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Scopus Author ID: 12240884600

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Employment (2)

Chongqing Medical University: Chongqing, CN

2022-01-01 to present | Professor
Employment
Source: Self-asserted source
Hai-Xin Yuan

Fudan University: Shanghai, Shanghai, CN

2014-11 to 2021-12-31 | Professor (Institutes for Biomedical Sciences)
Employment
Source: Self-asserted source
Hai-Xin Yuan

Education and qualifications (2)

University of California San Diego: La Jolla, CA, US

2009-09 to 2014-08 | Postdoctoral Fellow (Moores Cancer Center)
Education
Source: Self-asserted source
Hai-Xin Yuan

Shanghai Institutes for Biological Sciences: Shanghai, Shanghai, CN

2002-09 to 2009-04 | Ph.D. (Institutes of Biochemistry and Cell Biology)
Education
Source: Self-asserted source
Hai-Xin Yuan

Works (41)

Crizotinib and its enantiomer suppress ferroptosis by decreasing PE-O-PUFA content

Cell Death Discovery
2024 | Journal article
DOI: 10.1038/s41420-024-02127-8
EID:

2-s2.0-85201262082

Part of ISSN: 20587716
Contributors: Cen, S.-Y.; Lin, F.; Li, X.; Hu, Y.; Liu, J.-P.; Xue, Z.; Gao, Y.; Sun, Y.-P.; Zhu, S.; Dang, Y. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

PCK2 maintains intestinal homeostasis and prevents colitis by protecting antibody-secreting cells from oxidative stress

Immunology
2024 | Journal article
DOI: 10.1111/imm.13827
EID:

2-s2.0-85197219193

Part of ISSN: 13652567 00192805
Contributors: Duan, K.-L.; Wang, T.-X.; You, J.-W.; Wang, H.-N.; Wang, Z.-Q.; Huang, Z.-X.; Zhang, J.-Y.; Sun, Y.-P.; Xiong, Y.; Guan, K.-L. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Tanshinone functions as a coenzyme that confers gain of function of NQO1 to suppress ferroptosis

Life science alliance
2023 | Journal article
DOI: 10.26508/lsa.202201667
EID:

2-s2.0-85141156353

Part of ISSN: 25751077
Contributors: Wang, T.-X.; Duan, K.-L.; Huang, Z.-X.; Xue, Z.-A.; Liang, J.-Y.; Dang, Y.; Zhang, A.; Xiong, Y.; Ding, C.; Guan, K.-L. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4

ACS Chemical Biology
2022 | Journal article
DOI: 10.1021/acschembio.2c00445
EID:

2-s2.0-85143432726

Part of ISSN: 15548937 15548929
Contributors: Liu, J.-P.; Cen, S.-Y.; Xue, Z.; Wang, T.-X.; Gao, Y.; Zheng, J.; Zhang, C.; Hu, J.; Nie, S.; Xiong, Y. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

ALK fusion promotes metabolic reprogramming of cancer cells by transcriptionally upregulating PFKFB3

Oncogene
2022 | Journal article
DOI: 10.1038/s41388-022-02453-0
EID:

2-s2.0-85137502208

Part of ISSN: 14765594 09509232
Contributors: Hu, M.; Bao, R.; Lin, M.; Han, X.-R.; Ai, Y.-J.; Gao, Y.; Guan, K.-L.; Xiong, Y.; Yuan, H.-X.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier
grade
Preferred source (of 2)‎

Elevated nuclear localization of glycolytic enzyme TPI1 promotes lung adenocarcinoma and enhances chemoresistance

Cell Death and Disease
2022 | Journal article
DOI: 10.1038/s41419-022-04655-6
EID:

2-s2.0-85125802557

Part of ISSN: 20414889
Contributors: Liu, P.; Sun, S.-J.; Ai, Y.-J.; Feng, X.; Zheng, Y.-M.; Gao, Y.; Zhang, J.-Y.; Zhang, L.; Sun, Y.-P.; Xiong, Y. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Integration analysis identifies the role of metallothionein in the progression from hepatic steatosis to steatohepatitis

Frontiers in Endocrinology
2022 | Journal article
DOI: 10.3389/fendo.2022.951093
EID:

2-s2.0-85140958130

Part of ISSN: 16642392
Contributors: Li, X.; Zhong, S.; Sun, Y.; Huang, X.; Li, Y.; Wang, L.; Wu, Y.; Yang, M.; Yuan, H.-X.; Liu, J. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

TET2 deficiency sensitizes tumor cells to statins by reducing HMGCS1 expression

Oncogene
2022 | Journal article
DOI: 10.1038/s41388-022-02531-3
EID:

2-s2.0-85141513231

Part of ISSN: 14765594 09509232
Contributors: Sun, S.-J.; Ai, Y.-J.; Duan, K.-L.; Zhang, J.-Y.; Zhang, C.; Sun, Y.-P.; Xiong, Y.; Guan, K.-L.; Yuan, H.-X.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier
grade
Preferred source (of 2)‎

WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy

Molecular Cell
2022 | Journal article
DOI: 10.1016/j.molcel.2022.03.027
EID:

2-s2.0-85130141496

Part of ISSN: 10974164 10972765
Contributors: Qi, S.; Zhu, Y.; Liu, X.; Li, P.; Wang, Y.; Zeng, Y.; Yu, A.; Wang, Y.; Sha, Z.; Zhong, Z. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

CBFB-MYH11 Fusion Sequesters RUNX1 in Cytoplasm to Prevent DNMT3A Recruitment to Target Genes in AML

Frontiers in Cell and Developmental Biology
2021 | Journal article
DOI: 10.3389/fcell.2021.675424
EID:

2-s2.0-85111615538

Part of ISSN: 2296634X
Contributors: Liu, P.; Liu, J.-P.; Sun, S.-J.; Gao, Y.; Ai, Y.; Chen, X.; Sun, Y.; Zhou, M.; Liu, Y.; Xiong, Y. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK

Cell Death and Disease
2021 | Journal article
DOI: 10.1038/s41419-021-04264-9
EID:

2-s2.0-85117701939

Part of ISSN: 20414889
Contributors: Bao, R.; Meng, Y.; Zhang, H.; Yang, C.; Li, W.; Zhang, C.; Zhang, J.; Sun, R.; Li, Z.; Jiang, W. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Structural insights into TSC complex assembly and GAP activity on Rheb

Nature Communications
2021 | Journal article
DOI: 10.1038/s41467-020-20522-4
EID:

2-s2.0-85099250700

Part of ISSN: 20411723
Contributors: Yang, H.; Yu, Z.; Chen, X.; Li, J.; Li, N.; Cheng, J.; Gao, N.; Yuan, H.-X.; Ye, D.; Guan, K.-L. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier
grade
Preferred source (of 2)‎

Targeting ferroptosis alleviates methionine-choline deficient (MCD)-diet induced NASH by suppressing liver lipotoxicity

Liver International
2020 | Journal article
DOI: 10.1111/liv.14428
EID:

2-s2.0-85082039855

Part of ISSN: 14783231 14783223
Contributors: Li, X.; Wang, T.-X.; Huang, X.; Li, Y.; Sun, T.; Zang, S.; Guan, K.-L.; Xiong, Y.; Liu, J.; Yuan, H.-X.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier
grade
Preferred source (of 2)‎

Structural insights into TSC complex assembly and GAP activity on Rheb

2020-07-07 | Other
DOI: 10.21203/rs.3.rs-36453/v1
Contributors: Huirong Yang; Zishuo Yu; Xizi Chen; Jiabei Li; Ningning Li; Jiaxuan Cheng; Ning Gao; Hai-Xin Yuan; Dan Ye; Kun-Liang Guan et al.
Source: check_circle
Crossref

ELP3 Acetyltransferase is phosphorylated and regulated by the oncogenic anaplastic lymphoma kinase (ALK)

Biochemical Journal
2019 | Journal article
DOI: 10.1042/BCJ20190106
EID:

2-s2.0-85071139474

Part of ISSN: 14708728 02646021
Contributors: Li, M.-T.; Liang, J.-Y.; Sun, Y.-P.; Jin, J.; Xiong, Y.; Guan, K.-L.; Yuan, H.-X.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier
grade
Preferred source (of 2)‎

GPCR signaling inhibits mTORC1 via PKA phosphorylation of raptor

eLife
2019 | Journal article
DOI: 10.7554/eLife.43038
EID:

2-s2.0-85066434280

Part of ISSN: 2050084X
Contributors: Jewell, J.L.; Fu, V.; Hong, A.W.; Yu, F.-X.; Meng, D.; Melick, C.H.; Wang, H.; Lam, W.-L.M.; Yuan, H.-X.; Taylor, S.S. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis

Cell Death and Disease
2019 | Journal article
DOI: 10.1038/s41419-019-1984-4
EID:

2-s2.0-85073057898

Part of ISSN: 20414889
Contributors: Wang, T.-X.; Liang, J.-Y.; Zhang, C.; Xiong, Y.; Guan, K.-L.; Yuan, H.-X.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier
grade
Preferred source (of 2)‎

Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

Nature Communications
2018 | Journal article
DOI: 10.1038/s41467-018-02950-5
EID:

2-s2.0-85041652459

Part of ISSN: 20411723
Contributors: Li, F.-L.; Liu, J.-P.; Bao, R.-X.; Yan, G.; Feng, X.; Xu, Y.-P.; Sun, Y.-P.; Yan, W.; Ling, Z.-Q.; Xiong, Y. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

Oncogene
2018 | Journal article
DOI: 10.1038/s41388-017-0070-6
EID:

2-s2.0-85040685394

Part of ISSN: 14765594 09509232
Contributors: Liu, M.-X.; Jin, L.; Sun, S.-J.; Liu, P.; Feng, X.; Cheng, Z.-L.; Liu, W.-R.; Guan, K.-L.; Shi, Y.-H.; Yuan, H.-X. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Endothelin promotes colorectal tumorigenesis by activating YAP/TAZ

Cancer Research
2017 | Journal article
DOI: 10.1158/0008-5472.CAN-16-3229
EID:

2-s2.0-85019042219

Part of ISSN: 15387445 00085472
Contributors: Wang, Z.; Liu, P.; Zhou, X.; Wang, T.; Feng, X.; Sun, Y.-P.; Xiong, Y.; Yuan, H.-X.; Guan, K.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Osmotic stress-induced phosphorylation by NLK at Ser128 activates YAP

EMBO Reports
2017 | Journal article
DOI: 10.15252/embr.201642681
EID:

2-s2.0-85008151747

Part of ISSN: 14693178 1469221X
Contributors: Hong, A.W.; Meng, Z.; Yuan, H.-X.; Plouffe, S.W.; Moon, S.; Kim, W.; Jho, E.-H.; Guan, K.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

SIRT7 deacetylates DDB1 and suppresses the activity of the CRL4 E3 ligase complexes

FEBS Journal
2017 | Journal article
DOI: 10.1111/febs.14259
EID:

2-s2.0-85031088050

Part of ISSN: 17424658 1742464X
Contributors: Mo, Y.; Lin, R.; Liu, P.; Tan, M.; Xiong, Y.; Guan, K.-L.; Yuan, H.-X.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation

Oncogene
2016 | Journal article
DOI: 10.1038/onc.2015.482
EID:

2-s2.0-84953290297

Part of ISSN: 14765594 09509232
Contributors: Han, X.-R.; Zha, Z.; Yuan, H.-X.; Feng, X.; Xia, Y.-K.; Lei, Q.-Y.; Guan, K.-L.; Xiong, Y.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Structural insights of mTOR complex 1

Cell Research
2016 | Journal article
DOI: 10.1038/cr.2016.10
EID:

2-s2.0-84960117201

Part of ISSN: 17487838 10010602
Contributors: Yuan, H.-X.; Guan, K.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Thromboxane A2 activates YAP/TAZ protein to induce vascular smooth muscle cell proliferation and migration

Journal of Biological Chemistry
2016 | Journal article
DOI: 10.1074/jbc.M116.739722
EID:

2-s2.0-84984920689

Part of ISSN: 1083351X 00219258
Contributors: Feng, X.; Liu, P.; Zhou, X.; Li, M.-T.; Li, F.-L.; Wang, Z.; Meng, Z.; Sun, Y.-P.; Yu, Y.; Xiong, Y. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Estrogen regulates Hippo signaling via GPER in breast cancer

Journal of Clinical Investigation
2015 | Journal article
DOI: 10.1172/JCI79573
EID:

2-s2.0-84928984549

Part of ISSN: 15588238 00219738
Contributors: Zhou, X.; Wang, S.; Wang, Z.; Feng, X.; Liu, P.; Lv, X.-B.; Li, F.; Yu, F.-X.; Sun, Y.; Yuan, H. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

NLK phosphorylates Raptor to mediate stress-induced mTORC1 inhibition

Genes and Development
2015 | Journal article
DOI: 10.1101/gad.265116.115
EID:

2-s2.0-84947976753

Part of ISSN: 15495477 08909369
Contributors: Yuan, H.-X.; Wang, Z.; Yu, F.-X.; Li, F.; Russell, R.C.; Jewell, J.L.; Guan, K.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

The SIN1-PH domain connects mTORC2 to PI3K

Cancer Discovery
2015 | Journal article
DOI: 10.1158/2159-8290.CD-15-1125
EID:

2-s2.0-84946231699

Part of ISSN: 21598290 21598274
Contributors: Yuan, H.-X.; Guan, K.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Autophagy regulation by nutrient signaling

Cell Research
2014 | Journal article
DOI: 10.1038/cr.2013.166
EID:

2-s2.0-84891745585

Part of ISSN: 10010602 17487838
Contributors: Russell, R.C.; Yuan, H.-X.; Guan, K.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Nutrient Sensing, Metabolism, and Cell Growth Control

Molecular Cell
2013 | Journal article
DOI: 10.1016/j.molcel.2013.01.019
EID:

2-s2.0-84873469666

Part of ISSN: 10972765 10974164
Contributors: Yuan, H.-X.; Xiong, Y.; Guan, K.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Regulation of PIK3C3/VPS34 complexes by MTOR in nutrient stress-induced autophagy

Autophagy
2013 | Journal article
DOI: 10.4161/auto.26058
EID:

2-s2.0-84890848742

Part of ISSN: 15548627 15548635
Contributors: Yuan, H.-X.; Russell, R.C.; Guan, K.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase

Nature Cell Biology
2013 | Journal article
DOI: 10.1038/ncb2757
EID:

2-s2.0-84880331368

Part of ISSN: 14657392 14764679
Contributors: Russell, R.C.; Tian, Y.; Yuan, H.; Park, H.W.; Chang, Y.-Y.; Kim, J.; Kim, H.; Neufeld, T.P.; Dillin, A.; Guan, K.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling

Cell
2012 | Journal article
DOI: 10.1016/j.cell.2012.06.037
EID:

2-s2.0-84865260845

Part of ISSN: 10974172 00928674
Contributors: Yu, F.-X.; Zhao, B.; Panupinthu, N.; Jewell, J.L.; Lian, I.; Wang, L.H.; Zhao, J.; Yuan, H.; Tumaneng, K.; Li, H. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Regulation of mTORC1 by the Rab and Arf GTPases

Journal of Biological Chemistry
2010 | Journal article
DOI: 10.1074/jbc.C110.102483
EID:

2-s2.0-77953801358

Part of ISSN: 00219258 1083351X
Contributors: Li, L.; Kim, E.; Yuan, H.; Inoki, K.; Goraksha-Hicks, P.; Schiesher, R.L.; Neufeld, T.P.; Guan, K.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

The Tight Junction Protein, Occludin, Regulates the Directional Migration of Epithelial Cells

Developmental Cell
2010 | Journal article
DOI: 10.1016/j.devcel.2009.12.008
EID:

2-s2.0-74049086695

Part of ISSN: 15345807
Contributors: Du, D.; Xu, F.; Yu, L.; Zhang, C.; Lu, X.; Yuan, H.; Huang, Q.; Zhang, F.; Bao, H.; Jia, L. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Aberrant splicing of Hugl-1 is associated with hepatocellular carcinoma progression

Clinical Cancer Research
2009 | Journal article
DOI: 10.1158/1078-0432.CCR-08-2078
EID:

2-s2.0-66149186859

Part of ISSN: 10780432
Contributors: Lu, X.; Feng, X.; Man, X.; Yang, G.; Tang, L.; Du, D.; Zhang, F.; Yuan, H.; Huang, Q.; Zhang, Z. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Hepatocyte-specific deletion of Cdc42 results in delayed liver regeneration after partial hepatectomy in mice

Hepatology
2009 | Journal article
DOI: 10.1002/hep.22610
EID:

2-s2.0-58949104651

Part of ISSN: 02709139
Contributors: Yuan, H.; Zhang, H.; Wu, X.; Zhang, Z.; Du, D.; Zhou, W.; Zhou, S.; Brakebusch, C.; Chen, Z.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

RNase9, an androgen-dependent member of the RNase a family, is specifically expressed in the rat epididymis

Biology of Reproduction
2007 | Journal article
DOI: 10.1095/biolreprod.106.054635
EID:

2-s2.0-33845751480

Part of ISSN: 00063363
Contributors: Zhu, C.-F.; Liu, Q.; Zhang, L.; Yuan, H.-X.; Zhen, W.; Zhang, J.-S.; Chen, Z.-J.; Hall, S.H.; French, F.S.; Zhang, Y.-L.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Proteomic analysis reveals novel molecules involved in insulin signaling pathway

Journal of Proteome Research
2006 | Journal article
DOI: 10.1021/pr050391m
EID:

2-s2.0-33645795212

Part of ISSN: 15353893
Contributors: Wang, Y.; Li, R.; Du, D.; Zhang, C.; Yuan, H.; Zeng, R.; Chen, Z.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Proteomic profiling of regionalized proteins in rat epididymis indicates consistency between specialized distribution and protein functions

Journal of Proteome Research
2006 | Journal article
DOI: 10.1021/pr050324s
EID:

2-s2.0-32344441758

Part of ISSN: 15353893
Contributors: Yuan, H.; Zhang, L.; Liu, A.; Zhou, H.; Wang, Y.; Zhang, H.; Wang, G.; Zeng, R.; Zhang, Y.; Chen, Z.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

A novel mechanism of modulation of hyperpolarization-activated cyclic nucleotide-gated channels by Src kinase

Journal of Biological Chemistry
2005 | Journal article
DOI: 10.1074/jbc.M506544200
EID:

2-s2.0-26644469078

Part of ISSN: 00219258
Contributors: Zong, X.; Eckert, C.; Yuan, H.; Wahl-Schott, C.; Abicht, H.; Fang, L.; Li, R.; Mistrik, P.; Gerstner, A.; Much, B. et al.
Source: Self-asserted source
Hai-Xin Yuan via Scopus - Elsevier

Peer review (6 reviews for 6 publications/grants)

Review activity for Biochimica et biophysica acta. (1)
Review activity for Cell discovery. (1)
Review activity for Genes & diseases. (1)
Review activity for Heliyon. (1)
Review activity for Nature chemical biology. (1)
Review activity for Translational research. (1)
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