Personal information

Biography

I am currently a postdoctoral researcher at the Francis Crick Institute doing research in Leukaemia and Haematopoietic stem cells. I was before at the University of Manchester in the UK. I finished my Ph.D. at Heriot-Watt University in Edinburgh in 2012 and started as a postdoctoral researcher at Chalmers University of Technology in the lab of Systems and Synthetic Biology with Prof Jens Nielsen and then at the ETH Zurich in the Chemical and Biological Systems engineering lab in Switzerland. My research work has been related to systems biology and bioinformatics tools applied to biological systems. My general research interest relies in the analysis of biological systems with the primary goal to understand the interactions between different components and their regulation.

In biological sciences, recent advances in computational tools and an increasing availability of public genomic, proteomic and metabolomic databases have triggered the development of new strategies aimed at a better understanding of complex biological systems. By integrating various metabolic modelling tools it is possible to emulate biological behaviour for the identification of critical points in the regulation of metabolic processes where intervention could make a significant impact providing the foundations for drug discovery, production of valuable bio-chemicals, diagnostic of metabolic disorders, metabolic engineering, novel gene therapies and identification of disease biomarkers. To date, I have worked in the fields of bioinformatics, systems biology and biotechnology. As a bioinformatician I have used computational tools for metabolic network analysis and in silico simulations aiming to the prediction of the metabolic capability of different biological systems. Additionally, I have experience on transcriptomics and proteomics data analysis and I have worked in the development of web user interface of tools for metabolic pathways and omics analysis. My work in the field of systems biology has been related to the modelling of biological systems, studies in metabolic regulation and medical research. In the area of biotechnology, I have developed previous projects related to bio-chemicals, biofuels, microelectrode fabrication, dielectric spectroscopy and fermentations. My experience is not only limited to dry lab techniques and I have experience working with different microorganisms like yeast (Saccharomyces cerevisiae), marine microalgae (Nannochloropsis oculata), bacteria, mammalian and Jurkat cells. My research has always been conducted in a team-based setting in strong collaboration with biologists and computational engineers.

Since I have previously worked as a manager in the business environment, the nature of my research should be both fundamental and application-orientated and integrated with worldwide biotech companies and chemical industries to facilitate the dissemination and exploitation of the results. Projects should be of industrial relevance and transferrable to interested industrial partners and spin-off companies. My longer-term goals are focused on the impact on society by innovation and I am committed to applying my expertise to solve real-world problems.

Activities

Employment (4)

Francis Crick Institute: London, London, GB

2018-08-15 to present | Research associate (Haematopoietic Stem Cells)
Employment
Source: Self-asserted source
Manuel Garcia-Albornoz

University of Manchester: Manchester, Greater Manchester, GB

2016-02-01 to 2018-03-31 | Research associate
Employment
Source: Self-asserted source
Manuel Garcia-Albornoz

Eidgenössische Technische Hochschule Zürich: Zurich, ZH, CH

2014-10-01 to 2016-01-01 | Research associate
Employment
Source: Self-asserted source
Manuel Garcia-Albornoz

Chalmers University of Technology: Gothenburg, SE

2012-10-01 to 2014-10-01 | Research associate
Employment
Source: Self-asserted source
Manuel Garcia-Albornoz

Education and qualifications (1)

Heriot-Watt University: Edinburgh, Edinburgh, GB

2008-10-01 to 2012-10-01 | PhD
Education
Source: Self-asserted source
Manuel Garcia-Albornoz

Works (18)

Loss of TET2 in human hematopoietic stem cells alters the development and function of neutrophils

Cell Stem Cell
2023-06 | Journal article
Part of ISSN: 1934-5909
Contributors: Hector Huerga Encabo; Iker Valle Aramburu; Manuel Garcia-Albornoz; Marion Piganeau; Henry Wood; Anna Song; Alessandra Ferrelli; Aneesh Sharma; Carlos M. Minutti; Marie-Charlotte Domart et al.
Source: Self-asserted source
Manuel Garcia-Albornoz

Single cell analyses identify a highly regenerative and homogenous human CD34+ hematopoietic stem cell population

Nature Communications
2022-04-19 | Journal article
Contributors: Fernando Anjos-Afonso; Florian Buettner; Syed A. Mian; Hefin Rhys; Jimena Perez-Lloret; Manuel Garcia-Albornoz; Namrata Rastogi; Linda Ariza-McNaughton; Dominique Bonnet
Source: check_circle
Crossref

Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies

Nature Communications
2022-02-10 | Journal article
Contributors: Ibrahim E. Elsemman; Angelica Rodriguez Prado; Pranas Grigaitis; Manuel Garcia Albornoz; Victoria Harman; Stephen W. Holman; Johan van Heerden; Frank J. Bruggeman; Mark M. M. Bisschops; Nikolaus Sonnenschein et al.
Source: check_circle
Crossref

Whole-cell modeling in yeast predicts compartment-specific proteome constraints that drive metabolic strategies

2021-06-11 | Other
Contributors: Ibrahim E. Elsemman; Angelica Rodriguez Prado; Pranas Grigaitis; Manuel Garcia Albornoz; Victoria Harman; Stephen W. Holman; Johan van Heerden; Frank J. Bruggeman; Mark M.M. Bisschops; Nikolaus Sonnenschein et al.
Source: check_circle
Crossref

Integrated OMICs unveil the bone-marrow microenvironment in human leukemia

Cell Reports
2021-05 | Journal article
Part of ISSN: 2211-1247
Contributors: Diana Passaro; Manuel Garcia-Albornoz; Giovanni Diana; Probir Chakravarty; Linda Ariza-McNaughton; Antoniana Batsivari; Clara Borràs-Eroles; Ander Abarrategi; Alexander Waclawiczek; Luigi Ombrato et al.
Source: Self-asserted source
Manuel Garcia-Albornoz

Human Erythroid Progenitors Are Directly Infected by SARS-CoV-2: Implications for Emerging Erythropoiesis in Severe COVID-19 Patients

Stem Cell Reports
2021-03 | Journal article
Part of ISSN: 2213-6711
Contributors: Hector Huerga Encabo; William Grey; Manuel Garcia-Albornoz; Henry Wood; Rachel Ulferts; Iker Valle Aramburu; Austin G. Kulasekararaj; Ghulam Mufti; Venizelos Papayannopoulos; Rupert Beale et al.
Source: Self-asserted source
Manuel Garcia-Albornoz

Model Parameterization with Quantitative Proteomics: Case Study with Trehalose Metabolism in Saccharomyces cerevisiae

Processes
2021-01-12 | Journal article
Contributors: Chuan Fu Yap; Manuel Garcia-Albornoz; Andrew F. Jarnuczak; Simon J. Hubbard; Jean-Marc Schwartz
Source: check_circle
Crossref

A proteome-integrated, carbon source dependent genetic regulatory network in Saccharomyces cerevisiae

Molecular Omics
2020 | Journal article
Contributors: M. Garcia-Albornoz; S. W. Holman; T. Antonisse; P. Daran-Lapujade; B. Teusink; R. J. Beynon; S. J. Hubbard
Source: check_circle
Crossref

Activation of the receptor tyrosine kinase RET improves long-term hematopoietic stem cell outgrowth and potency

Blood
2020-11-26 | Journal article | Author
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: William Grey; R. Chauhan; Marion Piganeau; Hector Huerga Encabo; Manuel Garcia-Albornoz; neil mcdonald; Dominique Bonnet
Source: Self-asserted source
Manuel Garcia-Albornoz
grade
Preferred source (of 2)‎

Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia

The Journal of Clinical Investigation
2020-05-04 | Journal article
Source: Self-asserted source
Manuel Garcia-Albornoz

Glycolytic flux in Saccharomyces cerevisiae is dependent on RNA polymerase III and its negative regulator Maf1

Biochemical Journal
2019-04-15 | Journal article
Contributors: Roza Szatkowska; Manuel Garcia-Albornoz; Katarzyna Roszkowska; Stephen W. Holman; Emil Furmanek; Simon J. Hubbard; Robert J. Beynon; Malgorzata Adamczyk
Source: check_circle
Crossref

A quantitative and temporal map of proteostasis during heat shock in Saccharomyces cerevisiae

Molecular Omics
2018 | Journal article
Contributors: Andrew F. Jarnuczak; Manuel Garcia Albornoz; Claire E. Eyers; Christopher M. Grant; Simon J. Hubbard
Source: check_circle
Crossref

Targeting the IL33–NLRP3 axis improves therapy for experimental cerebral malaria

PNAS
2018-06-28 | Journal article
Source: Self-asserted source
Manuel Garcia-Albornoz

Temperature regulates NF-κB dynamics and function through timing of A20 transcription

PNAS
2018-05-14 | Journal article
Source: Self-asserted source
Manuel Garcia-Albornoz

Finding directionality and gene-disease predictions in disease associations.

BMC systems biology
2015 | Journal article
Contributors: Garcia-Albornoz M; Nielsen J
Source: Self-asserted source
Manuel Garcia-Albornoz via Europe PubMed Central

BioMet Toolbox 2.0: genome-wide analysis of metabolism and omics data.

Nucleic acids research
2014-07 | Journal article
Contributors: Garcia-Albornoz M; Thankaswamy-Kosalai S; Nilsson A; Väremo L; Nookaew I; Nielsen J
Source: Self-asserted source
Manuel Garcia-Albornoz via Europe PubMed Central

Application of Genome-Scale Metabolic Models in Metabolic Engineering

Industrial Biotechnology
2013-08 | Journal article
Part of ISSN: 1550-9087
Contributors: Manuel Alberto Garcia-Albornoz; Jens Nielsen
Source: Self-asserted source
Manuel Garcia-Albornoz via Crossref Metadata Search

Strategies to overcome interferences during biomass monitoring with dielectric spectroscopy

Heriot-Watt University
2013-05-01 | Dissertation or Thesis
Source: Self-asserted source
Manuel Garcia-Albornoz