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Employment (2)

Johns Hopkins University: Baltimore, US

Associate Professor (Molecular Microbiology and Immunology)
Employment
Source: Self-asserted source
Monica R Mugnier

Johns Hopkins Bloomberg School of Public Health: Baltimore, MD, US

2016-10-01 to 2024-03 | Assistant Professor (Molecular Microbiology and Immunology)
Employment
Source: Self-asserted source
Monica R Mugnier

Education and qualifications (2)

Rockefeller University: New York, NY, US

2009-09 to 2016-06 | PhD, Biomedical Science
Education
Source: Self-asserted source
Monica R Mugnier

Tufts University: Medford, MA, US

2005-09 to 2009-05 | BS (Biochemistry)
Education
Source: Self-asserted source
Monica R Mugnier

Funding (2)

Mapping the antibody response to Trypanosoma brucei variant surface glycoprotein

2022-06-03 to 2025-05-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.12911257
GRANT_NUMBER: R21AI163569
Source: Self-asserted source
Monica R Mugnier via DimensionsWizard

Variant surface glycoprotein diversification in Trypanosoma brucei

2016-09-19 to 2021-08-31 | Grant
NIH Office of the Director (Bethesda, US)
URL: https://grants.uberresearch.com/100000052/DP5OD023065/Variant-surface-glycoprotein-diversification-in-Trypanosoma-brucei
GRANT_NUMBER: DP5OD023065
Source: Self-asserted source
Monica R Mugnier via DimensionsWizard

Works (30)

Genomic determinants of antigen expression hierarchy in African trypanosomes

Nature
2025-03-12 | Journal article
DOI: 10.1038/s41586-025-08720-w
Contributors: Zhibek Keneskhanova; Kirsty R. McWilliam; Raúl O. Cosentino; Anna Barcons-Simon; Atai Dobrynin; Jaclyn E. Smith; Ines Subota; Monica R. Mugnier; Maria Colomé-Tatché; T. Nicolai Siegel
Source: check_circle
Crossref

A murine model of Trypanosoma brucei- induced myocarditis and cardiac dysfunction

Microbiology Spectrum
2025-02-04 | Journal article
DOI: 10.1128/spectrum.01623-24
Contributors: Nathan P. Crilly; Marcelle Dina Zita; Alexander K. Beaver; Polina Sysa-Shah; Aashik Bhalodia; Kathy Gabrielson; Luigi Adamo; Monica R. Mugnier; Neil A. Mabbott
Source: check_circle
Crossref

Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei.

Nature
2024-10 | Journal article
DOI: 10.1038/s41586-024-08151-z
PMID: 39478231
Contributors: Beaver AK; Keneskhanova Z; Cosentino RO; Weiss BL; Awuoche EO; Smallenberger GM; Buenconsejo GY; Crilly NP; Smith JE; Hakim JMC et al.
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

Whole-genome assembly of a hybrid Trypanosoma cruzi strain assembled with Nanopore sequencing alone.

G3 (Bethesda, Md.)
2024-06 | Journal article
DOI: 10.1093/g3journal/jkae076
PMID: 38592968
PMC: PMC11152063
Contributors: Hakim JMC; Gutierrez Guarnizo SA; Málaga Machaca E; Gilman RH; Mugnier MR
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

Myocardial B cells have specific gene expression and predicted interactions in dilated cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy.

Frontiers in immunology
2024-04 | Journal article
DOI: 10.3389/fimmu.2024.1327372
PMID: 38736889
PMC: PMC11082303
Contributors: Bermea KC; Duque C; Cohen CD; Bhalodia A; Rousseau S; Lovell J; Zita MD; Mugnier MR; Adamo L
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

DNA damage drives antigen diversification through mosaic Variant Surface Glycoprotein (VSG) formation in<i>Trypanosoma brucei</i>

2024-03 | Preprint
DOI: 10.1101/2024.03.22.582209
PPR: PPR827624
Contributors: Smith JE; Wang KJ; Kennedy EM; Hakim JM; So J; Beaver AK; Magesh A; Gilligan-Steinberg SD; Zheng J; Zhang B et al.
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

High-resolution scRNA-seq reveals genomic determinants of antigen expression hierarchy in African Trypanosomes

2024-03-22 | Preprint
DOI: 10.1101/2024.03.22.586247
Contributors: Kirsty R. McWilliam; Zhibek Keneskhanova; Raúl O. Cosentino; Atai Dobrynin; Jaclyn E. Smith; Ines Subota; Monica R. Mugnier; Maria Colomé-Tatché; T. Nicolai Siegel
Source: check_circle
Crossref

Immunologic changes are detectable in the peripheral blood transcriptome of clinically asymptomatic Chagas cardiomyopathy patients

2023-10 | Preprint
DOI: 10.1101/2023.10.03.560680
PPR: PPR736746
Contributors: Duque C; So J; Castro-Sesquen YE; DeToy K; Guarnizo SAG; Jahanbakhsh F; Machaca EM; Miranda-Schaeubinger M; Chakravarti I; Cooper V et al.
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

A murine model ofTrypanosoma brucei-induced myocarditis and cardiac dysfunction

2023-10-05 | Preprint
DOI: 10.1101/2023.10.05.560950
Contributors: Nathan P. Crilly; Marcelle Dina Zita; Alexander K. Beaver; Polina Sysa-Shah; Aashik Bhalodia; Kathy Gabrielson; Luigi Adamo; Monica R. Mugnier
Source: check_circle
Crossref

Amplicon Sequencing Reveals Complex Infection in Infants Congenitally Infected With Trypanosoma Cruzi and Informs the Dynamics of Parasite Transmission.

The Journal of infectious diseases
2023-09 | Journal article
DOI: 10.1093/infdis/jiad125
PMID: 37119236
PMC: PMC10503952
Contributors: Hakim JMC; Waltmann A; Tinajeros F; Kharabora O; Machaca EM; Calderon M; Del Carmen Menduiña M; Wang J; Rueda D; Zimic M et al.
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

Myocardial B cells have specific gene expression and predicted interactions in Dilated Cardiomyopathy and Arrhythmogenic Right Ventricular Cardiomyopathy

2023-09-23 | Preprint
DOI: 10.1101/2023.09.21.558902
Contributors: Kevin C. Bermea; Carolina Duque; Charles D. Cohen; Aashik Bhalodia; Sylvie Rousseau; Jana Lovell; Marcelle Dina Zita; Monica R. Mugnier; Luigi Adamo
Source: check_circle
Crossref

Whole Genome Assembly of a HybridTrypanosoma cruziStrain Assembled with Nanopore Sequencing Alone

2023-07-27 | Preprint
DOI: 10.1101/2023.07.27.550875
Contributors: Jill M.C. Hakim; Sneider A Gutierrez Guarnizo; Edith Málaga Machaca; Robert H. Gilman; Monica R. Mugnier
Source: check_circle
Crossref

mSphere of Influence: the Young Investigators in Parasitology Meeting—Investing in the Future of Our Scientific Community by Lifting Up and Connecting Junior Faculty

mSphere
2023-04-20 | Journal article
DOI: 10.1128/msphere.00615-22
Contributors: Monica R. Mugnier; Chi-Min Ho; Ira J. Blader
Source: check_circle
Crossref

VSGs Expressed during Natural T. b. gambiense Infection Exhibit Extensive Sequence Divergence and a Subspecies-Specific Bias towards Type B N-Terminal Domains

mBio
2022-12-20 | Journal article
DOI: 10.1128/mbio.02553-22
Contributors: Jaime So; Sarah Sudlow; Abeer Sayeed; Tanner Grudda; Stijn Deborggraeve; Dieudonné Mumba Ngoyi; Didier Kashiama Desamber; Bill Wickstead; Veerle Lejon; Monica R. Mugnier et al.
Source: check_circle
Crossref

Extravascular spaces are the primary reservoir of antigenic diversity inTrypanosoma bruceiinfection

2022-06-27 | Preprint
DOI: 10.1101/2022.06.27.497797
Contributors: Alexander K. Beaver; Nathan P. Crilly; Gracyn Y. Buenconsejo; Jill M.C. Hakim; Bailin Zhang; Bryce Bobb; Filipa Rijo-Ferreira; Luisa M. Figueiredo; Monica R. Mugnier
Source: check_circle
Crossref

Thinking outside the blood: Perspectives on tissue-resident Trypanosoma brucei

PLOS Pathogens
2021-09-16 | Journal article
DOI: 10.1371/journal.ppat.1009866
Contributors: Nathan P. Crilly; Bjorn F.C. Kafsack; Monica R. Mugnier
Source: check_circle
Crossref

VSGs expressed during natural T. b. gambiense infection exhibit extensive sequence divergence and a subspecies-specific expression bias

2021-09-09 | Preprint
DOI: 10.1101/2021.09.09.459620
Contributors: Jaime So; Sarah Sudlow; Abeer Sayeed; Tanner Grudda; Stijn Deborggraeve; Dieudonné Mumba Ngoyi; Didier Kashiama Desamber; Bill Wickstead; Veerle Lejon; Monica R. Mugnier
Source: check_circle
Crossref

Trypanosoma brucei.

Trends in parasitology
2019-11 | Journal article
DOI: 10.1016/j.pt.2019.10.007
PMID: 31757771
PMC: PMC7375462
Contributors: Romero-Meza G; Mugnier MR
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

Developmental competence and antigen switch frequency can be uncoupled in Trypanosoma brucei

Proceedings of the National Academy of Sciences
2019-11-05 | Journal article
DOI: 10.1073/pnas.1912711116
Contributors: Kirsty R. McWilliam; Alasdair Ivens; Liam J. Morrison; Monica R. Mugnier; Keith R. Matthews
Source: check_circle
Crossref

Detection of Trypanosoma brucei Variant Surface Glycoprotein Switching by Magnetic Activated Cell Sorting and Flow Cytometry.

2016-10 | Journal article
DOI: 10.3791/54715
PMID: 27805593
Contributors: Schulz D; Mugnier MR; Boothroyd CE; Papavasiliou FN
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

Masters of Disguise: Antigenic Variation and the VSG Coat in Trypanosoma brucei.

2016-09 | Journal article
DOI: 10.1371/journal.ppat.1005784
PMID: 27583379
PMC: PMC5008768
Contributors: Mugnier MR; Stebbins CE; Papavasiliou FN
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

Vesicles as Vehicles for Virulence.

2016-06 | Journal article
DOI: 10.1016/j.pt.2016.03.001
PMID: 27006155
Contributors: Mugnier MR; Papavasiliou FN; Schulz D
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

A Conserved DNA Repeat Promotes Selection of a Diverse Repertoire of Trypanosoma brucei Surface Antigens from the Genomic Archive.

2016-05 | Journal article
DOI: 10.1371/journal.pgen.1005994
PMID: 27149665
PMC: PMC4858185
Contributors: Hovel-Miner G; Mugnier MR; Goldwater B; Cross GA; Papavasiliou FN
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

A Host-Pathogen Interaction Reduced to First Principles: Antigenic Variation in T. brucei.

2015 | Journal article
DOI: 10.1007/978-3-319-20819-0_2
PMID: 26537376
Contributors: Hovel-Miner G; Mugnier M; Papavasiliou FN; Pinger J; Schulz D
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.

2015-12 | Journal article
DOI: 10.1371/journal.pbio.1002316
PMID: 26646171
PMC: PMC4672894
Contributors: Schulz D; Mugnier MR; Paulsen EM; Kim HS; Chung CW; Tough DF; Rioja I; Prinjha RK; Papavasiliou FN; Debler EW
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

The in vivo dynamics of antigenic variation in Trypanosoma brucei.

2015-03 | Journal article
DOI: 10.1126/science.aaa4502
PMID: 25814582
PMC: PMC4514441
Contributors: Mugnier MR; Cross GA; Papavasiliou FN
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

Telomere length affects the frequency and mechanism of antigenic variation in Trypanosoma brucei.

2012 | Journal article
DOI: 10.1371/journal.ppat.1002900
PMID: 22952449
PMC: PMC3431348
Contributors: Hovel-Miner GA; Boothroyd CE; Mugnier M; Dreesen O; Cross GA; Papavasiliou FN
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

Long-lived bone marrow plasma cells are induced early in response to T cell-independent or T cell-dependent antigens.

2012-06 | Journal article
DOI: 10.4049/jimmunol.1102808
PMID: 22529295
PMC: PMC4341991
Contributors: Bortnick A; Chernova I; Quinn WJ; Mugnier M; Cancro MP; Allman D
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

A dynamic T cell-limited checkpoint regulates affinity-dependent B cell entry into the germinal center.

2011-06 | Journal article
DOI: 10.1084/jem.20102477
PMID: 21576382
PMC: PMC3173244
Contributors: Schwickert TA; Victora GD; Fooksman DR; Kamphorst AO; Mugnier MR; Gitlin AD; Dustin ML; Nussenzweig MC
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central

DNA hypomethylation causes bile duct defects in zebrafish and is a distinguishing feature of infantile biliary atresia.

2011-03 | Journal article
DOI: 10.1002/hep.24106
PMID: 21319190
PMC: PMC3075951
Contributors: Matthews RP; Eauclaire SF; Mugnier M; Lorent K; Cui S; Ross MM; Zhang Z; Russo P; Pack M
Source: Self-asserted source
Monica R Mugnier via Europe PubMed Central
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