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Biography

Tao Ye obtained his PhD from Queen's University, Belfast (QUB) (1993). After pursuing a post-doctoral stay (1993-1994) with Professor Tony McKervey at QUB, he moved to Nottingham University (1994-1998) as a "Realising our Potential Award" (ROPA) fellow to engage in the total synthesis of marine natural products, working with Professor Gerry Pattenden, FRS. He started his independent career in 1998, initially at The University of Hong Kong and then joined The Hong Kong Polytechnic University in 2001. In 2015, he moved to Peking University Shenzhen Graduate School where as a Professor of Chemical Biology and currently serves as Deputy Dean of the School of Chemical Biology & Biotechnology. His research interests span the disciplines of natural product synthesis, chemical biology, synthetic biology and drug discovery, which include the discovery and development of new agents of medicinal value through major advances in chemical synthesis and biosynthesis. In addition to the completion of total synthesis of 80 natural products, he is well-known for contributions to the structural revision of the misassigned natural products. He received a "Xiaoyu Hu Memorial Award”, a “WuXi PharmaTech Life Science and Chemistry Award”, and has been admitted as a Fellow of the Royal Society of Chemistry.

Activities

Employment (5)

Peking University Shenzhen Graduate School: Nanshan, Shenzhen, CN

2015 to present | Professor & Deputy Dean (Chemical Biology & Biotechnology)
Employment
Source: Self-asserted source
Tao Ye

Hong Kong Polytechnic University: Kowloon, HK

2002 to 2015 | Associate Professor (Applied Biology & Chemical Technology)
Employment
Source: Self-asserted source
Tao Ye

University of Hong Kong: Hong Kong, HK

1998 to 2001 | Research Assistant Professor (Chemistry)
Employment
Source: Self-asserted source
Tao Ye

University of Nottingham: Nottingham, Nottingham, GB

1994 to 1998 | ROPA Fellow (Chemistry)
Employment
Source: Self-asserted source
Tao Ye

Queen's University Belfast: Belfast, Belfast, GB

1993 to 1994 | Postdoc (Chemistry)
Employment
Source: Self-asserted source
Tao Ye

Education and qualifications (1)

Queen's University Belfast: Belfast, Belfast, GB

1989 to 1993 | PhD (Chemistry)
Education
Source: Self-asserted source
Tao Ye

Works (50 of 182)

Items per page:
Page 1 of 4

Synergy of prediction rule and total synthesis in solving the stereochemical puzzle of eucalactam B

Organic Chemistry Frontiers
2025 | Journal article
Contributors: Chenqi Wang; Junyang Liu; Tao Ye
Source: check_circle
Crossref

Selective Synthesis of Cyclopeptides with a 2-Oxindole or 3a-Hydroxy-hexahydropyrrolo-[2,3-b]indole Structure by Cytochrome P450 Enzymes

Journal of the American Chemical Society
2025-01-29 | Journal article
Contributors: Chao Li; Junying Ma; Lu Guo; Chao Xu; Zijian Zhong; Pengwei Li; Yue Tang; Wenzhao Wang; Defeng Li; Tao Ye et al.
Source: check_circle
Crossref

Towards the total synthesis of mandelalide B: construction of the tetrahydrofuran/α-hydroxyl lactone fragment

Organic Chemistry Frontiers
2024 | Journal article
Contributors: Jia-Lei Yan; Jie Yu; Yingying Cheng; Mingze Yang; Zhengshuang Xu; Tao Ye
Source: check_circle
Crossref

Total Synthesis and Stereochemical Assignment of Roselipin 1A

Precision Chemistry
2024-12-10 | Journal article
Contributors: Yangyang Jiang; Junyang Liu; Yian Guo; Tao Ye
Source: check_circle
Crossref

Total Synthesis of Rhizopodin Enabled by a Late-Stage Oxazole Ring Formation Strategy

Organic Letters
2024-10-18 | Journal article
Contributors: Junyang Liu; Kai Chen; Yian Guo; Ying Chen; Tao Ye
Source: check_circle
Crossref

Total Syntheses and Stereochemical Assignment of Acremolides A and B

Molecules
2024-07-30 | Journal article
Contributors: Yi Xiao; Junyang Liu; Yangyang Jiang; Yian Guo; Tao Ye
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Synergy of Prediction Rule and Total Synthesis in Solving the Stereochemical Puzzle of Valactamides

Precision Chemistry
2024-03-25 | Journal article
Contributors: Tao Zhang; Jiaxuan Feng; Hideaki Oikawa; Yian Guo; Tao Ye
Source: check_circle
Crossref

Total Synthesis of Incarnatapeptins A and B

Angewandte Chemie
2024-02-26 | Journal article
Contributors: Feipeng Han; Jie Li; Shupeng Li; Zhuo Wang; Yian Guo; Tao Ye
Source: check_circle
Crossref

Total Synthesis of Incarnatapeptins A and B

Angewandte Chemie International Edition
2024-02-26 | Journal article
Contributors: Feipeng Han; Jie Li; Shupeng Li; Zhuo Wang; Yian Guo; Tao Ye
Source: check_circle
Crossref

Total Synthesis of Nicrophorusamide A and Structural Disproof of the Proposed Noursamycin A

Molecules
2023-11-06 | Journal article
Contributors: Xiaoyun Liao; Shupeng Li; Yian Guo; Tao Ye
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Total Syntheses of Colletopeptide A and Colletotrichamide A

Molecules
2023-10-20 | Journal article
Contributors: Jing Chen; Yangyang Jiang; Jialei Yan; Chao Xu; Tao Ye
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Design and Synthesis of Novel Helix Mimetics Based on the Covalent H-Bond Replacement and Amide Surrogate

Molecules
2023-01-12 | Journal article
Contributors: Junyang Liu; Shoubin Tang; Jia-Lei Yan; Tao Ye
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Assigning the stereochemical structures of aurantinin A and B with the assistance of biosynthetic investigations

Organic Chemistry Frontiers
2022 | Journal article
Contributors: Dacheng Wang; Pengwei Li; Jia-Lei Yan; Huijin Mao; Lilu Liu; Min Wang; Meng Chen; Tao Ye; Yihua Chen
Source: check_circle
Crossref

Total synthesis of thioamycolamide A using diastereoselective sulfa-Michael addition as the key step

Organic Chemistry Frontiers
2022 | Journal article
Contributors: Yi Xiao; Yangyang Jiang; Chao Xu; Pratanphorn Nakliang; Sanghee Yoon; Sun Choi; Yian Guo; Tao Ye
Source: check_circle
Crossref

Total Synthesis of des-Thiomethyllooekeyolide A

Organic Letters
2022-10-14 | Journal article
Contributors: Junyang Liu; Ying Chen; Hendrik Luesch; Tao Ye
Source: check_circle
Crossref

Extrasynaptic NMDA Receptors Bidirectionally Modulate Intrinsic Excitability of Inhibitory Neurons

The Journal of Neuroscience
2022-04-13 | Journal article
Contributors: Lulu Yao; Yi Rong; Xiaoyan Ma; Haifu Li; Di Deng; Yongjun Chen; Sungchil Yang; Tao Peng; Tao Ye; Feixue Liang et al.
Source: check_circle
Crossref

Biochemistry-Guided Prediction of the Absolute Configuration of Fungal Reduced Polyketides

Angew. Chem. Int. Ed.
2021-09-14 | Journal article
Source: Self-asserted source
Tao Ye

Total Synthesis of Pagoamide A

Molecules
2021-07 | Journal article | Author
Contributors: Fusong Wu; Jie Yu; Jiawei Meng; Yian Guo; Tao Ye
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Total Synthesis and Structural Reassignment of Laingolide A

Marine Drugs
2021-04-27 | Journal article
Source: Self-asserted source
Tao Ye

Biosynthesis of Cyclochlorotine: Identification of the Genes Involved in Oxidative Transformations and Intramolecular O,N-Transacylation

Organic Letters
2021-04-02 | Journal article
Contributors: Yulu Jiang; Taro Ozaki; Chengwei Liu; Yuya Igarashi; Ying Ye; Shoubin Tang; Tao Ye; Jun-ichi Maruyama; Atsushi Minami; Hideaki Oikawa
Source: check_circle
Crossref

Total Synthesis and Biological Evaluation of Kakeromamide A and Its Analogues

Frontiers in Chemistry 2020, 8, doi: 10.3389/fchem.2020.00410
2020 | Journal article
Source: Self-asserted source
Tao Ye

Total synthesis of antiallergic bicyclic peptide seongsanamide A

Organic Chemistry Frontiers
2020 | Journal article
Contributors: Feipeng Han; Yian Guo; Tao Ye
Source: check_circle
Crossref

Nine-Step Total Synthesis and Biological Evaluation of Rhizonin A

Chinese Journal of Chemistry 2020, 38, 1280-1284
2020-10-17 | Journal article
Source: Self-asserted source
Tao Ye

Asymmetric Total Syntheses of Kopsane Alkaloids via a PtCl2‐Catalyzed Intramolecular [3+2] Cycloaddition

Angewandte Chemie International Edition
2020-07-27 | Journal article
Contributors: Xuelei Jia; Honghui Lei; Feipeng Han; Tao Zhang; Ying Chen; Zhengshuang Xu; Pratanphorn Nakliang; Sun Choi; Yian Guo; Tao Ye
Source: check_circle
Crossref

Asymmetric Total Syntheses of Kopsane Alkaloids via a PtCl2‐Catalyzed Intramolecular [3+2] Cycloaddition

Angewandte Chemie
2020-07-27 | Journal article
Contributors: Xuelei Jia; Honghui Lei; Feipeng Han; Tao Zhang; Ying Chen; Zhengshuang Xu; Pratanphorn Nakliang; Sun Choi; Yian Guo; Tao Ye
Source: check_circle
Crossref

Total synthesis of antiallergic bicyclic peptide seongsanamide A

Organic Chemistry Frontiers 2020, 7, 1658-1662
2020-05-26 | Journal article
Source: Self-asserted source
Tao Ye

Asymmetric Total Syntheses of Kopsane Alkaloids via a PtCl2-Catalyzed Intramolecular [3+2] Cycloaddition

Angew. Chem. Int. Ed. 2020, 59, 12832-6
2020-05-25 | Journal article
Source: Self-asserted source
Tao Ye

Total Synthesis of Dysoxylactam A

Organic Letters
2020-03-06 | Journal article
Contributors: Mingze Yang; Wenquan Peng; Yian Guo; Tao Ye
Source: check_circle
Crossref

Proteomic study reveals the involvement of energy metabolism in the fast antidepressant effect of (2R, 6R)-hydroxy norketamine

Proteomics - Clinical Applications
2020-02-21 | Journal article
Source: Self-asserted source
Tao Ye

Total Synthesis of Dysoxylactam

Organic Letters, 2020, 22, 1776-1779
2020-02-12 | Journal article
Source: Self-asserted source
Tao Ye

Reductase of Mutanobactin Synthetase Triggers Sequential C–C Macrocyclization, C–S Bond Formation, and C–C Bond Cleavage

Organic Letters
2020-02-07 | Journal article
Contributors: Min Wang; Zhoujie Xie; Shoubin Tang; Ee Ling Chang; Yue Tang; Zhengyan Guo; Yinglu Cui; Bian Wu; Tao Ye; Yihua Chen
Source: check_circle
Crossref

Reductase of Mutanobactin Synthetase Triggers Sequential C−C Macrocyclization, C−S Bond Formation, and C−C Bond Cleavage

Org. Lett. 2020, 22, 960-4
2020-01-09 | Journal article
Source: Self-asserted source
Tao Ye

Solution-phase total synthesis of teixobactin

Organic & Biomolecular Chemistry
2019 | Journal article
Contributors: Bowen Gao; Sigui Chen; Yun Nan Hou; Yong Juan Zhao; Tao Ye; Zhengshuang Xu
Source: check_circle
Crossref

Total Synthesis of Endolides A and B

Synlett
2019-12 | Journal article
Contributors: Langlang Liu; Yian Guo; Qingchao Liu; Ranjala Ratnayake; Hendrik Luesch; Tao Ye
Source: check_circle
Crossref

Total Synthesis of Hoiamide A Using an Evans–Tishchenko Reaction as a Key Step

Organic Letters
2019-07-19 | Journal article
Contributors: Yian Guo; Jingjing Zhou; Bowen Gao; Meng Zhao; Jia-Lei Yan; Zhengshuang Xu; Sun Choi; Tao Ye
Source: check_circle
Crossref

Total Synthesis of Hoiamide A Using an Evans-Tishchenko Reaction As a Key Step

Org. Lett. 2019, 21, 5471-4
2019-07-05 | Journal article
Source: Self-asserted source
Tao Ye

Total Synthesis of Psymberin (Irciniastatin A)

Organic Letters
2019-05-17 | Journal article
Contributors: Jie Yu; Mingze Yang; Yian Guo; Tao Ye
Source: check_circle
Crossref

Total Synthesis of Psymberin (Irciniastatin A)

Org. Lett. 2019, 21, 3670-3673
2019-05-07 | Journal article
Source: Self-asserted source
Tao Ye

Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria

Organic Letters
2019-03-15 | Journal article
Contributors: Xiao Liang; Danmeng Luo; Jia-Lei Yan; Mohammad A. Rezaei; Lilibeth A. Salvador-Reyes; Sarath P. Gunasekera; Chenglong Li; Tao Ye; Valerie J. Paul; Hendrik Luesch
Source: check_circle
Crossref

Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria

Org. Lett. 2019, 21, 1622–1626
2019-02-19 | Journal article
Source: Self-asserted source
Tao Ye

Isolation, Structure Elucidation and Biological Evaluation of Lagunamide D: A New Cytotoxic Macrocyclic Depsipeptide from Marine Cyanobacteria

Mar. Drugs 2019, 17, 83
2019-02-01 | Journal article
Source: Self-asserted source
Tao Ye

Chemical and Metagenomic Studies of the Lethal Black Band 2 Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive 3 Mixed Polyketide/Peptide Macrocycles

J. Nat. Prod. 2019, 82, 111-121
2019-01-13 | Journal article
Source: Self-asserted source
Tao Ye

Solution-Phase Total Synthesis of Teixobactin

Org. Biomol. Chem. 2019, 16, 1141-1153
2019-01-02 | Journal article
Source: Self-asserted source
Tao Ye

Discovery and Characterization of Brintonamides A‒E, Novel Dual Protease and GPCR Modulators from a Marine Cyanobacterium Targeting Breast Cancer Metastasis

J. Med. Chem. 2018, 61, 6364-6378
2018 | Journal article
Source: Self-asserted source
Tao Ye

Formal Synthesis of Kanamienamide

Synlett, 2018, 29, 964-8
2018 | Journal article
Source: Self-asserted source
Tao Ye

Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids

J. Am. Chem, Soc. 2018, 140, 2067-2071.
2018 | Journal article
Source: Self-asserted source
Tao Ye

Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii

Bioorg. Med. Chem. Lett. 2018, 28, 2206-2209
2018 | Journal article
Source: Self-asserted source
Tao Ye

Sameuramide A, a new cyclic depsipeptide isolated from an ascidian of the family Didemnidae

Bioorg. Med. Chem. 2018, 26, 3852-3857
2018 | Journal article
Source: Self-asserted source
Tao Ye

Studies toward the Synthesis of Iriomoteolide-2a: Construction of the C(6)−C(28) Fragment

Org. Lett. 2018, 20, 2213-15
2018 | Journal article
Source: Self-asserted source
Tao Ye

Total synthesis of amphidinins E, F and epi-amphidinin F

Organic Chemistry Frontiers
2018 | Journal article
Contributors: Kai Chen; Zhengshuang Xu; Tao Ye
Source: check_circle
Crossref
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Peer review (58 reviews for 15 publications/grants)

Review activity for ACS chemical biology. (1)
Review activity for Angewandte Chemie. (6)
Review activity for Asian journal of organic chemistry (1)
Review activity for Chemistry - an Asian journal. (2)
Review activity for Chemistry. (1)
Review activity for European journal of organic chemistry. (2)
Review activity for Helvetica chimica acta. (1)
Review activity for Journal of medicinal chemistry. (1)
Review activity for Journal of organic chemistry. (20)
Review activity for Journal of the American Chemical Society. (1)
Review activity for Marine drugs. (1)
Review activity for Organic letters. (16)
Review activity for Organic process research & development. (1)
Review activity for Tetrahedron chem. (1)
Review activity for Tetrahedron letters. (3)