Personal information

Keywords

Neurodegeneration, Alzheimer's Disease, Metals, Iron, Amyloid Precursor Protein

Countries

United Kingdom, Australia, Singapore

Activities

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Employment (4)

The University of Melbourne: Melbourne, VIC, AU

2020-08-10 to present | Senior Research Associate (Department of Biochemistry and Pharmacology)
Employment
Source: Self-asserted source
Bruce Wong

University of Cambridge: Cambridge, Cambridgeshire, GB

2017-09 to 2019-10-01 | Postdoctoral Research Associate (ALBORADA Drug Discovery Institute)
Employment
Source: Self-asserted source
Bruce Wong

University of Leeds: Leeds, GB

2016-10-01 to 2017-08-31 | Research Fellow (Faculty of Biological Sciences)
Employment
Source: Self-asserted source
Bruce Wong

Florey Institute of Neuroscience and Mental Health: Parkville, VIC, AU

2011-04-01 to 2016-09-31 | Research Officer (Oxidation Biology Unit)
Employment
Source: Self-asserted source
Bruce Wong

Education and qualifications (2)

Murdoch University: Murdoch, WA, AU

BSc (Biomedical Science and Molecular Biology)
Education
Source: Self-asserted source
Bruce Wong

University of Western Australia: Crawley, WA, AU

2008-01-01 to 2011-04-31 | PhD / Dr (Medicine and Dentistry)
Education
Source: Self-asserted source
Bruce Wong

Funding (1)

The inflammatory mediator Lactorferrin induces rapid and pronounced amyloidogenic processing of APP

2016-01 to 2016-12 | Grant
Alzheimer's Australia Dementia Research Foundation (ACT, ACT, AU)
Source: Self-asserted source
Bruce Wong

Works (20)

Pharmacological inhibition of STING reduces neuroinflammation‐mediated damage post‐traumatic brain injury

British Journal of Pharmacology
2024-09 | Journal article
DOI: 10.1111/bph.16347
Contributors: Amelia L. Fryer; Amar Abdullah; Frank Mobilio; Andrew Jobling; Zachery Moore; Michael de Veer; Gang Zheng; Bruce X. Wong; Juliet M. Taylor; Peter J. Crack
Source: check_circle
Crossref

The acute phase protein lactoferrin is a key feature of Alzheimer’s disease and predictor of Aβ burden through induction of APP amyloidogenic processing

Molecular Psychiatry
2021-10 | Journal article
DOI: 10.1038/s41380-021-01248-1
Contributors: Andrew Tsatsanis; Andrew N. McCorkindale; Bruce X. Wong; Ellis Patrick; Tim M. Ryan; Robert W. Evans; Ashley I. Bush; Greg T. Sutherland; Asipu Sivaprasadarao; Boris Guennewig et al.
Source: check_circle
Crossref

Increased glutaminyl cyclase activity in brains of Alzheimer's disease individuals.

Journal of neurochemistry
2020-07 | Journal article
DOI: 10.1111/jnc.15114
PMID: 32614980
Contributors: Gunn AP; Wong BX; McLean C; Fowler C; Barnard PJ; Duce JA; Roberts BR; AIBL Research Group
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Amyloidogenic processing of Alzheimer's disease β-amyloid precursor protein induces cellular iron retention.

Molecular psychiatry
2020-05 | Journal article
DOI: 10.1038/s41380-020-0762-0
PMID: 32444869
Contributors: Tsatsanis A; Wong BX; Gunn AP; Ayton S; Bush AI; Devos D; Duce JA
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Post Translational Modulation of β-Amyloid Precursor Protein Trafficking to the Cell Surface Alters Neuronal Iron Homeostasis.

Neurochemical research
2019-02 | Journal article
DOI: 10.1007/s11064-019-02747-y
PMID: 30796750
Contributors: Tsatsanis A; Dickens S; Kwok JCF; Wong BX; Duce JA
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Marked Age-Related Changes in Brain Iron Homeostasis in Amyloid Protein Precursor Knockout Mice.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2018-08 | Journal article
DOI: 10.1007/s13311-018-0656-x
PMID: 30112699
Contributors: Belaidi AA; Gunn AP; Wong BX; Ayton S; Appukuttan AT; Roberts BR; Duce JA; Bush AI
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Evaluating Iron Flux in the Brain

Metals in the Brain: Measurement and Imaging
2017 | Book chapter
DOI: 10.1007/978-1-4939-6918-0_10
Part of ISBN: 978-1-4939-6918-0
Source: Self-asserted source
Bruce Wong
grade
Preferred source (of 2)‎

Amyloid precursor protein drives down-regulation of mitochondrial oxidative phosphorylation independent of amyloid beta.

Scientific Reports
2017-08 | Journal article
DOI: 10.1038/s41598-017-10233-0
PMID: 28852095
PMC: PMC5574989
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson's disease.

2017-06 | Journal article
DOI: 10.1186/s13024-017-0186-8
PMID: 28592304
PMC: PMC5463308
Contributors: Duce JA; Wong BX; Durham H; Devedjian JC; Smith DP; Devos D
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects.

2017-04 | Journal article
DOI: 10.1021/acschemneuro.6b00411
PMID: 28029772
Contributors: Lam LQ; Wong BX; Frugier T; Li QX; Collins SJ; Bush AI; Crack PJ; Duce JA
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons.

2016-03 | Journal article
DOI: 10.1074/jbc.M115.655183
PMID: 26697885
Contributors: Gunn AP; Wong BX; Johanssen T; Griffith JC; Masters CL; Bush AI; Barnham KJ; Duce JA; Cherny RA
Source: Self-asserted source
Bruce Wong via Europe PubMed Central
grade
Preferred source (of 2)‎

Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology.

2014 | Journal article
DOI: 10.3389/fnagi.2014.00091
PMID: 24860500
PMC: PMC4030154
Contributors: Wong BX; Hung YH; Bush AI; Duce JA
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders.

2014 | Journal article
DOI: 10.3389/fphar.2014.00081
PMID: 24795635
PMC: PMC4001010
Contributors: Wong BX; Duce JA
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

β-Amyloid precursor protein does not possess ferroxidase activity but does stabilize the cell surface ferrous iron exporter ferroportin.

2014 | Journal article
DOI: 10.1371/journal.pone.0114174
PMID: 25464026
PMC: PMC4252103
Contributors: Wong BX; Tsatsanis A; Lim LQ; Adlard PA; Bush AI; Duce JA
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

A comparison of ceruloplasmin to biological polyanions in promoting the oxidation of Fe(2+) under physiologically relevant conditions.

2014-12 | Journal article
DOI: 10.1016/j.bbagen.2014.08.006
PMID: 25152357
Contributors: Wong BX; Ayton S; Lam LQ; Lei P; Adlard PA; Bush AI; Duce JA
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.

2013-04 | Journal article
DOI: 10.1002/ana.23817
PMID: 23424051
Contributors: Ayton S; Lei P; Duce JA; Wong BX; Sedjahtera A; Adlard PA; Bush AI; Finkelstein DI
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

P2X7 receptor-mediated scavenger activity of mononuclear phagocytes toward non-opsonized particles and apoptotic cells is inhibited by serum glycoproteins but remains active in cerebrospinal fluid.

2012-05 | Journal article
DOI: 10.1074/jbc.M112.340885
PMID: 22461619
PMC: PMC3366774
Contributors: Gu BJ; Duce JA; Valova VA; Wong B; Bush AI; Petrou S; Wiley JS
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

2012-02 | Journal article
DOI: 10.1038/nm.2613
PMID: 22286308
Contributors: Lei P; Ayton S; Finkelstein DI; Spoerri L; Ciccotosto GD; Wright DK; Wong BX; Adlard PA; Cherny RA; Lam LQ et al.
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Dyslipidemic diabetic serum increases lipid accumulation and expression of stearoyl-CoA desaturase in human macrophages.

2011-10 | Journal article
DOI: 10.1007/s11745-011-3578-5
PMID: 21674150
Contributors: Wong BX; Kyle RA; Myhill PC; Croft KD; Quinn CM; Jessup W; Yeap BB
Source: Self-asserted source
Bruce Wong via Europe PubMed Central

Modulation of macrophage fatty acid content and composition by exposure to dyslipidemic serum in vitro.

2011-04 | Journal article
DOI: 10.1007/s11745-011-3528-2
PMID: 21286835
Contributors: Wong BX; Kyle RA; Croft KD; Quinn CM; Jessup W; Yeap BB
Source: Self-asserted source
Bruce Wong via Europe PubMed Central
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