR9 agonist.

2014-12 | Journal article
PMID: 25168392
Contributors: Fend L; Gatard-Scheikl T; Kintz J; Gantzer M; Schaedler E; Rittner K; Cochin S; Fournel S; Préville X
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Bone- and cartilage-protective effects of a monoclonal antibody against colony-stimulating factor 1 receptor in experimental arthritis.

2014-11 | Journal article
PMID: 24623505
Contributors: Toh ML; Bonnefoy JY; Accart N; Cochin S; Pohle S; Haegel H; De Meyer M; Zemmour C; Preville X; Guillen C et al.
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Cancer cell-autonomous contribution of type I interferon signaling to the efficacy of chemotherapy.

2014-11 | Journal article
PMID: 25344738
Contributors: Sistigu A; Yamazaki T; Vacchelli E; Chaba K; Enot DP; Adam J; Vitale I; Goubar A; Baracco EE; Remédios C et al.
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Yeast virus-derived stimulator of the innate immune system augments the efficacy of virus vector-based immunotherapy.

2014-05 | Journal article
PMID: 24574403
PMC: PMC4019141
Contributors: Claudepierre MC; Hortelano J; Schaedler E; Kleinpeter P; Geist M; Remy-Ziller C; Brandely R; Tosch C; Laruelle L; Jawhari A et al.
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Immunological characterization of a modified vaccinia virus Ankara vector expressing the human papillomavirus 16 E1 protein.

2014-02 | Journal article
PMID: 24307238
PMC: PMC3910931
Contributors: Remy-Ziller C; Germain C; Spindler A; Hoffmann C; Silvestre N; Rooke R; Bonnefoy JY; Préville X
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

A unique anti-CD115 monoclonal antibody which inhibits osteolysis and skews human monocyte differentiation from M2-polarized macrophages toward dendritic cells.

2013 | Journal article
PMID: 23924795
PMC: PMC3851226
Contributors: Haegel H; Thioudellet C; Hallet R; Geist M; Menguy T; Le Pogam F; Marchand JB; Toh ML; Duong V; Calcei A et al.
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Therapeutic effects of anti-CD115 monoclonal antibody in mouse cancer models through dual inhibition of tumor-associated macrophages and osteoclasts.

2013 | Journal article
PMID: 24019914
PMC: PMC3760897
Contributors: Fend L; Accart N; Kintz J; Cochin S; Reymann C; Le Pogam F; Marchand JB; Menguy T; Slos P; Rooke R et al.
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

TLR2 ligation protects effector T cells from regulatory T-cell mediated suppression and repolarizes T helper responses following MVA-based cancer immunotherapy.

2012-11 | Journal article
PMID: 23243590
PMC: PMC3518499
Contributors: Amiset L; Fend L; Gatard-Scheikl T; Rittner K; Duong V; Rooke R; Muller S; Bonnefoy JY; Préville X; Haegel H
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Improving administration regimens of CyaA-based vaccines using TRAP assays to detect antigen-specific CD8(+) T cells directly ex vivo.

2009-09 | Journal article
PMID: 19647811
Contributors: Daubeuf S; Préville X; Momot M; Misseri Y; Joly E; Hudrisier D
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Chemical labels metabolically installed into the glycoconjugates of the target cell surface can be used to track lymphocyte/target cell interplay via trogocytosis: comparisons with lipophilic dyes and biotin.

2007 | Journal article
PMID: 18161525
Contributors: Daubeuf S; Aucher A; Sampathkumar SG; Preville X; Yarema KJ; Hudrisier D
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

A very rapid and simple assay based on trogocytosis to detect and measure specific T and B cell reactivity by flow cytometry.

2006-03 | Journal article
PMID: 16482513
Contributors: Puaux AL; Campanaud J; Salles A; Préville X; Timmerman B; Joly E; Hudrisier D
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Eradication of established tumors by vaccination with recombinant Bordetella pertussis adenylate cyclase carrying the human papillomavirus 16 E7 oncoprotein.

2005-01 | Journal article
PMID: 15695409
Contributors: Préville X; Ladant D; Timmerman B; Leclerc C
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion.

2003-11 | Journal article
PMID: 12893746
Contributors: Michallet MC; Saltel F; Preville X; Flacher M; Revillard JP; Genestier L
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Functional antibodies to leukocyte adhesion molecules in antithymocyte globulins.

Transplantation
2003-03 | Journal article
DOI: 10.1097/01.tp.0000053198.99206.e6
PMID: 12640305
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

6-Methylprednisolone does not impair anti-thymocyte globulin (ATG) immunosuppressive activity in non-human primates.

Transplant immunology
2001-10 | Journal article
DOI: 10.1016/s0966-3274(01)00039-9
PMID: 11680573
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Mechanisms involved in antithymocyte globulin immunosuppressive activity in a nonhuman primate model.

2001-02 | Journal article
PMID: 11233911
Contributors: Préville X; Flacher M; LeMauff B; Beauchard S; Davelu P; Tiollier J; Revillard JP
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

First human hand transplantation. Case report.

2000 | Journal article
PMID: 11112064
Contributors: Dubernard JM; Owen E; Lefrançois N; Petruzzo P; Martin X; Dawahra M; Jullien D; Kanitakis J; Frances C; Preville X et al.
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

A quantitative flow cytometry assay for the preclinical testing and pharmacological monitoring of rabbit antilymphocyte globulins (rATG).

2000-11 | Journal article
PMID: 11042282
Contributors: Préville X; Nicolas L; Flacher M; Revillard J
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

TNF alpha and CD95-L contribute to apoptosis of activated lymphocytes triggered by ATGs.

1999 | Journal article
PMID: 10083328
Contributors: Bonnefoy-Berard N; Genestier L; Preville X; Revillard JP
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Regulation of Hsp27 oligomerization, chaperone function, and protective activity against oxidative stress/tumor necrosis factor alpha by phosphorylation.

1999-07 | Journal article
PMID: 10383393
Contributors: Rogalla T; Ehrnsperger M; Preville X; Kotlyarov A; Lutsch G; Ducasse C; Paul C; Wieske M; Arrigo AP; Buchner J et al.
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Mammalian small stress proteins protect against oxidative stress through their ability to increase glucose-6-phosphate dehydrogenase activity and by maintaining optimal cellular detoxifying machinery.

1999-02 | Journal article
PMID: 10047448
Contributors: Préville X; Salvemini F; Giraud S; Chaufour S; Paul C; Stepien G; Ursini MV; Arrigo AP
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Phosphorylation is not essential for protection of L929 cells by Hsp25 against H2O2-mediated disruption actin cytoskeleton, a protection which appears related to the redox change mediated by Hsp25.

1998-09 | Journal article
PMID: 9764758
PMC: PMC312962
Contributors: Préville X; Gaestel M; Arrigo AP
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Analysis of the role of Hsp25 phosphorylation reveals the importance of the oligomerization state of this small heat shock protein in its protective function against TNFalpha- and hydrogen peroxide-induced cell death.

1998-06 | Journal article
PMID: 9620170
Contributors: Préville X; Schultz H; Knauf U; Gaestel M; Arrigo AP
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Human hsp27, Drosophila hsp27 and human alphaB-crystallin expression-mediated increase in glutathione is essential for the protective activity of these proteins against TNFalpha-induced cell death.

1996-06 | Journal article
PMID: 8654367
PMC: PMC450205
Contributors: Mehlen P; Kretz-Remy C; Préville X; Arrigo AP
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Tumor necrosis factor-alpha induces changes in the phosphorylation, cellular localization, and oligomerization of human hsp27, a stress protein that confers cellular resistance to this cytokine.

1995-06 | Journal article
PMID: 7673331
Contributors: Mehlen P; Mehlen A; Guillet D; Preville X; Arrigo AP
Source: Self-asserted source
Xavier Preville via Europe PubMed Central

Constitutive expression of human hsp27, Drosophila hsp27, or human alpha B-crystallin confers resistance to TNF- and oxidative stress-induced cytotoxicity in stably transfected murine L929 fibroblasts.

1995-01 | Journal article
PMID: 7995955
Contributors: Mehlen P; Preville X; Chareyron P; Briolay J; Klemenz R; Arrigo AP
Source: Self-asserted source
Xavier Preville via Europe PubMed Central
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