Personal information

Activities

Employment (2)

Boston Children's Hospital: Boston, US

2024-08-01 to present | Assistant Professor (Pediatrics)
Employment
Source: Self-asserted source
Charles LeDuc

Columbia University: New York, NY, US

2020-01-01 to 2024-07-31 | Assistant Professor (Pediatrics)
Employment
Source: Self-asserted source
Charles LeDuc

Education and qualifications (2)

Columbia University: New York, NY, US

1990 to 1995 | PhD (Chemical Engineering)
Education
Source: Self-asserted source
Charles LeDuc

Cornell University: Ithaca, NY, US

1987 to 1990-05 | BS (Chemical Engineering)
Education
Source: Self-asserted source
Charles LeDuc

Works (50 of 78)

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Page 1 of 2

The association of higher offspring early‐childhood weight gain with prepregnancy metabolic and bariatric surgery

Obesity
2024-11 | Journal article
Contributors: Maya‐Jean Hilaire; Annelise Babcock; Glenn White; Cynthia F. Masson; Rany M. Salem; Uma M. Reddy; Dympna Gallagher; Charles A. LeDuc; Vidhu V. Thaker
Source: check_circle
Crossref

Neurodevelopmental Programming of Adiposity: Contributions to Obesity Risk

Endocrine Reviews
2024-03-04 | Journal article
Contributors: Alicja A Skowronski; Rudolph L Leibel; Charles A LeDuc
Source: check_circle
Crossref

Rare predicted loss of function alleles in Bassoon (BSN) are associated with obesity

npj Genomic Medicine
2023-10-21 | Journal article
Contributors: Na Zhu; Charles A. LeDuc; Ilene Fennoy; Blandine Laferrère; Claudia A. Doege; Yufeng Shen; Wendy K. Chung; Rudolph L. Leibel
Source: check_circle
Crossref

Biallelic Loss-of-Function Variants in BICD1 Are Associated with Peripheral Neuropathy and Hearing Loss

International Journal of Molecular Sciences
2023-05-17 | Journal article
Contributors: Yoel Hirsch; Wendy K. Chung; Sergey Novoselov; Louis H. Weimer; Alexander Rossor; Charles A. LeDuc; Amanda J. McPartland; Ernesto Cabrera; Josef Ekstein; Sholem Scher et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Predicted loss of function alleles in Bassoon (BSN) are associated with obesity

2023-02-23 | Preprint
Contributors: Na Zhu; Charles A. LeDuc; Ilene Fennoy; Blandine Laferrère; Claudia A. Doege; Yufeng Shen; Wendy K. Chung; Rudolph L. Leibel
Source: check_circle
Crossref

The Role of Leptin in the Development of Energy Homeostatic Systems and the Maintenance of Body Weight.

Frontiers in physiology
2021-12-10 | Journal article
Source: Self-asserted source
Charles LeDuc

Bi-allelic PAGR1 variants are associated with microcephaly and a severe neurodevelopmental disorder: Genetic evidence from two families.

American journal of medical genetics. Part A
2021-09-29 | Journal article
Source: Self-asserted source
Charles LeDuc

The postnatal leptin surge in mice is variable in both time and intensity and reflects nutritional status.

International journal of obesity (2005)
2021-09-02 | Journal article
Source: Self-asserted source
Charles LeDuc
grade
Preferred source (of 2)‎

Gene expression atlas of energy balance brain regions.

JCI insight
2021-08-23 | Journal article
Source: Self-asserted source
Charles LeDuc
grade
Preferred source (of 2)‎

Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension.

Cell metabolism
2021-05-04 | Journal article
Source: Self-asserted source
Charles LeDuc

Bardet-Biedl syndrome proteins regulate intracellular signaling and neuronal function in patient-specific iPSC-derived neurons

Journal of Clinical Investigation
2021-04-15 | Journal article
Contributors: Liheng Wang; Yang Liu; George Stratigopoulos; Sunil Panigrahi; Lina Sui; Yiying Zhang; Charles A. Leduc; Hannah J. Glover; Maria Caterina De Rosa; Lisa C. Burnett et al.
Source: check_circle
Crossref

Frequency and characterization of mutations in genes in a large cohort of patients referred to MODY registry.

Journal of pediatric endocrinology & metabolism : JPEM
2021-04-13 | Journal article
Source: Self-asserted source
Charles LeDuc

Weight-loss response to naltrexone/bupropion is modulated by the Taq1A genetic variant near DRD2 (rs1800497): A pilot study.

Diabetes, obesity & metabolism
2021-01-08 | Journal article
Source: Self-asserted source
Charles LeDuc

Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity.

Diabetes
2020-09-11 | Journal article
Source: Self-asserted source
Charles LeDuc

Physiological consequences of transient hyperleptinemia during discrete developmental periods on body weight in mice

Science Translational Medicine
2020-01 | Journal article
Contributors: Alicja A. Skowronski; Charles A. LeDuc; Kylie S. Foo; Yossef Goffer; Lisa C. Burnett; Dieter Egli; Rudolph L. Leibel
Source: check_circle
Crossref

Association Between Nitrate-Reducing Oral Bacteria and Cardiometabolic Outcomes: Results From ORIGINS.

Journal of the American Heart Association
2019-11-26 | Journal article
Source: Self-asserted source
Charles LeDuc

Subgingival Microbiota and Longitudinal Glucose Change: The Oral Infections, Glucose Intolerance and Insulin Resistance Study (ORIGINS).

Journal of dental research
2019-10-17 | Journal article
Source: Self-asserted source
Charles LeDuc

Auto-Regulation of Leptin Neurobiology.

Cell metabolism
2019-10-01 | Journal article
Source: Self-asserted source
Charles LeDuc

Homozygous noncanonical splice variant in LSM1 in two siblings with multiple congenital anomalies and global developmental delay

Molecular Case Studies
2019-06 | Journal article
Contributors: Volkan Okur; Charles A. LeDuc; Edwin Guzman; Zaheer M. Valivullah; Kwame Anyane-Yeboa; Wendy K. Chung
Source: check_circle
Crossref

Transgenic substitution with Greater Amberjack Seriola dumerili fish insulin 2 in NOD mice reduces beta cell immunogenicity.

Scientific reports
2019-03-21 | Journal article
Source: Self-asserted source
Charles LeDuc
grade
Preferred source (of 2)‎

Recessive Rare Variants in Deoxyhypusine Synthase, an Enzyme Involved in the Synthesis of Hypusine, Are Associated with a Neurodevelopmental Disorder.

American journal of human genetics
2019-01-17 | Journal article
Source: Self-asserted source
Charles LeDuc

Bi-allelic Mutations in Phe-tRNA Synthetase Associated with a Multi-system Pulmonary Disease Support Non-translational Function.

American journal of human genetics
2018-07-01 | Journal article
Source: Self-asserted source
Charles LeDuc

FTO mediates cell-autonomous effects on adipogenesis and adipocyte lipid content by regulating gene expression via 6mA DNA modifications.

Journal of lipid research
2018-06-22 | Journal article
Source: Self-asserted source
Charles LeDuc
grade
Preferred source (of 2)‎

Evidence for a Non-leptin System that Defends against Weight Gain in Overfeeding.

Cell metabolism
2018-06-21 | Journal article
Source: Self-asserted source
Charles LeDuc

DMSO increases efficiency of genome editing at two non-coding loci.

PloS one
2018-06-04 | Journal article
Source: Self-asserted source
Charles LeDuc

ILDR2 has a negligible role in hepatic steatosis.

PloS one
2018-05-30 | Journal article
Source: Self-asserted source
Charles LeDuc

The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2018-02-21 | Journal article
Source: Self-asserted source
Charles LeDuc

Energy homeostasis in leptin deficient Lepob/ob mice.

PloS one
2017-12-20 | Journal article
Source: Self-asserted source
Charles LeDuc
grade
Preferred source (of 2)‎

Loss of the imprinted, non-coding Snord116 gene cluster in the interval deleted in the Prader Willi syndrome results in murine neuronal and endocrine pancreatic developmental phenotypes.

Human molecular genetics
2017-12-01 | Journal article
Source: Self-asserted source
Charles LeDuc

The subgingival microbiome, systemic inflammation and insulin resistance: The Oral Infections, Glucose Intolerance and Insulin Resistance Study.

Journal of clinical periodontology
2017-01-27 | Journal article
Source: Self-asserted source
Charles LeDuc

Weight Perturbation Alters Leptin Signal Transduction in a Region-Specific Manner throughout the Brain.

PloS one
2017-01-20 | Journal article
Source: Self-asserted source
Charles LeDuc

iPSC-derived β cells model diabetes due to glucokinase deficiency.

The Journal of clinical investigation
2017-01-17 | Journal article
Source: Self-asserted source
Charles LeDuc

Determination of the half-life of circulating leptin in the mouse.

International journal of obesity (2005)
2016-12-27 | Journal article
Source: Self-asserted source
Charles LeDuc

Deficiency in prohormone convertase PC1 impairs prohormone processing in Prader-Willi syndrome.

The Journal of clinical investigation
2016-12-12 | Journal article
Source: Self-asserted source
Charles LeDuc

Induced pluripotent stem cells (iPSC) created from skin fibroblasts of patients with Prader-Willi syndrome (PWS) retain the molecular signature of PWS.

Stem cell research
2016-08-16 | Journal article
Source: Self-asserted source
Charles LeDuc

ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression.

Biochemical and biophysical research communications
2016-06-25 | Journal article
Source: Self-asserted source
Charles LeDuc

Hypomorphism of Fto and Rpgrip1l causes obesity in mice.

The Journal of clinical investigation
2016-04-11 | Journal article
Source: Self-asserted source
Charles LeDuc

Monoallelic and Biallelic Variants in EMC1 Identified in Individuals with Global Developmental Delay, Hypotonia, Scoliosis, and Cerebellar Atrophy.

American journal of human genetics
2016-03-01 | Journal article
Source: Self-asserted source
Charles LeDuc

Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.

Nature communications
2016-02-01 | Journal article
Source: Self-asserted source
Charles LeDuc

New Insights into the Genetics of Fetal Megacystis: ACTG2 Mutations, Encoding γ-2 Smooth Muscle Actin in Megacystis Microcolon Intestinal Hypoperistalsis Syndrome (Berdon Syndrome).

Fetal diagnosis and therapy
2015-05-13 | Journal article
Source: Self-asserted source
Charles LeDuc

Differentiation of hypothalamic-like neurons from human pluripotent stem cells.

The Journal of clinical investigation
2015-01-02 | Journal article
Source: Self-asserted source
Charles LeDuc

Comparable frequencies of coding mutations and loss of imprinting in human pluripotent cells derived by nuclear transfer and defined factors.

Cell stem cell
2014-11-06 | Journal article
Source: Self-asserted source
Charles LeDuc

Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.

Cell metabolism
2014-05-01 | Journal article
Source: Self-asserted source
Charles LeDuc

Effects of chronic leptin infusion on subsequent body weight and composition in mice: Can body weight set point be reset?

Molecular metabolism
2014-03-05 | Journal article
Source: Self-asserted source
Charles LeDuc

Effects of a novel MC4R agonist on maintenance of reduced body weight in diet-induced obese mice.

Obesity (Silver Spring, Md.)
2014-01-09 | Journal article
Source: Self-asserted source
Charles LeDuc

A differential dielectric affinity glucose sensor.

Lab on a chip
2013-11-13 | Journal article
Source: Self-asserted source
Charles LeDuc

β-cell dysfunction due to increased ER stress in a stem cell model of Wolfram syndrome.

Diabetes
2013-11-13 | Journal article
Source: Self-asserted source
Charles LeDuc

Novel association of early onset hepatocellular carcinoma with transaldolase deficiency.

JIMD reports
2013-10-06 | Journal article
Source: Self-asserted source
Charles LeDuc

Genetic loss of SH2B3 in acute lymphoblastic leukemia.

Blood
2013-08-01 | Journal article
Source: Self-asserted source
Charles LeDuc

ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis.

PloS one
2013-06-24 | Journal article
Source: Self-asserted source
Charles LeDuc
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Peer review (2 reviews for 2 publications/grants)

Review activity for Molecular psychiatry. (1)
Review activity for NPJ Parkinson's disease. (1)