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Biography

Now I am the Executive Director, Head of Pharmacology of BeiGene. I joined in Beigene in 2012 and have about 10 years experiences in pharmacology research of both small and large molecule drugs, including drug candidates for cancer targeted treatment, immune oncology and immunology & inflammation diseases. Before joining in BeiGene, I worked in Tsinghua University for 2 years as an assistant professor, focusing on the translational research on tumor microenvironment. I obtained my PhD degree in Tsinghua University in 2010.

My publications can be found through the Google Scholar link as below: https://scholar.google.com/citations?hl=en&user=hlSwpqcAAAAJ

Activities

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Employment (1)

BeiGene: Beijing, CN

2012-08-01 to present | Executive Director (Pharmacology)
Employment
Source: Self-asserted source
Xiaomin Song

Education and qualifications (1)

Tsinghua University: Beijing, Beijing, CN

2003-09-01 to 2010-07-01 | PhD (Biology)
Education
Source: Self-asserted source
Xiaomin Song

Works (21)

Pamiparib is a potent and selective PARP inhibitor with unique potential for the treatment of brain tumor.

Neoplasia (New York, N.Y.)
2020-07-08 | Journal article
DOI: 10.1016/j.neo.2020.06.009
LENSID: 036-650-177-206-700
PMC: 7350150
PMID: 32652442
Contributors: Yao Xiong; Yin Guo; Ye Liu; Hexiang Wang; Wenfeng Gong; Yong Liu; Xing Wang; Yajuan Gao; Fenglong Yu; Dan Su et al.
Source: Self-asserted source
Xiaomin Song via The Lens

Differential effects of BTK inhibitors ibrutinib and zanubrutinib on NK-cell effector function in patients with mantle cell lymphoma.

Haematologica
2020-01-31 | Journal article
DOI: 10.3324/haematol.2019.220590
LENSID: 044-692-348-343-837
PMC: 7012496
PMID: 31171645
Contributors: Thijs W. H. Flinsenberg; Charnelle C. Tromedjo; Nan Hu; Ye Liu; Yin Guo; Kevin Y. T. Thia; Tahereh Noori; Xiaomin Song; Han Xian Aw Yeang; Daniela Gm Tantalo et al.
Source: Self-asserted source
Xiaomin Song via The Lens

Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase

Journal of medicinal chemistry
2019-08-19 | Journal article
DOI: 10.1021/acs.jmedchem.9b00687.s002
DOI: 10.1021/acs.jmedchem.9b00687
LENSID: 096-464-406-131-990
PMID: 31381333
Contributors: yunhang guo; Ye Liu; Nan Hu; Desheng Yu; Changyou Zhou; Gongyin Shi; Bo Zhang; Min Wei; Junhua Liu; Lusong Luo et al.
Source: Self-asserted source
Xiaomin Song via The Lens

FcγR-Binding Is an Important Functional Attribute for Immune Checkpoint Antibodies in Cancer Immunotherapy.

Frontiers in immunology
2019-02-26 | Journal article
DOI: 10.3389/fimmu.2019.00292
LENSID: 074-181-639-277-191
PMC: 6399403
PMID: 30863404
Contributors: Xin Chen; Xiaomin Song; Kang Li; Tong Zhang
Source: Self-asserted source
Xiaomin Song via The Lens

The binding of an anti-PD-1 antibody to FcγRΙ has a profound impact on its biological functions.

Cancer immunology, immunotherapy : CII
2018-04-23 | Journal article
DOI: 10.1007/s00262-018-2160-x
LENSID: 040-822-060-256-969
PMID: 29687231
PMC: 6006217
Contributors: Tong Zhang; Xiaomin Song; Xu Lanlan; Jie Ma; Yanjuan Zhang; Wenfeng Gong; Yilu Zhang; Xiaosui Zhou; Zuobai Wang; Yali Wang et al.
Source: Self-asserted source
Xiaomin Song via The Lens

PLCγ1–PKCγ Signaling‐Mediated Hsp90α Plasma Membrane Translocation Facilitates Tumor Metastasis

Traffic (Copenhagen, Denmark)
2014-06-26 | Journal article
DOI: 10.1111/tra.12179
LENSID: 048-770-631-028-572
PMID: 24899266
Contributors: Jian Yang; Xiaomin Song; Yang Chen; Lu Xin An; Yan Fu; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis

Clinical cancer research : an official journal of the American Association for Cancer Research
2012-08-29 | Journal article
DOI: 10.1158/1078-0432.ccr-12-0708
LENSID: 051-749-458-204-991
PMID: 22932666
Contributors: Wei Zhuo; Lin Jia; Nan Song; Xin-an Lu; Yanping Ding; Xiaofeng Wang; Xiaomin Song; Yan Fu; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

Heat Shock Cognate 70 Regulates the Translocation and Angiogenic Function of Nucleolin

Arteriosclerosis, thrombosis, and vascular biology
2012-06-28 | Journal article
DOI: 10.1161/atvbaha.112.247502
LENSID: 020-257-621-142-255
PMID: 22743058
Contributors: Yanping Ding; Nan Song; Chang Liu; Ting He; Wei Zhuo; Xiaoli He; Yang Chen; Xiaomin Song; Yan Fu; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

The nuclear translocation of endostatin is mediated by its receptor nucleolin in endothelial cells.

Angiogenesis
2012-06-19 | Journal article
DOI: 10.1007/s10456-012-9284-y
LENSID: 059-294-990-041-925
PMID: 22711211
Contributors: Nan Song; Yanping Ding; Wei Zhuo; Ting He; Zhiguang Fu; Yang Chen; Xiaomin Song; Yan Fu; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

Endostatin specifically targets both tumor blood vessels and lymphatic vessels

Frontiers of medicine
2011-12-27 | Journal article
DOI: 10.1007/s11684-011-0163-5
LENSID: 099-709-905-006-360
PMID: 22198745
Contributors: Wei Zhuo; Yang Chen; Xiaomin Song; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

Thr90 phosphorylation of Hsp90α by protein kinase A regulates its chaperone machinery.

The Biochemical journal
2011-12-14 | Journal article
DOI: 10.1042/bj20110855
LENSID: 081-707-126-766-130
PMID: 21919888
Contributors: Xiaofeng Wang; Xin-an Lu; Xiaomin Song; Wei Zhuo; Lin Jia; Yushan Jiang; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

Tumor-Associated Macrophages Promote Angiogenesis and Melanoma Growth via Adrenomedullin in a Paracrine and Autocrine Manner

Clinical cancer research : an official journal of the American Association for Cancer Research
2011-10-12 | Journal article
DOI: 10.1158/1078-0432.ccr-11-1354
LENSID: 065-755-285-592-170
PMID: 21994414
Contributors: Peiwen Chen; Yujie Huang; Rosabel Bong; Yanping Ding; Nan Song; Xiaofeng Wang; Xiaomin Song; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

The Regulatory Mechanism of Extracellular Hsp90α on Matrix Metalloproteinase-2 Processing and Tumor Angiogenesis *

The Journal of biological chemistry
2010-10-11 | Journal article
DOI: 10.1074/jbc.m110.181941
LENSID: 037-977-754-605-228
PMID: 20937816
PMC: 3000986
Contributors: Xiaomin Song; Xiaofeng Wang; Wei Zhuo; Hubing Shi; Dan Feng; Yi Sun; Yun Liang; Yan Fu; Daifu Zhou; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

Endostatin inhibits tumour lymphangiogenesis and lymphatic metastasis via cell surface nucleolin on lymphangiogenic endothelial cells

The Journal of pathology
2010-07-26 | Journal article
DOI: 10.1002/path.2760
LENSID: 175-857-748-672-704
PMID: 20814900
Contributors: Wei Zhuo; Chong Luo; Xiaofeng Wang; Xiaomin Song; Yan Fu; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

The regulatory mechanism of Hsp90α secretion from endothelial cells and its role in angiogenesis during wound healing

Biochemical and biophysical research communications
2010-06-15 | Journal article
DOI: 10.1016/j.bbrc.2010.06.046
LENSID: 147-125-302-750-078
PMID: 20558142
Contributors: Xiaomin Song; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

The regulatory mechanism of Hsp90α secretion and its function in tumor malignancy

Proceedings of the National Academy of Sciences of the United States of America
2009-11-24 | Journal article
DOI: 10.1073/pnas.0908151106
LENSID: 124-777-170-351-487
PMC: 2795546
PMID: 19965370
Contributors: Xiaofeng Wang; Xiaomin Song; Wei Zhuo; Yan Fu; Hubing Shi; Yun Liang; Maomeng Tong; Guodong Chang; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

Overexpression of Platelet-Derived Growth Factor-BB Increases Tumor Pericyte Content via Stromal-Derived Factor-1α/CXCR4 Axis

Cancer research
2009-07-07 | Journal article
DOI: 10.1158/0008-5472.can-08-2007
LENSID: 040-322-210-296-106
PMID: 19584297
Contributors: Nan Song; Yujie Huang; Hubing Shi; Shaopeng Yuan; Yanping Ding; Xiaomin Song; Yan Fu; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

Soluble tissue factor has unique angiogenic activities that selectively promote migration and differentiation but not proliferation of endothelial cells.

Biochemical and biophysical research communications
2008-04-04 | Journal article
DOI: 10.1016/j.bbrc.2008.03.133
LENSID: 007-789-192-739-569
PMID: 18395519
Contributors: Yingbo He; Guodong Chang; Shunli Zhan; Xiaomin Song; Xiaofeng Wang; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

Voltage-dependent anion channel 1 is involved in endostatin-induced endothelial cell apoptosis

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2008-04-01 | Journal article
DOI: 10.1096/fj.08-107417
LENSID: 074-134-208-852-041
PMID: 18381814
Contributors: Shaopeng Yuan; Yan Fu; Xiaofeng Wang; Hubing Shi; Yujie Huang; Xiaomin Song; Ling Li; Nan Song; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

Nucleolin is a receptor that mediates antiangiogenic and antitumor activity of endostatin

Blood
2007-07-05 | Journal article
DOI: 10.1182/blood-2007-01-064428
LENSID: 034-816-550-323-919
PMID: 17615292
Contributors: Hubing Shi; Yujie Huang; Hao Zhou; Xiaomin Song; Shaopeng Yuan; Yan Fu; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens

The angiogenic function of nucleolin is mediated by vascular endothelial growth factor and nonmuscle myosin.

Blood
2006-01-10 | Journal article
DOI: 10.1182/blood-2005-07-2961
LENSID: 081-735-031-486-900
PMID: 16403913
Contributors: Yujie Huang; Hubing Shi; Hao Zhou; Xiaomin Song; Shaopeng Yuan; Yongzhang Luo
Source: Self-asserted source
Xiaomin Song via The Lens
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