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Employment (1)

Genentech Inc: South San Francisco, CA, US

2014 to present | current: Senior Principal Scientist & Director (Synthetic Molecule Process Chemistry)
Employment
Source: Self-asserted source
Lauren E. Sirois

Works (22)

Manufacturing Process for 6-Bromo-N,N-bis(4-methoxybenzyl)-4-methyl-5-(trifluoromethyl)pyridin-2-amine, a Key Intermediate in the Synthesis of KRAS G12C Inhibitor Divarasib

Organic Process Research & Development
2023-12-29 | Journal article | Author
DOI: 10.1021/acs.oprd.3c00366
Part of ISSN: 1083-6160
Part of ISSN: 1520-586X
Contributors: Jeff Shen; Nicholas White; Qingping Tian; Lauren E. Sirois; Haiming Zhang; Francis Gosselin
Source: Self-asserted source
Lauren E. Sirois

Second-Generation Atroposelective Synthesis of KRAS G12C Covalent Inhibitor GDC-6036

Organic Letters
2023-05-19 | Journal article | Author
DOI: 10.1021/acs.orglett.3c00961
Part of ISSN: 1523-7060
Part of ISSN: 1523-7052
Contributors: Jie Xu; Ngiap-Kie Lim; Jacob C. Timmerman; Jeff Shen; Kyle Clagg; Ugo Orcel; Raphael Bigler; Etienne Trachsel; Roland Meier; Nicholas White et al.
Source: Self-asserted source
Lauren E. Sirois

Atroposelective Negishi Coupling Optimization Guided by Multivariate Linear Regression Analysis: Asymmetric Synthesis of KRAS G12C Covalent Inhibitor GDC-6036

Journal of the American Chemical Society
2022-11-16 | Journal article | Author
DOI: 10.1021/jacs.2c09917
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Contributors: Jie Xu; Samantha Grosslight; Kyle A. Mack; Sierra C. Nguyen; Kyle Clagg; Ngiap-Kie Lim; Jacob C. Timmerman; Jeff Shen; Nicholas White; Lauren E. Sirois et al.
Source: Self-asserted source
Lauren E. Sirois

Stereoselective Synthesis of the IDO Inhibitor Navoximod

The Journal of Organic Chemistry
2022-04-01 | Journal article | Author
DOI: 10.1021/acs.joc.1c02994
Part of ISSN: 0022-3263
Part of ISSN: 1520-6904
Contributors: Frédéric St-Jean; Rémy Angelaud; Stephan Bachmann; Diane E. Carrera; Travis Remarchuk; Katarzyna A. Piechowicz; Katrin Niedermann; Hans Iding; Roland Meier; Haiyun Hou et al.
Source: Self-asserted source
Lauren E. Sirois

Stereoconvergent and -divergent Synthesis of Tetrasubstituted Alkenes by Nickel-Catalyzed Cross-Couplings

Journal of the American Chemical Society
2021-11-17 | Journal article | Author
DOI: 10.1021/jacs.1c08399
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Contributors: Daniel Zell; Cian Kingston; Janis Jermaks; Sleight R. Smith; Natalie Seeger; Jana Wassmer; Lauren E. Sirois; Chong Han; Haiming Zhang; Matthew Sigman et al.
Source: Self-asserted source
Lauren E. Sirois

Achiral–Chiral Two-Dimensional Liquid Chromatography Platform to Support Automated High-Throughput Experimentation in the Field of Drug Development

Analytical Chemistry
2020-11-17 | Journal article | Author
DOI: 10.1021/acs.analchem.0c03754
Part of ISSN: 0003-2700
Part of ISSN: 1520-6882
Contributors: Alexandre Goyon; Colin Masui; Lauren E. Sirois; Chong Han; Peter Yehl; Francis Gosselin; Kelly Zhang
Source: Self-asserted source
Lauren E. Sirois

Practical Synthesis of a Stable Precursor for Positron Emission Tomography Imaging Agent 18F-GTP1

Organic Process Research & Development
2020-09-18 | Journal article | Author
DOI: 10.1021/acs.oprd.0c00301
Part of ISSN: 1083-6160
Part of ISSN: 1520-586X
Contributors: Nicholas White; Kyle Clagg; Lauren E. Sirois; Ngiap-Kie Lim; William A. Nack; Paul D. O’Shea; Haiming Zhang; Francis Gosselin
Source: Self-asserted source
Lauren E. Sirois

Process Development Overcomes a Challenging Pd-Catalyzed C–N Coupling for the Synthesis of RORc Inhibitor GDC-0022

Organic Process Research & Development
2020-04-17 | Journal article | Author
DOI: 10.1021/acs.oprd.0c00012
Part of ISSN: 1083-6160
Part of ISSN: 1520-586X
Contributors: Lauren E. Sirois; David Lao; Jie Xu; Rémy Angelaud; Jerry Tso; Brandon Scott; Paroma Chakravarty; Sushant Malhotra; Francis Gosselin
Source: Self-asserted source
Lauren E. Sirois

Phosphoramidates as Steering Elements for Highly Selective Access to Complementary Imidazo[1,2-a]pyrimidine Isomers

Organic Letters
2019-12-06 | Journal article | Author
DOI: 10.1021/acs.orglett.9b03702
Part of ISSN: 1523-7060
Part of ISSN: 1523-7052
Contributors: Nicholas White; Kyle Clagg; Lauren E. Sirois; Kyle A. Mack; Mohammad A. Al-Sayah; William A. Nack; Paul D. O’Shea; Haiming Zhang; Francis Gosselin
Source: Self-asserted source
Lauren E. Sirois

Identification of an acetonitrile addition impurity formed during peptide disulfide bond reduction using dithiothreitol and Tris(2-carboxyethyl)phosphine

Journal of Pharmaceutical and Biomedical Analysis
2019-09 | Journal article
DOI: 10.1016/j.jpba.2019.06.020
Part of ISSN: 0731-7085
Contributors: Eileen Zhao; Frédéric St-Jean; Sarah J. Robinson; Lauren E. Sirois; Jackson Pellett; Mohammad A. Al-Sayah
Source: Self-asserted source
Lauren E. Sirois

Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp3–sp2 Suzuki Coupling of a Benzyl Carbonate

Organic Process Research & Development
2019-01-18 | Journal article | Author
DOI: 10.1021/acs.oprd.8b00325
Part of ISSN: 1083-6160
Part of ISSN: 1520-586X
Contributors: Lauren E. Sirois; MATTHEW ZHAO; Ngiap-Kie Lim; Mark S. Bednarz; Bryce A. Harrison; Wenxue Wu
Source: Self-asserted source
Lauren E. Sirois

Study of a Competing Hydrodefluorination Reaction During the Directed ortho-Lithiation/Borylation of 2-Fluorobenzaldehyde

Organometallics
2019-01-14 | Journal article | Author
DOI: 10.1021/acs.organomet.8b00730
Part of ISSN: 0276-7333
Part of ISSN: 1520-6041
Contributors: Frédéric St-Jean; Katarzyna A. Piechowicz; Lauren E. Sirois; Rémy Angelaud; Francis Gosselin
Source: Self-asserted source
Lauren E. Sirois

Practical Synthesis of a 6-Triazolylazabicyclo[3.1.0]hexane

Organic Process Research & Development
2018-06-15 | Journal article | Author
DOI: 10.1021/acs.oprd.8b00101
Part of ISSN: 1083-6160
Part of ISSN: 1520-586X
Contributors: Lauren E. Sirois; Jie Xu; Remy Angelaud; David Lao; Francis Gosselin
Source: Self-asserted source
Lauren E. Sirois

Characterization of Pharmaceutical Cocrystals and Salts by Dynamic Nuclear Polarization-Enhanced Solid-State NMR Spectroscopy

Crystal Growth & Design
2018-04-04 | Journal article
DOI: 10.1021/acs.cgd.8b00203
Part of ISSN: 1528-7483
Part of ISSN: 1528-7505
Contributors: Li Zhao; Michael P. Hanrahan; Paroma Chakravarty; Antonio G. DiPasquale; Lauren E. Sirois; karthik nagapudi; Joseph Lubach; Aaron Rossini
Source: Self-asserted source
Lauren E. Sirois

Function through bio-inspired, synthesis-informed design: step-economical syntheses of designed kinase inhibitors†Dedicated to Max Malacria, a friend and scholar whose science and creative contributions to step-economical synthesis have inspired us all and moved the field closer to the ideal.‡Electronic supplementary information (ESI) available: Synthetic procedures and spectral data. See DOI: 10.1039/c4qo00228hClick here for additional data file.

Organic chemistry frontiers : an international journal of organic chemistry
2014-12 | Journal article
DOI: 10.1039/c4qo00228h
PMID: 25632347
PMC: PMC4304288
Contributors: Wender PA; Axtman AD; Golden JE; Kee JM; Sirois LE; Quiroz RV; Stevens MC
Source: Self-asserted source
Lauren E. Sirois via Europe PubMed Central

Ligand effects on rates and regioselectivities of Rh(I)-catalyzed (5 + 2) cycloadditions: a computational study of cyclooctadiene and dinaphthocyclooctatetraene as ligands.

Journal of the American Chemical Society
2012-07 | Journal article
DOI: 10.1021/ja3041724
PMID: 22668243
Contributors: Xu X; Liu P; Lesser A; Sirois LE; Wender PA; Houk KN
Source: Self-asserted source
Lauren E. Sirois via Europe PubMed Central

Rhodium dinaphthocyclooctatetraene complexes: synthesis, characterization and catalytic activity in [5+2] cycloadditions.

Angewandte Chemie (International ed. in English)
2012-03 | Journal article
DOI: 10.1002/anie.201108270
PMID: 22298411
Contributors: Wender PA; Lesser AB; Sirois LE
Source: Self-asserted source
Lauren E. Sirois via Europe PubMed Central

THE PREPARATION OF CYCLOHEPT-4-ENONES BY RHODIUM-CATALYZED INTERMOLECULAR [5+2] CYCLOADDITION

Organic Syntheses
2011 | Journal article
DOI: 10.15227/orgsyn.088.0109
Source: Self-asserted source
Lauren E. Sirois

Electronic and steric control of regioselectivities in Rh(I)-catalyzed (5 + 2) cycloadditions: experiment and theory.

Journal of the American Chemical Society
2010-07 | Journal article
DOI: 10.1021/ja103253d
PMID: 20586494
Contributors: Liu P; Sirois LE; Cheong PH; Yu ZX; Hartung IV; Rieck H; Wender PA; Houk KN
Source: Self-asserted source
Lauren E. Sirois via Europe PubMed Central

Highly efficient, facile, room temperature intermolecular [5 + 2] cycloadditions catalyzed by cationic rhodium(I): one step to cycloheptenes and their libraries.

Organic letters
2010-04 | Journal article
DOI: 10.1021/ol100337m
PMID: 20196579
Contributors: Wender PA; Sirois LE; Stemmler RT; Williams TJ
Source: Self-asserted source
Lauren E. Sirois via Europe PubMed Central

A metal-catalyzed intermolecular [5+2] cycloaddition/Nazarov cyclization sequence and cascade.

Journal of the American Chemical Society
2010-03 | Journal article
DOI: 10.1021/ja910696x
PMID: 20141136
Contributors: Wender PA; Stemmler RT; Sirois LE
Source: Self-asserted source
Lauren E. Sirois via Europe PubMed Central

Macrolactonization via hydrocarbon oxidation.

Journal of the American Chemical Society
2006-07 | Journal article
DOI: 10.1021/ja063096r
PMID: 16834366
PMC: PMC2720785
Contributors: Fraunhoffer KJ; Prabagaran N; Sirois LE; White MC
Source: Self-asserted source
Lauren E. Sirois via Europe PubMed Central
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