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Biography

My research program is focused on understanding how gut immune systems interface with the environment, specifically the microbial components, i.e., the microbiome, and how these interactions shape immune (and developmental) ontogeny. We also study why lysogenized bacteria, or those that carry “dormant” viruses or prophages, matter within animal microbiomes. While I am focused on understanding how secreted immune effectors evolved to shape the ecology of microbiomes, the long-term interest is to contribute to our understanding of not just the evolution of gut immunity across phyla but also how exposure to diverse microbes shapes animal development and immune maturation, and this applies to human infants (especially those born prematurely). Our research leverages simpler model systems and focuses on premature infants in the neonatal intensive care unit to address these questions better.

Activities

Employment (3)

University of South Florida: Tampa, FL, US

2024 to present | Professor (College of Medicine, Pediatrics)
Employment
Source: Self-asserted source
Larry J. Dishaw

University of South Florida: Tampa, US

2016-07 to 2023 | Associate Professor (Pediatrics)
Employment
Source: Self-asserted source
Larry J. Dishaw

University of South Florida: Tampa, Florida, US

2010 to 2016 | Assistant Professor (Pediatrics)
Employment
Source: Self-asserted source
Larry J. Dishaw

Education and qualifications (1)

Florida International University: Miami, FL, US

1997 to 2002 | PhD (Biology)
Education
Source: Self-asserted source
Larry J. Dishaw

Professional activities (2)

American Society for Microbiology: Washington, DC, US

Membership
Source: Self-asserted source
Larry J. Dishaw

American Association of Immunologists: Md., Md., US

Membership
Source: Self-asserted source
Larry J. Dishaw

Funding (4)

Collaborative Proposal: Prophages and how they manipulate model microbiomes

2023-08 to 2026-07 | Grant
National Science Foundation (Tampa, FL, US)
GRANT_NUMBER:

2226050

Source: Self-asserted source
Larry J. Dishaw

Functional consequences of bacterial-fungal dysbiosis in E/VLBW infants

2022-02-09 to 2024-01-31 | Grant
Eunice Kennedy Shriver National Institute of Child Health and Human Development (Bethesda, US)
GRANT_NUMBER: R03HD104887
Source: Self-asserted source
Larry J. Dishaw via DimensionsWizard

Investigations of an invertebrate secreted immune effector that influences microbial communities of the gut

2018-07-01 to 2022-06-30 | Grant
Directorate for Biological Sciences (Arlington, US)
GRANT_NUMBER: 1817308
Source: Self-asserted source
Larry J. Dishaw via DimensionsWizard

Role of Phages in Structuring Bacterial Communities: Ciona Intestinalis as a Model Organism

2015-05-01 to 2018-04-30 | Grant
National Science Foundation - Directorate for Biological Sciences (Arlington, US)
GRANT_NUMBER: 1456301
Source: Self-asserted source
Larry J. Dishaw via DimensionsWizard

Works (50 of 51)

Items per page:
Page 1 of 2

Associations of microbial diversity with age and other clinical variables among pediatric chronic rhinosinusitis (CRS) patients

2022-10-21 | Preprint
Contributors: Shen Jean Lim; Warit Jithpratuck; Kathleen Wasylik; Panida Sriaroon; Larry J. Dishaw
Source: check_circle
Crossref

Secreted immunoglobulin domain effector molecules of invertebrates and management of gut microbial ecology

Immunogenetics
2022-02 | Journal article
Contributors: Assunta Liberti; Ojas Natarajan; Celine Grace F. Atkinson; Larry J. Dishaw
Source: check_circle
Crossref

Contributors to Dysbiosis in Very-Low-Birth-Weight Infants

JOGNN - Journal of Obstetric, Gynecologic, and Neonatal Nursing
2020 | Journal article
EID:

2-s2.0-85084342461

Part of ISBN:

15526909 08842175

Contributors: Groer, M.W.; Miller, E.M.; D'Agata, A.; Ho, T.T.B.; Dutra, S.V.; Yoo, J.Y.; Yee, A.L.; Gilbert, J.A.; Dishaw, L.J.
Source: Self-asserted source
Larry J. Dishaw via Scopus - Elsevier
grade
Preferred source (of 2)‎

Predicted metabolic pathway distributions in stool bacteria in very-low-birth-weight infants: Potential relationships with NICU faltered growth

Nutrients
2020 | Journal article
EID:

2-s2.0-85084344199

Part of ISBN:

20726643

Contributors: Groer, M.; Miller, E.M.; Sarkar, A.; Dishaw, L.J.; Dutra, S.V.; Yoo, J.Y.; Morgan, K.; Ji, M.; Ho, T.
Source: Self-asserted source
Larry J. Dishaw via Scopus - Elsevier
grade
Preferred source (of 2)‎

The development of intestinal dysbiosis in anemic preterm infants

Journal of Perinatology
2020 | Journal article
EID:

2-s2.0-85078679095

Part of ISBN:

14765543 07438346

Contributors: Ho, T.T.B.; Kumar, A.; Louis-Jacques, A.F.; Dishaw, L.J.; Yee, A.L.; Groer, M.W.
Source: Self-asserted source
Larry J. Dishaw via Scopus - Elsevier
grade
Preferred source (of 2)‎

A Soluble Immune Effector Binds Both Fungi and Bacteria via Separate Functional Domains.

Frontiers in Immunology
2019-03-06 | Journal article
Source: Self-asserted source
Larry J. Dishaw
grade
Preferred source (of 3)‎

Longitudinal Microbiome Composition and Stability Correlate with Increased Weight and Length of Very-Low-Birth-Weight Infants.

mSystems
2019-01-01 | Journal article
Source: Self-asserted source
Larry J. Dishaw
grade
Preferred source (of 2)‎

Unprecedented Diversity of ssDNA Phages from the Family Microviridae Detected within the Gut of a Protochordate Model Organism (Ciona robusta)

Viruses
2018-07 | Journal article
Part of ISSN: 1999-4915
Contributors: Alexandria Creasy; Karyna Rosario; Brittany Leigh; Larry Dishaw; Mya Breitbart
Source: Self-asserted source
Larry J. Dishaw via Crossref Metadata Search

Genome Sequence of PM2-Like Phage Cr39582, Induced from a Pseudoalteromonas sp. Isolated from the Gut of Ciona robusta

Genome Announcements
2018-05 | Journal article
Part of ISSN: 2169-8287
Contributors: Brittany A. Leigh; Mya Breitbart; Hanna M. Oksanen; Dennis H. Bamford; Larry J. Dishaw
Source: Self-asserted source
Larry J. Dishaw via Crossref Metadata Search

The gut virome of the protochordate model organism, Ciona intestinalis subtype A

Virus Research
2018-01 | Journal article
Part of ISSN: 0168-1702
Contributors: Brittany A. Leigh; Anni Djurhuus; Mya Breitbart; Larry J. Dishaw
Source: Self-asserted source
Larry J. Dishaw via Crossref Metadata Search

Isolation and Characterization of a Shewanella Phage-Host System from the Gut of the Tunicate, Ciona intestinalis

Viruses
2017-03 | Journal article
Source: Self-asserted source
Larry J. Dishaw

Chitin protects gut epithelial barrier in a protochordate model of DSS-induced colitis

Biology Open
2017-01-01 | Journal article
Contributors: Assunta Liberti; Ivana Zucchetti; Daniela Melillo; Diana Skapura; Yoshimi Shibata; Rosaria De Santis; Maria Rosaria Pinto; Gary W. Litman; Larry J. Dishaw
Source: check_circle
Crossref

Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria

Nature Communications
2016 | Journal article
Source: Self-asserted source
Larry J. Dishaw

Generation of Germ-Free Ciona intestinalis for Studies of Gut-Microbe Interactions

Frontiers in Microbiology
2016-12 | Journal article
Source: Self-asserted source
Larry J. Dishaw

An immune effector system in the protochordate gut sheds light on fundamental aspects of vertebrate immunity

Results and Problems in Cell Differentiation
2015 | Book chapter
EID:

2-s2.0-84946570026

Part of ISBN:

18610412 00801844

Contributors: Liberti, A.; Leigh, B.; De Santis, R.; Pinto, M.R.; Cannon, J.P.; Dishaw, L.J.; Litman, G.W.
Source: Self-asserted source
Larry J. Dishaw via Scopus - Elsevier
grade
Preferred source (of 2)‎

Development of a Serological Assay for the Sea Lion (Zalophus californianus) Anellovirus, ZcAV

Scientific Reports
2015 | Journal article
DOI:

10.1038/srep09637

WOSUID:

WOS:000354307600001

Contributors: Fahsbender, Elizabeth; Rosario, Karyna; Cannon, John P.; Gulland, Frances; Dishaw, Larry J.; Breitbart, Mya
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Early histocompatibility: color the mechanism green and red

Current Biology
2015 | Journal article
Source: Self-asserted source
Larry J. Dishaw

Massive expansion and functional divergence of innate immune genes in a protostome

Scientific Reports
2015 | Journal article
DOI:

10.1038/srep08693

WOSUID:

WOS:000350350500014

Contributors: Zhang, Linlin; Li, Li; Guo, Ximing; Litman, Gary W.; Dishaw, Larry J.; Zhang, Guofan
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Development of the preterm infant gut microbiome: A research priority

Microbiome
2014 | Journal article
EID:

2-s2.0-84938484921

Part of ISBN:

20492618

Contributors: Groer, M.W.; Luciano, A.A.; Dishaw, L.J.; Ashmeade, T.L.; Miller, E.; Gilbert, J.A.
Source: Self-asserted source
Larry J. Dishaw via Scopus - Elsevier
grade
Preferred source (of 2)‎

Expression of Ciona intestinalis Variable Region-Containing Chitin-Binding Proteins during Development of the Gastrointestinal Tract and Their Role in Host-Microbe Interactions

Plos One
2014 | Journal article
DOI:

10.1371/journal.pone.0094984

WOSUID:

WOS:000336655700023

Contributors: Liberti, Assunta; Melillo, Daniela; Zucchetti, Ivana; Natale, Lenina; Dishaw, Larry J.; Litman, Gary W.; De Santis, Rosaria; Pinto, Maria Rosaria
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Immune-directed support of rich microbial communities in the gut has ancient roots

Developmental and Comparative Immunology
2014 | Journal article
DOI:

10.1016/j.dci.2014.06.011

WOSUID:

WOS:000342275400005

Contributors: Dishaw, Larry J.; Cannon, John P.; Litman, Gary W.; Parker, William
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

The Gut of Geographically Disparate Ciona intestinalis Harbors a Core Microbiota

Plos One
2014 | Journal article
DOI:

10.1371/journal.pone.0093386

WOSUID:

WOS:000334103000066

Contributors: Dishaw, Larry J.; Flores-Torres, Jaime; Lax, Simon; Gemayel, Kristina; Leigh, Brittany; Melillo, Daniela; Mueller, M. Gail; Natale, Lenina; Zucchetti, Ivana; De Santis, Rosaria et al.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Changing views of the evolution of immunity

Frontiers in Immunology
2013 | Journal article
EID:

2-s2.0-84883812636

Part of ISBN:

16643224

Contributors: Dishaw, L.J.; Litman, G.W.
Source: Self-asserted source
Larry J. Dishaw via Scopus - Elsevier
grade
Preferred source (of 2)‎

Histocompatibility: Clarifying Fusion Confusion

Current Biology
2013 | Journal article
DOI:

10.1016/j.cub.2013.08.048

WOSUID:

WOS:000326317300015

Contributors: Litman, Gary W.; Dishaw, Larry J.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

A basal chordate model for studies of gut microbial immune interactions

Frontiers in Immunology
2012 | Journal article
EID:

2-s2.0-84874177229

Part of ISBN:

16643224

Contributors: Dishaw, L.J.; Flores-Torres, J.A.; Mueller, M.G.; Karrer, C.R.; Skapura, D.P.; Melillo, D.; Zucchetti, I.; De Santis, R.; Pinto, M.R.; Litman, G.W.
Source: Self-asserted source
Larry J. Dishaw via Scopus - Elsevier
grade
Preferred source (of 2)‎

The amphioxus genome provides unique insight into the evolution of immunity

Briefings in Functional Genomics
2012 | Journal article
DOI:

10.1093/bfgp/els007

WOSUID:

WOS:000301972300009

Contributors: Dishaw, Larry J.; Haire, Robert N.; Litman, Gary W.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions

Proceedings of the National Academy of Sciences of the United States of America
2011 | Journal article
DOI:

10.1073/pnas.1109687108

WOSUID:

WOS:000295536000054

Contributors: Dishaw, Larry J.; Giacomelli, Stefano; Melillo, Daniela; Zucchetti, Ivana; Haire, Robert N.; Natale, Lenina; Russo, Nicola A.; De Santis, Rosaria; Litman, Gary W.; Pinto, Maria Rosaria
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Transfection-Based Genomic Readout for Identifying Rare Transcriptional Splice Variants

Immune Receptors: Methods and Protocols
2011 | Journal article
DOI:

10.1007/978-1-61779-139-0_17

WOSUID:

WOS:000292990200017

Contributors: Dishaw, Larry J.; Mueller, M. Gail; Haire, Robert N.; Litman, Gary W.; Rast, JP; Booth, JWD
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Recognition of additional roles for immunoglobulin domains in immune function

Semin Immunol
2010 | Journal article
DOI:

S1044-5323(09)00121-3 [pii] 10.1016/j.smim.2009.11.006

Contributors: Cannon, J. P.; Dishaw, L. J.; Haire, R. N.; Litman, R. T.; Ostrov, D. A.; Litman, G. W.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID
grade
Preferred source (of 2)‎

The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus

Immunogenetics
2010 | Journal article
DOI:

10.1007/s00251-010-0464-x

WOSUID:

WOS:000281396500006

Contributors: Dishaw, Larry J.; Ota, Tatsuya; Mueller, M. Gail; Cannon, John P.; Haire, Robert N.; Gwatney, Natasha R.; Litman, Ronda T.; Litman, Gary W.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

FOXP3 expression following bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning

Immunol Res
2009 | Journal article
DOI:

10.1007/s12026-009-8112-y

Contributors: Dorsey, M. J.; Petrovic, A.; Morrow, M. R.; Dishaw, L. J.; Sleasman, J. W.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID
grade
Preferred source (of 2)‎

Invertebrate allorecognition: the origins of histocompatibility

Curr Biol
2009 | Journal article
DOI:

S0960-9822(09)00745-3 [pii] 10.1016/j.cub.2009.02.035

Contributors: Dishaw, L. J.; Litman, G. W.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID
grade
Preferred source (of 2)‎

Genomic complexity of the variable region-containing chitin-binding proteins in amphioxus

BMC Genet
2008 | Journal article
DOI:

1471-2156-9-78 [pii] 10.1186/1471-2156-9-78

Contributors: Dishaw, L. J.; Mueller, M. G.; Gwatney, N.; Cannon, J. P.; Haire, R. N.; Litman, R. T.; Amemiya, C. T.; Ota, T.; Rowen, L.; Glusman, G. et al.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID
grade
Preferred source (of 2)‎

Novel genes dramatically alter regulatory network topology in amphioxus

Genome Biol
2008 | Journal article
DOI:

gb-2008-9-8-r123 [pii] 10.1186/gb-2008-9-8-r123

Contributors: Zhang, Q.; Zmasek, C. M.; Dishaw, L. J.; Mueller, M. G.; Ye, Y.; Litman, G. W.; Godzik, A.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID
grade
Preferred source (of 2)‎

The amphioxus genome illuminates vertebrate origins and cephalochordate biology

Genome Res
2008 | Journal article
DOI:

gr.073676.107 [pii] 10.1101/gr.073676.107

Contributors: Holland, L. Z.; Albalat, R.; Azumi, K.; Benito-Guti�rrez, E.; Blow, M. J.; Bronner-Fraser, M.; Brunet, F.; Butts, T.; Candiani, S.; Dishaw, L. J. et al.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID
grade
Preferred source (of 2)‎

The amphioxus genome illuminates vertebrate origins and cephalochordate biology (Genome Research (2008) 18, (1100-1111))

Genome Research
2008 | Journal article
EID:

2-s2.0-48949100896

Part of ISBN:

10889051 15495469

Contributors: Holland, L.Z.; Albalat, R.; Azumi, K.; Benito-Gutiérrez, È.; Blow, M.J.; Bronner-Fraser, M.; Brunet, F.; Butts, T.; Candiani, S.; Dishaw, L.J. et al.
Source: Self-asserted source
Larry J. Dishaw via Scopus - Elsevier
grade
Preferred source (of 2)‎

Alternative mechanisms of immune receptor diversity

Curr Opin Immunol
2007 | Journal article
DOI:

S0952-7915(07)00113-6 [pii] 10.1016/j.coi.2007.07.001

Contributors: Litman, G. W.; Dishaw, L. J.; Cannon, J. P.; Haire, R. N.; Rast, J. P.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID
grade
Preferred source (of 2)‎

Foxp3 expression following bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning

Clinical Immunology
2007 | Journal article
DOI:

10.1016/j.clim.2007.03.299

WOSUID:

WOS:000247137200111

Contributors: Dorsey, Morna J.; Petrovic, Aleksandra; Morrow, Matthew R.; Sleasman, John W.; Dishaw, Larry J.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors

Immunologic Research
2007 | Journal article
DOI:

10.1007/s12026-007-0014-2

WOSUID:

WOS:000250372300034

Contributors: Litman, Gary W.; Cannon, John P.; Dishaw, Larry J.; Haire, Robert N.; Eason, Donna D.; Yoder, Jeffrey A.; Prada, Jose Hernandez; Ostrov, David A.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Characterization and phylogenetic analysis of a cnidarian LMP X-like cDNA

Immunogenetics
2006 | Journal article
DOI:

10.1007/s00251-006-0105-6

WOSUID:

WOS:000238014900014

Contributors: Dishaw, LJ; Herrera, ML; Bigger, CH
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Characterization of a C3-like cDNA in a coral: phylogenetic implications

Immunogenetics
2005 | Journal article
DOI:

10.1007/s00251-005-0005-1

WOSUID:

WOS:000232340200007

Contributors: Dishaw, LJ; Smith, SL; Bigger, CH
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Reconstructing immune phylogeny: new perspectives

Nat Rev Immunol
2005 | Journal article
DOI:

nri1712 [pii] 10.1038/nri1712

Contributors: Litman, G. W.; Cannon, J. P.; Dishaw, L. J.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID
grade
Preferred source (of 2)‎

C3 and factor I isoforms in the nurse shark, Ginglymostoma cirratum

Faseb Journal
2003 | Journal article
WOSUID:

WOS:000182367000510

Contributors: Nakamura, K; Shin, DH; Dishaw, LJ; Smith, SL
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Molecular characterization of serine proteases in a coral

Faseb Journal
2003 | Journal article
WOSUID:

WOS:000182367000242

Contributors: Ramon, HE; Dishaw, LJ; Gomez, ME; Herrera, ML; Bigger, CH
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Phylogenetic implications of two factor B-like genes from two shark species

Faseb Journal
2003 | Journal article
WOSUID:

WOS:000182367000513

Contributors: Smith, SL; Shin, DH; Dishaw, LJ; Webb, B
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Role of Pax genes in eye evolution: A cnidarian PaxB gene uniting Pax2 and Pax6 functions

Developmental Cell
2003 | Journal article
DOI:

10.1016/S1534-5807(03)00325-3

WOSUID:

WOS:000186544400014

Contributors: Kozmik, Z; Daube, M; Frei, E; Norman, B; Kos, L; Dishaw, LJ; Noll, M; Piatigorsky, J
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Ancient origins for the C3-like ancestor of complement components C3/C4/C5

International Immunopharmacology
2002 | Journal article
WOSUID:

BIOSIS:PREV200200597360

Contributors: DISHAW, L. J.; BIGGER, C. H.; SMITH, S. L.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

Evidence for an ancestral C3-like protein in a gorgonian coral, Swiftia exserta

Faseb Journal
2002 | Journal article
WOSUID:

WOS:000174533603786

Contributors: Dishaw, LJ; Herrera, ML; Smith, SL; Bigger, CH
Source: Self-asserted source
Larry J. Dishaw via ResearcherID

J3-crystallin of the jellyfish lens: similarity to saposins

Proc Natl Acad Sci U S A
2001 | Journal article
DOI:

98/22/12362 [pii] 10.1073/pnas.231310698

Contributors: Piatigorsky, J.; Norman, B.; Dishaw, L. J.; Kos, L.; Horwitz, J.; Steinbach, P. J.; Kozmik, Z.
Source: Self-asserted source
Larry J. Dishaw via ResearcherID
grade
Preferred source (of 2)‎

Sequence and phylogenetic analysis of partial cDNA clones from a coral, encoding a thiolester-containing A2M/C3-like protein.

Faseb Journal
2001 | Journal article
WOSUID:

WOS:000167438103941

Contributors: Dishaw, LJ; Smith, SL; Bigger, CH
Source: Self-asserted source
Larry J. Dishaw via ResearcherID
Items per page:
Page 1 of 2

Peer review (8 reviews for 5 publications/grants)

Review activity for Applied and environmental microbiology. (2)
Review activity for Communications biology. (1)
Review activity for Microbiome (3)
Review activity for Nature immunology. (1)
Review activity for Philosophical transactions. (1)