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Employment (3)

Delft University of Technology: Delft, NL

2025-01-01 to present | NWO Veni Fellow (Chemical Engineering)
Employment
Source: Self-asserted source
Mark A.R. de Geus

Leibniz-Forschungsinstitut für Molekulare Pharmakologie im Forschungsverbund Berlin eV: Berlin, Berlin, DE

2021-01-15 to 2024-12-31 | Postdoctoral Researcher (Hackerberger Group - Chemical Biology II)
Employment
Source: Self-asserted source
Mark A.R. de Geus

Leiden University: Leiden, NL

2016-01-01 to 2020-09-30 | PhD Candidate (Van Kasteren Group - Bio-Organic Synthesis)
Employment
Source: Self-asserted source
Mark A.R. de Geus

Education and qualifications (3)

Leiden University: Leiden, NL

2016-01 to 2020-10 | Doctor of Philosophy (PhD) (Leiden Institute of Chemistry - Bio-Organic Synthesis )
Education
Source: Self-asserted source
Mark A.R. de Geus

Leiden University: Leiden, NL

2012-09 to 2015-07 | Master of Science (MSc) (Research in Chemistry)
Education
Source: Self-asserted source
Mark A.R. de Geus

Leiden University: Leiden, NL

2009-09 to 2012-12 | Bachelor of Science (BSc) (Bio-Pharmaceutical Sciences)
Education
Source: Self-asserted source
Mark A.R. de Geus

Funding (2)

NWO Talent Programme - VENI 2023

2025-01 to 2028-04 | Grant
Netherlands Organisation for Scientific Research (The Hague, NL)
URL: https://www.nwo.nl/en/researchprogrammes/nwo-talent-programme/projects-veni/veni-2023
GRANT_NUMBER: VI.Veni.232.338
Source: Self-asserted source
Mark A.R. de Geus

Humboldt Research Fellowship for Postdocs

Source: Self-asserted source
Mark A.R. de Geus

Works (13)

Effective eradication of acute myeloid leukemia stem cells with FLT3-directed antibody-drug conjugates

Leukemia
2025-03 | Journal article | Author
DOI: 10.1038/s41375-024-02510-5
Part of ISSN: 0887-6924
Part of ISSN: 1476-5551
Contributors: Marina Able; Marc-André Kasper; Binje Vick; Jonathan Schwach; Xiang Gao; Saskia Schmitt; Belay Tizazu; Amrei Fischer; Künzl Sarah; Marit Leilich et al.
Source: Self-asserted source
Mark A.R. de Geus

Synthesis of Peptides Containing a Combination of Free and 2‐<i>trans</i>‐Cyclooctene Carbamate Protected Lysine Residues

ChemBioChem
2024-02-16 | Journal article | Author
DOI: 10.1002/cbic.202300786
Part of ISSN: 1439-4227
Part of ISSN: 1439-7633
Contributors: Ward Doelman; Nina A.M. Ligthart; M. A. T. van de Plassche; Mark A.R. de Geus; L. Reinalda; Marjolein Isendoorn; Dmitri V. Filippov; S. I. van Kasteren
Source: Self-asserted source
Mark A.R. de Geus
grade
Preferred source (of 2)‎

A Lysosome-Targeted Tetrazine for Organelle-Specific Click-to-Release Chemistry in Antigen Presenting Cells

Journal of the American Chemical Society
2023-06-14 | Journal article | Author
DOI: 10.1021/jacs.3c02139
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Contributors: Nina A.M. Ligthart; Mark A.R. de Geus; Merel A.T. van de Plassche; Diana Torres García; Marjolein M.E. Isendoorn; Luuk Reinalda; Daniëlle Ofman; Tyrza van Leeuwen; 0000-0003-3733-818X
Source: Self-asserted source
Mark A.R. de Geus
grade
Preferred source (of 2)‎

DFT‐Guided Discovery of Ethynyl‐Triazolyl‐Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling

Angewandte Chemie International Edition
2022-10-10 | Journal article
DOI: 10.1002/anie.202205348
Part of ISSN: 1433-7851
Part of ISSN: 1521-3773
Contributors: Christian Stieger; Yerin Park; Mark A. R. de Geus; Dongju Kim; Christiane Huhn; J. Sophia Slenczka; Philipp Ochtrop; Judith M. Müchler; Roderich Süssmuth; Johannes Broichhagen et al.
Source: Self-asserted source
Mark A.R. de Geus

Inverse electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology

2021-10-07 | Dissertation or Thesis
Contributors: Mark A.R. de Geus
Source: Self-asserted source
Mark A.R. de Geus

Synthetic methodology towards allylic trans-cyclooctene-ethers enables modification of carbohydrates: bioorthogonal manipulation of the<i>lac</i>repressor

Chemical Science
2020 | Journal article | Author
DOI: 10.1039/d0sc03216f
Part of ISSN: 2041-6520
Part of ISSN: 2041-6539
Contributors: Mark A.R. de Geus; G. J. Mirjam Groenewold; Elmer Maurits; Can Araman; 0000-0003-3733-818X
Source: Self-asserted source
Mark A.R. de Geus

Fluorogenic Bifunctional trans‐Cyclooctenes as Efficient Tools for Investigating Click‐to‐Release Kinetics

Chemistry – A European Journal
2020-08-06 | Journal article | Author
DOI: 10.1002/chem.201905446
Part of ISSN: 0947-6539
Part of ISSN: 1521-3765
Contributors: Mark A.R. de Geus; Elmer Maurits; Alexi J. C. Sarris; Thomas Hansen; Max Kloet; Kiki Kamphorst; Wolter Hoeve; Marc Robillard; Andrea Pannwitz; Sylvestre Bonnet et al.
Source: Self-asserted source
Mark A.R. de Geus
grade
Preferred source (of 2)‎

Conditionally Controlling Human TLR2 Activity via Trans-Cyclooctene Caged Ligands

Bioconjugate Chemistry
2020-06-17 | Journal article | Author
DOI: 10.1021/acs.bioconjchem.0c00237
Part of ISSN: 1043-1802
Part of ISSN: 1520-4812
Contributors: Michel J. van de Graaff; Timo Oosenbrug; Mikkel H. S. Marqvorsen; Clarissa R. Nascimento; Mark A.R. de Geus; Bénédicte Manoury; Maaike E. Ressing; 0000-0003-3733-818X
Source: Self-asserted source
Mark A.R. de Geus
grade
Preferred source (of 2)‎

Fast and pH‐Independent Elimination of trans‐Cyclooctene by Using Aminoethyl‐Functionalized Tetrazines

Chemistry – A European Journal
2018-12-05 | Journal article
DOI: 10.1002/chem.201803839
Part of ISSN: 0947-6539
Part of ISSN: 1521-3765
Contributors: Alexi J. C. Sarris; Thomas Hansen; Mark A. R. de Geus; Elmer Maurits; Ward Doelman; Herman S. Overkleeft; Jeroen D. C. Codée; Dmitri V. Filippov; Sander I. van Kasteren
Source: Self-asserted source
Mark A.R. de Geus

Click‐to‐Release from trans‐Cyclooctenes: Mechanistic Insights and Expansion of Scope from Established Carbamate to Remarkable Ether Cleavage

Angewandte Chemie International Edition
2018-08-13 | Journal article
DOI: 10.1002/anie.201800402
Part of ISSN: 1433-7851
Part of ISSN: 1521-3773
Contributors: Ron M. Versteegen; Wolter ten Hoeve; Raffaella Rossin; Mark A. R. de Geus; Henk M. Janssen; Marc Robillard
Source: Self-asserted source
Mark A.R. de Geus

Chemical Control over T-Cell Activation in Vivo Using Deprotection of trans-Cyclooctene-Modified Epitopes

ACS Chemical Biology
2018-06-15 | Journal article
DOI: 10.1021/acschembio.8b00155
Part of ISSN: 1554-8929
Part of ISSN: 1554-8937
Contributors: Anouk M. F. van der Gracht; Mark A. R. de Geus; Marcel G. M. Camps; Tracy J. Ruckwardt; Alexi J. C. Sarris; Jessica Bremmers; Elmer Maurits; Joanna B. Pawlak; Michelle M. Posthoorn; Kimberly Bonger et al.
Source: Self-asserted source
Mark A.R. de Geus

Human Alpha Galactosidases Transiently Produced in Nicotiana benthamiana Leaves: New Insights in Substrate Specificities with Relevance for Fabry Disease

Frontiers in Plant Science
2017-06-21 | Journal article
DOI: 10.3389/fpls.2017.01026
Part of ISSN: 1664-462X
Contributors: Kassiani Kytidou; Thomas J. M. Beenakker; Lotte B. Westerhof; Cornelis H. Hokke; Geri F. Moolenaar; Nora Goosen; Mina Mirzaian; Maria J. Ferraz; Mark de Geus; Wouter W. Kallemeijn et al.
Source: Self-asserted source
Mark A.R. de Geus

Synthesis of 6-Hydroxysphingosine and α-Hydroxy Ceramide Using a Cross-Metathesis Strategy

The Journal of Organic Chemistry
2015-07-17 | Journal article
DOI: 10.1021/acs.joc.5b00823
Part of ISSN: 0022-3263
Part of ISSN: 1520-6904
Contributors: Patrick Wisse; Mark A. R. de Geus; Gen Cross; Adrianus M. C. H. van den Nieuwendijk; Eva J. van Rooden; Richard J. B. H. N. van den Berg; Johannes M. F. G. Aerts; Gijsbert A. van der Marel; Jeroen D. C. Codée; Herman S. Overkleeft
Source: Self-asserted source
Mark A.R. de Geus

Peer review (1 review for 1 publication/grant)

Review activity for Nature communications (1)
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