Personal information

Websites & social links

Lab website
Departmental profile

Other IDs

ResearcherID: J-9663-2016
Loop profile: 549442
Scopus Author ID: 14014543600

Keywords

Neurobiology, Brain blood vessels, Neuro-vascular interactions, Neurological disorders, Angiogenesis, Neurotanatomy, Electron microscopy, Vascular networks, Stroke, Dementia, Mouse genetics, autism spectrum disorders

Countries

Canada

Biography

Our research is about the formation, function and maintenance of brain blood vessels and neuro-vascular interactions in health and disease. We are particularly interested in mechanisms underlying the influence of cerebrovascular function/dysfunction on neuronal development, plasticity and repair. Studying neurovascular interactions is key for a better understanding of neurological disorders, a very promising avenue in the neurobiology of brain & mind health at both basic and translational levels.

Specialties: cerebrovascular physiology, cerebral blood flow, angiogenesis, developmental neurosciences, mouse genetics, stroke, autism, neuroanatomy, imaging, mouse behaviour, electron microscopy.

Activities

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Employment (4)

University of Ottawa: Ottawa, Ontario, CA

2022-09 to present | Associate Professor (Cellular and Molecular Medicine)
Employment
Source: Self-asserted source
Baptiste Lacoste

University of Ottawa: Ottawa, ON, CA

2016-02-01 to present | Assistant Professor (Cellular and Molecular Medicine)
Employment
Source: Self-asserted source
Baptiste Lacoste

Harvard University: Cambridge, MA, US

2012-09-01 to 2015-12-31 | Postdoctoral Fellow (Harvard Medical School, Dpt. of Neurobiology)
Employment
Source: Self-asserted source
Baptiste Lacoste

McGill University: Montreal, QC, CA

2009-09-01 to 2012-07-31 | Postdoctoral Fellow (Dpts. of Neurology and Neurosurgery, and of Psychiatry)
Employment
Source: Self-asserted source
Baptiste Lacoste

Education and qualifications (4)

Université de Montréal: Montreal, QC, CA

2004-05-01 to 2009-06-29 | Ph.D. / Neurological Sciences (Dpts. of Pathology and Cellular Biology, and of Physiology)
Education
Source: Self-asserted source
Baptiste Lacoste

Université de Montréal: Montreal, QC, CA

2003-05-01 to 2004-04-30 | Master's equivalent / Neurobiology and Neuroanatomy (Dpts. of Pathology and Cellular Biology, and of Physiology)
Education
Source: Self-asserted source
Baptiste Lacoste

Université Bordeaux Segalen: Bordeaux, Aquitaine, FR

2000-09-01 to 2002-06-30 | M.Sc. / Neurobiology and Neuropharmacology (INSERM / CNRS)
Education
Source: Self-asserted source
Baptiste Lacoste

Université Bordeaux Segalen: Bordeaux, Aquitaine, FR

1997-09-01 to 2000-09-30 | B.Sc. / Biochemistry, Cellular Biology and Physiology (INSERM / CNRS)
Education
Source: Self-asserted source
Baptiste Lacoste

Funding (3)

Cellular and molecular mechanisms underlying neurovascular deficiencies in autism

2020-03 to 2022-03 | Grant
New Frontiers in Research Fund - Exploration (Ottawa, ON, CA)
GRANT_NUMBER:

NFRFE-2019-00641
Source: Self-asserted source
Baptiste Lacoste

Role of astrocytes in the control of cerebrovascular patterning during postnatal development

2018-07 to 2023-06 | Grant
National Science and Engineering Research Council of Canada (Ottawa, ON, CA)
GRANT_NUMBER:

RGPIN-2018-04456

Source: Self-asserted source
Baptiste Lacoste

Role of cerebrovascular abnormalities in the pathophysiology of autism spectrum disorders

2018-04 to 2023-03 | Grant
Canadian Institutes of Health Research (Ottawa, ON, CA)
GRANT_NUMBER:

388805
Source: Self-asserted source
Baptiste Lacoste

Works (41)

Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation

Nature Communications
2023-08-16 | Journal article
DOI: 10.1038/s41467-023-40682-3
Part of ISSN: 2041-1723
Contributors: Moises Freitas-Andrade; Cesar H. Comin; Peter Van Dyken; Julie Ouellette; Joanna Raman-Nair; Nicole Blakeley; Qing Yan Liu; Sonia Leclerc; Youlian Pan; Ziying Liu et al.
Source: Self-asserted source
Baptiste Lacoste

16p11.2 haploinsufficiency reduces mitochondrial biogenesis in brain endothelial cells and alters brain metabolism in adult mice.

Cell reports
2023-05-06 | Journal article
DOI: 10.1016/j.celrep.2023.112485
PMID: 37149866
Contributors: Béland-Millar A; Kirby A; Truong Y; Ouellette J; Yandiev S; Bouyakdan K; Pileggi C; Naz S; Yin M; Carrier M et al.
Source: Self-asserted source
Baptiste Lacoste

Neonatal hyperoxia in mice triggers long-term cognitive deficits via impairments in cerebrovascular function and neurogenesis.

The Journal of clinical investigation
2022-11-15 | Journal article
DOI: 10.1172/jci146095
PMID: 36136598
PMC: PMC9663164
Contributors: Lithopoulos MA; Toussay X; Zhong S; Xu L; Shamimunisa Mustafa; Ouellette J; Moises Freitas-Andrade; Comin CH; Bassam HA; Baker AN et al.
Source: Self-asserted source
Baptiste Lacoste

An analysis of the influence of transfer learning when measuring the tortuosity of blood vessels.

Computer methods and programs in biomedicine
2022-07-16 | Journal article
DOI: 10.1016/j.cmpb.2022.107021
PMID: 35914440
Contributors: da Silva MV; Ouellette J; Lacoste B; Comin CH
Source: Self-asserted source
Baptiste Lacoste

Unbiased analysis of mouse brain endothelial networks from two- or three-dimensional fluorescence images.

Neurophotonics
2022-05-18 | Journal article
DOI: 10.1117/1.nph.9.3.031916
PMID: 35620183
PMC: PMC9125696
Contributors: Moises Freitas-Andrade; Cesar H Comin; da Silva MV; Costa LDF; Lacoste B
Source: Self-asserted source
Baptiste Lacoste

Engineered Wnt ligands enable blood-brain barrier repair in neurological disorders.

Science (New York, N.Y.)
2022-02-18 | Journal article | Author
DOI: 10.1126/science.abm4459
PMID: 35175798
Contributors: Maud Martin; Simon Vermeiren; Naguissa Bostaille; Marie Eubelen; Spitzer D; Vermeersch M; Caterina P. Profaci; Pozuelo E; Xavier Toussay; Raman-Nair J et al.
Source: Self-asserted source
Baptiste Lacoste

Sex differences in developmental patterns of neocortical astroglia: A mouse translatome database.

Cell reports
2022-02-01 | Journal article
DOI: 10.1016/j.celrep.2022.110310
PMID: 35108542
Contributors: Gareth M. Rurak; Stephanie Simard; Moises Freitas-Andrade; Lacoste B; Charih F; Van Geel A; John Stead; Woodside B; Green JR; gianfilippo coppola et al.
Source: Self-asserted source
Baptiste Lacoste

Maternal high-fat diet in mice induces cerebrovascular, microglial and long-term behavioural alterations in offspring.

Communications biology
2022-01-11 | Journal article | Author
DOI: 10.1038/s42003-021-02947-9
PMID: 35017640
PMC: PMC8752761
Contributors: Bordeleau M; Comin CH; Fernández de Cossío L; Lacabanne C; Freitas-Andrade M; Fernando González Ibáñez; Raman-Nair J; Wakem M; Chakravarty M; Costa LDF et al.
Source: Self-asserted source
Baptiste Lacoste

Isolation and functional characterization of primary endothelial cells from mouse cerebral cortex.

STAR protocols
2021-12-11 | Journal article
DOI: 10.1016/j.xpro.2021.101019
PMID: 34950893
PMC: PMC8672097
Contributors: Ouellette J; Lacoste B
Source: Self-asserted source
Baptiste Lacoste

Naked mole-rat brown fat thermogenesis is diminished during hypoxia through a rapid decrease in UCP1.

Nature communications
2021-11-23 | Journal article | Author
DOI: 10.1038/s41467-021-27170-2
PMID: 34815412
PMC: PMC8610999
Contributors: Hang Cheng; Sebaa R; Malholtra N; Baptiste Lacoste; Ziyad El Hankouri; Kirby A; Bennett NC; Barry van Jaarsveld; Daniel W Hart; Glenn J Tattersall et al.
Source: Self-asserted source
Baptiste Lacoste

From Neurodevelopmental to Neurodegenerative Disorders: The Vascular Continuum.

Frontiers in aging neuroscience
2021-10-20 | Journal article
DOI: 10.3389/fnagi.2021.749026
PMID: 34744690
PMC: PMC8570842
Contributors: Ouellette J; Lacoste B
Source: Self-asserted source
Baptiste Lacoste

An Exercise Mimetic Approach to Reduce Poststroke Deconditioning and Enhance Stroke Recovery.

Neurorehabilitation and neural repair
2021-04-07 | Journal article
DOI: 10.1177/15459683211005019
PMID: 33825581
PMC: PMC8135250
Contributors: Matthew McDonald; Matthew Jeffers; Issa L; Carter A; Ripley A; Lydia Kuhl; Morse C; Comin CH; Jasmin BJ; Lacoste B et al.
Source: Self-asserted source
Baptiste Lacoste

Distinct Basal Metabolism in Three Mouse Models of Neurodevelopmental Disorders.

eNeuro
2021-03-01 | Journal article
DOI: 10.1523/eneuro.0292-20.2021
PMID: 33820803
PMC: PMC8174051
Contributors: Menzies C; Naz S; Patten D; Thierry Alquier; Bennett BM; Lacoste B
Source: Self-asserted source
Baptiste Lacoste

An antibody for analysis of autophagy induction

Nature Methods
2020 | Journal article
DOI: 10.1038/s41592-019-0661-y
EID:

2-s2.0-85075418602

Part of ISBN:

15487105 15487091
Contributors: Tian, W.; Alsaadi, R.; Guo, Z.; Kalinina, A.; Carrier, M.; Tremblay, M.-E.; Lacoste, B.; Lagace, D.; Russell, R.C.
Source: Self-asserted source
Baptiste Lacoste via Scopus - Elsevier

Influence of metabolic syndrome on cerebral perfusion and cognition

Neurobiology of Disease
2020 | Journal article
DOI: 10.1016/j.nbd.2020.104756
EID:

2-s2.0-85078190863

Part of ISBN:

1095953X 09699961
Contributors: Livingston, J.M.; McDonald, M.W.; Gagnon, T.; Jeffers, M.S.; Gomez-Smith, M.; Antonescu, S.; Cron, G.O.; Boisvert, C.; Lacoste, B.; Corbett, D.
Source: Self-asserted source
Baptiste Lacoste via Scopus - Elsevier

Structural and Functional Remodeling of the Brain Vasculature Following Stroke.

Frontiers in physiology
2020-08-07 | Journal article
DOI: 10.3389/fphys.2020.00948
PMID: 32848875
PMC: PMC7433746
Source: Self-asserted source
Baptiste Lacoste

Vascular contributions to 16p11.2 deletion autism syndrome modeled in mice.

Nature neuroscience
2020-07-13 | Journal article
DOI: 10.1038/s41593-020-0663-1
PMID: 32661394
Source: Self-asserted source
Baptiste Lacoste

Laser Doppler Flowmetry to Study the Regulation of Cerebral Blood Flow by G Protein-Coupled Receptors in Rodents

Methods in Molecular Biology
2019 | Book chapter
DOI: 10.1007/978-1-4939-9121-1_22
EID:

2-s2.0-85064721166

Part of ISBN:

19406029 10643745
Contributors: Toussay, X.; Tiberi, M.; Lacoste, B.
Source: Self-asserted source
Baptiste Lacoste via Scopus - Elsevier

Impact of metabolic syndrome on neuroinflammation and the blood–brain barrier

Front Neurosci
2018-12 | Journal article
PMID: 30618559
Source: Self-asserted source
Baptiste Lacoste

Spreading depolarizations trigger caveolin-1-dependent endothelial transcytosis

Ann Neurol
2018-09 | Journal article
PMID: 30014540
Source: Self-asserted source
Baptiste Lacoste

Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice

Clin Sci (Lond)
2018-07 | Journal article
PMID: 29739827
Source: Self-asserted source
Baptiste Lacoste

Joint volumetric extraction and enhancement of vasculature from low-SNR 3-D fluorescence microscopy images

Pattern Recognition
2017 | Journal article
DOI: 10.1016/j.patcog.2016.09.031
EID:

2-s2.0-84994462645

Part of ISBN:

00313203
Contributors: Almasi, S.; Ben-Zvi, A.; Lacoste, B.; Gu, C.; Miller, E.L.; Xu, X.
Source: Self-asserted source
Baptiste Lacoste via Scopus - Elsevier

The aPKC-CBP Pathway Regulates Post-stroke Neurovascular Remodeling and Functional Recovery

Stem Cell Reports
2017-12 | Journal article
PMID: 29173896
Source: Self-asserted source
Baptiste Lacoste

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis

Neuron
2017-05 | Journal article
PMID: 28416077
Source: Self-asserted source
Baptiste Lacoste

Dark microglia: Why are they dark?

Commun Integr Biol
2016-10 | Journal article
PMID: 28042375
Source: Self-asserted source
Baptiste Lacoste

Control of cerebrovascular patterning by neural activity during postnatal development

Mech Dev
2015-11 | Journal article
PMID: 26116138
Source: Self-asserted source
Baptiste Lacoste

Neuronal and vascular interactions

Annu Rev Neurosci
2015-07 | Journal article
PMID: 25782970
Source: Self-asserted source
Baptiste Lacoste

Anatomical and cellular localization of melatonin MT1 and MT2 receptors in the adult rat brain

J Pineal Res
2015-05 | Journal article
PMID: 25726952
Source: Self-asserted source
Baptiste Lacoste

A novel method for identifying a graph-based representation of 3-D microvascular networks from fluorescence microscopy image stacks

Med Image Anal
2015-02 | Journal article
PMID: 25515433
Source: Self-asserted source
Baptiste Lacoste

Selective melatonin MT2 receptor ligands relieve neuropathic pain through modulation of brainstem descending antinociceptive pathways

Pain
2015-02 | Journal article
PMID: 25599452
Source: Self-asserted source
Baptiste Lacoste

Neurotherapeutic effects of novel HO-1 inhibitors in vitro and in a transgenic mouse model of Alzheimer's disease

J Neurochem
2014-12 | Journal article
PMID: 25111043
Source: Self-asserted source
Baptiste Lacoste

Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding

eLife
2014-09 | Journal article
PMID: 25244320
Source: Self-asserted source
Baptiste Lacoste

Mfsd2a is critical for the formation and function of the blood-brain barrier

Nature
2014-05 | Journal article
PMID: 24828040
Source: Self-asserted source
Baptiste Lacoste

Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex

Neuron
2014-03 | Journal article
PMID: 25155955
Source: Self-asserted source
Baptiste Lacoste

Father absence in the monogamous california mouse impairs social behavior and modifies dopamine and glutamate synapses in the medial prefrontal cortex

Cereb Cortex
2013-12 | Journal article
PMID: 24304503
Source: Self-asserted source
Baptiste Lacoste

Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer's disease mice

J Neuroinflamm
2013-05 | Journal article
PMID: 23642031
Source: Self-asserted source
Baptiste Lacoste

Locus coeruleus stimulation recruits a broad cortical neuronal network and increases cortical perfusion

J Neurosci
2013-02 | Journal article
PMID: 23426667
Source: Self-asserted source
Baptiste Lacoste

Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand

J Neurosci
2011-12 | Journal article
PMID: 22171046
Source: Self-asserted source
Baptiste Lacoste

Trafficking of neurokinin-1 receptors in serotonin neurons is controlled by substance P within the rat dorsal raphe nucleus

Eur J Neurosci
2009-06 | Journal article
PMID: 19490080
Source: Self-asserted source
Baptiste Lacoste

Developmental profile of neuregulin receptor ErbB4 in postnatal rat cerebral cortex and hippocampus

Neuroscience
2007-10 | Journal article
PMID: 17630218
Source: Self-asserted source
Baptiste Lacoste

Immunocytochemical evidence for the existence of substance P receptor (NK1) in serotonin neurons of rat and mouse dorsal raphe nucleus

Eur J Neurosci
2006-06 | Journal article
PMID: 16819984
Source: Self-asserted source
Baptiste Lacoste
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