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Works (10)

The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation

Nature Neuroscience
2023-12 | Journal article
DOI: 10.1038/s41593-023-01480-8
Contributors: Maxine R. Nelson; Peng Liu; Ayushi Agrawal; Oscar Yip; Jessica Blumenfeld; Michela Traglia; Min Joo Kim; Nicole Koutsodendris; Antara Rao; Brian Grone et al.
Source: check_circle
Crossref

APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release

Cell Reports
2023-10-19 | Journal article
DOI: 10.1016/j.celrep.2023.113252
Part of ISSN: 2211-1247
Contributors: Nicole Koutsodendris; Jessica Blumenfeld; Ayushi Agrawal; Michela Traglia; Oscar Yip; Antara Rao; Min Joo Kim; Maxine R. Nelson; Yung-Hua Wang; Brian Grone et al.
Source: Self-asserted source
Nicole Koutsodendris

Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits

Nature Aging
2023-02-20 | Journal article
DOI: 10.1038/s43587-023-00368-3
Contributors: Nicole Koutsodendris; Jessica Blumenfeld; Ayushi Agrawal; Michela Traglia; Brian Grone; Misha Zilberter; Oscar Yip; Antara Rao; Maxine R. Nelson; Yanxia Hao et al.
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Crossref

Apolipoprotein E and Alzheimer's Disease: Findings, Hypotheses, and Potential Mechanisms

Annual Review of Pathology: Mechanisms of Disease
2022-01-24 | Journal article
DOI: 10.1146/annurev-pathmechdis-030421-112756
Part of ISSN: 1553-4006
Part of ISSN: 1553-4014
Source: Self-asserted source
Nicole Koutsodendris

Dentate gyrus and CA3 GABAergic interneurons bidirectionally modulate signatures of internal and external drive to CA1

Cell Reports
2021-12-28 | Journal article
DOI: 10.1016/j.celrep.2021.110159
Part of ISSN: 2211-1247
Source: Self-asserted source
Nicole Koutsodendris

Experimental and real-world evidence supporting the computational repurposing of bumetanide for APOE4-related Alzheimer’s disease

Nature Aging
2021-10 | Journal article
DOI: 10.1038/s43587-021-00122-7
Part of ISSN: 2662-8465
Source: Self-asserted source
Nicole Koutsodendris

Neuronal ApoE upregulates MHC-I expression to drive selective neurodegeneration in Alzheimer’s disease

Nature Neuroscience
2021-06 | Journal article
DOI: 10.1038/s41593-021-00851-3
Contributors: Kelly A. Zalocusky; Ramsey Najm; Alice L. Taubes; Yanxia Hao; Seo Yeon Yoon; Nicole Koutsodendris; Maxine R. Nelson; Antara Rao; David A. Bennett; Jason Bant et al.
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Crossref

In Vivo Chimeric Alzheimer’s Disease Modeling of Apolipoprotein E4 Toxicity in Human Neurons

Cell Reports
2020-07 | Journal article
DOI: 10.1016/j.celrep.2020.107962
Part of ISSN: 2211-1247
Source: Self-asserted source
Nicole Koutsodendris
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Small molecule inhibition of PIKFYVE kinase rescues gain- and loss-of-function C9ORF72 ALS/FTD disease processes in vivo

bioRxiv
2019-06-28 | Journal article
DOI: 10.1101/685800
Source: Self-asserted source
Nicole Koutsodendris

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

Nature Medicine
2018-03 | Journal article
DOI: 10.1038/nm.4490
Part of ISSN: 1078-8956
Part of ISSN: 1546-170X
Source: Self-asserted source
Nicole Koutsodendris
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