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Works (9)

The Development of an Age-Appropriate Fixed Dose Combination for Tuberculosis Using Physiologically-Based Pharmacokinetic Modeling (PBBM) and Risk Assessment

Pharmaceutics
2024-12-12 | Journal article
DOI: 10.3390/pharmaceutics16121587
Contributors: Xavier J. H. Pepin; Juliana Johansson Soares Medeiros; Livia Deris Prado; Sandra Suarez Sharp
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Understanding the mechanisms of food effect on omaveloxolone pharmacokinetics through physiologically based biopharmaceutics modeling

CPT: Pharmacometrics & Systems Pharmacology
2024-10 | Journal article
DOI: 10.1002/psp4.13221
Contributors: Xavier J. H. Pepin; Scott M. Hynes; Hamim Zahir; Deborah Walker; Lois Q. Semmens; Sandra Suarez‐Sharp
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Parameterization of Physiologically Based Biopharmaceutics Models: Workshop Summary Report

Molecular Pharmaceutics
2024-08-05 | Journal article
DOI: 10.1021/acs.molpharmaceut.4c00526
Contributors: Xavier Pepin; Sumit Arora; Luiza Borges; Mario Cano-Vega; Tessa Carducci; Parnali Chatterjee; Grace Chen; Rodrigo Cristofoletti; André Dallmann; Poonam Delvadia et al.
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Physiologically Based Biopharmaceutics Modeling (PBBM): Best Practices for Drug Product Quality, Regulatory and Industry Perspectives: 2023 Workshop Summary Report

Molecular Pharmaceutics
2024-05-06 | Journal article
DOI: 10.1021/acs.molpharmaceut.4c00202
Contributors: Claire Mackie; Sumit Arora; Paul Seo; Rebecca Moody; Bhagwant Rege; Xavier Pepin; Tycho Heimbach; Christer Tannergren; Amitava Mitra; Sandra Suarez-Sharp et al.
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Effect of Food Composition on the PK of Isoniazid Quantitatively Explained Using Physiologically Based Biopharmaceutics Modeling

The AAPS Journal
2024-04-24 | Journal article
DOI: 10.1208/s12248-024-00923-9
Contributors: Xavier J. H. Pepin; Sandra Suarez-Sharp
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Predicting Surface pH in Unbuffered Conditions for Acids, Bases, and Their Salts – A Review of Modeling Approaches and Their Performance

Molecular Pharmaceutics
2024-02-05 | Journal article
DOI: 10.1021/acs.molpharmaceut.3c00661
Contributors: Tommaso Casalini; James Mann; Xavier Pepin
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Acalabrutinib Maleate Tablets: The Physiologically Based Biopharmaceutics Model behind the Drug Product Dissolution Specification

Molecular Pharmaceutics
2023-04-03 | Journal article
DOI: 10.1021/acs.molpharmaceut.3c00005
Contributors: Xavier Pepin; Vivien McAlpine; Andrea Moir; James Mann
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Mechanistic Models for USP2 Dissolution Apparatus, Including Fluid Hydrodynamics and Sedimentation

Journal of Pharmaceutical Sciences
2022-01 | Journal article
DOI: 10.1016/j.xphs.2021.10.006
Contributors: Xavier Pepin; Matéo Goetschy; Susanna Abrahmsén-Alami
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Understanding Mechanisms of Food Effect and Developing Reliable PBPK Models Using a Middle-out Approach

The AAPS Journal
2021-01-04 | Journal article
DOI: 10.1208/s12248-020-00548-8
Contributors: Xavier J. H. Pepin; James E. Huckle; Ravindra V. Alluri; Sumit Basu; Stephanie Dodd; Neil Parrott; Arian Emami Riedmaier
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Peer review (6 reviews for 2 publications/grants)

Review activity for Molecular pharmaceutics. (4)
Review activity for Pharmaceutical research. (2)
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