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Scopus Author ID: 55929678100

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Employment (2)

Nottingham Trent University: Nottingham, Nottinghamshire, GB

2014-08-01 to present | Research Fellow (John VanGeest Cancer Research Centre)
Employment
Source: Self-asserted source
Jayakumar Vadakekolathu

Indian Institute of Spices Research: Calicut, Kerala, IN

2002-06-01 to 2005-04-30 | Senior Research Fellow (Crop Improvement and Biotechnology)
Employment
Source: Self-asserted source
Jayakumar Vadakekolathu

Education and qualifications (2)

Nottingham Trent University: Nottingham, Nottinghamshire, GB

2010-08-01 to 2014-06-01 | PhD, Tumour Immunology (Bioscience)
Education
Source: Self-asserted source
Jayakumar Vadakekolathu

University of Nottingham: Nottingham, Nottinghamshire, GB

2008-08-01 to 2009-08-01 | MRes, Advanced Genomic and Proteomic Sciences (Bioscience)
Education
Source: Self-asserted source
Jayakumar Vadakekolathu

Works (50)

SOCS1 protects acute myeloid leukemia against allogeneic T cell-mediated cytotoxicity

Blood Cancer Discovery
2025-02-10 | Journal article
DOI: 10.1158/2643-3230.BCD-24-0140
Contributors: Enoch Tin; Sergio Rutella; Ismat Khatri; Yoosu Na; Yongran Yan; Neil MacLean; Jayakumar Vadakekolathu; Mark D. Minden; Aaron D. Schimmer; JongBok Lee et al.
Source: check_circle
Crossref

Escape from T-cell–targeting immunotherapies in acute myeloid leukemia

Blood
2024-06-27 | Journal article
DOI: 10.1182/blood.2023019961
Contributors: Jayakumar Vadakekolathu; Sergio Rutella
Source: check_circle
Crossref

Generation of transplantable and biologically responsive colonic tissue from human induced pluripotent stem cells using a rapid co-differentiation platform

2023-12-09 | Preprint
DOI: 10.1101/2023.12.08.570795
Contributors: William Dalleywater; Alexander V. Predeus; Batuhan Cakir; Pavel Mazin; Jayakumar Vadakekolathu; Sergio Rutella; Marian L. Meakin; Alison A. Ritchie; Shamir Montazid; Sara Cuevas Ocaña et al.
Source: check_circle
Crossref

Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells

2023-03-31 | Preprint
DOI: 10.1158/1078-0432.c.6532505
Contributors: Giulia Corradi; Barbara Bassani; Giorgia Simonetti; Sabina Sangaletti; Jayakumar Vadakekolathu; Maria Chiara Fontana; Martina Pazzaglia; Alessandro Gulino; Claudio Tripodo; Gianluca Cristiano et al.
Source: check_circle
Crossref

Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells

2023-03-31 | Preprint
DOI: 10.1158/1078-0432.c.6532505.v1
Contributors: Giulia Corradi; Barbara Bassani; Giorgia Simonetti; Sabina Sangaletti; Jayakumar Vadakekolathu; Maria Chiara Fontana; Martina Pazzaglia; Alessandro Gulino; Claudio Tripodo; Gianluca Cristiano et al.
Source: check_circle
Crossref

Supplementary Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells

2023-03-31 | Preprint
DOI: 10.1158/1078-0432.22487375.v1
Contributors: Giulia Corradi; Barbara Bassani; Giorgia Simonetti; Sabina Sangaletti; Jayakumar Vadakekolathu; Maria Chiara Fontana; Martina Pazzaglia; Alessandro Gulino; Claudio Tripodo; Gianluca Cristiano et al.
Source: check_circle
Crossref

Supplementary Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells

2023-03-31 | Preprint
DOI: 10.1158/1078-0432.22487375
Contributors: Giulia Corradi; Barbara Bassani; Giorgia Simonetti; Sabina Sangaletti; Jayakumar Vadakekolathu; Maria Chiara Fontana; Martina Pazzaglia; Alessandro Gulino; Claudio Tripodo; Gianluca Cristiano et al.
Source: check_circle
Crossref

Supplementary Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells

2023-03-31 | Preprint
DOI: 10.1158/1078-0432.22487372
Contributors: Giulia Corradi; Barbara Bassani; Giorgia Simonetti; Sabina Sangaletti; Jayakumar Vadakekolathu; Maria Chiara Fontana; Martina Pazzaglia; Alessandro Gulino; Claudio Tripodo; Gianluca Cristiano et al.
Source: check_circle
Crossref

Supplementary Data from Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells

2023-03-31 | Preprint
DOI: 10.1158/1078-0432.22487372.v1
Contributors: Giulia Corradi; Barbara Bassani; Giorgia Simonetti; Sabina Sangaletti; Jayakumar Vadakekolathu; Maria Chiara Fontana; Martina Pazzaglia; Alessandro Gulino; Claudio Tripodo; Gianluca Cristiano et al.
Source: check_circle
Crossref

Signatures of immune dysfunction predict outcomes and define checkpoint blockade-unresponsive microenvironments in acute myeloid leukemia.

The Journal of clinical investigation
2022-09-13 | Journal article
DOI: 10.1172/jci159579
PMID: 36099049
Contributors: Jayakumar Vadakekolathu
Source: Self-asserted source
Jayakumar Vadakekolathu

Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy.

Cancers
2022-08-17 | Journal article
DOI: 10.3390/cancers14163975
PMID: 36010968
PMC: PMC9406384
Contributors: Jayakumar Vadakekolathu
Source: Self-asserted source
Jayakumar Vadakekolathu

Release of IFNγ by Acute Myeloid Leukemia Cells Remodels Bone Marrow Immune Microenvironment by Inducing Regulatory T Cells

Clinical Cancer Research
2022-07-15 | Journal article
DOI: 10.1158/1078-0432.CCR-21-3594
Contributors: Giulia Corradi; Barbara Bassani; Giorgia Simonetti; Sabina Sangaletti; Jayakumar Vadakekolathu; Maria Chiara Fontana; Martina Pazzaglia; Alessandro Gulino; Claudio Tripodo; Gianluca Cristiano et al.
Source: check_circle
Crossref

Hyperactive neutrophil chemotaxis contributes to anti‐tumor necrosis factor‐α treatment resistance in inflammatory bowel disease

Journal of Gastroenterology and Hepatology
2022-03 | Journal article
DOI: 10.1111/jgh.15764
Contributors: Tung On Yau; Jayakumar Vadakekolathu; Gemma Ann Foulds; Guodong Du; Benjamin Dickins; Christos Polytarchou; Sergio Rutella
Source: check_circle
Crossref

Nanobugs as Drugs: Bacterial Derived Nanomagnets Enhance Tumor Targeting and Oncolytic Activity of HSV-1 Virus.

Small (Weinheim an der Bergstrasse, Germany)
2022-01-25 | Journal article
DOI: 10.1002/smll.202104763
PMID: 35076148
Contributors: Jayakumar Vadakekolathu
Source: Self-asserted source
Jayakumar Vadakekolathu

MiR-423-5p prevents MALAT1-mediated proliferation and metastasis in prostate cancer.

Journal of experimental & clinical cancer research : CR
2022-01-11 | Journal article
DOI: 10.1186/s13046-021-02233-w
PMID: 35016717
PMC: PMC8751098
Contributors: Jayakumar Vadakekolathu
Source: Self-asserted source
Jayakumar Vadakekolathu

IL-1B drives opposing responses in primary tumours and bone metastases; harnessing combination therapies to improve outcome in breast cancer

npj Breast Cancer
2021-12 | Journal article
DOI: 10.1038/s41523-021-00305-w
Part of ISSN: 2374-4677
Source: Self-asserted source
Jayakumar Vadakekolathu

Hyperactive chemotaxis contributes to anti-TNFα treatment resistance in inflammatory bowel disease

2021-08-15 | Other
DOI: 10.1101/2021.08.15.456400
Contributors: Tung On Yau; Jayakumar Vadakekolathu; Gemma Ann Foulds; Guodong Du; Christos Polytarchou; Benjamin Dickins; Sergio Rutella
Source: check_circle
Crossref

A Novel HAGE/WT1-ImmunoBody® Vaccine Combination Enhances Anti-Tumour Responses When Compared to Either Vaccine Alone

Frontiers in Oncology
2021-06-28 | Journal article
DOI: 10.3389/fonc.2021.636977
Part of ISSN: 2234-943X
Source: Self-asserted source
Jayakumar Vadakekolathu

SARS-CoV-2 Infection Induces Psoriatic Arthritis Flares and Enthesis Resident Plasmacytoid Dendritic Cell Type-1 Interferon Inhibition by JAK Antagonism Offer Novel Spondyloarthritis Pathogenesis Insights

Frontiers in Immunology
2021-04-15 | Journal article
DOI: 10.3389/fimmu.2021.635018
Part of ISSN: 1664-3224
Source: Self-asserted source
Jayakumar Vadakekolathu

Macrophages Mediate the Antitumor Effects of the Oncolytic Virus HSV1716 in Mammary Tumors

Molecular Cancer Therapeutics
2021-03 | Journal article
DOI: 10.1158/1535-7163.mct-20-0748
Part of ISSN: 1535-7163
Part of ISSN: 1538-8514
Source: Self-asserted source
Jayakumar Vadakekolathu

Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia

Blood
2021-02-11 | Journal article
DOI: 10.1182/blood.2020007732
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Jayakumar Vadakekolathu

An Immune Senescence and Exhaustion-Related RNA Profile Predicts Clinical Outcomes in Acute Myeloid Leukemia

Blood
2020-11-05 | Journal article
DOI: 10.1182/blood-2020-134779
Part of ISSN: 0006-4971
Contributors: Jayakumar Vadakekolathu; Tung On Yau; Heidi Altmann; Sarah E. Church; Hanna A Knaus; Mark D. Minden; Jan K Davidson-Moncada; Sarah K Tasian; Martin Bornhäuser; Ivana Gojo et al.
Source: Self-asserted source
Jayakumar Vadakekolathu via Crossref Metadata Search

TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML

Blood Advances
2020-10-27 | Journal article
DOI: 10.1182/bloodadvances.2020002512
Part of ISSN: 2473-9529
Part of ISSN: 2473-9537
Source: Self-asserted source
Jayakumar Vadakekolathu

56th EASD Annual Meeting of the European Association for the Study of Diabetes

Diabetologia
2020-09 | Journal article
DOI: 10.1007/s00125-020-05221-5
Part of ISSN: 0012-186X
Part of ISSN: 1432-0428
Source: Self-asserted source
Jayakumar Vadakekolathu

Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia

Science Translational Medicine
2020-06-03 | Journal article
DOI: 10.1126/scitranslmed.aaz0463
Contributors: Jayakumar Vadakekolathu; Mark D. Minden; Tressa Hood; Sarah E. Church; Stephen Reeder; Heidi Altmann; Amy H. Sullivan; Elena J. Viboch; Tasleema Patel; Narmin Ibrahimova et al.
Source: check_circle
Crossref

PYK2 promotes HER2-positive breast cancer invasion

Journal of Experimental & Clinical Cancer Research
2019-12 | Journal article
DOI: 10.1186/s13046-019-1221-0
Part of ISSN: 1756-9966
Source: Self-asserted source
Jayakumar Vadakekolathu
grade
Preferred source (of 2)‎

An IDO1-Related 3-Gene Signature Predicts Overall Survival in Intermediate-Risk Acute Myeloid Leukemia

Blood
2019-11 | Journal article
DOI: 10.1182/blood-2019-128348
Part of ISSN: 0006-4971
Contributors: Simone Ragaini; Sarah Wagner; Giovanni Marconi; Sarah Parisi; Chiara Sartor; Jacopo Nanni; Gianluca Cristiano; Annalisa Talami; Matteo Olivi; Darina Ocadlikova et al.
Source: Self-asserted source
Jayakumar Vadakekolathu via Crossref Metadata Search

Tipifarnib Modulates Interferon (IFN)-γ-Inducible Genes in Acute Myeloid Leukemia

Blood
2019-11 | Journal article
DOI: 10.1182/blood-2019-124717
Part of ISSN: 0006-4971
Contributors: Jayakumar Vadakekolathu; Stephen Reeder; Clare Coveney; Sergio Rutella
Source: Self-asserted source
Jayakumar Vadakekolathu via Crossref Metadata Search

Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia

2019-07-26 | Other
DOI: 10.1101/702001
Contributors: Jayakumar Vadakekolathu; Mark D. Minden; Tressa Hood; Sarah E. Church; Stephen Reeder; Heidi Altmann; Amy H. Sullivan; Elena Viboch; Tasleema Patel; Narmin Ibrahimova et al.
Source: check_circle
Crossref

A parsimonious 3-gene signature predicts clinical outcomes in an acute myeloid leukemia multicohort study

Blood Advances
2019-04-23 | Journal article
DOI: 10.1182/bloodadvances.2018030726
Part of ISSN: 2473-9529
Part of ISSN: 2473-9537
Source: Self-asserted source
Jayakumar Vadakekolathu

Abstract B118: Development of a novel prostatic acid phosphatase-derived vaccine for the treatment of advanced prostate cancer

Novel Vaccine Platforms and Combinations
2019-02 | Other
DOI: 10.1158/2326-6074.cricimteatiaacr18-b118
Contributors: Pauline Le Vu; Jayakumar Vadakekolathu; Dennis Christensen; Lindy Durrant; Graham Pockley; Stephanie E.B. McArdle
Source: Self-asserted source
Jayakumar Vadakekolathu via Crossref Metadata Search

Abstract B152: Generation of monoclonal antibodies against a newly identified target for invasive prostate cancer and their use in the development of an antibody-based targeting therapy

Other Topics
2019-02 | Other
DOI: 10.1158/2326-6074.cricimteatiaacr18-b152
Contributors: Anna Di Biase; Tarik Regad; Jayakumar Vadakekolathu; Desmond Powe; Hans-Martin Jäck; Edith Roth
Source: Self-asserted source
Jayakumar Vadakekolathu via Crossref Metadata Search

Immune Gene Expression Profiling in Children and Adults with Acute Myeloid Leukemia Identifies Distinct Phenotypic Patterns

Blood 2017 130:3942
2018 | Conference paper
Source: Self-asserted source
Jayakumar Vadakekolathu

Abstract B62: Immune gene expression profiling identifies predictors of relapse in childhood acute myeloid leukemia

Tumor Microenvironment
2018-09 | Other
DOI: 10.1158/2326-6074.tumimm17-b62
Contributors: Jayakumar Vadakekolathu; Gemma A. Foulds; Tasleema Patel; Stephen Reeder; Alan Graham Pockley; Sarah K. Tasian; Sergio Rutella
Source: Self-asserted source
Jayakumar Vadakekolathu via Crossref Metadata Search

Immune-Phenotyping and Transcriptomic Profiling of Peripheral Blood Mononuclear Cells From Patients With Breast Cancer: Identification of a 3 Gene Signature Which Predicts Relapse of Triple Negative Breast Cancer

Frontiers in Immunology
2018-09-11 | Journal article
DOI: 10.3389/fimmu.2018.02028
Part of ISSN: 1664-3224
Source: Self-asserted source
Jayakumar Vadakekolathu

MTSS1 and SCAMP1 cooperate to prevent invasion in breast cancer.

Cell death & disease
2018-03 | Journal article
DOI: 10.1038/s41419-018-0364-9
PMID: 29497041
PMC: PMC5832821
Contributors: Vadakekolathu J; Al-Juboori SIK; Johnson C; Schneider A; Buczek ME; Di Biase A; Pockley AG; Ball GR; Powe DG; Regad T
Source: Self-asserted source
Jayakumar Vadakekolathu via Europe PubMed Central

Capturing the complexity of the immune microenvironment of acute myeloid leukemia with 3D biology technology.

Journal of Clinical Oncology 36(5_suppl):50-50
2018-02 | Conference paper
Source: Self-asserted source
Jayakumar Vadakekolathu

Identification and characterisation of NANOG+/ OCT-4high/SOX2+ doxorubicin-resistant stem-like cells from transformed trophoblastic cell lines.

Oncotarget
2018-01 | Journal article
DOI: 10.18632/oncotarget.24151
PMID: 29467949
PMC: PMC5805535
Contributors: Balahmar RM; Boocock DJ; Coveney C; Ray S; Vadakekolathu J; Regad T; Ali S; Sivasubramaniam S
Source: Self-asserted source
Jayakumar Vadakekolathu via Europe PubMed Central

Abstracts from the 4th ImmunoTherapy of Cancer Conference: Prague, Czech Republic. 20–22 March 2017.

Journal for immunotherapy of cancer
2017 | Journal article
PMC: PMC5374589
Contributors: Ženka J; Caisová V; Uher O; Nedbalová P; Kvardová K; Masáková K; Krejčová G; Paďouková L; Jochmanová I; Wolf KI et al.
Source: Self-asserted source
Jayakumar Vadakekolathu via Europe PubMed Central

Interferon-γ Induces Distinct mRNA and Protein Profiles in Acute and Chronic Myeloid Leukemia

Blood 2017 130:3945
2017 | Conference paper
Source: Self-asserted source
Jayakumar Vadakekolathu

Discovery and application of immune biomarkers for hematological malignancies

Expert Review of Molecular Diagnostics
2017-11-02 | Journal article
DOI: 10.1080/14737159.2017.1381560
Contributors: Dimitrios Zafeiris; Jayakumar Vadakekolathu; Sarah Wagner; Alan Graham Pockley; Graham Roy Ball; Sergio Rutella
Source: check_circle
Crossref

T-Cell Manipulation Strategies to Prevent Graft-Versus-Host Disease in Haploidentical Stem Cell Transplantation.

Biomedicines
2017-06 | Journal article
DOI: 10.3390/biomedicines5020033
PMID: 28635677
PMC: PMC5489819
Source: Self-asserted source
Jayakumar Vadakekolathu via Europe PubMed Central
grade
Preferred source (of 2)‎

A novel spontaneous model of epithelial-mesenchymal transition (EMT) using a primary prostate cancer derived cell line demonstrating distinct stem-like characteristics.

Scientific reports
2017-01 | Journal article
DOI: 10.1038/srep40633
PMID: 28094783
PMC: PMC5240554
Source: Self-asserted source
Jayakumar Vadakekolathu via Europe PubMed Central

E-MTAB-4966 - Expression profiling of a prostate cancer cell line(OPCT1) and its clonal progenies with different functional characteristics

2016 | Dataset
OTHER-ID:

E-MTAB-4966
Source: check_circle
EMBL-EBI

Membrane Hsp70 as a biomarker for aggressive prostate cancer and therapeutic target

European Journal of Cancer
2016-07-01 | Conference paper
Source: Self-asserted source
Jayakumar Vadakekolathu

Novel prostate acid phosphatase-based peptide vaccination strategy induces antigen-specific T-cell responses and limits tumour growth in mice

European Journal of Immunology
2014 | Journal article
DOI:

10.1002/eji.201343863

EID:

2-s2.0-84897989921
Contributors: Saif, J.M.S.; Vadakekolathu, J.; Rane, S.S.; Mcdonald, D.; Ahmad, M.; Mathieu, M.; Pockley, A.G.; Durrant, L.; Metheringham, R.; Rees, R.C. et al.
Source: Self-asserted source
Jayakumar Vadakekolathu via Scopus - Elsevier

Identification of tumor antigens for clinical evaluation

Tumor Immunology and Immunotherapy
2014-05 | Other
DOI:

10.1093/med/9780199676866.003.0009
Contributors: Jayakumar Vadakekolathu; Amanda K Miles; David J Boocock; Stephanie EB McArdle
Source: Self-asserted source
Jayakumar Vadakekolathu via Crossref Metadata Search

The Twelfth International Conference on Progress in Vaccination Against Cancer (PIVAC 12), Nottingham, UK, 11-13 September 2012: Insights into the dynamics of anti-tumour immunity and the development of cancer vaccines

Cancer Immunology, Immunotherapy
2013 | Journal article
DOI:

10.1007/s00262-013-1440-8

EID:

2-s2.0-84880922390
Contributors: Malhi, S.K.; Saif, J.; Vadakekolathu, J.N.
Source: Self-asserted source
Jayakumar Vadakekolathu via Scopus - Elsevier

E-MEXP-3054 - Transcription profiling of single colon cancer cell CT26

2011 | Dataset
OTHER-ID:

E-MEXP-3054
Source: check_circle
EMBL-EBI

Genetic variations and interrelationships in Vanilla planifolia and few related species as expressed by RAPD polymorphism

2008-05 | Other
DOI:

10.1007/s10722-007-9252-3

OTHER-ID:

IND44047575
Contributors: Minoo D; Jayakumar VN; Veena SS; Vimala J; Basha A; Saji KV; Nirmal Babu K; Peter KV
Source: Self-asserted source
Jayakumar Vadakekolathu via Europe PubMed Central

Peer review (14 reviews for 3 publications/grants)

Review activity for Current opinion in pharmacology. (1)
Review activity for Journal of mammary gland biology and neoplasia. (1)
Review activity for Journal of translational medicine. (12)
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