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Scopus Author ID: 53164182400

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Employment (1)

Uppsala University: Uppsala, SE

2013-01-17 to present | Associate Professor, PI, Researcher (Pharmacy)
Employment
Source: Self-asserted source
Irena Loryan

Funding (2)

IM2PACT

Grant
European Commission (Uppsala, SE)
URL: http://im2pact.org/
Source: Self-asserted source
Irena Loryan

NeuroDeRisk

Grant
European Commission (Uppsala, SE)
URL: https://neuroderisk.eu/
Source: Self-asserted source
Irena Loryan

Works (21)

Assessing central nervous system drug delivery

Expert Opinion on Drug Delivery
2025-03-04 | Journal article
DOI: 10.1080/17425247.2025.2462767
Contributors: Margareta Hammarlund-Udenaes; Irena Loryan
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Ceftazidime-avibactam (CAZ-AVI) pharmacokinetics in critically ill patients undergoing continuous venovenous hemodiafiltration (CVVHDF)

International Journal of Antimicrobial Agents
2025-01 | Journal article
DOI: 10.1016/j.ijantimicag.2024.107394
Contributors: Amaury O'Jeanson; Konstantinos Ioannidis; Elisabet I. Nielsen; Lamprini Galani; Aghavni Ginosyan; Harry Paskalis; Irena Loryan; Helen Giamarellou; Lena E. Friberg; Ilias Karaiskos
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Active Uptake of Oxycodone at Both the Blood-Cerebrospinal Fluid Barrier and The Blood-Brain Barrier without Sex Differences: A Rat Microdialysis Study

Pharmaceutical Research
2023-11 | Journal article
DOI: 10.1007/s11095-023-03583-0
Contributors: Frida Bällgren; Margareta Hammarlund-Udenaes; Irena Loryan
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Pharmacokinetics of Novel Dopamine Transporter Inhibitor CE-123 and Modafinil with a Focus on Central Nervous System Distribution

International Journal of Molecular Sciences
2023-11-29 | Journal article
DOI: 10.3390/ijms242316956
Contributors: Iva Spreitzer; Josefin Keife; Tobias Strasser; Predrag Kalaba; Jana Lubec; Winfried Neuhaus; Gert Lubec; Thierry Langer; Judith Wackerlig; Irena Loryan
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Differential Blood–Brain Barrier Transport and Cell Uptake of Cyclic Peptides In Vivo and In Vitro

Pharmaceutics
2023-05-16 | Journal article
DOI: 10.3390/pharmaceutics15051507
Contributors: Erik Melander; Camilla Eriksson; Sara Wellens; Kimia Hosseini; Robert Fredriksson; Fabien Gosselet; Maxime Culot; Ulf Göransson; Margareta Hammarlund-Udenaes; Irena Loryan
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Unbound Brain-to-Plasma Partition Coefficient, Kp,uu,brain—a Game Changing Parameter for CNS Drug Discovery and Development

Pharmaceutical Research
2022-07 | Journal article
DOI: 10.1007/s11095-022-03246-6
Contributors: Irena Loryan; Andreas Reichel; Bo Feng; Christoffer Bundgaard; Christopher Shaffer; Cory Kalvass; Dallas Bednarczyk; Denise Morrison; Dominique Lesuisse; Edmund Hoppe et al.
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Neuropharmacokinetic visualization of regional and subregional unbound antipsychotic drug transport across the blood–brain barrier

Molecular Psychiatry
2021-12 | Journal article
DOI: 10.1038/s41380-021-01267-y
Contributors: Dominika Luptáková; Theodosia Vallianatou; Anna Nilsson; Reza Shariatgorji; Margareta Hammarlund-Udenaes; Irena Loryan; Per E. Andrén
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Molecular basis of mood and cognitive adverse events elucidated via a combination of pharmacovigilance data mining and functional enrichment analysis

Archives of Toxicology
2020-08-05 | Journal article
DOI: 10.1007/s00204-020-02788-1
Contributors: Christos Andronis; João Pedro Silva; Eftychia Lekka; Vassilis Virvilis; Helena Carmo; Konstantina Bampali; Margot Ernst; Yang Hu; Irena Loryan; Jacques Richard et al.
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Rate and extent of mitragynine and 7‐hydroxymitragynine blood–brain barrier transport and their intra‐brain distribution: the missing link in pharmacodynamic studies

Addiction Biology
2019-09 | Journal article
DOI: 10.1111/adb.12661
Contributors: Siti R. Yusof; Mahathir Mohd Uzid; Eng‐Huat Teh; Nur Aziah Hanapi; Mazlin Mohideen; Ahmad Saifuddin Mohamad Arshad; Mohd Nizam Mordi; Irena Loryan; Margareta Hammarlund‐Udenaes
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Mechanistic Study on the Use of the l-Type Amino Acid Transporter 1 for Brain Intracellular Delivery of Ketoprofen via Prodrug: A Novel Approach Supporting the Development of Prodrugs for Intracellular Targets

Molecular Pharmaceutics
2019-07-01 | Journal article
DOI: 10.1021/acs.molpharmaceut.9b00502
Contributors: Elena Puris; Mikko Gynther; Elizabeth C.M. de Lange; Seppo Auriola; Margareta Hammarlund-Udenaes; Kristiina M. Huttunen; Irena Loryan
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Heterogeneous drug tissue binding in brain regions of rats, Alzheimer’s patients and controls: impact on translational drug development

Scientific Reports
2019-03-29 | Journal article
DOI: 10.1038/s41598-019-41828-4
Contributors: Sofia Gustafsson; Dag Sehlin; Erik Lampa; Margareta Hammarlund-Udenaes; Irena Loryan
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Quantitative Assessment of Drug Delivery to Tissues and Association with Phospholipidosis: A Case Study with Two Structurally Related Diamines in Development

Molecular Pharmaceutics
2017-12-04 | Journal article
DOI: 10.1021/acs.molpharmaceut.7b00480
Contributors: Irena Loryan; Edmund Hoppe; Klaus Hansen; Felix Held; Achim Kless; Klaus Linz; Virginia Marossek; Bert Nolte; Paul Ratcliffe; Derek Saunders et al.
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In-depth neuropharmacokinetic analysis of antipsychotics based on a novel approach to estimate unbound target-site concentration in CNS regions: link to spatial receptor occupancy

Molecular Psychiatry
2016-11 | Journal article
DOI: 10.1038/mp.2015.229
Contributors: I Loryan; E Melander; M Svensson; M Payan; F König; B Jansson; M Hammarlund-Udenaes
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Mechanistic Understanding of Brain Drug Disposition to Optimize the Selection of Potential Neurotherapeutics in Drug Discovery

2014 | Journal article
DOI:

10.1007/s11095-014-1319-1

Part of ISSN:

07248741 1573904X

EID:

2-s2.0-84895778441
Contributors: Loryan, I.; Sinha, V.; Mackie, C.; Van Peer, A.; Drinkenburg, W.; Vermeulen, A.; Morrison, D.; Monshouwer, M.; Heald, D.; Hammarlund-Udenaes, M.
Source: Self-asserted source
Irena Loryan via Scopus - Elsevier

Molecular Properties Determining Unbound Intracellular and Extracellular Brain Exposure of CNS Drug Candidates

Molecular Pharmaceutics
2014-12-15 | Journal article
Source: Self-asserted source
Irena Loryan

Effect of transporter inhibition on the distribution of cefadroxil in rat brain

Fluids and Barriers of the CNS
2014-11-14 | Journal article
Source: Self-asserted source
Irena Loryan

Sex difference in formation of propofol metabolites: A replication study

2013 | Journal article
DOI:

10.1111/bcpt.12070

Part of ISSN:

17427835 17427843

EID:

2-s2.0-84880312309
Contributors: Choong, E.; Loryan, I.; Lindqvist, M.; Nordling, A.; El Bouazzaoui, S.; van Schaik, R.H.; Johansson, I.; Jakobsson, J.; Ingelman-Sundberg, M.
Source: Self-asserted source
Irena Loryan via Scopus - Elsevier

The brain slice method for studying drug distribution in the CNS

2013 | Journal article
DOI:

10.1186/2045-8118-10-6

EID:

2-s2.0-84875283780

Part of ISSN:

20458118
Contributors: Loryan, I.; Fridén, M.; Hammarlund-Udenaes, M.
Source: Self-asserted source
Irena Loryan via Scopus - Elsevier

Drug Discovery Methods for Studying Brain Drug Delivery and Distribution

2013-11-13 | Book chapter
DOI:

10.1007/978-1-4614-9105-7_10
Source: Self-asserted source
Irena Loryan

Influence of sex on propofol metabolism, a pilot study: Implications for propofol anesthesia

2012 | Journal article
DOI:

10.1007/s00228-011-1132-2

Part of ISSN:

00316970 14321041

EID:

2-s2.0-84860268964
Contributors: Loryan, I.; Lindqvist, M.; Johansson, I.; Hiratsuka, M.; Van Der Heiden, I.; Van Schaik, R.H.; Jakobsson, J.; Ingelman-Sundberg, M.
Source: Self-asserted source
Irena Loryan via Scopus - Elsevier

UGT1A4*3 encodes significantly increased glucuronidation of olanzapine in patients on maintenance treatment and in recombinant systems

2012 | Journal article
DOI:

10.1038/clpt.2012.46

Part of ISSN:

00099236 15326535

EID:

2-s2.0-84864138748
Contributors: Haslemo, T.; Loryan, I.; Ueda, N.; Mannheimer, B.; Bertilsson, L.; Ingelman-Sundberg, M.; Molden, E.; Eliasson, E.
Source: Self-asserted source
Irena Loryan via Scopus - Elsevier

Peer review (21 reviews for 7 publications/grants)

Review activity for Fluids and barriers of the CNS. (5)
Review activity for Immunologic research. (1)
Review activity for Journal of pharmaceutical & biomedical analysis. (1)
Review activity for Molecular pharmaceutics. (7)
Review activity for Nature communications (2)
Review activity for Pharmaceutical research. (4)
Review activity for PloS one. (1)
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