Maria Babak (0000-0002-2009-7837)

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Dr Masha Babak (in publications - Maria V. Babak) has obtained her BSc/MSc with honours at the Higher Chemical College of Russian Academy of Sciences in Moscow, Russian Federation in 2010. During her undergraduate studies (2005-2010), she was working at the Laboratory of Transition Metal Pi-complexes under the supervision of Prof. Dmitry S. Perekalin investigating photochemical arene exchange reactions in organometallic complexes. From 2007 to 2009 she was also working as a visiting researcher at the laboratory "Miniaturization for Synthesis, Analytics and Proteomics (MSAP)" in Lille, France, under the supervision of Prof. Christian Rolando, where she was developing novel ruthenium fluorescent dyes for in gel protein staining.

In 2010 she has joined the laboratory of Prof. Bernhard K. Keppler at the University of Vienna to pursue her Ph.D. in chemistry under the supervision of Prof. Christian G. Hartinger, looking into the functionalization of metal-based drugs in the quest for new chemotherapeutics and studies of their mode of action. Subsequently, in 2014 she joined the laboratory of Prof. Wee Han Ang at the National University of Singapore to investigate the mechanism of action of metal-based drugs at the cellular level.

Building on her deep interest in cancer and drug development, Dr Masha has completed the postgraduate High-Impact Cancer Research program at Harvard Medical School and started her independent career at City University of Hong Kong in 2020. Her laboratory is working on the drug discovery and translational development of metal-based drugs for aggressive and resistant cancers.

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City University of Hong Kong: HK, HK

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Maria Babak

https://orcid.org/0000-0002-2009-7837

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Employment (3)

City University of Hong Kong: HK, HK

City University of Hong Kong: Hong Kong, HK

National University of Singapore: Singapore, SG

Education and qualifications (2)

University of Vienna: Vienna, AT

Dmitry Mendeleev University of Chemical Technology of Russia: Moscow, RU

Professional activities (1)

Stronghold Diagnosting Laboratory: Singapore, SG

Works (50 of 74)

Leveraging Immunogenic Cell Death to Enhance the Immune Response against Malignant Pleural Mesothelioma Tumors

Exploring the Anticancer Potential of NO-Donor Oxadiazole Assemblies Against Malignant Pleural Mesothelioma

Silver N‐Heterocyclic Biscarbene Complexes: Potent Inhibitors of Thioredoxin Reductase with Anticancer Activity in Vitro and in Vivo

Bidentate Lewis Base Ligand-Mediated Surface Stabilization and Modulation of the Electronic Structure of CsPbBr3 Perovskite Nanocrystals

A manifesto on improving cancer care in conflict-impacted populations

Dinuclear gold(I) complexes with pyrimidine- and m-carborane-based bisphosphine ligands

Synergism of primary and secondary interactions in a crystalline hydrogen peroxide complex with tin

First Global Summit on War and Cancer

Ruthenium Arene Schiff-Base Complexes And Uses Thereof

A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execution of colorectal cancer cells upon drug-induced activation of mutant KRAS

Genomics-driven derivatization of the bioactive fungal sesterterpenoid variecolin

Gold(i) complexes with redox active BIAN and MIAN ligands

The humanitarian crisis in Nagorno-Karabakh

Synthesis, characterization and antiproliferative activity of platinum(II) complexes with 3-(2-pyridyl)-N1,2-methyl-1,2,4-triazoles

Effects of Bis(imino)acenaphthene (Bian)-Derived Ligands on the Cytotoxicity, DNA Interactions, and Redox Activity of Palladium(II) Bipyridine Complexes

Toward “E‐Ring‐Free” Lamellarin Analogues: Synthesis and Preliminary Biological Evaluation

Organoantimony Dihydroperoxides: Synthesis, Crystal Structures, and Hydrogen Bonding Networks

Coordination of Ru(II)-Arene Fragments to Dipyridophenazine Ligands Leads to the Modulation of Their In Vitro and In Vivo Anticancer Activity

Metal-Based Anticancer Complexes and p53: How Much Do We Know?

Modeling glioblastoma complexity with organoids for personalized treatments

Targeting emerging cancer hallmarks by transition metal complexes

Deletion of Annexin A1 in Mice Upregulates the Expression of Its Receptor, Fpr2/3, and Reactivity to the AnxA1 Mimetic Peptide in Platelets

Targeting emerging cancer hallmarks by transition metal complexes

Synthesis, structural characterization and anticancer properties of p-cymene Ru(II) complexes with 2-(N-methyl-1H-1,2,4-triazol-3-yl)pyridines

Organometallic Chemistry of Anticancer Ruthenium and Osmium Complexes

Elucidation of Structure–Activity Relationships in Indolobenzazepine-Derived Ligands and Their Copper(II) Complexes: the Role of Key Structural Components and Insight into the Mechanism of Action

Biological Properties of Transition Metal Complexes with Metformin and Its Analogues

Heteroleptic Pd(II) and Pt(II) Complexes with Redox-Active Ligands

Inhibition of Microtubule Dynamics in Cancer Cells by Indole-Modified Latonduine Derivatives and Their Metal Complexes

Modulation of intracellular copper levels as the mechanism of action of anticancer copper complexes

Coumarin-Based Triapine Derivatives and Their Copper(II) Complexes: Synthesis, Cytotoxicity and mR2 RNR Inhibition Activity

Interfering with Metabolic Profile of Triple‐Negative Breast Cancers Using Rationally Designed Metformin Prodrugs

Interfering with Metabolic Profile of Triple‐Negative Breast Cancers Using Rationally Designed Metformin Prodrugs

PIPAC-OX

Highly cytotoxic gold(i)-phosphane dithiocarbamate complexes trigger an ER stress-dependent immune response in ovarian cancer cells

Heterogeneity and vascular permeability of breast cancer brain metastases

Frontispiece: PlatinER: A Highly Potent Anticancer Platinum(II) Complex that Induces Endoplasmic Reticulum Stress Driven Immunogenic Cell Death

Frontispiz: PlatinER: A Highly Potent Anticancer Platinum(II) Complex that Induces Endoplasmic Reticulum Stress Driven Immunogenic Cell Death

PlatinER: A Highly Potent Anticancer Platinum(II) Complex that Induces Endoplasmic Reticulum Stress Driven Immunogenic Cell Death

PlatinER: A Highly Potent Anticancer Platinum(II) Complex that Induces Endoplasmic Reticulum Stress Driven Immunogenic Cell Death

Triapine Derivatives Act as Copper Delivery Vehicles to Induce Deadly Metal Overload in Cancer Cells

Heteroleptic Ruthenium(II) Complexes with Bathophenanthroline and Bathophenanthroline Disulfonate Disodium Salt as Fluorescent Dyes for In-Gel Protein Staining

Design, Synthesis and Evaluation of New Indolylpyrimidylpiperazines for Gastrointestinal Cancer Therapy

Synthesis and evaluation of biological activity of homodrimane sesquiterpenoids bearing hydrazinecarbothioamide or 1,2,4-triazole unit

Dual‐Targeting Dual‐Action Platinum(IV) Platform for Enhanced Anticancer Activity and Reduced Nephrotoxicity

Dual‐Targeting Dual‐Action Platinum(IV) Platform for Enhanced Anticancer Activity and Reduced Nephrotoxicity

Redox-Active Organoruthenium(II)– and Organoosmium(II)–Copper(II) Complexes, with an Amidrazone–Morpholine Hybrid and [CuICl2]− as Counteranion and Their Antiproliferative Activity

New Water-Soluble Copper(II) Complexes with Morpholine–Thiosemicarbazone Hybrids: Insights into the Anticancer and Antibacterial Mode of Action

Designed Precursor for the Controlled Synthesis of Highly Active Atomic and Sub-nanometric Platinum Catalysts on Mesoporous Silica

Induction of the Endoplasmic Reticulum Stress Pathway by Highly Cytotoxic Organoruthenium Schiff-Base Complexes

Peer review (29 reviews for 8 publications/grants)