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The Ohio State University: Columbus, Ohio, US

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Amanda Hummon

Works (43)

Quantitative top-down proteomics reveals significant differences in histone proteoforms between metastatic and nonmetastatic colorectal cancer cells

2025-02-05 | Preprint
Contributors: Fei Fang; Brian Fries; Zhige Wang; Xiaowen Liu; Amanda Hummon; Liangliang Sun
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Crossref

Quantitative mass spectrometry imaging: therapeutics & biomolecules

Chemical Communications
2024 | Journal article
Contributors: Joseph H. Holbrook; Gabrielle E. Kemper; Amanda B. Hummon
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Single Cell MALDI-MSI Analysis of Lipids and Proteins within a Replicative Senescence Fibroblast Model

Journal of the American Society for Mass Spectrometry
2024-12-04 | Journal article
Contributors: Emily R. Sekera; Lorena Rosas; Joseph H. Holbrook; Quetzalli D. Angeles-Lopez; Timur Khaliullin; Mauricio Rojas; Ana L. Mora; Amanda B. Hummon
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Uptake of Self-Assembling Amphiphilic Tryptophan-Based Polymer Nanoparticles in Three-Dimensional Cell Culture Models

ACS Applied Nano Materials
2024-09-13 | Journal article
Contributors: Shreyasi Mukherjee; Anuja Kulkarni; Joseph H. Holbrook; Gaya S. Dasanayake; Duoyi Hu; Eden E. L. Tanner; Amanda B. Hummon; Davita L. Watkins
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Crossref

FAS Inhibited Proteomics and Phosphoproteomics Profiling of Colorectal Cancer Spheroids Shows Activation of Ferroptotic Death Mechanism

Journal of Proteome Research
2024-09-06 | Journal article
Contributors: Brian D. Fries; Amanda B. Hummon
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Gas-Phase Fractionation Data-Independent Acquisition Analysis of 3D Cocultured Spheroid Tumor Model Reveals Altered Translational Processes and Signaling Using Proteomics

Journal of Proteome Research
2024-08-02 | Journal article
Contributors: Ariana E. Shannon; Claire E. Boos; Brian C. Searle; Amanda B. Hummon
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Crossref

Lipidomics Profiling Reveals Differential Alterations after FAS Inhibition in 3D Colon Cancer Cell Culture Models

Journal of Proteome Research
2024-08-02 | Journal article
Contributors: Brian D. Fries; Fernando Tobias; Yijia Wang; Joseph H. Holbrook; Amanda B. Hummon
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Crossref

Tracking Drugs and Lipids: Quantitative Mass Spectrometry Imaging of Liposomal Doxorubicin Delivery and Bilayer Fate in Three-Dimensional Tumor Models

Analytical Chemistry
2024-06-04 | Journal article
Contributors: Arbil Lopez; Joseph H. Holbrook; Gabrielle E. Kemper; Jessica K. Lukowski; William T. Andrews; Amanda B. Hummon
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Crossref

Single Cell MALDI-MSI Analysis of Lipids and Proteins within a Replicative Senescence Fibroblast Model

2024-03-13 | Preprint
Contributors: Emily R. Sekera; Lorena Rosas; Joseph H. Holbrook; Quetzalli D. Angeles-Lopez; Timur Khaliullin; Mauricio Rojas; Ana L. Mora; Amanda B. Hummon
Source: check_circle
Crossref

Mass Spectrometry Imaging and Histology for the Analysis of Budding Intestinal Organoids

Analytical Chemistry
2024-03-12 | Journal article
Contributors: Emily R. Sekera; Kubra B. Akkaya-Colak; Arbil Lopez; Maria M. Mihaylova; Amanda B. Hummon
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Crossref

Workflow for Evaluating Normalization Tools for Omics Data Using Supervised and Unsupervised Machine Learning

Journal of the American Society for Mass Spectrometry
2023-12-06 | Journal article
Contributors: Aleesa E. Chua; Leah D. Pfeifer; Emily R. Sekera; Amanda B. Hummon; Heather Desaire
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Evaluating the Pharmacokinetics and Pharmacodynamics of Chemotherapeutics within a Spatial SILAC-Labeled Spheroid Model System

Analytical Chemistry
2023-08-01 | Journal article
Contributors: Nicole C. Beller; Yijia Wang; Amanda B. Hummon
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Enhancement of Lipid Signals in Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry with Ammonium Fluoride as a Matrix Additive

Analytical Chemistry
2023-07-18 | Journal article
Contributors: Joseph H. Holbrook; Emily R. Sekera; Arbil Lopez; Brian D. Fries; Fernando Tobias; Kubra Akkaya; Maria M. Mihaylova; Amanda B. Hummon
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Crossref

Quantification of Irinotecan in Single Spheroids Using Internal Standards by MALDI Mass Spectrometry Imaging

Analytical Chemistry
2023-06-20 | Journal article
Contributors: Yijia Wang; Amanda B. Hummon
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Development of Spheroid-FPOP: An In-Cell Protein Footprinting Method for 3D Tumor Spheroids

Journal of the American Society for Mass Spectrometry
2023-03-01 | Journal article
Contributors: Raquel L. Shortt; Yijia Wang; Amanda B. Hummon; Lisa M. Jones
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Advances in stable isotope labeling: dynamic labeling for spatial and temporal proteomic analysis

Molecular Omics
2022 | Journal article
Contributors: Nicole C. Beller; Amanda B. Hummon
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Deep top-down proteomics revealed significant proteoform-level differences between metastatic and nonmetastatic colorectal cancer cells

Science Advances
2022-12-23 | Journal article
Contributors: Elijah N. McCool; Tian Xu; Wenrong Chen; Nicole C. Beller; Scott M. Nolan; Amanda B. Hummon; Xiaowen Liu; Liangliang Sun
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Generation of Proteins with Free N-Terminal Cysteine by Aminopeptidases

Journal of the American Chemical Society
2022-11-30 | Journal article
Contributors: Jordan P. Hempfling; Emily R. Sekera; Amar Sarkar; Amanda B. Hummon; Dehua Pei
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Lipidomic comparison of 2D and 3D colon cancer cell culture models

Journal of Mass Spectrometry
2022-08 | Journal article
Contributors: Fernando Tobias; Amanda B. Hummon
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Spatial Stable Isotopic Labeling by Amino Acids in Cell Culture: Pulse-Chase Labeling of Three-Dimensional Multicellular Spheroids for Global Proteome Analysis

Analytical Chemistry
2021-12-07 | Journal article
Contributors: Nicole C. Beller; Jessica K. Lukowski; Katelyn R. Ludwig; Amanda B. Hummon
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MS imaging of multicellular tumor spheroids and organoids as an emerging tool for personalized medicine and drug discovery

Journal of Biological Chemistry
2021-10 | Journal article
Contributors: Yijia Wang; Amanda B. Hummon
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Electroblotting through Enzymatic Membranes to Enhance Molecular Tissue Imaging

Journal of the American Society for Mass Spectrometry
2021-07-07 | Journal article
Contributors: William T. Andrews; Adrianna N. Bickner; Fernando Tobias; Kendall A. Ryan; Merlin L. Bruening; Amanda B. Hummon
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Co‐culturing multicellular tumor models: Modeling the tumor microenvironment and analysis techniques

PROTEOMICS
2021-05 | Journal article
Contributors: Ariana E. Shannon; Claire E. Boos; Amanda B. Hummon
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Mass spectrometric investigations of caloric restriction mimetics

PROTEOMICS
2021-05 | Journal article
Contributors: Michael J. Bibyk; Melanie J. Campbell; Amanda B. Hummon
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Electroblotting through a tryptic membrane for LC-MS/MS analysis of proteins separated in electrophoretic gels

The Analyst
2020 | Journal article
Contributors: A. N. Bickner; M. M. Champion; A. B. Hummon; M. L. Bruening
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Cyclic Peptidyl Inhibitors against CAL/CFTR Interaction for Treatment of Cystic Fibrosis

Journal of Medicinal Chemistry
2020-12-24 | Journal article
Contributors: Patrick G. Dougherty; Jack H. Wellmerling; Amritendu Koley; Jessica K. Lukowski; Amanda B. Hummon; Estelle Cormet-Boyaka; Dehua Pei
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A Peptidyl Inhibitor that Blocks Calcineurin–NFAT Interaction and Prevents Acute Lung Injury

Journal of Medicinal Chemistry
2020-11-12 | Journal article
Contributors: Patrick G. Dougherty; Manjula Karpurapu; Amritendu Koley; Jessica K. Lukowski; Ziqing Qian; Teja Srinivas Nirujogi; Luiza Rusu; Sangwoon Chung; Amanda B. Hummon; Hao W. Li et al.
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Considerations for MALDI-Based Quantitative Mass Spectrometry Imaging Studies

Journal of Proteome Research
2020-09-04 | Journal article
Contributors: Fernando Tobias; Amanda B. Hummon
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How to Apply Supervised Machine Learning Tools to MS Imaging Files: Case Study with Cancer Spheroids Undergoing Treatment with the Monoclonal Antibody Cetuximab

Journal of the American Society for Mass Spectrometry
2020-07-01 | Journal article
Contributors: David Hua; Xin Liu; Eden P. Go; Yijia Wang; Amanda B. Hummon; Heather Desaire
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Developing a Drug Screening Platform: MALDI-Mass Spectrometry Imaging of Paper-Based Cultures

Analytical Chemistry
2019-12-17 | Journal article
Contributors: Fernando Tobias; Julie C. McIntosh; Gabriel J. LaBonia; Matthew W. Boyce; Matthew R. Lockett; Amanda B. Hummon
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Capillary Zone Electrophoresis–Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line

Analytical Chemistry
2019-02-05 | Journal article
Contributors: Daoyang Chen; Katelyn R. Ludwig; Oleg V. Krokhin; Vic Spicer; Zhichang Yang; Xiaojing Shen; Amanda B. Hummon; Liangliang Sun
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Magnetic bead-based peptide extraction methodology for tissue imaging

The Analyst
2018 | Journal article
Contributors: William T. Andrews; Susan B. Skube; Amanda B. Hummon
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MALDI-MSI of Immunotherapy: Mapping the EGFR-Targeting Antibody Cetuximab in 3D Colon-Cancer Cell Cultures

Analytical Chemistry
2018-12-18 | Journal article
Contributors: Xin Liu; Jessica K. Lukowski; Colin Flinders; Seungil Kim; Rebecca A. Georgiadis; Shannon M. Mumenthaler; Amanda B. Hummon
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Combined Short-Term Glucose Starvation and Chemotherapy in 3D Colorectal Cancer Cell Culture Decreases 14-3-3 Family Protein Expression and Phenotypic Response to Therapy

Journal of The American Society for Mass Spectrometry
2018-10-17 | Journal article
Contributors: Monica M. Schroll; Katelyn R. Ludwig; Gabriel J. LaBonia; Emily L. Herring; Amanda B. Hummon
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Comparison of In-Solution, FASP, and S-Trap Based Digestion Methods for Bottom-Up Proteomic Studies

Journal of Proteome Research
2018-07-06 | Journal article
Contributors: Katelyn R. Ludwig; Monica M. Schroll; Amanda B. Hummon
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MALDI Mass Spectrometry Imaging for Evaluation of Therapeutics in Colorectal Tumor Organoids

Journal of The American Society for Mass Spectrometry
2018-03-05 | Journal article
Contributors: Xin Liu; Colin Flinders; Shannon M. Mumenthaler; Amanda B. Hummon
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Virtual Issue Highlighting Selected Women Analytical Chemists

Analytical Chemistry
2018-02-06 | Journal article
Contributors: Christy L. Haynes; Amanda Hummon; B. Jill Venton
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iTRAQ Quantitative Proteomic Profiling and MALDI–MSI of Colon Cancer Spheroids Treated with Combination Chemotherapies in a 3D Printed Fluidic Device

Analytical Chemistry
2018-01-16 | Journal article
Contributors: Gabriel J. LaBonia; Katelyn R. Ludwig; C. Bruce Mousseau; Amanda B. Hummon
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Mass spectrometry for the discovery of biomarkers of sepsis

Molecular BioSystems
2017 | Journal article
Contributors: Katelyn R. Ludwig; Amanda B. Hummon
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Analyzing Liposomal Drug Delivery Systems in Three-Dimensional Cell Culture Models Using MALDI Imaging Mass Spectrometry

Analytical Chemistry
2017-08-15 | Journal article
Contributors: Jessica K. Lukowski; Eric M. Weaver; Amanda B. Hummon
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Glucose Restriction Combined with Autophagy Inhibition and Chemotherapy in HCT 116 Spheroids Decreases Cell Clonogenicity and Viability Regulated by Tumor Suppressor Genes

Journal of Proteome Research
2017-08-04 | Journal article
Contributors: Monica M. Schroll; Gabriel J. LaBonia; Katelyn R. Ludwig; Amanda B. Hummon
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Multicellular Tumor Spheroids Combined with Mass Spectrometric Histone Analysis To Evaluate Epigenetic Drugs

Analytical Chemistry
2017-03-07 | Journal article
Contributors: Peter E. Feist; Simone Sidoli; Xin Liu; Monica M. Schroll; Sharif Rahmy; Rina Fujiwara; Benjamin A. Garcia; Amanda B. Hummon
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Nutrient restriction of glucose or serum results in similar proteomic expression changes in 3D colon cancer cell cultures

Nutrition Research
2016-10 | Journal article
Contributors: Monica M. Schroll; Xin Liu; Sarah K. Herzog; Susan B. Skube; Amanda B. Hummon
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Peer review (78 reviews for 6 publications/grants)

Review activity for ACS central science. (1)
Review activity for ACS chemical neuroscience. (1)
Review activity for Analytical chemistry. (48)
Review activity for Journal of proteome research. (17)
Review activity for Journal of the American Society for Mass Spectrometry. (10)
Review activity for Nature protocols (1)