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Nucleic Acid Structure Research Group

Other IDs

ResearcherID: M-2262-2019

Keywords

LONG NON-CODING RNA (LNCRNA), NON-CODING RNA, PROTEIN-NUCLEIC ACIDS INTERACTIONS, RIBOSWITCHES,

Activities

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Employment (3)

Sun Yat-Sen University: Guangzhou, CN

2019-09-04 to present | Principle Investigator (RNA Biomedical Institute, Sun Yat-Sen Memorial Hospital)
Employment
Source: Self-asserted source
Lin Huang

University of Dundee: Dundee, GB

2015-01-01 to 2019-08-31 | Senior Research Associate (CR-UK Nucleic Acid Structure Research Group)
Employment
Source: Self-asserted source
Lin Huang

University of Dundee: Dundee, GB

2011-01-12 to 2014-12-31 | Postdoctoral Research Assistant (CR-UK Nucleic Acid Structure Research Group)
Employment
Source: Self-asserted source
Lin Huang

Education and qualifications (1)

Wuhan University : Wuhan, Hubei, CN

2005-09-01 to 2010-12-30 | PhD (School of Life Sciences)
Education
Source: Self-asserted source
Lin Huang

Works (42)

RNA catalysis moving towards metabolic reactions: progress with ribozyme catalyzed alkyl transfer

Trends in Biochemical Sciences
2025-03 | Journal article
DOI: 10.1016/j.tibs.2025.01.011
Contributors: David M.J. Lilley; Lin Huang
Source: check_circle
Crossref

Structural basis for tRNA mimicry by mascRNA and menRNA

Cell Discovery
2025-01-02 | Journal article
DOI: 10.1038/s41421-024-00761-1
Contributors: Yuanlin He; Jie Deng; Xiaowei Lin; Zhizhong Lu; Liangliang Wang; Liang Xu; Yin Zhang; Jia Wang; Lin Huang
Source: check_circle
Crossref

A general strategy for engineering GU base pairs to facilitate RNA crystallization

Nucleic Acids Research
2024-12-26 | Journal article
DOI: 10.1093/nar/gkae1218
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Ren Yangyi; Xiaowei Lin; Wenjian Liao; Xuemei Peng; Jie Deng; Zhe Zhang; Jian Zhan; Yaoqi Zhou; Eric Westhof; David Lilley et al.
Source: Self-asserted source
Lin Huang

RNA-Puzzles Round V: blind predictions of 23 RNA structures.

Nature methods
2024-12-02 | Journal article | Author
DOI: 10.1038/s41592-024-02543-9
PMID: 39623050
Contributors: Bu F; Yagoub Adam; Adamiak RW; Maciej Antczak; de Aquino BRH; Badepally NG; Robert Batey; Eugene F. Baulin; Boinski P; Boniecki MJ et al.
Source: Self-asserted source
Lin Huang

The Role of General Acid Catalysis in the Mechanism of an Alkyl Transferase Ribozyme

ACS Catalysis
2024-10-18 | Journal article
DOI: 10.1021/acscatal.4c04571
Contributors: Timothy J. Wilson; Erika McCarthy; Şölen Ekesan; Timothy J. Giese; Nan-Sheng Li; Lin Huang; Joseph A. Piccirilli; Darrin M. York; David M. J. Lilley
Source: check_circle
Crossref

Ribocentre-switch: a database of riboswitches

Nucleic Acids Research
2024-01-05 | Journal article | Author
DOI: 10.1093/nar/gkad891
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Fan Bu; Xiaowei Lin; Wenjian Liao; Zhizhong Lu; Yuanlin He; Yuhang Luo; Xuemei Peng; Mengxiao Li; Yuanyin Huang; Xiaoxue Chen et al.
Source: Self-asserted source
Lin Huang

Effective Antitumor Immunity Can Be Triggered by Targeting VISTA in Combination with a TLR3-Specific Adjuvant

Cancer Immunology Research
2023-12-01 | Journal article
DOI: 10.1158/2326-6066.CIR-23-0117
Contributors: Bo Wang; Ziwei Ou; Wenlong Zhong; Lin Huang; Wenjian Liao; Yiyu Sheng; Zhixing Guo; Junyu Chen; Wenjuan Yang; Ke Chen et al.
Source: check_circle
Crossref

RNA structure determination: From 2D to 3D

Fundamental Research
2023-09 | Journal article
DOI: 10.1016/j.fmre.2023.06.001
Contributors: Jie Deng; Xianyang Fang; Lin Huang; Shanshan Li; Lilei Xu; Keqiong Ye; Jinsong Zhang; Kaiming Zhang; Qiangfeng Cliff Zhang
Source: check_circle
Crossref

Structure and ion-dependent folding of k-junctions

RNA
2023-09 | Journal article
DOI: 10.1261/rna.079678.123
Contributors: Mengxiao Li; Jie Deng; Xuemei Peng; Jia Wang; Timothy J. Wilson; Lin Huang; David M.J. Lilley
Source: check_circle
Crossref

Linking folding dynamics and function of SAM/SAH riboswitches at the single molecule level

Nucleic Acids Research
2023-09-22 | Journal article
DOI: 10.1093/nar/gkad633
Contributors: Ting-Wei Liao; Lin Huang; Timothy J Wilson; Laura R Ganser; David M J Lilley; Taekjip Ha
Source: check_circle
Crossref

NAT10 Drives Cisplatin Chemoresistance by Enhancing ac4C-Associated DNA Repair in Bladder Cancer

Cancer Research
2023-05-15 | Journal article
DOI: 10.1158/0008-5472.CAN-22-2233
Contributors: Ruihui Xie; Liang Cheng; Ming Huang; Lin Huang; Ziyue Chen; Qiang Zhang; Hong Li; Junlin Lu; Hongjin Wang; Qianghua Zhou et al.
Source: check_circle
Crossref

Crystal structures of the NAD+-II riboswitch reveal two distinct ligand-binding pockets

Nucleic Acids Research
2023-04-11 | Journal article
DOI: 10.1093/nar/gkad102
Contributors: Xuemei Peng; Wenjian Liao; Xiaowei Lin; David M J Lilley; Lin Huang
Source: check_circle
Crossref

Ribocentre: a database of ribozymes

Nucleic Acids Research
2022-09-30 | Journal article
DOI: 10.1093/nar/gkac840
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Lin Huang
Source: Self-asserted source
Lin Huang

Structure and mechanism of a methyltransferase ribozyme

Nature Chemical Biology
2022-05 | Journal article
DOI: 10.1038/s41589-022-00982-z
Contributors: Jie Deng; Timothy J. Wilson; Jia Wang; Xuemei Peng; Mengxiao Li; Xiaowei Lin; Wenjian Liao; David M. J. Lilley; Lin Huang
Source: check_circle
Crossref

Structure and folding of four putative kink turns identified in structured RNA species in a test of structural prediction rules.

Nucleic acids research
2021-06-01 | Journal article
DOI: 10.1093/nar/gkab333
PMID: 33978763
PMC: PMC8191799
Source: Self-asserted source
Lin Huang

Crystal structure and ligand-induced folding of the SAM/SAH riboswitch.

Nucleic acids research
2020-07-01 | Journal article
DOI: 10.1093/nar/gkaa493
PMID: 32520325
PMC: PMC7367207
Source: Self-asserted source
Lin Huang
grade
Preferred source (of 2)‎

RNA-Puzzles Round IV: 3D structure predictions of four ribozymes and two aptamers.

RNA (New York, N.Y.)
2020-05-05 | Journal article
DOI: 10.1261/rna.075341.120
PMID: 32371455
PMC: PMC7373991
Source: Self-asserted source
Lin Huang
grade
Preferred source (of 2)‎

Functional organization of box C/D RNA-guided RNA methyltransferase.

Nucleic acids research
2020-05-01 | Journal article
DOI: 10.1093/nar/gkaa247
PMID: 32297938
PMC: PMC7229835
Source: Self-asserted source
Lin Huang
grade
Preferred source (of 2)‎

Structure and ligand binding of the ADP-binding domain of the NAD+ riboswitch.

RNA (New York, N.Y.)
2020-04-15 | Journal article
DOI: 10.1261/rna.074898.120
PMID: 32295864
PMC: PMC7297122
Source: Self-asserted source
Lin Huang
grade
Preferred source (of 2)‎

Structure-guided design of a high-affinity ligand for a riboswitch

2019 | Other
DOI: 10.1261/rna.069567.118
SOURCE-WORK-ID: BASE:f69d168373e4b0c5de67d07d9b68be9071f482b72344b53581186bc273e34a6c
Contributors: Huang, Lin; Wang, Jia; Wilson, Timothy J.; Lilley, David M.J.
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine
grade
Preferred source (of 2)‎

The Interaction Between L7Ae Family of Proteins and RNA Kink Turns

BIOPHOTONICS
2019 | Journal article
DOI: 10.1007/978-1-4939-9726-8_2
WOSUID: WOS:000544117600002
Contributors: Huang, Lin; Lilley, David M. J.
Source: check_circle
Web of Science Researcher Profile Sync

The role of RNA structure in translational regulation by L7Ae protein in archaea

2019 | Other
DOI: 10.1261/rna.068510.118
SOURCE-WORK-ID: BASE:5a78205a5480a34b4a20a561cad8c8992a215629b89245e295f556625f03e5ee
Contributors: Huang, Lin; Ashraf, Saira; Lilley, David M.J.
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine
grade
Preferred source (of 2)‎

G-quadruplex structures trigger RNA phase separation.

Nucleic acids research
2019-12-01 | Journal article
DOI: 10.1093/nar/gkz978
PMID: 31722410
PMC: PMC7145655
Source: Self-asserted source
Lin Huang
grade
Preferred source (of 3)‎

Effect of methylation of adenine N6 on kink turn structure depends on location

RNA Biology
2019-06-24 | Journal article
DOI: 10.1080/15476286.2019.1630797
Part of ISSN: 1547-6286
Part of ISSN: 1555-8584
Source: Self-asserted source
Lin Huang
grade
Preferred source (of 3)‎

Structure and ligand binding of the glutamine-II riboswitch

Nucleic Acids Research
2019-06-19 | Journal article
DOI: 10.1093/nar/gkz539
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Source: Self-asserted source
Lin Huang
grade
Preferred source (of 3)‎

Structure and ligand binding of the SAM-V riboswitch

2018 | Other
DOI: 10.1093/nar/gky520
SOURCE-WORK-ID: BASE:0a718ba298d84b2c964c6dde54135137cb9ce370bc10c38c8eac1554bb78920c
Contributors: Huang, Lin; Lilley, David M J
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine
grade
Preferred source (of 2)‎

The kink-turn in the structural biology of RNA

Quarterly Reviews of Biophysics
2018 | Journal article
DOI: 10.1017/S0033583518000033
WOSUID: WOS:000455257000001
Source: check_circle
Web of Science Researcher Profile Sync

Control of box C/D snoRNP assembly by N-6-methylation of adenine

EMBO Reports
2017 | Journal article
DOI: 10.15252/EMBR.201743967
WOSUID: WOS:000408824300020
Contributors: Huang, Lin; Ashraf, Saira; Wang, Jia; Lilley, David M. J.
Source: check_circle
Web of Science Researcher Profile Sync

Sequence determinants of the folding properties of box C/D kink-turns in RNA

2017 | Other
DOI: 10.1261/rna.063453.117
SOURCE-WORK-ID: BASE:7833dd5bb732796064bf0d4bf113f8c4b8d2d0f3e0f8deb741560e4254290291
Contributors: Ashraf, Saira; Huang, Lin; Lilley, David M.J.
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine
grade
Preferred source (of 2)‎

Structure of the Guanidine III Riboswitch

2017 | Other
DOI: 10.1016/j.chembiol.2017.08.021
SOURCE-WORK-ID: BASE:75257fa9b672570ff40799e2ec707181a66765995fc91be61233e41afc3b61ab
Contributors: Huang, Lin; Wang, Jia; Wilson, Timothy J.; Lilley, David M.J.
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine
grade
Preferred source (of 2)‎

The Structure of the Guanidine-II Riboswitch

2017 | Journal article
SOURCE-WORK-ID: BASE:394d8c98ac6be39a6d74ba6589ec061e61a302a8baea0f80e79a67f271723174
Contributors: Huang, Lin; Wang, Jia; Lilley, David M. J.
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine

A critical base pair in k-turns determines the conformational class adopted, and correlates with biological function

2016 | Journal article
SOURCE-WORK-ID: BASE:c10fe05d85101c4b171aea802e39d1805b4ccc957548332aed226c6fd82079d1
Contributors: Huang, Lin; Wang, Jia; Lilley, David M J
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine

A quasi-cyclic RNA nano-scale molecular object constructed using kink turns

2016 | Journal article
SOURCE-WORK-ID: BASE:21bdd820ad2f4241edf03524015032c4a56d4b6a0a6788c1d78c568f9633668a
Contributors: Huang, Lin; Lilley, David M. J.
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine

The Kink Turn, a Key Architectural Element in RNA Structure

2016 | Journal article
SOURCE-WORK-ID: BASE:a4fe08b9e8c3970fe9618e111df06e322d29f0b3e2555589746be581b762f42c
Contributors: Huang, Lin; Lilley, David M.J.
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine

The solution structural ensembles of RNA kink-turn motifs and their protein complexes

2016 | Journal article
SOURCE-WORK-ID: BASE:5a339bdfa2ebd2a0677af19a15c9a37ded5a1d0f660654fa830eccdd0845934f
Contributors: Shi, Xuesong; Huang, Lin; Lilley, David M. J.; Harbury, Pehr B.; Herschlag, Daniel
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine

From sequence to nanostructure: a critical base pair in RNA k-turns that confers folding and structural characteristics, and correlates with biological function

Acta Crystallographica Section A: Foundations and Advances
2015 | Journal article
DOI: 10.1107/S2053273315099489
WOSUID: WOS:000480363600052
Contributors: Huang, Lin; Shi, Xuesong; Heirschlag, Daniel; Lilley, David
Source: check_circle
Web of Science Researcher Profile Sync

A critical base pair in k-turns that confers folding characteristics and correlates with biological function

2014 | Journal article
SOURCE-WORK-ID: BASE:8da7005244abd2f50096fa4c399f6b77c7d625dec06e5765ab30904d0b96026b
Contributors: McPhee, Scott A.; Huang, Lin; Lilley, David M. J.
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine

Structure of a rare non-standard sequence k-turn bound by L7Ae protein

2014 | Journal article
SOURCE-WORK-ID: BASE:c44deb593ddd4788266a028b60429d3c929be678d3938b5ba3efc20d5ce33556
Contributors: Huang, Lin; Lilley, David M J
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine

The k-junction motif in RNA structure

2014 | Journal article
SOURCE-WORK-ID: BASE:a46d4b683fbcf1136a8ec923cdc3693043e11a9330415120c3c18f3255f05f79
Contributors: Wang, Jia; Daldrop, Peter; Huang, Lin; Lilley, David M. J.
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine

The combination of U1A protein and a G center dot U pair facilitates RNA-protein crystallization and structure determination

Acta Crystallographica Section A: Foundations and Advances
2013 | Journal article
DOI: 10.1107/S0108767313096773
WOSUID: WOS:000483126500323
Contributors: Huang, Lin; Lilley, David M. J.
Source: check_circle
Web of Science Researcher Profile Sync

The molecular recognition of kink-turn structure by the L7Ae class of proteins

RNA
2013 | Journal article
DOI: 10.1261/RNA.041517.113
WOSUID: WOS:000327445700011
Contributors: Huang, Lin; Lilley, David M. J.
Source: check_circle
Web of Science Researcher Profile Sync

Crystal structure and centromere binding of the plasmid segregation protein ParB from pCXC100

2011 | Other
DOI: 10.1093/nar/gkq915
SOURCE-WORK-ID: BASE:2a9f608048fc73ca40ba1b037d3c659c72d2e6c10b1395556f609a84b3ef5195
Contributors: Huang, Lin; Yin, Ping; Zhu, Xing; Zhang, Yi; Ye, Keqiong
Source: Self-asserted source
Lin Huang via BASE - Bielefeld Academic Search Engine
grade
Preferred source (of 2)‎

Peer review (5 reviews for 3 publications/grants)

Review activity for Biology. (1)
Review activity for Nucleic acids research. (3)
Review activity for Science China. (1)
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