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Jena University Hospital: Jena, DE

2005-01-01 to present (Department of Anesthesiology and Intensive Care Medicine)
Employment
Source: Self-asserted source
Christoph Sponholz

Works (50 of 62)

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Predictive Value of Serial Model of End-Stage Liver Disease Score Determination in Patients with Postcardiotomy Extracorporeal Membrane Oxygenation

Journal of Clinical Medicine
2024-03-23 | Journal article
DOI: 10.3390/jcm13071856
Contributors: Oliver Sommerfeld; Caroline Neumann; Marcel-Dominic Pfeifer; Gloria Faerber; Hristo Kirov; Christian von Loeffelholz; Torsten Doenst; Christoph Sponholz
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Extracorporeal albumin dialysis in critically ill patients with liver failure: Comparison of four different devices—A retrospective analysis

The International Journal of Artificial Organs
2023-09 | Journal article
DOI: 10.1177/03913988231191952
Contributors: Oliver Sommerfeld; Caroline Neumann; Jan Becker; Christian von Loeffelholz; Johannes Roth; Andreas Kortgen; Michael Bauer; Christoph Sponholz
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Intraoperative Cell Savage, Infection and Organ Failure in Infective Endocarditis Patients—A Retrospective Single Center Evaluation

Journal of Clinical Medicine
2023-01-03 | Journal article
DOI: 10.3390/jcm12010382
Contributors: Christoph Sponholz; Oliver Sommerfeld; Caroline Moehl; Thomas Lehmann; Marcus Franz; Michael Bauer; Torsten Doenst; Gloria Faerber; Mahmoud Diab
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Associations of Betatrophin/ANGPTL8 with Septic Dyslipidemia in Human Peritonitis: An Explorative Analysis

Biomedicines
2022-12-06 | Journal article
DOI: 10.3390/biomedicines10123151
Contributors: Paul Horn; Sascha Radtke; Uta Barbara Metzing; Ricardo Steidl; Christoph Sponholz; Oliver Sommerfeld; Johannes Roth; Ralf A. Claus; Andreas L. Birkenfeld; Utz Settmacher et al.
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Association between Intraoperative Blood Transfusion, Regional Anesthesia and Outcome after Pediatric Tumor Surgery for Nephroblastoma

Cancers
2022-11-14 | Journal article
DOI: 10.3390/cancers14225585
Contributors: Sarah D. Müller; Christian P. Both; Christoph Sponholz; Maria Theresa Voelker; Holger Christiansen; Felix Niggli; Achim Schmitz; Markus Weiss; Jörg Thomas; Sebastian N. Stehr et al.
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Videoassistierte Thorakoskopie unter Erhalt der Spontanatmung – eine anästhesiologische Perspektive

Zentralblatt für Chirurgie - Zeitschrift für Allgemeine, Viszeral-, Thorax- und Gefäßchirurgie
2021-09-11 | Journal article
DOI: 10.1055/a-1263-1504
Contributors: Christoph Sponholz; Michael Winkens; Frank Fuchs; Alexandros Moschovas; Matthias Steinert
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Comparison of albumin dialysis devices molecular adsorbent recirculating system and ADVanced Organ Support system in critically ill patients with liver failure—A retrospective analysis

Therapeutic Apheresis and Dialysis
2021-04 | Journal article
DOI: 10.1111/1744-9987.13533
Contributors: Christoph Falkensteiner; Andreas Kortgen; Julia Leonhardt; Michael Bauer; Christoph Sponholz
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Risk of postoperative neurological exacerbation in patients with infective endocarditis and intracranial haemorrhage

European Journal of Cardio-Thoracic Surgery
2021-01-29 | Journal article
DOI: 10.1093/ejcts/ezaa347
Contributors: Mahmoud Diab; Rita Musleh; Thomas Lehmann; Christoph Sponholz; Mathias W Pletz; Marcus Franz; P Christian Schulze; Otto W Witte; Klaus Kirchhof; Torsten Doenst et al.
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Ex vivoImmune Profiling in Patient Blood enables Quantification of innate immune Effector Functions

2020-10-01 | Preprint
DOI: 10.1101/2020.10.01.322032
Contributors: Teresa Lehnert; Ines Leonhardt; Sandra Timme; Daniel Thomas-Rüddel; Frank Bloos; Christoph Sponholz; Oliver Kurzai; Marc Thilo Figge; Kerstin Hünniger
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Association between high dose catecholamine support and liver dysfunction following cardiac surgery

Journal of Cardiac Surgery
2020-06-25 | Journal article
DOI: 10.1111/jocs.14555
Contributors: Oliver Sommerfeld; Christian von Loeffelholz; Mahmoud Diab; Stefan Kiessling; Torsten Doenst; Michael Bauer; Christoph Sponholz
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Assessing efficacy of CytoSorb haemoadsorber for prevention of organ dysfunction in cardiac surgery patients with infective endocarditis: REMOVE-protocol for randomised controlled trial

BMJ Open
2020-03 | Journal article
DOI: 10.1136/bmjopen-2019-031912
Contributors: Mahmoud Diab; Stephanie Platzer; Albrecht Guenther; Christoph Sponholz; Andre Scherag; Thomas Lehmann; Ilia Velichkov; Stefan Hagel; Michael Bauer; Frank M Brunkhorst et al.
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Minimally‐invasive parasternal aortic valve replacement–A slow learning curve towards improved outcomes

Journal of Cardiac Surgery
2020-03-15 | Journal article
DOI: 10.1111/jocs.14412
Contributors: Sophio Tkebuchava; Gloria Färber; Christoph Sponholz; Frank Fuchs; Petra Heinisch; Michael Bauer; Torsten Doenst
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Intraoperative reduction of vasopressors using processed electroencephalographic monitoring in patients undergoing elective cardiac surgery: a randomized clinical trial

Journal of Clinical Monitoring and Computing
2020-02-19 | Journal article
DOI: 10.1007/s10877-019-00284-1
Contributors: C. Sponholz; C. Schuwirth; L. Koenig; H. Hoyer; S. M. Coldewey; C. Schelenz; T. Doenst; A. Kortgen; M. Bauer
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Open Albumin Dialysis (OPAL) Using New Micro-Structured Charcoal Adsorbents Is Significantly More Effective in Removing Toxins and Improving Related Complications of Aoclf Than MARS-a Multicenter Trial

Hepatology
2018 | Journal article
WOSUID: WOS:000446020500294
Contributors: Christoph Sponholz
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Epistemology in the intensive care unit-what is the purpose of a definition? Paradigm shift in sepsis research

Der Anaesthesist
2017 | Journal article
DOI: 10.1007/S00101-017-0315-3
WOSUID: WOS:000407371900013
Contributors: Dickmann, P.; Scherag, A.; Coldewey, S. M.; Sponholz, C.; Brunkhorst, F. M.; Bauer, M.
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Impact of higher-order heme degradation products on hepatic function and hemodynamics

Journal of Hepatology
2017 | Journal article
DOI: 10.1016/J.JHEP.2017.03.037
WOSUID: WOS:000405497200012
Contributors: Seidel, Raphael A.; Claudel, Thierry; Schleser, Franziska A.; Ojha, Navin K.; Westerhausen, Matthias; Nietzsche, Sandor; Sponholz, Christoph; Cuperus, Frans; Coldewey, Sina M.; Heinemann, Stefan H. et al.
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Organ-specific effects on inflammation and apoptosis of recombinant human activated protein C in a murine model of sepsis

European Journal of Inflammation
2017 | Journal article
DOI: 10.1177/1721727X17721088
WOSUID: WOS:000407471100002
Contributors: Simon, Tim-Philipp; Mueckenheim, Hendrik; Wagner, Tobias; Sponholz, Christoph; Claus, Ralf Alexander; Saenger, Joerg; Marx, Gernot; Schuerholz, Tobias
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The Opportunities and Limitations of Minimally Invasive Cardiac Surgery

Deutsches Ärzteblatt International
2017 | Journal article
DOI: 10.3238/ARZTEBL.2017.0777
WOSUID: WOS:000417647100001
Contributors: Doenst, Torsten; Diab, Mahmoud; Sponholz, Christoph; Bauer, Michael; Faerber, Gloria
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TLR-expressing cells as biosensor for bacterial ligands

Infection
2017 | Journal article
WOSUID: WOS:000407678000031
Contributors: Christoph Sponholz
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Impact of perioperative liver dysfunction on in-hospital mortality and long-term survival in infective endocarditis patients

Infection
2017-12-30 | Journal article
DOI: 10.1007/s15010-017-1064-6
Contributors: M. Diab; C. Sponholz; C. von Loeffelholz; P. Scheffel; M. Bauer; A. Kortgen; T. Lehmann; G. Färber; M. W. Pletz; T. Doenst
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Can radiological characteristics of preoperative cerebral lesions predict postoperative intracranial haemorrhage in endocarditis patients?

European Journal of Cardio-thoracic Surgery
2016 | Journal article
DOI: 10.1093/EJCTS/EZW014
WOSUID: WOS:000378501300005
Contributors: Diab, Mahmoud; Guenther, Albrecht; Scheffel, Philipp; Sponholz, Christoph; Lehmann, Thomas; Hedderich, Johannes; Faerber, Gloria; Brunkhorst, Frank; Pletz, Mathias W.; Doenst, Torsten
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Chemerin in peritoneal sepsis and its associations with glucose metabolism and prognosis: a translational cross-sectional study.

2016 | Journal article
DOI: 10.1186/s13054-016-1209-5
PMID: 26873079
PMC: PMC4751629
Contributors: Horn P; Metzing UB; Steidl R; Romeike B; Rauchfuß F; Sponholz C; Thomas-Rüddel D; Ludewig K; Birkenfeld AL; Settmacher U et al.
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central
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Elevation of serum sphingosine-1-phosphate attenuates impaired cardiac function in experimental sepsis

Scientific Reports
2016 | Journal article
DOI: 10.1038/SREP27594
WOSUID: WOS:000377347000001
Contributors: Coldewey, Sina M.; Benetti, Elisa; Collino, Massimo; Pfeilschifter, Josef; Sponholz, Christoph; Bauer, Michael; Huwiler, Andrea; Thiemermann, Christoph
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Fetuin A is a Predictor of Liver Fat in Preoperative Patients with Nonalcoholic Fatty Liver Disease

Journal of Investigative Surgery
2016 | Journal article
DOI: 10.3109/08941939.2016.1149640
WOSUID: WOS:000384017200004
Contributors: von Loeffelholz, C.; Horn, P.; Birkenfeld, A. L.; Claus, R. A.; Metzing, B. U.; Doecke, S.; Jahreis, G.; Heller, R.; Hoppe, S.; Stockmann, M. et al.
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Genetic Factors of the Disease Course After Sepsis: Rare Deleterious Variants Are Predictive

EBioMedicine
2016 | Journal article
DOI: 10.1016/J.EBIOM.2016.08.037
WOSUID: WOS:000386878500039
Contributors: Taudien, Stefan; Lausser, Ludwig; Giamarellos-Bourboulis, Evangelos J.; Sponholz, Christoph; Schoeneweck, Franziska; Felder, Marius; Schirra, Lyn-Rouven; Schmid, Florian; Gogos, Charalambos; Groth, Susann et al.
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Pre-operative stroke and neurological disability do not independently affect short- and long-term mortality in infective endocarditis patients

Clinical Research in Cardiology
2016 | Journal article
DOI: 10.1007/S00392-016-0993-X
WOSUID: WOS:000384881800005
Contributors: Diab, Mahmoud; Guenther, Albrecht; Sponholz, Christoph; Lehmann, Thomas; Faerber, Gloria; Matz, Anna; Franz, Marcus; Witte, Otto W.; Pletz, Mathias W.; Doenst, Torsten
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Genetic Factors of the Disease Course after Sepsis: A Genome-Wide Study for 28 Day Mortality

EBioMedicine
2016-10 | Journal article
DOI: 10.1016/j.ebiom.2016.08.043
Contributors: André Scherag; Franziska Schöneweck; Miriam Kesselmeier; Stefan Taudien; Matthias Platzer; Marius Felder; Christoph Sponholz; Anna Rautanen; Adrian V.S. Hill; Charles J. Hinds et al.
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Polymorphisms of cystathionine beta-synthase gene are associated with susceptibility to sepsis

European Journal of Human Genetics
2016-07 | Journal article
DOI: 10.1038/ejhg.2015.231
Contributors: Christoph Sponholz; Marcel Kramer; Franziska Schöneweck; Uwe Menzel; Kolsoum Inanloo Rahatloo; Evangelos J Giamarellos-Bourboulis; Vassileios Papavassileiou; Korina Lymberopoulou; Maria Pavlaki; Ioannis Koutelidakis et al.
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Can radiological characteristics of preoperative cerebral lesions predict postoperative intracranial haemorrhage in endocarditis patients?†.

2016-02 | Journal article
PMID: 26888461
Contributors: Diab M; Guenther A; Scheffel P; Sponholz C; Lehmann T; Hedderich J; Faerber G; Brunkhorst F; Pletz MW; Doenst T
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central

Low sulfide levels and a high degree of cystathionine β-synthase (CBS) activation by S-adenosylmethionine (SAM) in the long-lived naked mole-rat.

2016-01 | Journal article
DOI: 10.1016/j.redox.2016.01.008
PMID: 26803480
PMC: PMC4732021
Contributors: Dziegelewska M; Holtze S; Vole C; Wachter U; Menzel U; Morhart M; Groth M; Szafranski K; Sahm A; Sponholz C et al.
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central
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Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure – a prospective, randomised crossover study

Critical Care
2016-01-04 | Journal article
DOI: 10.1186/s13054-015-1159-3
Contributors: Christoph Sponholz; Katja Matthes; Dina Rupp; Wolf Backaus; Sebastian Klammt; Diana Karailieva; Astrid Bauschke; Utz Settmacher; Matthias Kohl; Mark G. Clemens et al.
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Alternative splicing of SMPD1 in human sepsis.

2015 | Journal article
DOI: 10.1371/journal.pone.0124503
PMID: 25898364
PMC: PMC4405572
Contributors: Kramer M; Quickert S; Sponholz C; Menzel U; Huse K; Platzer M; Bauer M; Claus RA
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central
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Higher order metabolites of heme increase under conditions of hyperbilirubinemia, trigger cholestasis and impair hepatocellular integrity

Hepatology
2015 | Journal article
WOSUID: WOS:000368375402132
Contributors: Christoph Sponholz
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The influence of radiological lesions on neurological outcome in endocarditis patients with preoperative stroke

European Heart Journal
2015 | Journal article
WOSUID: WOS:000361205104083
Contributors: Diab, M.; Guenther, A.; Scheffel, P.; Sponholz, C.; Lehmann, T.; Franz, M.; Faerber, G.; Doenst, T.
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Understanding patients' genetic variants for bacterial induced sepsis to identify potential drug targets

Infection
2015 | Journal article
WOSUID: WOS:000359930400069
Contributors: Kolte, A.; Taudien, S.; Giamarellos-Bourboulis, E. J.; Sponholz, C.; Kurzai, O.; Bauer, M.; Platzer, M.; Koenig, R.
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Regional citrate anticoagulation for continuous renal replacement therapy in the perioperative care of liver transplant recipients: a single center experience.

2015-02 | Journal article
DOI: 10.1111/1744-9987.12196
PMID: 25196675
Contributors: Sponholz C; Settmacher U; Bauer M; Kortgen A
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central
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Anticoagulation Strategies in Venovenous Hemodialysis in Critically Ill Patients: A Five-Year Evaluation in a Surgical Intensive Care Unit

The Scientific World Journal
2014 | Journal article
DOI: 10.1155/2014/808320
Contributors: Christoph Sponholz; Ole Bayer; Björn Kabisch; Karin Wurm; Katharina Ebert; Michael Bauer; Andreas Kortgen
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Catecholamine and volume therapy for cardiac surgery in Germany--results from a postal survey.

2014 | Journal article
DOI: 10.1371/journal.pone.0103996
PMID: 25084362
PMC: PMC4118968
Contributors: Sponholz C; Schelenz C; Reinhart K; Schirmer U; Stehr SN
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central
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Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation.

2014 | Journal article
DOI: 10.1186/s13054-014-0543-8
PMID: 25260379
PMC: PMC4201918
Contributors: Ekaney ML; Otto GP; Sossdorf M; Sponholz C; Boehringer M; Loesche W; Rittirsch D; Wilharm A; Kurzai O; Bauer M et al.
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central
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Monitoring the Liver Function

Der Anaesthesist
2014 | Journal article
DOI: 10.1007/S00101-014-2373-0
WOSUID: WOS:000343752700011
Contributors: Sponholz, C.; Gonnert, F. A.; Kortgen, A.; Bauer, M.
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[Monitoring liver function].

2014-10 | Journal article
PMID: 25453128
Contributors: Sponholz C; Gonnert FA; Kortgen A; Bauer M
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central

[Monitoring liver function].

2014-10 | Journal article
PMID: 25513187
Contributors: Sponholz C; Gonnert FA; Kortgen A; Bauer M
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central

[Monitoring of liver function in the critically ill].

2014-07 | Journal article
DOI: 10.1007/s00101-014-2326-7
PMID: 24997165
Contributors: Sponholz C; Gonnert FA; Kortgen A; Bauer M
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central
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Alternative 5' untranslated regions are involved in expression regulation of human heme oxygenase-1.

2013 | Journal article
DOI: 10.1371/journal.pone.0077224
PMID: 24098580
PMC: PMC3788786
Contributors: Kramer M; Sponholz C; Slaba M; Wissuwa B; Claus RA; Menzel U; Huse K; Platzer M; Bauer M
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central
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Alternative five untranslated regions are involved in expression regulation of human heme oxygenase-1

Infection
2013 | Journal article
WOSUID: WOS:000324281600007
Contributors: Christoph Sponholz
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Alternative splicing of SMPD1 in patients with SIRS or severe sepsis

Infection
2013 | Journal article
WOSUID: WOS:000324281600042
Contributors: Quickert, S.; Kramer, M.; Sponholz, C.; Bauer, M.; Claus, R. A.
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Plasma histone levels in critically ill patients

Infection
2013 | Journal article
WOSUID: WOS:000324281600076
Contributors: Christoph Sponholz
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Liver dysfunction and phosphatidylinositol-3-kinase signalling in early sepsis: experimental studies in rodent models of peritonitis.

2012 | Journal article
DOI: 10.1371/journal.pmed.1001338
PMID: 23152722
PMC: PMC3496669
Contributors: Recknagel P; Gonnert FA; Westermann M; Lambeck S; Lupp A; Rudiger A; Dyson A; Carré JE; Kortgen A; Krafft C et al.
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central
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Gene polymorphisms in the heme degradation pathway and outcome of severe human sepsis.

2012-11 | Journal article
DOI: 10.1097/SHK.0b013e31826ae951
PMID: 23042203
Contributors: Sponholz C; Huse K; Kramer M; Giamarellos-Bourboulis EJ; Claus RA; Kern A; Engel C; Kuhnt E; Kiehntopf M; Routsi C et al.
Source: Self-asserted source
Christoph Sponholz via Europe PubMed Central
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Extracorporeal liver support in liver failure: parameters associated with indication and risk factors of negative outcome a single center experience

Infection
2011 | Journal article
WOSUID: WOS:000294888800108
Contributors: Christoph Sponholz
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Peer review (57 reviews for 19 publications/grants)

Review activity for Artificial organs. (9)
Review activity for BioMed research international. (2)
Review activity for Cardiology research. (2)
Review activity for Case reports in nephrology and dialysis. (1)
Review activity for Endocrine practice. (1)
Review activity for Intensive care medicine experimental. (3)
Review activity for International journal of artificial organs. (6)
Review activity for Journal of clinical anesthesia and pain management. (1)
Review activity for Journal of clinical medicine. (2)
Review activity for Journal of infection in developing countries. (1)
Review activity for Journal of investigative surgery. (3)
Review activity for Journal of the Saudi Heart Association. (1)
Review activity for Medical science monitor (1)
Review activity for Oxidative medicine and cellular longevity. (1)
Review activity for Pediatric transplantation. (1)
Review activity for Scientific reports. (4)
Review activity for Therapeutic apheresis and dialysis. (14)
Review activity for Transplantation. (3)
Review activity for Trends in anaesthesia and critical care. (1)
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