Personal information

Emails & domains

Verified email domains

Websites & social links

Liton's Lab
Research Gate

Other IDs

Scopus Author ID: 6505833952

Keywords

trabecular meshwork, glaucoma, autophagy, phagocytosis, lysosomes

Countries

United States

Biography

Associate Professor in Ophthalmology & Pathology
Duke University, Department of Ophthalmology

Activities

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Funding (1)

Autophagy and Neurodegeneration in Glaucoma

2012-07-01 to 2014-06-30 | Grant
BrightFocus Foundation (Clarksburg, US)
GRANT_NUMBER:

G2012022
Source: check_circle
ProposalCentral

Works (47)

Class I PI3Ks activate stretch-induced autophagy in trabecular meshwork cells

Cellular and Molecular Life Sciences
2025-02-22 | Journal article
DOI: 10.1007/s00018-025-05615-x
Contributors: Myoung Sup Shim; Ethan J. Sim; Kevin Betsch; Vaibhav Desikan; Chien-Chia Su; Diego Pastor-Valverde; Yang Sun; Paloma B. Liton
Source: check_circle
Crossref

Autophagy deficiency protects against ocular hypertension and glaucoma

Autophagy Reports
2024-12-31 | Journal article
DOI: 10.1080/27694127.2023.2285214
Contributors: Angela Dixon; Myoung Sup Shim; April Nettesheim; Aislyn Coyne; Chien-Chia Su; Haiyan Gong; Paloma B. Liton
Source: check_circle
Crossref

Autophagy in the eye: from physiology to pathophysiology

Autophagy Reports
2023-12-31 | Journal article
DOI: 10.1080/27694127.2023.2178996
Contributors: Paloma B. Liton; Kathleen Boesze-Battaglia; Michael E. Boulton; Patricia Boya; Thomas A. Ferguson; Ian G. Ganley; Anu Kauppinnen; Gordon W. Laurie; Noboru Mizushima; Hideaki Morishita et al.
Source: check_circle
Crossref

Shear stress induces autophagy in Schlemm’s canal cells via primary cilia-mediated SMAD2/3 signaling pathway

Autophagy Reports
2023-12-31 | Journal article
DOI: 10.1080/27694127.2023.2236519
Contributors: Myoung Sup Shim; Angela Dixon; April Nettesheim; Kristin M. Perkumas; W. Daniel Stamer; Yang Sun; Paloma B. Liton
Source: check_circle
Crossref

Autophagy deficiency protects against ocular hypertension and neurodegeneration in experimental and spontaneous glaucoma mouse models

Cell Death & Disease
2023-08-24 | Journal article
DOI: 10.1038/s41419-023-06086-3
Contributors: Angela Dixon; Myoung Sup Shim; April Nettesheim; Aislyn Coyne; Chien-Chia Su; Haiyan Gong; Paloma B. Liton
Source: check_circle
Crossref

Autophagy in age-related macular degeneration

Autophagy
2023-02-01 | Journal article
DOI: 10.1080/15548627.2022.2069437
Contributors: Kai Kaarniranta; Janusz Blasiak; Paloma Liton; Michael Boulton; Daniel J. Klionsky; Debasish Sinha
Source: check_circle
Crossref

The physiological and pathophysiological roles of the autophagy lysosomal system in the conventional aqueous humor outflow pathway: More than cellular clean up

Progress in Retinal and Eye Research
2022-09 | Journal article
DOI: 10.1016/j.preteyeres.2022.101064
Contributors: Myoung Sup Shim; Paloma B. Liton
Source: check_circle
Crossref

Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells

Proceedings of the National Academy of Sciences
2021-03-30 | Journal article
DOI: 10.1073/pnas.2021942118
Contributors: Myoung Sup Shim; April Nettesheim; Angela Dixon; Paloma B. Liton
Source: check_circle
Crossref

The autophagic protein LC3 translocates to the nucleus and localizes in the nucleolus associated to NUFIP1 in response to cyclic mechanical stress

Autophagy
2020-07-02 | Journal article
DOI: 10.1080/15548627.2019.1662584
Contributors: Myoung Sup Shim; April Nettesheim; Joshua Hirt; Paloma B. Liton
Source: check_circle
Crossref

Transcriptome analysis reveals autophagy as regulator of TGFβ/Smad-induced fibrogenesis in trabecular meshwork cells.

Scientific reports
2019-11-06 | Journal article
DOI: 10.1038/s41598-019-52627-2
PMID: 31695131
PMC: PMC6834604
Source: Self-asserted source
Paloma B. Liton, PhD

Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model

Cell Death Discovery
2018-07-17 | Journal article
DOI: 10.1038/s41420-018-0077-y
Contributors: Joshua Hirt; Kris Porter; Angela Dixon; Stuart McKinnon; Paloma B. Liton
Source: check_circle
Crossref

Autophagy and mechanotransduction in outflow pathway cells

Experimental Eye Research
2017-05 | Journal article
DOI: 10.1016/j.exer.2016.06.021
Contributors: Joshua Hirt; Paloma B. Liton
Source: Self-asserted source
Paloma B. Liton, PhD via Crossref Metadata Search
grade
Preferred source (of 2)‎

Measles Virus Hemagglutinin epitopes immunogenic in natural infection and vaccination are targeted by broad or genotype-specific neutralizing monoclonal antibodies

Virus Research
2017-05 | Journal article
DOI: 10.1016/j.virusres.2017.04.018
Contributors: Miguel Angel Muñoz-Alía; José M. Casasnovas; María Luisa Celma; Juan Carabaña; Paloma B. Liton; Rafael Fernandez-Muñoz
Source: Self-asserted source
Paloma B. Liton, PhD via Crossref Metadata Search

Successful Implementation of a Program for Increasing Donor Eyes for Research: The Duke-Miracles In Sight Program

Journal of Ocular Pharmacology and Therapeutics
2016-04 | Journal article
DOI: 10.1089/jop.2015.0107
Contributors: Andrew M. Williams; Kristin M. Perkumas; Isaac Perry; Joanne C. Wen; Janet Keeling; Michael Tramber; Paloma B. Liton; W. Daniel Stamer
Source: Self-asserted source
Paloma B. Liton, PhD via Crossref Metadata Search

The autophagic lysosomal system in outflow pathway physiology and pathophysiology

Experimental Eye Research
2016-03 | Journal article
DOI: 10.1016/j.exer.2015.07.013
Contributors: Paloma B. Liton
Source: Self-asserted source
Paloma B. Liton, PhD via Crossref Metadata Search

Autophagic dysregulation in glaucomatous trabecular meshwork cells

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
2015-03 | Journal article
DOI: 10.1016/j.bbadis.2014.11.021
Contributors: Kristine Porter; Joshua Hirt; W. Daniel Stamer; Paloma B. Liton
Source: Self-asserted source
Paloma B. Liton, PhD via Crossref Metadata Search

MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
2014-06 | Journal article
DOI: 10.1016/j.bbamcr.2014.02.010
Contributors: Kristine M. Porter; Nallathambi Jeyabalan; Paloma B. Liton
Source: Self-asserted source
Paloma B. Liton, PhD via Crossref Metadata Search

Ascorbic Acid Modulation of Iron Homeostasis and Lysosomal Function in Trabecular Meshwork Cells

Journal of Ocular Pharmacology and Therapeutics
2014-03 | Journal article
DOI: 10.1089/jop.2013.0183
Contributors: Ping Xu; Yizhi Lin; Kristine Porter; Paloma B. Liton
Source: Self-asserted source
Paloma B. Liton, PhD via Crossref Metadata Search

Activated αvβ3 integrin regulates αvβ5 integrin-mediated phagocytosis in trabecular meshwork cells

Investigative Ophthalmology and Visual Science
2013 | Journal article
DOI:

10.1167/iovs.13-12084
Contributors: Gagen, D.; Filla, M.S.; Clark, R.; Liton, P.; Peters, D.M.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Cathepsin B Is Up-Regulated and Mediates Extracellular Matrix Degradation in Trabecular Meshwork Cells Following Phagocytic Challenge

PLoS ONE
2013 | Journal article
DOI:

10.1371/journal.pone.0068668
Contributors: Porter, K.; Lin, Y.; Liton, P.B.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells Implications for glaucoma pathogenesis

Autophagy
2013 | Journal article
DOI:

10.4161/auto.23568
Contributors: Porter, K.; Nallathambi, J.; Lin, Y.; Liton, P.B.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Guidelines for the use and interpretation of assays for monitoring autophagy

Autophagy
2012 | Journal article
DOI:

10.4161/auto.19496
Contributors: Klionsky, D.J.; Abdalla, F.C.; Abeliovich, H.; Abraham, R.T.; Acevedo-Arozena, A.; Adeli, K.; Agholme, L.; Agnello, M.; Agostinis, P.; Aguirre-Ghiso, J.A. et al.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Up-regulated expression of extracellular matrix remodeling genes in phagocytically challenged trabecular meshwork cells

PLoS ONE
2012 | Journal article
DOI:

10.1371/journal.pone.0034792
Contributors: Porter, K.M.; Epstein, D.L.; Liton, P.B.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Intralysosomal iron induces lysosomal membrane permeabilization and cathepsin D-mediated cell death in trabecular meshwork cells exposed to oxidative stress

Investigative Ophthalmology and Visual Science
2010 | Journal article
DOI:

10.1167/iovs.10-5410
Contributors: Lin, Y.; Epstein, D.L.; Liton, P.B.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Alterations in gene expression induced by cyclic mechanical stress in trabecular meshwork cells

Molecular Vision
2009 | Journal article
EID: 2-s2.0-65249126796
Contributors: Luna, C.; Li, G.; Liton, P.B.; Epstein, D.L.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Cross-talk between TGF-β1 and IL-6 in human trabecular meshwork cells

Molecular Vision
2009 | Journal article
EID: 2-s2.0-60849091056
Contributors: Liton, P.B.; Li, G.; Luna, C.; Gonzalez, P.; Epstein, D.L.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma

Autophagy
2009 | Journal article
DOI:

10.1167/iovs.08-1915
Contributors: Liton, P.B.; Lin, Y.; Gonzalez, P.; Epstein, D.L.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier
grade
Preferred source (of 2)‎

Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells

Food and Chemical Toxicology
2009 | Journal article
DOI:

10.1016/j.fct.2008.10.029
Contributors: Luna, C.; Li, G.; Liton, P.B.; Qiu, J.; Epstein, D.L.; Challa, P.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

The role of proteolytic cellular systems in trabecular meshwork homeostasis

Experimental Eye Research
2009 | Journal article
DOI:

10.1016/j.exer.2008.11.002
Contributors: Liton, P.B.; Gonzalez, P.; Epstein, D.L.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Potential role of lysosomal dysfunction in the pathogenesis of primary open angle glaucoma

Autophagy
2009-01 | Journal article
DOI: 10.4161/auto.5.1.7304
Contributors: Paloma B. Liton; Yizhi Lin; Pedro Gonzalez; David L. Epstein
Source: Self-asserted source
Paloma B. Liton, PhD via Crossref Metadata Search

Stress response of the trabecular meshwork

Journal of Glaucoma
2008 | Journal article
DOI:

10.1097/IJG.0b013e31815f52a8
Contributors: Liton, P.B.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier
grade
Preferred source (of 2)‎

Cytoprotective effects of proteasome β5 subunit overexpression in lens epithelial cells

Molecular Vision
2007 | Journal article
EID: 2-s2.0-33846307109
Contributors: Liu, Y.; Liu, X.; Zhang, T.; Luna, C.; Liton, P.B.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Effect of cellular senescence on the P2Y-receptor mediated calcium response in trabecular meshwork cells

Molecular Vision
2007 | Journal article
EID: 2-s2.0-35448973404
Contributors: Chow, J.; Liton, P.B.; Luna, C.; Wong, F.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Sustained stress response after oxidative stress in trabecular meshwork cells

Molecular Vision
2007 | Journal article
EID: 2-s2.0-37349056711
Contributors: Li, G.; Luna, C.; Liton, P.B.; Navarro, I.; Epstein, D.L.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Characterization of free-floating spheres from human trabecular meshwork (HTM) cell culture in vitro

Experimental Eye Research
2006 | Journal article
DOI:

10.1016/j.exer.2005.10.006
Contributors: Gonzalez, P.; Epstein, D.L.; Luna, C.; Liton, P.B.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Genome-wide expression profile of human trabecular meshwork cultured cells, nonglaucomatous and primary open angle glaucoma tissue

Molecular Vision
2006 | Journal article
EID: 2-s2.0-33745885317
Contributors: Liton, P.B.; Luna, C.; Challa, P.; Epstein, D.L.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Cellular senescence in the glaucomatous outflow pathway

Experimental Gerontology
2005 | Journal article
DOI:

10.1016/j.exger.2005.06.005
Contributors: Liton, P.B.; Challa, P.; Stinnett, S.; Luna, C.; Epstein, D.L.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Induction of IL-6 expression by mechanical stress in the trabecular meshwork

Biochemical and Biophysical Research Communications
2005 | Journal article
DOI:

10.1016/j.bbrc.2005.09.182
Contributors: Liton, P.B.; Luna, C.; Bodman, M.; Hong, A.; Epstein, D.L.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Induction of TGF-β1 in the trabecular meshwork under cyclic mechanical stress

Journal of Cellular Physiology
2005 | Journal article
DOI:

10.1002/jcp.20404
Contributors: Liton, P.B.; Liu, X.; Challa, P.; Epstein, D.L.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Lentiviral mediated gene delivery to the anterior chamber of rodent eyes

Molecular Vision
2005 | Journal article
EID: 2-s2.0-26244451621
Contributors: Challa, P.; Luna, C.; Liton, P.B.; Chamblin, B.S.; Wakefiled, J.K.; Ramabhadran, R.; Epstein, D.L.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Specific targeting of gene expression to a subset of human trabecular meshwork cells using the chitinase 3-like 1 promoter

Investigative Ophthalmology and Visual Science
2005 | Journal article
DOI:

10.1167/iovs.04-0330
Contributors: Liton, P.B.; Liu, X.; Stamer, W.D.; Challa, P.; Epstein, D.L.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Effects of donor age on proteasome activity and senescence in trabecular meshwork cells

Biochemical and Biophysical Research Communications
2004 | Journal article
DOI:

10.1016/j.bbrc.2004.08.195
Contributors: Caballero, M.; Liton, P.B.; Challa, P.; Epstein, D.L.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Expression analysis of the matrix GLA protein and VE-cadherin gene promoters in the outflow pathway

Investigative Ophthalmology and Visual Science
2004 | Journal article
DOI:

10.1167/iovs.03-0537
Contributors: Gonzalez, P.; Caballero, M.; Liton, P.B.; Stamer, W.D.; Epstein, D.L.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Proteasome inhibition by chronic oxidative stress in human trabecular meshwork cells

Biochemical and Biophysical Research Communications
2003 | Journal article
DOI:

10.1016/S0006-291X(03)01385-8
Contributors: Caballero, M.; Liton, P.B.; Epstein, D.L.; Gonzalez, P.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier
grade
Preferred source (of 2)‎

Clinical isolates of measles virus use CD46 as a cellular receptor

Journal of Virology
2000 | Journal article
DOI:

10.1128/JVI.74.9.3967-3974.2000
Contributors: Manchester, M.; Eto, D.S.; Valsamakis, A.; Liton, P.B.; Fernandez-Muñoz, R.; Rota, P.A.; Bellini, W.J.; Forthal, D.N.; Oldstone, M.B.A.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Molecular epidemiology of the measles virus | Epidemiologia molecular del virus del sarampion

Revista Espanola de Salud Publica
1999 | Journal article
EID: 2-s2.0-0033182342
Contributors: Fernández-Muñoz, R.; Carabaña, J.; Caballero, M.; Liton, P.B.; Duque, B.M.; García-Villalón, M.D.; Celma, M.L.
Source: Self-asserted source
Paloma B. Liton, PhD via Scopus - Elsevier

Epidemiología molecular del virus del sarampión

Revista Española de Salud Pública
1999-09 | Journal article
DOI: 10.1590/s1135-57271999000500010
Contributors: Rafael Fernández-Muñoz; Juan Carabaña; Montserrat Caballero; Paloma B. Liton; Beatriz M Duque; Dolores García-Villalón; María Luisa Celma
Source: Self-asserted source
Paloma B. Liton, PhD via Crossref Metadata Search

Peer review (1 review for 1 publication/grant)

Review activity for Nature communications (1)
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