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MEDULLOBLASTOMA, GLIOBLASTOMA, IMMUNOTHERAPY, CHECKPOINT INHIBITOR, MYELOID CHECKPOINT, PEDIATRIC BRAIN TUMOR, Brain Metastasis, CD47, innate immunity, immunotherapy, tumor microenvironment
United States

Biography

Dr. Mitra is currently an Assistant professor of pediatrics at the University of Colorado School of medicine and Childrenā€™s Hospital Colorado in the Division of hematology-oncology and bone marrow transplant. He was previously a Senior Scientist at the Stanford Institute for stem cell biology and regenerative medicine and the Ludwig center for cancer stem cell research and medicine. He originally hails from northern India where he completed his undergraduate and masterā€™s degrees from the basic medical sciences honors school program at Panjab University in Chandigarh, India [B.Sc (Honors) and M.Sc (Honors)]. In 1999 he joined the graduate program at the State University of New York at Buffalo where he completed a Ph.D. in Molecular Cell biology. He went on to do his postdoctoral training in developmental neurobiology at the center for neuroscience at the University of California, Davis, and then at the brain tumor research laboratories at Stanford University School of Medicine. In 2010 he was appointed as a Senior Scientist at the Stanford Institute for Stem Cell Research and Regenerative Medicine to head the CNS immuno-therapeutics program for a CIRM-funded anti-CD47 disease team project. In 2016 he was appointed as the director for Translational NeuroOncology at Lucille Packard Childrenā€™s Hospital and Stanford University Medical Center. In 2018 The Mitra laboratory moved to the University of Colorado, School of Medicine in Denver. A major goal within the laboratory is to understand the molecular physiology of immune cells within tumors and to identify mechanisms that define the biology of immune cell communities within brain tumors. The research interests primarily pertain to the immune-microenvironment of malignant brain tumors with a specific interest in overcoming immune evasion mechanisms in CNS malignancies.

Activities

Employment (3)

University of Colorado Denver School of Medicine: Aurora, CO, US

2018-02-01 to present | Assistant Professor (Pediatrics)
Employment
Source: Self-asserted source
Siddhartha Mitra

Stanford University School of Medicine: Stanford, CA, US

2010-01-01 to 2018-01-31 | Senior Scientist (Neurosurgery and Stem cell Biology)
Employment
Source: Self-asserted source
Siddhartha Mitra

Stanford University School of Medicine: Stanford, CA, US

2007-01-01 to 2009-12-31 | Postdoctoral Scholar (Neurosurgery)
Employment
Source: Self-asserted source
Siddhartha Mitra

Education and qualifications (3)

University at Buffalo, State University of New York: Buffalo, New York, US

1999-09-01 to 2005-03-31 | PhD (Biological Sciences)
Education
Source: Self-asserted source
Siddhartha Mitra

Panjab University Faculty of Science: Chandigarh, Punjab, IN

1997-08-01 to 1999-07-31 | M.Sc (Honors Program) (Biophysics)
Education
Source: Self-asserted source
Siddhartha Mitra

Panjab University Faculty of Science: Chandigarh, Punjab, IN

1994-08-01 to 1997-07-31 | B.SC. (HONORS) (BIOPHYSICS)
Education
Source: Self-asserted source
Siddhartha Mitra

Works (8)

Spatial transcriptomic analysis delineates epithelial and mesenchymal subpopulations and transition stages in childhood ependymoma.

Neuro-oncology
2022-10-10 | Journal article
Contributors: Siddhartha Mitra; Fu R; Norris GA; Willard N; Griesinger AM; Kent Riemondy; Amani V; Grimaldo E; Harris F; Hankinson TC et al.
Source: Self-asserted source
Siddhartha Mitra

Mapping the tumor-infiltrating immune cells during glioblastoma progression

Nature Immunology
2022-06 | Journal article
Contributors: Senthilnath Lakshmanachetty; Siddhartha S. Mitra
Source: check_circle
Crossref

Venetoclax Cooperates with Ionizing Radiation to Attenuate Diffuse Midline Glioma Tumor Growth.

Clinical cancer research : an official journal of the American Association for Cancer Research
2022-06-01 | Journal article | Author
Contributors: Krishna Madhavan; Balakrishnan I; Senthilnath Lakshmanachetty; Pierce A; Sanford B; Fosmire S; Elajaili HB; Faye Walker; Wang D; Nozik ES et al.
Source: Self-asserted source
Siddhartha Mitra

Targeting the TP53/MDM2 axis enhances radiation sensitivity in atypical teratoid rhabdoid tumors.

International journal of oncology
2022-02-18 | Journal article
Contributors: Siddhartha Mitra; Alimova I; Wang D; Danis E; Pierce A; Donson A; Serkova N; Madhavan K; Senthilnath Lakshmanachetty; Balakrishnan I et al.
Source: Self-asserted source
Siddhartha Mitra

Regulation of reverse electron transfer at mitochondrial complex I by unconventional Notch action in cancer stem cells.

Developmental cell
2022-01-01 | Journal article
Contributors: Siddhartha Mitra; Ojha R; Tantray I; SUMAN RIMAL; Mitra S; Cheshier S; Lu B
Source: Self-asserted source
Siddhartha Mitra

Innate Immune Checkpoint Inhibitors: The Next Breakthrough in Medical Oncology?

Molecular Cancer Therapeutics
2021-06-01 | Journal article
Contributors: Robert W. Lentz; Meryl D. Colton; Siddhartha S. Mitra; Wells A. Messersmith
Source: check_circle
Crossref

Nanoparticle enhanced MRI can monitor macrophage response to CD47 mAb immunotherapy in osteosarcoma

Cell Death & Disease
2019-01-15 | Journal article
Contributors: Suchismita Mohanty; Ketan Yerneni; Johanna Lena Theruvath; Claus Moritz Graef; Hossein Nejadnik; Olga Lenkov; Laura Pisani; Jarrett Rosenberg; Siddhartha Mitra; Alejandro Sweet Cordero et al.
Source: check_circle
Crossref

Disrupting the CD47-SIRPĪ± anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

Science Translational Medicine
2017-03-15 | Journal article
Contributors: Sharareh Gholamin; Siddhartha S. Mitra; Abdullah H. Feroze; Jie Liu; Suzana A. Kahn; Michael Zhang; Rogelio Esparza; Chase Richard; Vijay Ramaswamy; Marc Remke et al.
Source: check_circle
Crossref

Peer review (21 reviews for 11 publications/grants)

Review activity for Acta neuropathologica communications. (1)
Review activity for Brain, behavior, & immunity. (1)
Review activity for EMBO molecular medicine. (1)
Review activity for Journal for immunotherapy of cancer. (3)
Review activity for Nature communications (2)
Review activity for Nature immunology. (1)
Review activity for Nature reviews. (1)
Review activity for Neuro-oncology advances. (1)
Review activity for Neuro-oncology. (8)
Review activity for Science translational medicine. (1)
Review activity for Trends in cancer. (1)