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Distinct Stromal Cell Populations Define the B-cell Acute Lymphoblastic Leukemia Microenvironment

2024-09-14 | Preprint
Contributors: Mauricio N. Ferrao Blanco; Bexultan Kazybay; Mirjam Belderbos; Olaf Heidenreich; Hermann Josef Vormoor
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Crossref

Chimeric Antigen Receptor (CAR) T-Cell Products for Pediatric Cancers: Why Alternative Development Paths Are Needed

Journal of Clinical Oncology
2024-01-20 | Journal article
Contributors: Claudia Rossig; Andrew D. Pearson; Gilles Vassal; Nicole Scobie; Nick Bird; Patricia Blanc; H. Josef Vormoor; Friso G. Calkoen; Franco Locatelli; Francesca del Bufalo et al.
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Novel Adaption of the SARC-F Score to Classify Pediatric Hemato-Oncology Patients with Functional Sarcopenia

Cancers
2023-01 | Journal article | Author
Contributors: Emma Jacobine Verwaaijen; Patrick van der Torre; Hermann Josef Vormoor; Rob Pieters; Marta Fiocco; Annelies Hartman; Marry M. van den Heuvel-Eibrink
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Ex vivo and in vivo complex drug combination analysis for improved efficacy and specificity in high-risk childhood acute lymphoblastic leukaemia

Klinische Pädiatrie
2022 | Journal article
Contributors: Law, E.; McKenzie, L.; Blair, H.; Szoltysek, K.; Singh, M.; Bomken, S.; Lunec, J.; Irving, J.; Vormoor, J.; Heidenreich, O.
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Selumetinib in combination with dexamethasone for the treatment of relapsed/refractory RAS-pathway mutated paediatric and adult acute lymphoblastic leukaemia (SeluDex): study protocol for an international, parallel-group, dose-finding with expansion phase I/II trial

BMJ Open
2022 | Journal article
Contributors: Menne, Tobias; Slade, Daniel; Savage, Joshua; Johnson, Sarah; Irving, Julie; Kearns, Pamela; Plummer, Ruth; Shenton, Geoff; Veal, Gareth J.; Vormoor, Britta et al.
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Targeted inhibitors and antibody immunotherapies: Novel therapies for paediatric leukaemia and lymphoma

European Journal of Cancer
2022 | Journal article
Contributors: Brivio, Erica; Baruchel, Andre; Beishuizen, Auke; Bourquin, Jean-Pierre; Brown, Patrick A.; Cooper, Todd; Gore, Lia; Kolb, E. Anders; Locatelli, Franco; Maude, Shannon L. et al.
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MAPK-ERK is a central pathway in T-cell acute lymphoblastic leukemia that drives steroid resistance

Leukemia
2021 | Journal article
Contributors: van der Zwet, Jordy C. G.; Buijs-Gladdines, Jessica G. C. A. M.; Cordo', Valentina; Debets, Donna O.; Smits, Willem K.; Chen, Zhongli; Dylus, Jelle; Zaman, Guido J. R.; Altelaar, Maarten; Oshima, Koichi et al.
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Phase II-like murine trial identifies synergy between dexamethasone and dasatinib in T-cell acute lymphoblastic leukemia

Haematologica
2021 | Journal article
Contributors: Shi, Yuzhe; Beckett, Melanie C.; Blair, Helen J.; Tirtakusuma, Ricky; Nakjang, Sirintra; Enshaei, Amir; Halsey, Christina; Vormoor, Josef; Heidenreich, Olaf; Krippner-Heidenreich, Anja et al.
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COVID-19 - Impact on Childhood Haematology Patients

HemaSphere
2020 | Journal article
Contributors: Wolfs, Tom F. W.; Attarbaschi, Andishe; Balduzzi, Adriana; Bernardo, Maria Ester; Bomken, Simon; Borkhardt, Arndt; Bourquin, Jean-Pierre; Dufour, Carlo; Gennery, Andrew; Grainger, John et al.
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The Central Role of MAPK-ERK Signaling in IL7-Dependent and IL7-Independent Steroid Resistance Reveals a Broad Application of MEK-Inhibitors Compared to JAK1/2-Inhibition in T-ALL

Blood
2020 | Journal article
Contributors: Van der Zwet, Jordy C. G.; Buijs-Gladdines, Jessica G. C. A. M.; Cordo', Valentina; Debets, Donna; Smits, Willem K.; Chen, Zhongli; Dylus, Jelle; Zaman, Guido; Altelaar, Maarten; Oshima, Koichi et al.
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Allogeneic hematopoietic cell transplantation in Farber disease

Journal of Inherited Metabolic Disease
2019 | Journal article
Contributors: Ehlert, Karoline; Levade, Thierry; Di Rocco, Maja; Lanino, Edoardo; Albert, Michael H.; Fuehrer, Monika; Jarisch, Andrea; Guengoer, Tayfun; Ayuk, Francis; Vormoor, Josef
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Glucocorticoids and selumetinib are highly synergistic in RAS pathway-mutated childhood acute lymphoblastic leukemia through upregulation of BIM

Haematologica
2019 | Journal article
Contributors: Matheson, Elizabeth C.; Thomas, Huw; Case, Marian; Blair, Helen; Jackson, Rosanna K.; Masic, Dino; Veal, Gareth; Halsey, Chris; Newell, David R.; Vormoor, Josef et al.
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The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation (vol 34, pg 626, 2018)

Cancer Cell
2019 | Journal article
Contributors: Martinez-Soria, Natalia; McKenzie, Lynsey; Draper, Julia; Ptasinska, Anetta; Issa, Hasan; Potluri, Sandeep; Blair, Helen J.; Pickin, Anna; Isa, Asmida; Chin, Paulynn Suyin et al.
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The SF3b Splicing Complex Regulates DNA Damage Response in Acute Lymphoblastic Leukemia

Blood
2019 | Journal article
Contributors: Sankar, Shalini; Navarro, Miriam Guillen; Ponthan, Frida; Bomken, Simon; Nakjang, Sirintra; Grinev, Vasily; McNeill, Hesta; Zwaan, Michel C.; Vormoor, Josef; Stam, Ronald W. et al.
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Whole-Genome CRISPR Screen Reveals the Mechanism of Relapse in Patient-Derived Cells Representing High-Risk Paediatric ALL

Blood
2019 | Journal article
Contributors: Szoltysek, Katarzyna; Blair, Helen; Nakjang, Sirintra; Tirtakusuma, Ricky; Singh, Mankaran; Nelson, Ryan; McNeill, Hesta; Dodd, Catherine; Beckett, Melanie; McKenzie, Lynsey et al.
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Accelerating drug development in pediatric cancer: a novel Phase I study design of venetoclax in relapsed/refractory malignancies

Future Oncology
2018 | Journal article
Contributors: Place, Andrew E.; Goldsmith, Kelly; Bourquin, Jean-Pierre; Loh, Mignon L.; Gore, Lia; Morgenstern, Daniel A.; Sanzgiri, Yeshwant; Hoffman, David; Zhou, Ying; Ross, Jeremy A. et al.
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Epidemiology and biology of relapse after stem cell transplantation

Bone Marrow Transplantation
2018 | Journal article
Contributors: Horowitz, Mary; Schreiber, Hans; Elder, Alex; Heidenreich, Olaf; Vormoor, Josef; Toffalori, Christina; Vago, Luca; Kroeger, Nicolaus
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The <i>MLL</i> recombinome of acute leukemias in 2017

Leukemia
2018 | Journal article
Contributors: Meyer, C.; Burmeister, T.; Groeger, D.; Tsaur, G.; Fechina, L.; Renneville, A.; Sutton, R.; Venn, N. C.; Emerenciano, M.; Pombo-de-Oliveira, M. S. et al.
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The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

Cancer Cell
2018 | Journal article
Contributors: Martinez-Soria, Natalia; McKenzie, Lynsey; Draper, Julia; Ptasinska, Anetta; Issa, Hasan; Potluri, Sandeep; Blair, Helen J.; Pickin, Anna; Isa, Asmida; Chin, Paulynn Suyin et al.
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A phase I/II trial of AT9283, a selective inhibitor of aurora kinase in children with relapsed or refractory acute leukemia: challenges to run early phase clinical trials for children with leukemia

Pediatric Blood and Cancer
2017 | Journal article
Contributors: Vormoor, B.; Veal, G. J.; Griffin, M. J.; Boddy, A. V.; Irving, J.; Minto, L.; Case, M.; Banerji, U.; Swales, K. E.; Tall, J. R. et al.
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A population pharmacokinetic model of AT9283 in adults and children to predict the maximum tolerated dose in children with leukaemia

British Journal of Clinical Pharmacology
2017 | Journal article
Contributors: Duong, Janna K.; Griffin, Melanie J.; Hargrave, Darren; Vormoor, Josef; Edwards, David; Boddy, Alan V.
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Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia

Leukemia
2017 | Journal article
Contributors: Elder, A.; Bomken, S.; Wilson, I.; Blair, H. J.; Cockell, S.; Ponthan, F.; Dormon, K.; Pal, D.; Heidenreich, O.; Vormoor, J.
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Early phase clinical trials of anticancer agents in children and adolescents - an ITCC perspective

Nature Reviews Clinical Oncology
2017 | Journal article
Contributors: Moreno, Lucas; Pearson, Andrew D. J.; Paoletti, Xavier; Jimenez, Irene; Geoerger, Birgit; Kearns, Pamela R.; Zwaan, C. Michel; Doz, Francois; Baruchel, Andre; Vormoor, Josef et al.
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From class waivers to precision medicine in paediatric oncology

The Lancet Oncology
2017 | Journal article
Contributors: Pearson, Andrew D. J.; Pfister, Stefan M.; Baruchel, Andre; Bourquin, Jean-Pierre; Casanova, Michela; Chesler, Louis; Doz, Francois; Eggert, Angelika; Geoerger, Birgit; Jones, David T. W. et al.
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THERAPEUTIC TARGETING OF PRE-B CELL RECEPTOR SIGNALLING IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

Haematologica
2017 | Journal article
Contributors: Alhammer, A.; Case, M.; Matheson, E.; Blair, H.; Vormoor, J.; Irving, J.
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"Including" Patients in the North. Development of an Early Phase Trials Network in the North of Britain

Pediatric Blood and Cancer
2016 | Journal article
Contributors: Hewson, Q. Campbell; Johnstone, H.; Vormoor, J.; Price, L.; Forster, G.; Bell, G.; Davis, J.
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BCP-ALL blasts are not dependent on CD19 expression for leukaemic maintenance

Leukemia
2016 | Journal article
Contributors: Weiland, J.; Pal, D.; Case, M.; Irving, J.; Ponthan, F.; Koschmieder, S.; Heidenreich, O.; von Stackelberg, A.; Eckert, C.; Vormoor, J. et al.
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Dormancy Stems the Tide of Chemotherapy

Cancer Cell
2016 | Journal article
Contributors: Pal, Deepali; Heidenreich, Olaf; Vormoor, Josef
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Exploring Pre-B Cell Receptor Signalling As a Therapeutic Target in Acute Lymphoblastic Leukaemia

Blood
2016 | Journal article
Contributors: Alhammer, Ali; Case, Marian; Blair, Helen J.; Vormoor, Josef; Irving, Julie
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Identification of CCND2 As a RUNX1/ETO Target Required for Leukaemic Propagation

Blood
2016 | Journal article
Contributors: McKenzie, Lynsey; Martinez-Soria, Natalia; Draper, Julia; Nakjang, Sirintra; Blair, Helen J.; Wichmann, Christian; Vormoor, Josef; Bonifer, Constanze; Lacaud, Georges; Heidenreich, Olaf
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Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia

Leukemia
2016 | Journal article
Contributors: Pal, D.; Blair, H. J.; Elder, A.; Dormon, K.; Rennie, K. J.; Coleman, D. J. L.; Weiland, J.; Rankin, K. S.; Filby, A.; Heidenreich, O. et al.
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The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukemia blasts

Blood
2016 | Journal article
Contributors: Williams, Mark T. S.; Yousafzai, Yasar M.; Elder, Alex; Rehe, Klaus; Bomken, Simon; Frishman-Levy, Liron; Tavor, Sigal; Sinclair, Paul; Dormon, Katie; Masic, Dino et al.
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A Whole Genome In Vivo Crispr Screen in Primary ALL Predicts Leukaemic Relapse

Blood
2015 | Journal article
Contributors: Dormon, Katherine; Latif, Elda S.; Bashton, Matthew; Pal, Deepali; Selby, Matthew; Blair, Helen; Rand, Vikki; Hall, Andrew G.; Vormoor, Josef; Heidenreich, Olaf
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CD19: A multifunctional immunological target molecule and its implications for Blineage acute lymphoblastic leukemia

Pediatric Blood and Cancer
2015 | Journal article
Contributors: Weiland, Judith; Elder, Alex; Forster, Victoria; Heidenreich, Olaf; Koschmieder, Steffen; Vormoor, Josef
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Childhood pre-B acute lymphoblastic leukaemia cells capable of central nervous system engraftment are common, heterogeneous and transit the blood-cerebrospinal fluid barrier

British Journal of Haematology
2015 | Journal article
Contributors: Yousafzai, Y. M.; Williams, M. T. S.; Bhatti, S.; Cousins, A.; Rehe, K.; Bomken, S.; Sinclair, P.; Weston, V. J.; Russell, L. J.; Heidenreich, O. et al.
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High Abundance of Acute Lymphoblastic Leukaemia Founder Clones Does Not Translate to Functional Heterogeneity

Blood
2015 | Journal article
Contributors: Elder, Alex; Blair, Helen; Dormon, Katherine; Bomken, Simon; Cockell, Simon J.; Heidenreich, Olaf; Vormoor, Josef
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Patient-derived xenograft and <i>in vivo</i> bioluminescent modelling of B-cell NHL

British Journal of Haematology
2015 | Journal article
Contributors: Bell, N.; Blair, H.; Noble, R.; Price, L.; Wood, K.; Vormoor, J.; Bacon, C.; Rand, V.; Heidenreich, O.; Wedge, S. et al.
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Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition (vol 124, pg 3420, 2014)

Blood
2015 | Journal article
Contributors: Irving, Julie; Matheson, Elizabeth; Minto, Lynne; Blair, Helen; Case, Marian; Halsey, Christina; Swidenbank, Isabella; Ponthan, Frida; Kirschner-Schwabe, Renate; Groeneveld-Krentz, Stefanie et al.
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The pre-B-cell receptor checkpoint in acute lymphoblastic leukaemia

Leukemia
2015 | Journal article
Contributors: Eswaran, J.; Sinclair, P.; Heidenreich, O.; Irving, J.; Russell, L. J.; Hall, A.; Calado, D. P.; Harrison, C. J.; Vormoor, J.
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A Genome-Wide RNAi Screen to Identify Novel Genes Involved in Clonal Maintenance of ALL

Blood
2014 | Journal article
Contributors: Ponthan, Frida; Bomken, Simon; Pal, Deepali; Elder, Alex; McNeill, Hesta; Vormoor, Josef; Heidenreich, Olaf
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Development of <i>in Vivo</i> Models of Paediatric Burkitt Lymphoma Allowing Therapeutic Target Analysis and Drug Testing

Blood
2014 | Journal article
Contributors: Bell, Natalie; Blair, Helen J.; Vormoor, Josef; Bacon, Chris; Rand, Vikki; Heidenreich, Olaf; Bomken, Simon
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Development of a Preclinical Orthotopic Xenograft Model of Ewing Sarcoma and Other Human Malignant Bone Disease Using Advanced In Vivo Imaging

Plos One
2014 | Journal article
Contributors: Vormoor, Britta; Knizia, Henrike K.; Batey, Michael A.; Almeida, Gilberto S.; Wilson, Ian; Dildey, Petra; Sharma, Abhishek; Blair, Helen; Hide, I. Geoff; Heidenreich, Olaf et al.
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Differential expression of miR-17∼92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia

Leukemia
2014 | Journal article
Contributors: Scherr, M.; Elder, A.; Battmer, K.; Barzan, D.; Bomken, S.; Ricke-Hoch, M.; Schroeder, A.; Venturini, L.; Blair, H. J.; Vormoor, J. et al.
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Preclinical modelling of childhood acute lymphoblastic leukaemia

The Lancet
2014 | Journal article
Contributors: Bomken, Simon; Elder, Alex; Blair, Helen; Scherr, Michaela; Eder, Matthias; Vormoor, Josef; Heidenreich, Olaf
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Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition

Blood
2014 | Journal article
Contributors: Irving, Julie; Matheson, Elizabeth; Minto, Lynne; Blair, Helen; Case, Marian; Halsey, Christina; Swidenbank, Isabella; Ponthan, Frida; Kirschner-Schwabe, Renate; Groeneveld-Krentz, Stefanie et al.
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Acute B lymphoblastic leukaemia-propagating cells are present at high frequency in diverse lymphoblast populations

EMBO Molecular Medicine
2013 | Journal article
Contributors: Rehe, Klaus; Wilson, Kerrie; Bomken, Simon; Williamson, Daniel; Irving, Julie; den Boer, Monique L.; Stanulla, Martin; Schrappe, Martin; Hall, Andrew G.; Heidenreich, Olaf et al.
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Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression

Leukemia
2013 | Journal article
Contributors: Bomken, S.; Buechler, L.; Rehe, K.; Ponthan, F.; Elder, A.; Blair, H.; Bacon, C. M.; Vormoor, J.; Heidenreich, O.
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Lentiviral marking of patient-derived acute lymphoblastic leukaemic cells allows in vivo tracking of disease progression (vol 27, pg 718, 2013)

Leukemia
2013 | Journal article
Contributors: Bomken, S.; Buechler, L.; Rehe, K.; Ponthan, F.; Elder, A.; Blair, H.; Bacon, C. M.; Vormoor, J.; Heidenreich, O.
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Mir∼17-92 Identifies BCL2 As a Therapeutic Target In BCR-ABL Positive B-Lineage Acute Lymphoblastic Leukemia

Blood
2013 | Journal article
Contributors: Eder, Matthias; Elder, Alex; Barzan, David; Battmer, Karin; Bomken, Simon; Ricke-Hoch, Melanie; Schroeder, Anke; Venturini, Letizia; Pfeiffer, Heike; Blair, Helen J. et al.
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RAS Pathway Mutations Are Highly Prevalent In Relapsed Childhood Acute Lymphoblastic Leukaemia, Are Frequently Relapse-Drivers and Confer Sensitivity To MEK Inhibition

Blood
2013 | Journal article
Contributors: Irving, Julie; Matheson, Elizabeth C.; Minto, Lynne; Blair, Helen; Case, Marian; Halsey, Christina; Swidenbank, Isabella; Ponthan, Frida; Kirschner-Schwabe, Renate; Groeneveld-Krentz, Stefanie et al.
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Peer review (3 reviews for 3 publications/grants)

Review activity for EMBO molecular medicine. (1)
Review activity for HemaSphere. (1)
Review activity for Nature reviews. (1)