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University of Leeds: Leeds, West Yorkshire, GB

(School of Medicine)
Employment
Source: Self-asserted source
Mark Iles

Works (50 of 81)

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Page 1 of 2

GENOME-WIDE ANALYSES CHARACTERIZE SHARED HERITABILITY AMONG CANCERS AND IDENTIFY NOVEL CANCER SUSCEPTIBILITY REGIONS

2023-03-15 | Other
DOI: 10.1093/jnci/djad043
Contributors: Sara Lindstroem; Peter Kraft; Peter Kanetsky; Nicholas Mancuso; Mattias Johansson; Immaculata De Vivo; Matthew Law; Mark Iles; Bogdan Pasaniuc; Beatrice Melin et al.
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Crossref

Metabolic Drivers of Dysglycemia in Pregnancy: Ethnic-Specific GWAS of 146 Metabolites and 1-Sample Mendelian Randomisation Analyses in a UK Multi-Ethnic Birth Cohort

2022-12-22 | Preprint
DOI: 10.1101/2022.12.21.22283768
Contributors: Harriett Fuller; Mark M Iles; J. Bernadette Moore; Michael A. Zulyniak
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Crossref

Unique Metabolic Profiles Associate with Gestational Diabetes and Ethnicity in Low- and High-Risk Women Living in the UK

The Journal of Nutrition
2022-10 | Journal article
DOI: 10.1093/jn/nxac163
Contributors: Harriett Fuller; Mark Iles; J Bernadette Moore; Michael A Zulyniak
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Crossref

Higher polygenic risk for melanoma is associated with improved survival in a high ultraviolet radiation setting

Journal of Translational Medicine
2022-09-05 | Journal article
DOI: 10.1186/s12967-022-03613-2
Contributors: Mathias Seviiri; Richard A. Scolyer; D. Timothy Bishop; Julia A. Newton-Bishop; Mark M. Iles; Serigne N. Lo; Johnathan R. Stretch; Robyn P. M. Saw; Omgo E. Nieweg; Kerwin F. Shannon et al.
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Crossref

Differences in the management of patients requiring an emergency resection for colonic cancer in two European populations

BJS Open
2022-09-02 | Journal article
DOI: 10.1093/bjsopen/zrac126
Contributors: John C Taylor; Lene H Iversen; Dermot Burke; Paul J Finan; Mark M Iles; Eva J A Morris; Philip Quirke; K Absolom; D Swinson; D Tolan et al.
Source: check_circle
Crossref

Unique Metabolic Profiles Associate with Gestational Diabetes and Ethnicity in Low and High-Risk Women Living in the UK

2022-04-14 | Preprint
DOI: 10.1101/2022.04.11.22273658
Contributors: Harriett Fuller; Mark Iles; J. Bernadette Moore; Michael A. Zulyniak
Source: check_circle
Crossref

Higher polygenic risk for melanoma is associated with improved survival

2022-03-12 | Preprint
DOI: 10.1101/2022.03.07.22272003
Contributors: Mathias Seviiri; Richard A. Scolyer; D. Timothy Bishop; Mark M. Iles; Serigne N. Lo; Johnathan R. Stretch; Robyn P.M. Saw; Omgo E. Nieweg; Kerwin F. Shannon; Andrew J. Spillane et al.
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Crossref

Germline variants are associated with increased primary melanoma tumor thickness at diagnosis

Human Molecular Genetics
2021-01-06 | Journal article
DOI: 10.1093/hmg/ddaa222
Contributors: Ernest Mangantig; Stuart MacGregor; Mark M Iles; Richard A Scolyer; Anne E Cust; Nicholas K Hayward; Grant W Montgomery; David L Duffy; John F Thompson; Anjali Henders et al.
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Crossref

Multiplex melanoma families are enriched for polygenic risk

Human Molecular Genetics
2020-10-10 | Journal article
DOI: 10.1093/hmg/ddaa156
Contributors: Matthew H Law; Lauren G Aoude; David L Duffy; Georgina V Long; Peter A Johansson; Antonia L Pritchard; Kiarash Khosrotehrani; Graham J Mann; Grant W Montgomery; Mark M Iles et al.
Source: check_circle
Crossref

Overlapping genetic architecture between Parkinson disease and melanoma.

Acta neuropathologica
2019-12 | Journal article
DOI: 10.1007/s00401-019-02110-z
PMID: 31845298
Contributors: Dube U; Ibanez L; Budde JP; Benitez BA; Davis AA; Harari O; Iles MM; Law MH; Brown KM; 23andMe Research Team et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Does polygenic risk influence associations between sun exposure and melanoma?: a prospective cohort analysis.

The British journal of dermatology
2019-11 | Journal article
DOI: 10.1111/bjd.18703
PMID: 31747047
Contributors: Olsen CM; Pandeya N; Law MH; MacGregor S; Iles MM; Thompson BS; Green AC; Neale RE; Whiteman DC; QSkin Study
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Is there a causal relationship between vitamin D and melanoma risk? A Mendelian randomization study.

The British journal of dermatology
2019-09 | Journal article
DOI: 10.1111/bjd.18238
PMID: 31218665
Contributors: Liyanage UE; Law MH; Melanoma Meta-analysis Consortium; Barrett JH; Iles MM; MacGregor S
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibility locus that shows a long-range interaction with the SLC16A1 gene.

Carcinogenesis
2019-09 | Journal article
DOI: 10.1093/carcin/bgz153
PMID: 31605138
Contributors: Avitabile M; Succoio M; Testori A; Cardinale A; Vaksman Z; Lasorsa VA; Cantalupo S; Esposito M; Cimmino F; Montella A et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Assessment of Polygenic Architecture and Risk Prediction based on Common Variants Across Fourteen Cancers

2019-08 | Other
DOI: 10.1101/723825
OTHER-ID:

PPR88616
Contributors: Zhang Y; Wilcox AN; Zhang H; Choudhury PP; Easton DF; Milne RL; Simard J; Hall P; Michailidou K; Dennis J et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Overlapping Genetic Architecture between Parkinson Disease and Melanoma

2019-08 | Other
DOI: 10.1101/740589
OTHER-ID:

PPR90271
Contributors: Dube U; Ibanez L; Budde JP; Benitez BA; Davis AA; Harari O; Iles MM; Law MH; Brown KM; Cruchaga C et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central
grade
Preferred source (of 2)‎

Ultraviolet radiation exposure and melanoma: evidence for gene-environment interaction in a large prospective cohort

2019-06 | Other
DOI: 10.1101/666123
OTHER-ID:

PPR82535
Contributors: Olsen CM; Pandeya N; Law MH; MacGregor S; Iles MM; Thompson BS; Green AC; Neale RE; Whiteman DC; for the QSkin Study
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Assessment of melanoma candidate genes in a meta-analysis of 16 534 melanoma cases.

Journal of the European Academy of Dermatology and Venereology : JEADV
2019-05 | Journal article
DOI: 10.1111/jdv.15662
PMID: 31071243
Contributors: Ntritsos G; Dimou N; Kypreou K; Stefanaki I; Loizidou MA; Hadjisavvas A; Kyriacou K; Melanoma Meta-Analysis Consortium; MacGregor S; Law MH et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Massively parallel reporter assays combined with cell-type specific eQTL informed multiple melanoma loci and identified a pleiotropic function of HIV-1 restriction gene, MX2, in melanoma promotion

2019-05 | Other
DOI: 10.1101/625400
OTHER-ID:

PPR77900
Contributors: Choi J; Zhang T; Vu A; Ablain J; Makowski MM; Colli LM; Xu M; Rothschild H; Gräwe C; Kovacs MA et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Publisher Correction: Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.

Nature communications
2019-01 | Journal article
DOI: 10.1038/s41467-018-08078-w
PMID: 30643134
PMC: PMC6331636
Contributors: Duffy DL; Zhu G; Li X; Sanna M; Iles MM; Jacobs LC; Evans DM; Yazar S; Beesley J; Law MH et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Combining common genetic variants and non-genetic risk factors to predict risk of cutaneous melanoma.

Human molecular genetics
2018-12 | Journal article
DOI: 10.1093/hmg/ddy282
PMID: 30060076
PMC: PMC6240742
Contributors: Gu F; Chen TH; Pfeiffer RM; Fargnoli MC; Calista D; Ghiorzo P; Peris K; Puig S; Menin C; De Nicolo A et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways.

Nature communications
2018-11 | Journal article
DOI: 10.1038/s41467-018-06649-5
PMID: 30429480
PMC: PMC6235897
Contributors: Duffy DL; Zhu G; Li X; Sanna M; Iles MM; Jacobs LC; Evans DM; Yazar S; Beesley J; Law MH et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes.

Genome research
2018-10 | Journal article
DOI: 10.1101/gr.233304.117
PMID: 30333196
PMC: PMC6211648
Contributors: Zhang T; Choi J; Kovacs MA; Shi J; Xu M; NISC Comparative Sequencing Program; Melanoma Meta-Analysis Consortium; Goldstein AM; Trower AJ; Bishop DT et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Assessing the Incremental Contribution of Common Genomic Variants to Melanoma Risk Prediction in Two Population-Based Studies.

The Journal of investigative dermatology
2018-06 | Journal article
DOI: 10.1016/j.jid.2018.05.023
PMID: 29890168
PMC: PMC6249137
Contributors: Cust AE; Drummond M; Kanetsky PA; Australian Melanoma Family Study Investigators; Leeds Case-Control Study Investigators; Goldstein AM; Barrett JH; Bishop DT
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Genome-wide association study in 176,678 Europeans reveals genetic loci for tanning response to sun exposure.

Nature communications
2018-05 | Journal article
DOI: 10.1038/s41467-018-04086-y
PMID: 29739929
PMC: PMC5940788
Contributors: Visconti A; Duffy DL; Liu F; Zhu G; Wu W; Chen Y; Hysi PG; Zeng C; Sanna M; Iles MM et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Polyunsaturated fatty acids and risk of melanoma: A Mendelian randomisation analysis.

International journal of cancer
2018-03 | Journal article
DOI: 10.1002/ijc.31334
PMID: 29473154
Contributors: Liyanage UE; Law MH; Ong JS; Cust AE; Mann GJ; Ward SV; Melanoma Meta-Analysis Consortium; Gharahkhani P; Iles MM; MacGregor S
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Publisher correction: Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148.

Nature communications
2018-03 | Journal article
DOI: 10.1038/ncomms16159
PMID: 29596408
PMC: PMC6454265
Contributors: Fang J; Jia J; Makowski M; Xu M; Wang Z; Zhang T; Hoskins JW; Choi J; Han Y; Zhang M et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Cell-type specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes

2017-12 | Other
DOI: 10.1101/231423
OTHER-ID:

PPR21440
Contributors: Zhang T; Choi J; Kovacs MA; Shi J; Xu M; Goldstein AM; Iles MM; Duffy D; MacGregor S; Amundadottir LT et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Novel pleiotropic risk loci for melanoma and nevus density implicate multiple biological pathways

2017-08 | Other
DOI: 10.1101/173112
OTHER-ID:

PPR25922
Contributors: Duffy DL; Zhu G; Li X; Sanna M; Iles M; Jacobs LC; Evans DM; Yazar S; Beesley J; Law M et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF.

Nature genetics
2017-07 | Journal article
DOI: 10.1038/ng.3927
PMID: 28759004
Contributors: Choi J; Xu M; Makowski MM; Zhang T; Law MH; Kovacs MA; Granzhan A; Kim WJ; Parikh H; Gartside M et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Association Between Telomere Length and Risk of Cancer and Non-Neoplastic Diseases: A Mendelian Randomization Study.

JAMA oncology
2017-05 | Journal article
DOI: 10.1001/jamaoncol.2016.5945
PMID: 28241208
PMC: PMC5638008
Contributors: Telomeres Mendelian Randomization Collaboration; Haycock PC; Burgess S; Nounu A; Zheng J; Okoli GN; Bowden J; Wade KH; Timpson NJ; Evans DM et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Functional characterization of a multi-cancer risk locus on chr5p15.33 reveals regulation of TERT by ZNF148.

Nature communications
2017-05 | Journal article
DOI: 10.1038/ncomms15034
PMID: 28447668
PMC: PMC5414179
Contributors: Fang J; Jia J; Makowski M; Xu M; Wang Z; Zhang T; Hoskins JW; Choi J; Han Y; Zhang M et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Rare variants analysis of cutaneous malignant melanoma genes in Parkinson's disease.

Neurobiology of aging
2016-07 | Journal article
DOI: 10.1016/j.neurobiolaging.2016.07.013
PMID: 27640074
PMC: PMC5096891
Contributors: Lubbe SJ; Escott-Price V; Brice A; Gasser T; Pittman AM; Bras J; Hardy J; Heutink P; Wood NM; Singleton AB et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.

Nature communications
2016-02 | Journal article
DOI: 10.1038/ncomms10495
PMID: 26833246
PMC: PMC4740398
Contributors: Lu Y; Day FR; Gustafsson S; Buchkovich ML; Na J; Bataille V; Cousminer DL; Dastani Z; Drong AW; Esko T et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma.

Nature genetics
2015-08 | Journal article
DOI: 10.1038/ng.3373
PMID: 26237428
PMC: PMC4557485
Contributors: Law MH; Bishop DT; Lee JE; Brossard M; Martin NG; Moses EK; Song F; Barrett JH; Kumar R; Easton DF et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Response.

Journal of the National Cancer Institute
2015-08 | Journal article
DOI: 10.1093/jnci/djv238
PMID: 26311299
Contributors: Iles MM; Bishop DT; Barrett JH; GenoMEL consortium
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Telomere length and common disease: study design and analytical challenges.

Human genetics
2015-05 | Journal article
DOI: 10.1007/s00439-015-1563-4
PMID: 25986438
PMC: PMC4460268
Contributors: Barrett JH; Iles MM; Dunning AM; Pooley KA
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis.

The lancet. Diabetes & endocrinology
2015-02 | Journal article
DOI: 10.1016/S2213-8587(15)00034-0
PMID: 25726324
PMC: PMC4648058
Contributors: Interleukin 1 Genetics Consortium
Source: Self-asserted source
Mark Iles via Europe PubMed Central

The effect on melanoma risk of genes previously associated with telomere length.

Journal of the National Cancer Institute
2014-09 | Journal article
DOI: 10.1093/jnci/dju267
PMID: 25231748
PMC: PMC4196080
Contributors: Iles MM; Bishop DT; Taylor JC; Hayward NK; Brossard M; Cust AE; Dunning AM; Lee JE; Moses EK; Akslen LA et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Fine mapping of genetic susceptibility loci for melanoma reveals a mixture of single variant and multiple variant regions.

International journal of cancer
2014-08 | Journal article
DOI: 10.1002/ijc.29099
PMID: 25077817
PMC: PMC4328144
Contributors: Barrett JH; Taylor JC; Bright C; Harland M; Dunning AM; Akslen LA; Andresen PA; Avril MF; Azizi E; Bianchi Scarrà G et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Identification of a melanoma susceptibility locus and somatic mutation in TET2.

Carcinogenesis
2014-06 | Journal article
DOI: 10.1093/carcin/bgu140
PMID: 24980573
PMC: PMC4146422
Contributors: Song F; Amos CI; Lee JE; Lian CG; Fang S; Liu H; MacGregor S; Iles MM; Law MH; Lindeman NI et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Statistical perspectives for genome-wide association studies (GWAS).

Methods in molecular biology (Clifton, N.J.)
2014-01 | Journal article
DOI: 10.1007/978-1-4939-0847-9_4
PMID: 24870130
Contributors: Barrett JH; Taylor JC; Iles MM
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Evaluation of PAX3 genetic variants and nevus number.

Pigment cell & melanoma research
2013-07 | Journal article
DOI: 10.1111/pcmr.12130
PMID: 23751107
Contributors: Ogbah Z; Badenas C; Harland M; Puig-Butille JA; Elliot F; Bonifaci N; Guino E; Randerson-Moor J; Chan M; Iles MM et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

A variant in FTO shows association with melanoma risk not due to BMI.

Nature genetics
2013-03 | Journal article
DOI: 10.1038/ng.2571
PMID: 23455637
PMC: PMC3640814
Contributors: Iles MM; Law MH; Stacey SN; Han J; Fang S; Pfeiffer R; Harland M; Macgregor S; Taylor JC; Aben KK et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Association between putative functional variants in the PSMB9 gene and risk of melanoma--re-analysis of published melanoma genome-wide association studies.

Pigment cell & melanoma research
2013-03 | Journal article
DOI: 10.1111/pcmr.12069
PMID: 23360169
PMC: PMC3721546
Contributors: Qian J; Liu H; Wei S; Liu Z; Li Y; Wang LE; Chen WV; Amos CI; Lee JE; GenoMEL investigators et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Association between functional polymorphisms in genes involved in the MAPK signaling pathways and cutaneous melanoma risk.

Carcinogenesis
2013-01 | Journal article
DOI: 10.1093/carcin/bgs407
PMID: 23291271
PMC: PMC3616673
Contributors: Liu H; Wang LE; Liu Z; Chen WV; Amos CI; Lee JE; Q-MEGA and AMFS Investigators; GenoMEL Investigators; Iles MM; Law MH et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Cleft, crevice, or the inner thigh: 'another place' for the establishment of the invasive barnacle Austrominius modestus (Darwin, 1854).

PloS one
2012-11 | Journal article
DOI: 10.1371/journal.pone.0048863
PMID: 23145000
PMC: PMC3492251
Contributors: Bracewell SA; Spencer M; Marrs RH; Iles M; Robinson LA
Source: Self-asserted source
Mark Iles via Europe PubMed Central

High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.

Nature genetics
2012-11 | Journal article
DOI: 10.1038/ng.2462
PMID: 23143596
PMC: PMC3605761
Contributors: Eyre S; Bowes J; Diogo D; Lee A; Barton A; Martin P; Zhernakova A; Stahl E; Viatte S; McAllister K et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Hypothesis-based analysis of gene-gene interactions and risk of myocardial infarction.

PloS one
2012-08 | Journal article
DOI: 10.1371/journal.pone.0041730
PMID: 22876292
PMC: PMC3410908
Contributors: Lucas G; Lluís-Ganella C; Subirana I; Musameh MD; Gonzalez JR; Nelson CP; Sentí M; Myocardial Infarction Genetics Consortium; Elosua R
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression.

PloS one
2011-12 | Journal article
DOI: 10.1371/journal.pone.0029451
PMID: 22216283
PMC: PMC3246481
Contributors: Schoof N; Iles MM; Bishop DT; Newton-Bishop JA; Barrett JH; Genomel Consortium
Source: Self-asserted source
Mark Iles via Europe PubMed Central

Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3.

Nature genetics
2011-10 | Journal article
DOI: 10.1038/ng.958
PMID: 21983785
PMC: PMC3227560
Contributors: Macgregor S; Montgomery GW; Liu JZ; Zhao ZZ; Henders AK; Stark M; Schmid H; Holland EA; Duffy DL; Zhang M et al.
Source: Self-asserted source
Mark Iles via Europe PubMed Central
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Page 1 of 2

Peer review (19 reviews for 8 publications/grants)

Review activity for EClinicalMedicine. (1)
Review activity for Nature communications (1)
Review activity for PLOS genetics. (1)
Review activity for The Lancet Healthy Longevity (1)
Review activity for The lancet. (1)
Review activity for The Lancet. (1)
Review activity for The Lancet. (3)
Review activity for The Lancet. (10)
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