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Employment (1)

University of Murcia: Murcia, Murcia, ES

2019-07-18 to present | Associate Professor (Pharmacology)
Employment
Source: Self-asserted source
Pilar Almela

Education and qualifications (3)

University of Murcia: Murcia, Murcia, ES

2008 | PhD (Pharmacology)
Education
Source: Self-asserted source
Pilar Almela

University of Murcia: Murcia, Murcia, ES

2001 to 2005 | Degree in Food Science and Technology
Education
Source: Self-asserted source
Pilar Almela

University of Granada: Granada, Andalucía, ES

1996 to 2001 | Degree in Pharmacy
Education
Source: Self-asserted source
Pilar Almela

Works (41)

Identification of Benzodiazepine Use Based on Dried Blood Stains Analysis

Pharmaceuticals
2024-06 | Journal article | Author
DOI: 10.3390/ph17060799
Contributors: Lucía Fernández-López; Sandra Rodríguez; Alberto Cánovas-Cabanes; Francisco-Javier Teruel-Fernández; Pilar Almela; JUAN PEDRO HERNANDEZ DEL RINCON; Javier Navarro-Zaragoza; María Falcón
Source: check_circle
Multidisciplinary Digital Publishing Institute

Cut-off value for β-trace protein (β-TP) as a rapid diagnostic of cerebrospinal fluid (CSF) leak detection.

Laryngoscope Investigative Otolaryngology
2023-08-31 | Journal article | Author
DOI: 10.1002/lio2.1150
PMID: 37899857
PMC: PMC10601553
Contributors: Almela MT; Javier Navarro-Zaragoza; Laorden ML; Sánchez-Celemín F; Pilar Almela
Source: Self-asserted source
Pilar Almela

Upregulation of Heat-Shock Protein (hsp)-27 in a Patient with Heterozygous SPG11 c.1951C>T and SYNJ1 c.2614G>T Mutations Causing Clinical Spastic Paraplegia

Genes
2023-06 | Journal article | Author
DOI: 10.3390/genes14071320
Contributors: Juan Antonio Garcia-Carmona; Joaquín Amores-Iniesta; José Soler-Usero; María Cerdán-Sánchez; Javier Navarro-Zaragoza; María López-López; Juan José Soria-Torrecillas; Ainhoa Ballesteros-Arenas; José Antonio Pérez-Vicente; Pilar Almela
Source: check_circle
Multidisciplinary Digital Publishing Institute

7-Nitroindazole reduces L-DOPA-induced dyskinesias in non-human Parkinsonian primate.

Open Biology
2023-05-17 | Journal article
DOI: 10.1098/rsob.220370
PMID: 37192671
PMC: PMC10188238
Contributors: MARIA TRINIDAD HERRERO; JOSE ENRIQUE YUSTE; Lorena Cuenca Bermejo; Almela P; Arenas-Betancur L; De Pablos V; Gonzalez-Cuello A; Del Bel E; Navarro-Zaragoza J; Fernández-Villalba E
Source: Self-asserted source
Pilar Almela

Bases neurobiológicas de la adicción a opioides

Lo que debes saber sobre medicamentos y salud
2022 | Book chapter
Contributors: Ruiz-González M; Cánovas A; Teruel J; Laorden ML; Navarro-Zaragoza J; Pilar Almela
Source: Self-asserted source
Pilar Almela

Cardiac Changes in Parkinson’s Disease: Lessons from Clinical and Experimental Evidence

International Journal of Molecular Sciences
2021-12 | Journal article | Author
DOI: 10.3390/ijms222413488
Contributors: Lorena Cuenca Bermejo; Pilar Almela; Javier Navarro-Zaragoza; Emiliano Fernández Villalba; Ana-María González-Cuello; María-Luisa Laorden; MARIA TRINIDAD HERRERO
Source: check_circle
Multidisciplinary Digital Publishing Institute

Cardiac tyrosine hydroxylase activation and MB-COMT in dyskinetic monkeys.

Scientific Reports
2021-10-06 | Journal article | Author
DOI: 10.1038/s41598-021-99237-5
PMID: 34615910
PMC: PMC8494805
Contributors: Lorena Cuenca Bermejo; Pilar Almela; Pablo Gallo Soljancic; JOSE ENRIQUE YUSTE; Vicente de pablos; Victor Bautista-Hernandez; EMILIANO FERNANDEZ-VILLALBA; María Luisa Laorden; MARIA TRINIDAD HERRERO
Source: Self-asserted source
Pilar Almela

Could Small Heat Shock Protein HSP27 Be a First-Line Target for Preventing Protein Aggregation in Parkinson’s Disease?

International Journal of Molecular Sciences
2021-03 | Journal article | Author
DOI: 10.3390/ijms22063038
Contributors: Javier Navarro-Zaragoza; Lorena Cuenca Bermejo; Pilar Almela; María-Luisa Laorden; MARIA TRINIDAD HERRERO
Source: check_circle
Multidisciplinary Digital Publishing Institute

Naloxone-induced conditioned place aversion score and extinction period are higher in C57BL/6J morphine-dependent mice than in Swiss: Role of HPA axis.

Pharmacology, Biochemistry, and Behavior
2021-01-12 | Journal article
DOI: 10.1016/j.pbb.2021.173106
PMID: 33444599
Contributors: Javier Navarro-Zaragoza; Martínez-Laorden E; Teruel-Fernández FJ; Victoria Gómez Murcia; Cánovas A; Milanés MV; Laorden ML; Almela P
Source: Self-asserted source
Pilar Almela

Corticotrophin-releasing factor (CRF) through CRF1 receptor facilitates the expression of morphine-related positive and aversive memory in mice

Opioids. From analgesic use to addiction
2020 | Book chapter
Contributors: Pilar Almela; García-Carmona JA; Martínez-Laorden E; Milanés MV; Laorden ML
Source: Self-asserted source
Pilar Almela

Introductory Chapter: Opioid Analgesics - History, Uses and Risks

Opioids. From analgesic use to addiction
2020 | Book chapter
Contributors: Pilar Almela
Source: Self-asserted source
Pilar Almela

Cardiac Protective Role of Heat Shock Protein 27 in the Stress Induced by Drugs of Abuse

International Journal of Molecular Sciences
2020-05 | Journal article | Author
DOI: 10.3390/ijms21103623
Contributors: Elena Martínez-Laorden; Javier Navarro-Zaragoza; María Victoria Milanés; María Luisa Laorden; Pilar Almela
Source: check_circle
Multidisciplinary Digital Publishing Institute

Cardiac Noradrenaline Turnover and Heat Shock Protein 27 Phosphorylation in Dyskinetic Monkeys.

Movement Disorders
2019-12-24 | Journal article
DOI: 10.1002/mds.27958
PMID: 31872915
Contributors: Almela P; Lorena Cuenca Bermejo; Yuste JE; Estrada C; de Pablos V; Victor Bautista-Hernandez; Fernández-Villalba E; Laorden ML; Herrero MT
Source: Self-asserted source
Pilar Almela

Liposome-Encapsulated Morphine Affords a Prolonged Analgesia While Facilitating Extinction of Reward and Aversive Memories.

Frontiers in Pharmacology
2019-09-20 | Journal article
DOI: 10.3389/fphar.2019.01082
PMID: 31616299
PMC: PMC6764324
Contributors: Victoria Gómez Murcia; Bruno Ribeiro Do Couto; Gómez-Fernández JC; Milanés MV; Laorden ML; Almela P
Source: Self-asserted source
Pilar Almela

Conditioned aversive memory associated with morphine withdrawal increases brain-derived neurotrophic factor in dentate gyrus and basolateral amygdala.

Addiction Biology
2019-07-08 | Journal article
DOI: 10.1111/adb.12792
PMID: 31282111
Contributors: Martínez-Laorden E; Javier Navarro-Zaragoza; M. Victoria Milanés; Laorden ML; Almela P
Source: Self-asserted source
Pilar Almela

Pharmacological modulation of the behavioral effects of social defeat in memory and learning in male mice.

Psychopharmacology
2019-05-02 | Journal article
DOI: 10.1007/s00213-019-05256-6
PMID: 31049607
Contributors: M.Carmen Blanco-Gandia; Sandra Montagud Romero; Javier Navarro-Zaragoza; Martínez-Laorden E; Almela P; Cristina Núñez; M. Victoria Milanés; Laorden ML; Miñarro J; Marta Rodriguez-Arias
Source: Self-asserted source
Pilar Almela

The involvement of CRF1 receptor within the basolateral amygdala and dentate gyrus in the naloxone-induced conditioned place aversion in morphine-dependent mice.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
2018-01-31 | Journal article
DOI: 10.1016/j.pnpbp.2018.01.018
PMID: 29407532
Contributors: Valero E; Gómez-Milanés I; Almela P; Bruno Ribeiro Do Couto; Laorden ML; M. Victoria Milanés; Cristina Núñez
Source: Self-asserted source
Pilar Almela

Protocolo alimentario en diabetes mellitus

Recomendaciones dietéticas en patologías crónicas
2017 | Book chapter
Contributors: Bermúdez-Soto MJ; Zaragoza MP; Pilar Almela; Sierra-Alarcón S; Cerdá B; Zamora S
Source: Self-asserted source
Pilar Almela

Protocolo alimentario en dislipemias

Recomendaciones dietéticas en patologías crónicas
2017 | Book chapter
Contributors: Bermúdez-Soto MJ; Pilar Almela; Zaragoza MP; Sierra-Alarcón S; García-Galbís J
Source: Self-asserted source
Pilar Almela

Protocolo alimentario en obesidad y sobrepeso

Recomendaciones dietéticas en patologías crónicas
2017 | Book chapter
Contributors: Pilar Almela; Bermúdez-Soto MJ; Zaragoza MP; Cerdá B; Zaragozá F
Source: Self-asserted source
Pilar Almela

Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB receptor in the mesolimbic system.

Psychopharmacology
2017-05-02 | Journal article
DOI: 10.1007/s00213-017-4612-y
PMID: 28466092
Contributors: Sandra Montagud Romero; Cristina Núñez; M.Carmen Blanco-Gandia; Martínez-Laorden E; MARIA A AGUILAR; Javier Navarro-Zaragoza; Almela P; M. Victoria Milanés; Laorden ML; Miñarro J et al.
Source: Self-asserted source
Pilar Almela

Development of Poly(lactide-co-glicolide) Nanoparticles Incorporating Morphine Hydrochloride to Prolong its Circulation in Blood.

Current Pharmaceutical Design
2017-01-01 | Journal article
DOI: 10.2174/1381612822666161201152604
PMID: 27908267
Contributors: Victoria Gómez Murcia; M. G. Montalbán; Juan C. Gomez-Fernandez; Almela P
Source: Self-asserted source
Pilar Almela

Expression of heat shock protein 27 and troponin T and troponin I after naloxone-precipitated morphine withdrawal.

European Journal of Pharmacology
2015-10-09 | Journal article
DOI: 10.1016/j.ejphar.2015.10.006
PMID: 26452515
Contributors: Martínez-Laorden E; Almela P; M. Victoria Milanés; Laorden ML
Source: Self-asserted source
Pilar Almela

CP-154,526 Modifies CREB Phosphorylation and Thioredoxin-1 Expression in the Dentate Gyrus following Morphine-Induced Conditioned Place Preference.

PloS One
2015-08-27 | Journal article
DOI: 10.1371/journal.pone.0136164
PMID: 26313266
PMC: PMC4551807
Contributors: Juan Antonio Garcia-Carmona; Camejo DM; Almela P; Jiménez A; M. Victoria Milanés; Francisca Sevilla; Laorden ML
Source: Self-asserted source
Pilar Almela

Crosstalk between G protein-coupled receptors (GPCRs) and tyrosine kinase receptor (TXR) in the heart after morphine withdrawal.

Frontiers in Pharmacology
2013-12-27 | Journal article
DOI: 10.3389/fphar.2013.00164
PMID: 24409147
PMC: PMC3873507
Contributors: Almela P; Juan Antonio Garcia-Carmona; Martínez-Laorden E; M. Victoria Milanés; Laorden ML
Source: Self-asserted source
Pilar Almela

Pathways involved in the cardiac adaptive changes observed during morphine withdrawal

Addictions: From Pathophysiology to Treatment
2012 | Book chapter
Contributors: Laorden ML; Milanés MV; Pilar Almela
Source: Self-asserted source
Pilar Almela

Role of corticotropin-releasing factor (CRF) receptor-1 on the catecholaminergic response to morphine withdrawal in the nucleus accumbens (NAc).

PloS One
2012-10-10 | Journal article
DOI: 10.1371/journal.pone.0047089
PMID: 23071721
PMC: PMC3468529
Contributors: Almela P; Javier Navarro-Zaragoza; Juan Antonio Garcia-Carmona; Mora L; Hidalgo J; M. Victoria Milanés; Laorden ML
Source: Self-asserted source
Pilar Almela
grade
Preferred source (of 2)‎

Accumbal dopamine, noradrenaline and serotonin activity after naloxone-conditioned place aversion in morphine-dependent mice.

Neurochemistry International
2012-06-17 | Journal article
DOI: 10.1016/j.neuint.2012.06.011
PMID: 22713675
Contributors: Gómez-Milanés I; Almela P; Juan Antonio Garcia-Carmona; García-Gutiérrez MS; Aracil-Fernández A; Jorge Manzanares; Jorge Manzanares; Milanés Maquilón MV; Laorden ML
Source: Self-asserted source
Pilar Almela

Morphine withdrawal activates hypothalamic-pituitary-adrenal axis and heat shock protein 27 in the left ventricle: the role of extracellular signal-regulated kinase.

The Journal of Pharmacology and Experimental Therapeutics
2012-05-30 | Journal article
DOI: 10.1124/jpet.112.193581
PMID: 22647273
Contributors: Martínez-Laorden E; Maria Amor Hurle; M. Victoria Milanés; Laorden ML; Almela P
Source: Self-asserted source
Pilar Almela

Pregabalin and topiramate regulate behavioural and brain gene transcription changes induced by spontaneous cannabinoid withdrawal in mice.

Addiction Biology
2011-10-21 | Journal article
DOI: 10.1111/j.1369-1600.2011.00406.x
PMID: 22017514
Contributors: Aracil-Fernández A; Almela P; Jorge Manzanares
Source: Self-asserted source
Pilar Almela

Restricted role of CRF1 receptor for the activity of brainstem catecholaminergic neurons in the negative state of morphine withdrawal.

Psychopharmacology
2011-09-21 | Journal article
DOI: 10.1007/s00213-011-2478-y
PMID: 21947312
Contributors: Juan Antonio Garcia-Carmona; Almela P; Alberto Baroja-Mazo; M. Victoria Milanés; Laorden ML
Source: Self-asserted source
Pilar Almela

Naloxone-precipitated morphine withdrawal evokes phosphorylation of heat shock protein 27 in rat heart through extracellular signal-regulated kinase.

Journal of Molecular and Cellular Cardiology
2011-04-17 | Journal article
DOI: 10.1016/j.yjmcc.2011.04.002
PMID: 21530534
Contributors: Almela P; Martínez-Laorden E; Atucha NM; M. Victoria Milanés; Laorden ML
Source: Self-asserted source
Pilar Almela

Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart.

The Journal of Pharmacology and Experimental Therapeutics
2009-06-30 | Journal article
DOI: 10.1124/jpet.109.154583
PMID: 19567779
Contributors: Almela P; Atucha NM; M. Victoria Milanés; Laorden ML
Source: Self-asserted source
Pilar Almela

Tyrosine hydroxylase phosphorylation after naloxone-induced morphine withdrawal in the left ventricle.

Basic Research in Cardiology
2008-12-22 | Journal article
DOI: 10.1007/s00395-008-0768-2
PMID: 19104749
Contributors: Almela P; Victoria Milanés M; Luisa Laorden M
Source: Self-asserted source
Pilar Almela

Tolerance to the antinociceptive effects of peripherally administered opioids. Expression of beta-arrestins.

Brain Research
2008-11-07 | Journal article
DOI: 10.1016/j.brainres.2008.10.065
PMID: 19026993
Contributors: Hernández L; Romero A; Almela P; García-Nogales P; Laorden ML; Puig MM
Source: Self-asserted source
Pilar Almela

Effects of chronic inflammation and morphine tolerance on the expression of phospho-ERK 1/2 and phospho-P38 in the injured tissue.

Naunyn-Schmiedeberg's Archives of Pharmacology
2008-10-07 | Journal article
DOI: 10.1007/s00210-008-0356-x
PMID: 18839150
Contributors: Almela P; García-Nogales P; Romero A; M. Victoria Milanés; Laorden ML; Puig MM
Source: Self-asserted source
Pilar Almela

The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts.

British Journal of Pharmacology
2008-06-09 | Journal article
DOI: 10.1038/bjp.2008.224
PMID: 18536752
PMC: PMC2527841
Contributors: Almela P; M. Victoria Milanés; Laorden M
Source: Self-asserted source
Pilar Almela

Activation of the ERK signalling pathway contributes to the adaptive changes in rat hearts during naloxone-induced morphine withdrawal.

British Journal of Pharmacology
2007-06-04 | Journal article
DOI: 10.1038/sj.bjp.0707301
PMID: 17549049
PMC: PMC2014132
Contributors: Almela P; M. Victoria Milanés; Laorden ML
Source: Self-asserted source
Pilar Almela

Differential involvement of 3', 5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos and tyrosine hydroxylase expression in the heart after naloxone induced morphine withdrawal.

Naunyn-Schmiedeberg's Archives of Pharmacology
2006-11-25 | Journal article
DOI: 10.1007/s00210-006-0120-z
PMID: 17216288
Contributors: Almela P; Cerezo M; González-Cuello A; M. Victoria Milanés; Laorden ML
Source: Self-asserted source
Pilar Almela

Role of PKC in regulation of Fos and TH expression after naloxone induced morphine withdrawal in the heart.

Naunyn-Schmiedeberg's Archives of Pharmacology
2006-02-11 | Journal article
DOI: 10.1007/s00210-006-0032-y
PMID: 16474935
Contributors: Almela P; Cerezo M; M. Victoria Milanés; Laorden ML
Source: Self-asserted source
Pilar Almela

Morphine withdrawal-induced c-fos expression in the hypothalamic paraventricular nucleus is dependent on the activation of catecholaminergic neurones.

Journal of Neurochemistry
2002-10-01 | Journal article
DOI: 10.1046/j.1471-4159.2002.01123.x
PMID: 12358736
Contributors: Laorden ML; Cristina Núñez; Almela P; M. Victoria Milanés
Source: Self-asserted source
Pilar Almela
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