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Scopus Author ID: 37102738200

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Employment (1)

College of Medicine, University of Nebraska Medical Center: Omaha, NE, US

2019-07-01 to present | Assistant professor (Biochemistry and molecular biology)
Employment
Source: Self-asserted source
Parthasarathy Seshacharyulu

Education and qualifications (2)

University of Madras: Chennai, Tamil Nadu, IN

2005-12-01 to 2010-07-10 | Ph.D in Biochemistry (Zoology)
Education
Source: Self-asserted source
Parthasarathy Seshacharyulu

Bharathidasan University: Tiruchirappalli, Tamil Nadu, IN

1999-04-01 to 2001-05-31 | Master of Science (Biochemistry )
Education
Source: Self-asserted source
Parthasarathy Seshacharyulu

Professional activities (9)

University of Nebraska Medical Center: Omaha, NE, US

2021-01-21 | Silver U Award (Chancellors Council)
Distinction
Source: Self-asserted source
Parthasarathy Seshacharyulu

University of Nebraska Medical Center College of Medicine: Omaha, NE, US

2017-08-08 | Award for Excellence in postdoctoral/instructor oral presentation (Biochemistry and Molecular Biology)
Distinction
Source: Self-asserted source
Parthasarathy Seshacharyulu

University of Nebraska Medical Center College of Medicine: Omaha, NE, US

2014-12-15 | Outstanding Performance Scholarship (Department of Biochemistry and Molecular Biology)
Distinction
Source: Self-asserted source
Parthasarathy Seshacharyulu

University of Nebraska Medical Center College of Medicine: Omaha, NE, US

2013-12-12 | Outstanding Performance Scholarship (Department of Biochemistry and Molecular Biology)
Distinction
Source: Self-asserted source
Parthasarathy Seshacharyulu

University of Madras: Chennai, Tamil Nadu, IN

2010-07-01 to 2010-10-30 | Invited Lecturer (Department of Nano science and technology)
Invited position
Source: Self-asserted source
Parthasarathy Seshacharyulu

Anna University, Chennai: Chennai, Tamil Nadu, IN

2009-10-01 to 2010-04-30 | Guest Lecture (Department of Biotechnology)
Invited position
Source: Self-asserted source
Parthasarathy Seshacharyulu

Indian Society of Gastroenterology: Bangalore, Karnataka, IN

2007-10-12 | Best Poster Award (ISGCON)
Distinction
Source: Self-asserted source
Parthasarathy Seshacharyulu

Indian Society of Gastroenterology: Mumbai, Maharashtra, IN

2006-10-09 | Best poster Award (ISGCON)
Distinction
Source: Self-asserted source
Parthasarathy Seshacharyulu

University Grants Commission: New Delhi, Delhi, IN

2006-03-01 | Project Fellow (Department of Zoology, University of Madras)
Distinction
Source: Self-asserted source
Parthasarathy Seshacharyulu

Works (45)

PAF1-mediated transcriptional reprogramming confers docetaxel resistance in advanced prostate cancer

Cancer Letters
2025-01 | Journal article
DOI: 10.1016/j.canlet.2024.217355
Contributors: Sakthivel Muniyan; Raghupathy Vengoji; Rama Krishna Nimmakayala; Parthasarathy Seshacharyulu; Balaji Perumalsamy; Zahraa Wajih Alsafwani; Sham S. Kakar; Lynette M. Smith; Nicole Shonka; Benjamin A. Teply et al.
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Crossref

Oncogenic potential of truncated-Gli3 via the Gsk3β/Gli3/AR-V7 axis in castration-resistant prostate cancer

Oncogene
2025-01-16 | Journal article
DOI: 10.1038/s41388-024-03266-z
Contributors: Jyoti B. Kaushal; Pratima Raut; Sushanta Halder; Zahraa W. Alsafwani; Seema Parte; Gunjan Sharma; K. M. Abdullah; Parthasarathy Seshacharyulu; Subodh M. Lele; Surinder K. Batra et al.
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Rac1 GTPase Regulates the βTrCP-Mediated Proteolysis of YAP Independently of the LATS1/2 Kinases

Cancers
2024-10-25 | Journal article
DOI: 10.3390/cancers16213605
Contributors: Chitra Palanivel; Tabbatha N. Somers; Bailey M. Gabler; Yuanhong Chen; Yongji Zeng; Jesse L. Cox; Parthasarathy Seshacharyulu; Jixin Dong; Ying Yan; Surinder K. Batra et al.
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Understanding the function of Pax5 in development of docetaxel-resistant neuroendocrine-like prostate cancers

Cell Death & Disease
2024-08-25 | Journal article
DOI: 10.1038/s41419-024-06916-y
Contributors: Sreyashi Bhattacharya; Hannah L. Harris; Ridwan Islam; Sanika Bodas; Navatha Polavaram; Juhi Mishra; Dipanwita Das; Parthasarathy Seshacharyulu; Achyuth Kalluchi; Anirban Pal et al.
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Crossref

Understanding the role of Pax5 in development of taxane-resistant neuroendocrine like prostate cancers

2023-12-11 | Preprint
DOI: 10.21203/rs.3.rs-3464475/v1
Contributors: Samikshan Dutta; Sreyashi Bhattacharya; Hanna Harris; Ridwan Islam; Sanika Bodas; Navatha Polavaram; Juhi Mishra; Dipanwita Das; Parthasarathy Seshacharyulu; Achyuth Kalluchi et al.
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Crossref

Targeting novel LIF/LIFR/c-Myc axis to overcome docetaxel resistance in castration resistant prostate cancer

2023-07-03 | Data management plan
DOI: 10.48321/D11W7W
Source: check_circle
California Digital Library DMP Tool

Mitigation of radioresistance and immunosuppression in pancreatic cancer

2023-05-16 | Data management plan
DOI: 10.48321/D1P04P
Source: check_circle
California Digital Library DMP Tool

Targeting the EGFR signaling pathway in cancer therapy: What’s new in 2023?

Expert Opinion on Therapeutic Targets
2023-05-04 | Journal article
DOI: 10.1080/14728222.2023.2218613
Contributors: Sushanta Halder; Soumi Basu; Shobhit P. Lall; Apar K. Ganti; Surinder K. Batra; Parthasarathy Seshacharyulu
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Crossref

Novel drug identified through system biology approach to treat pancreatic cancer

2023-02-06 | Data management plan
DOI: 10.48321/D1V03V
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California Digital Library DMP Tool

Muc16 depletion diminishes KRAS-induced tumorigenesis and metastasis by altering tumor microenvironment factors in pancreatic ductal adenocarcinoma

Oncogene
2022-11-25 | Journal article
DOI: 10.1038/s41388-022-02493-6
Contributors: Imayavaramban Lakshmanan; Saravanakumar Marimuthu; Sanjib Chaudhary; Parthasarathy Seshacharyulu; Satyanarayana Rachagani; Sakthivel Muniyan; Ramakanth Chirravuri-Venkata; Pranita Atri; Sanchita Rauth; Rama Krishna Nimmakayala et al.
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Crossref

Disruption of FDPS/Rac1 axis radiosensitizes pancreatic ductal adenocarcinoma by attenuating DNA damage response and immunosuppressive signalling

eBioMedicine
2022-01 | Journal article
DOI: 10.1016/j.ebiom.2021.103772
Contributors: Parthasarathy Seshacharyulu; Sushanta Halder; Ramakrishna Nimmakayala; Satyanarayana Rachagani; Sanjib Chaudhary; Pranita Atri; Ramakanth Chirravuri-Venkata; Michel M. Ouellette; Joseph Carmicheal; Shailendra K. Gautam et al.
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Crossref

GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation

Bone Research
2022-01-20 | Journal article
DOI: 10.1038/s41413-021-00178-6
Contributors: Jawed Akhtar Siddiqui; Parthasarathy Seshacharyulu; Sakthivel Muniyan; Ramesh Pothuraju; Parvez Khan; Raghupathy Vengoji; Sanjib Chaudhary; Shailendra Kumar Maurya; Subodh Mukund Lele; Maneesh Jain et al.
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Crossref

Reduction in O-glycome induces differentially glycosylated CD44 to promote stemness and metastasis in pancreatic cancer

Oncogene
2022-01-03 | Journal article
DOI: 10.1038/s41388-021-02047-2
Contributors: Frank Leon; Parthasarathy Seshacharyulu; Rama K. Nimmakayala; Seema Chugh; Saswati Karmakar; Palanisamy Nallasamy; Raghupathy Vengoji; Satyanarayana Rachagani; Jesse L. Cox; Kavita Mallya et al.
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Crossref

ST6GalNAc‐I promotes lung cancer metastasis by altering MUC5AC sialylation

Molecular Oncology
2021-07 | Journal article
DOI: 10.1002/1878-0261.12956
Contributors: Imayavaramban Lakshmanan; Sanjib Chaudhary; Raghupathy Vengoji; Parthasarathy Seshacharyulu; Satyanarayana Rachagani; Joseph Carmicheal; Rahat Jahan; Pranita Atri; Ramakanth Chirravuri‐Venkata; Rohitesh Gupta et al.
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Crossref

Amyloid Precursor-like Protein 2 Expression Increases during Pancreatic Cancer Development and Shortens the Survival of a Spontaneous Mouse Model of Pancreatic Cancer

Cancers
2021-03-26 | Journal article
DOI: 10.3390/cancers13071535
Contributors: Brittany J. Poelaert; Shelby M. Knoche; Alaina C. Larson; Poomy Pandey; Parthasarathy Seshacharyulu; Nuzhat Khan; H. Carlo Maurer; Kenneth P. Olive; Yuri Sheinin; Rizwan Ahmad et al.
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Selective inhibition of stemness through EGFR/FOXA2/SOX9 axis reduces pancreatic cancer metastasis

Oncogene
2021-01-28 | Journal article
DOI: 10.1038/s41388-020-01564-w
Contributors: Garima Kaushik; Parthasarathy Seshacharyulu; Sanchita Rauth; Palanisamy Nallasamy; Satyanarayana Rachagani; Rama Krishna Nimmakayala; Raghupathy Vengoji; Kavita Mallya; Ramakanth Chirravuri-Venkata; Amar B. Singh et al.
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Crossref

Sildenafil Potentiates the Therapeutic Efficacy of Docetaxel in Advanced Prostate Cancer by Stimulating NO-cGMP Signaling

Clinical Cancer Research
2020-11-01 | Journal article
DOI: 10.1158/1078-0432.CCR-20-1569
Contributors: Sakthivel Muniyan; Satyanarayana Rachagani; Seema Parte; Sushanta Halder; Parthasarathy Seshacharyulu; Prakash Kshirsagar; Jawed Akhtar Siddiqui; Raghupathy Vengoji; Sanchita Rauth; Ridwan Islam et al.
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Crossref

Acinar transformed ductal cells exhibit differential mucin expression in a tamoxifen-induced pancreatic ductal adenocarcinoma mouse model

Biology Open
2020-01-01 | Journal article
DOI: 10.1242/bio.052878
Contributors: Kavita Mallya; Dhanya Haridas; Parthasarathy Seshacharyulu; Ramesh Pothuraju; Wade M. Junker; Shiv Ram Krishn; Sakthivel Muniyan; Raghupathy Vengoji; Surinder K. Batra; Satyanarayana Rachagani
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Crossref

FDPS cooperates with PTEN loss to promote prostate cancer progression through modulation of small GTPases/AKT axis

Oncogene
2019 | Journal article
DOI: 10.1038/s41388-019-0791-9
EID:

2-s2.0-85063565187
Contributors: Seshacharyulu, P.; Rachagani, S.; Muniyan, S.; Siddiqui, J.A.; Cruz, E.; Sharma, S.; Krishnan, R.; Killips, B.J.; Sheinin, Y.; Lele, S.M. et al.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

PR55α regulatory subunit of PP2A inhibits the MOB1/LATS cascade and activates YAP in pancreatic cancer cells.

Oncogenesis
2019-10-28 | Journal article
DOI: 10.1038/s41389-019-0172-9
PMID: 31659153
Source: Self-asserted source
Parthasarathy Seshacharyulu

Focal adhesion kinase a potential therapeutic target for pancreatic cancer and malignant pleural mesothelioma

Cancer Biology and Therapy
2018 | Journal article
DOI: 10.1080/15384047.2017.1416937
EID:

2-s2.0-85042362150
Contributors: Kanteti, R.; Mirzapoiazova, T.; Riehm, J.J.; Dhanasingh, I.; Mambetsariev, B.; Wang, J.; Kulkarni, P.; Kaushik, G.; Seshacharyulu, P.; Ponnusamy, M.P. et al.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Cigarette Smoke Induces Stem Cell Features of Pancreatic Cancer Cells via PAF1

Gastroenterology
2018-09 | Journal article
DOI: 10.1053/j.gastro.2018.05.041
Contributors: Rama Krishna Nimmakayala; Parthasarathy Seshacharyulu; Imayavaramban Lakshmanan; Satyanarayana Rachagani; Seema Chugh; Saswati Karmakar; Sanchita Rauth; Raghupathy Vengoji; Pranita Atri; Geoffrey A. Talmon et al.
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Afatinib radiosensitizes head and neck squamous cell carcinoma cells by targeting cancer stem cells

Oncotarget
2017 | Journal article
DOI: 10.18632/oncotarget.15468
EID:

2-s2.0-85016440875
Contributors: Macha, M.A.; Rachagani, S.; Qazi, A.K.; Jahan, R.; Gupta, S.; Patel, A.; Seshacharyulu, P.; Lin, C.; Li, S.; Wang, S. et al.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Biological determinants of radioresistance and their remediation in pancreatic cancer

Biochimica et Biophysica Acta - Reviews on Cancer
2017 | Journal article
DOI: 10.1016/j.bbcan.2017.02.003
EID:

2-s2.0-85014707248
Contributors: Seshacharyulu, P.; Baine, M.J.; Souchek, J.J.; Menning, M.; Kaur, S.; Yan, Y.; Ouellette, M.M.; Jain, M.; Lin, C.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

hPaf1/PD2 interacts with OCT3/4 to promote self-renewal of ovarian cancer stem cells

Oncotarget
2017 | Journal article
DOI: 10.18632/oncotarget.14775
EID:

2-s2.0-85014066886
Contributors: Karmakar, S.; Seshacharyulu, P.; Lakshmanan, I.; Vaz, A.P.; Chugh, S.; Sheinin, Y.M.; Mahapatra, S.; Batra, S.K.; Ponnusamy, M.P.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

MUC16 regulates TSPYL5 for lung cancer cell growth and chemoresistance by suppressing p53

Clinical Cancer Research
2017 | Journal article
DOI: 10.1158/1078-0432.CCR-16-2530
EID:

2-s2.0-85024099643
Contributors: Lakshmanan, I.; Salfity, S.; Seshacharyulu, P.; Rachagani, S.; Thomas, A.; Das, S.; Majhi, P.D.; Nimmakayala, R.K.; Vengoji, R.; Lele, S.M. et al.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

MUC16 contributes to the metastasis of pancreatic ductal adenocarcinoma through focal adhesion mediated signaling mechanism

Genes and Cancer
2016 | Journal article
EID:

2-s2.0-85014744276
Contributors: Muniyan, S.; Haridas, D.; Chugh, S.; Rachagani, S.; Lakshmanan, I.; Gupta, S.; Seshacharyulu, P.; Smith, L.M.; Ponnusamy, M.P.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

MUC5AC interactions with integrin β4 enhances the migration of lung cancer cells through FAK signaling

Oncogene
2016 | Journal article
DOI: 10.1038/onc.2015.478
EID:

2-s2.0-84954546507
Contributors: Lakshmanan, I.; Rachagani, S.; Hauke, R.; Krishn, S.R.; Paknikar, S.; Seshacharyulu, P.; Karmakar, S.; Nimmakayala, R.K.; Kaushik, G.; Johansson, S.L. et al.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling

Cancer Research
2016 | Journal article
DOI: 10.1158/0008-5472.CAN-15-2119
EID:

2-s2.0-84970954356
Contributors: Hein, A.L.; Seshacharyulu, P.; Rachagani, S.; Sheinin, Y.M.; Ouellette, M.M.; Ponnusamy, M.P.; Mumby, M.C.; Batra, S.K.; Yan, Y.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Amyloid precursor-like protein 2 (APLP2) affects the actin cytoskeleton and increases pancreatic cancer growth and metastasis

Oncotarget
2015 | Journal article
EID:

2-s2.0-84923013443
Contributors: Pandey, P.; Rachagani, S.; Das, S.; Seshacharyulu, P.; Sheinin, Y.; Naslavsky, N.; Pan, Z.; Smith, B.L.; Peters, H.L.; Radhakrishnan, P. et al.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Clinical implications of miRNAs in the pathogenesis, diagnosis and therapy of pancreatic cancer

Advanced Drug Delivery Reviews
2015 | Journal article
DOI: 10.1016/j.addr.2014.10.020
EID:

2-s2.0-84922254330
Contributors: Rachagani, S.; Macha, M.A.; Heimann, N.; Seshacharyulu, P.; Haridas, D.; Chugh, S.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Inhibition of hedgehog signaling improves the anti-carcinogenic effects of docetaxel in prostate cancer

Oncotarget
2015 | Journal article
EID:

2-s2.0-84924266993
Contributors: Mimeault, M.; Rachagani, S.; Muniyan, S.; Seshacharyulu, P.; Johansson, S.L.; Datta, K.; Lin, M.-F.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Novel HER3/MUC4 oncogenic signaling aggravates the tumorigenic phenotypes of pancreatic cancer cells

Oncotarget
2015 | Journal article
EID:

2-s2.0-84940774311
Contributors: Lakshmanan, I.; Seshacharyulu, P.; Haridas, D.; Rachagani, S.; Gupta, S.; Joshi, S.; Guda, C.; Yan, Y.; Jain, M.; Ganti, A.K. et al.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Targeting EGF-receptor(s) - STAT1 axis attenuates tumor growth and metastasis through downregulation of MUC4 mucin in human pancreatic cancer

Oncotarget
2015 | Journal article
EID:

2-s2.0-84925002884
Contributors: Seshacharyulu, P.; Ponnusamy, M.P.; Rachagani, S.; Lakshmanan, I.; Haridas, D.; Yan, Y.; Ganti, A.K.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

MicroRNAs (miRNAs) as biomarker(s) for prognosis and diagnosis of gastrointestinal (GI) cancers

Current Pharmaceutical Design
2014 | Journal article
EID:

2-s2.0-84907689638
Contributors: Macha, M.A.; Seshacharyulu, P.; Krishn, S.R.; Pai, P.; Rachagani, S.; Jain, M.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

MUC16: Molecular analysis and its functional implications in benign and malignant conditions

FASEB Journal
2014 | Journal article
DOI: 10.1096/fj.14-257352
EID:

2-s2.0-84907682726
Contributors: Haridas, D.; Ponnusamy, M.P.; Chugh, S.; Lakshmanan, I.; Seshacharyulu, P.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

A concise review on the current understanding of pancreatic cancer stem cells.

Journal of cancer stem cell research
2014-01-01 | Journal article
DOI: 10.14343/jcscr.2014.2e1004
PMID: 26451384
PMC: PMC4594952
Source: Self-asserted source
Parthasarathy Seshacharyulu

Emerging role of mucins in epithelial to mesenchymal transition

Current Cancer Drug Targets
2013 | Journal article
EID:

2-s2.0-84890825478
Contributors: Ponnusamy, M.P.; Seshacharyulu, P.; Lakshmanan, I.; Vaz, A.P.; Chugh, S.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Impaired expression of protein phosphatase 2A subunits enhances metastatic potential of human prostate cancer cells through activation of AKT pathway

British Journal of Cancer
2013 | Journal article
DOI: 10.1038/bjc.2013.160
EID:

2-s2.0-84879687996
Contributors: Pandey, P.; Seshacharyulu, P.; Das, S.; Rachagani, S.; Ponnusamy, M.P.; Yan, Y.; Johansson, S.L.; Datta, K.; Lin, M.F.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer

Cancer Letters
2013 | Journal article
DOI: 10.1016/j.canlet.2013.02.036
EID:

2-s2.0-84878431342
Contributors: Seshacharyulu, P.; Pandey, P.; Datta, K.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Mucin (Muc) expression during pancreatic cancer progression in spontaneous mouse model: Potential implications for diagnosis and therapy

Journal of Hematology and Oncology
2012 | Journal article
DOI: 10.1186/1756-8722-5-68
EID:

2-s2.0-84867801436
Contributors: Rachagani, S.; Torres, M.P.; Kumar, S.; Haridas, D.; Baine, M.; MacHa, M.A.; Kaur, S.; Ponnusamy, M.P.; Dey, P.; Seshacharyulu, P. et al.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Targeting the EGFR signaling pathway in cancer therapy

Expert Opinion on Therapeutic Targets
2012 | Journal article
DOI: 10.1517/14728222.2011.648617
EID:

2-s2.0-84855884072
Contributors: Seshacharyulu, P.; Ponnusamy, M.P.; Haridas, D.; Jain, M.; Ganti, A.K.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Aberrant expression of epidermal growth factor receptor and its interaction with protein kinase C δ in inflammation associated neoplastic transformation of human esophageal epithelium in high risk populations

Journal of Gastroenterology and Hepatology (Australia)
2011 | Journal article
DOI: 10.1111/j.1440-1746.2010.06526.x
EID:

2-s2.0-78851472411
Contributors: Parthasarathy, S.; Dhayaparan, D.; Jayanthi, V.; Devaraj, S.N.; Devaraj, H.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

MUC4 stabilizes HER2 expression and maintains the cancer stem cell population in ovarian cancer cells

Journal of Ovarian Research
2011 | Journal article
DOI: 10.1186/1757-2215-4-7
EID:

2-s2.0-79955105128
Contributors: Ponnusamy, M.P.; Seshacharyulu, P.; Vaz, A.; Dey, P.; Batra, S.K.
Source: Self-asserted source
Parthasarathy Seshacharyulu via Scopus - Elsevier

Easi-CRISPR: a robust method for one-step generation of mice carrying conditional and insertion alleles using long ssDNA donors and CRISPR ribonucleoproteins.

Journal article
DOI: 10.1186/s13059-017-1220-4
Source: Self-asserted source
Parthasarathy Seshacharyulu
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Peer review (4 reviews for 3 publications/grants)

Review activity for Biochimica et biophysica acta. (1)
Review activity for Clinical immunology (1)
Review activity for PloS one. (2)
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