Personal information

Emails & domains

Verified email addresses

Websites & social links

LinkedIN

Other IDs

Scopus Author ID: 23479697500

Keywords

Alzheimer's Disease , Down Syndrome, Neurodegeneration, Neuroinflammation, Biomarkers, Healthy aging

Countries

United States

Activities

Collapse all

Employment (4)

Medical University of South Carolina: Charleston, SC, US

2018-03-01 to present | Assistant Professor (Pathology and Laboratory Medicine)
Employment
Source: Self-asserted source
Eric D. Hamlett

University of Denver: Denver, CO, US

2016-07-01 to 2018-01-30 | Post Doctoral Researcher (Knoebel Institute for Healthy Aging)
Employment
Source: Self-asserted source
Eric D. Hamlett

UNC Medical Center: Chapel Hill, NC, US

2010-07-01 to 2012-05-31 | Manager (Systems Proteomics Center)
Employment
Source: Self-asserted source
Eric D. Hamlett

UNC Medical Center: Chapel Hill, NC, US

2003-01-01 to 2010-06-30 | Research Specialist III (Cell Biology and Physiology)
Employment
Source: Self-asserted source
Eric D. Hamlett

Education and qualifications (4)

Medical University of South Carolina: Charleston, SC, US

2012-08-01 to 2017-06-01 | Ph.D. (Neuroscience)
Education
Source: Self-asserted source
Eric D. Hamlett

The University of North Carolina at Chapel Hill: Chapel Hill, NC, US

2002-06-01 to 2010-05-31 | Continuing studies (Cell Biology, Microbiology, Chemistry)
Education
Source: Self-asserted source
Eric D. Hamlett

Western Carolina University: Cullowhee, NC, US

2000-01-01 to 2002-05-31 | B.SC. (Biology)
Education
Source: Self-asserted source
Eric D. Hamlett

Rockingham Community College: Wentworth, North Carolina, US

1997-08-01 to 1999-12-31 | A.Sc.
Education
Source: Self-asserted source
Eric D. Hamlett

Professional activities (8)

2021 JoVE Research Innovation Award: Charleston, SC, US

Distinction
Source: Self-asserted source
Eric D. Hamlett

Keystone Symposia: Silverthorne, CO, US

2022-02-25 | ECITA Award
Distinction
Source: Self-asserted source
Eric D. Hamlett

Quanterix (United States): Lexington, Massachusetts, US

2020 | Quanterix Discovery Award
Distinction
Source: Self-asserted source
Eric D. Hamlett

Trisomy21 Research Society: Groningen, NL

2019 | Karmiloff-Smith Research Award
Distinction
Source: Self-asserted source
Eric D. Hamlett

Volkswagen Foundation: Hanover, DE

2018 | Ethics in Translational Neuroscience Prize
Distinction
Source: Self-asserted source
Eric D. Hamlett

ASNTR: Clearwater, FL, US

2018 | Neural Therapies Award
Distinction
Source: Self-asserted source
Eric D. Hamlett

EMD Millipore Co: Burlington, MA, US

2017 | MilliporeSigma Neuroscience Discovery Award
Distinction
Source: Self-asserted source
Eric D. Hamlett

Center for Advancing Innovation: Bethesda, Maryland, US

2016 | Innovation Excellence Award (Nano-Startup Challenge)
Distinction
Source: Self-asserted source
Eric D. Hamlett

Funding (5)

Mechanisms of resolution reprogramming in Alzheimer's disease inflammation

2021-07 to 2022-06 | Grant
NIH/ NIGMS (Bethesda, MD, US)
GRANT_NUMBER:

U54-GM104941
Source: Self-asserted source
Eric D. Hamlett

The Role of Pericytes in the Vascular Dysfunction of Sepsis

2020-09-21 to 2021-08-31 | Grant
National Institute of General Medical Sciences (Bethesda, NATIONAL INSTITUTE ON AGING, US)
URL: https://app.dimensions.ai/details/grant/grant.7753374
GRANT_NUMBER: R01GM130653-03S1
Source: Self-asserted source
Eric D. Hamlett

Experimental and Clinical Studies of Presbyacusis

2020-09-01 to 2021-08-31 | Grant
National Institute on Deafness and Other Communication Disorders (Bethesda, NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS, US)
URL: https://app.dimensions.ai/details/grant/grant.2440341
GRANT_NUMBER: P50DC000422 (Admin Supplement)
Source: Self-asserted source
Eric D. Hamlett

Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics

2019-09-22 to 2020-05-31 | Grant
National Institute of Child Health and Human Development (Bethesda, NATIONAL INSTITUTE ON AGING, US)
URL: https://app.dimensions.ai/details/grant/grant.7725610
GRANT_NUMBER: 3R01HD096501-02S1
Source: Self-asserted source
Eric D. Hamlett

Tau pathology in Down syndrome and Alzheimer's

2019-02-01 to 2024-01-31 | Contract
National Institute on Aging (Baltimore, NATIONAL INSTITUTE ON AGING, US)
URL: https://app.dimensions.ai/details/grant/grant.8745685
GRANT_NUMBER: RF1AG061566
Source: Self-asserted source
Eric D. Hamlett

Works (31)

The Role of Tau Pathology in Alzheimer’s Disease and Down Syndrome

Journal of Clinical Medicine
2024-02 | Journal article | Author
DOI: 10.3390/jcm13051338
Contributors: Ann-Charlotte Granholm-Bentley; Eric D. Hamlett
Source: check_circle
Multidisciplinary Digital Publishing Institute

Greater diffusion restriction in white matter in Preclinical Alzheimer's disease.

Annals of neurology
2022-03-13 | Journal article
DOI: 10.1002/ana.26353
PMID: 35285067
Source: Self-asserted source
Eric D. Hamlett

Suppression of Fli-1 protects against pericyte loss and cognitive deficits in Alzheimer's disease.

Molecular therapy : the journal of the American Society of Gene Therapy
2022-01-14 | Journal article
DOI: 10.1016/j.ymthe.2022.01.023
PMID: 35038582
Source: Self-asserted source
Eric D. Hamlett

Biofluid biomarkers for Alzheimer's disease in Down syndrome: current status and novel trends

Aging & Down Syndrome
2021 | Book chapter
Source: Self-asserted source
Eric D. Hamlett

Chronic cannabis smoking-enriched oral pathobiont drives behavioral changes, macrophage infiltration, and increases β-amyloid protein production in the brain.

EBioMedicine
2021-11-23 | Journal article
DOI: 10.1016/j.ebiom.2021.103701
PMID: 34826801
PMC: PMC8626580
Source: Self-asserted source
Eric D. Hamlett

Small Neuron-Derived Extracellular Vesicles from Individuals with Down Syndrome Propagate Tau Pathology in the Wildtype Mouse Brain.

Journal of clinical medicine
2021-08-31 | Journal article
DOI: 10.3390/jcm10173931
PMID: 34501378
PMC: PMC8432237
Source: Self-asserted source
Eric D. Hamlett

Building future therapies for DS: The Third International Conference of the T21 Research Society

Molecular Syndromology
2021-03-08 | Journal article
Source: Self-asserted source
Eric D. Hamlett

Inhibitory designer receptors aggravate memory loss in a mouse model of down syndrome

Neurobiology of Disease
2020 | Journal article
DOI: 10.1016/j.nbd.2019.104616
EID:

2-s2.0-85074342889

Part of ISBN:

1095953X 09699961
Contributors: Hamlett, E.D.; Ledreux, A.; Gilmore, A.; Vazey, E.M.; Aston-Jones, G.; Boger, H.A.; Paredes, D.; Granholm, A.-C.E.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Regional binding of tau and amyloid PET tracers in Down syndrome autopsy brain tissue

Molecular Neurodegeneration
2020 | Journal article
DOI: 10.1186/s13024-020-00414-3
EID:

2-s2.0-85096374040

Part of ISBN:

17501326
Contributors: Lemoine, L.; Ledreux, A.; Mufson, E.J.; Perez, S.E.; Simic, G.; Doran, E.; Lott, I.; Carroll, S.; Bharani, K.; Thomas, S. et al.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

RvE1 treatment prevents memory loss and neuroinflammation in the Ts65Dn mouse model of Down syndrome

GLIA
2020 | Journal article
DOI: 10.1002/glia.23779
EID:

2-s2.0-85078046955

Part of ISBN:

10981136 08941491
Contributors: Hamlett, E.D.; Hjorth, E.; Ledreux, A.; Gilmore, A.; Schultzberg, M.; Granholm, A.C.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Resolving inflammation: Could it prevent memory loss in Down Syndrome and Alzheimer’s

AAAS EurekeAlert
2020-03 | Newsletter article
Source: Self-asserted source
Eric D. Hamlett

Exosome release and cargo in Down syndrome

Developmental Neurobiology
2019 | Journal article
DOI: 10.1002/dneu.22712
EID:

2-s2.0-85070722043

Part of ISBN:

1932846X 19328451
Contributors: Hamlett, E.D.; LaRosa, A.; Mufson, E.J.; Fortea, J.; Ledreux, A.; Granholm, A.-C.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Neuronally derived extracellular vesicles: An emerging tool for understanding Alzheimer's disease

Molecular Neurodegeneration
2019 | Journal article
DOI: 10.1186/s13024-019-0317-5
EID:

2-s2.0-85067170493

Part of ISBN:

17501326
Contributors: Watson, L.S.; Hamlett, E.D.; Stone, T.D.; Sims-Robinson, C.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Exosomal biomarkers in Down syndrome and Alzheimer's disease

Free Radical Biology and Medicine
2018 | Journal article
DOI: 10.1016/j.freeradbiomed.2017.08.028
EID:

2-s2.0-85029577548

Part of ISBN:

18734596 08915849
Contributors: Hamlett, E.D.; Ledreux, A.; Potter, H.; Chial, H.J.; Patterson, D.; Espinosa, J.M.; Bettcher, B.M.; Granholm, A.-C.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome

Alzheimer's and Dementia
2017 | Journal article
DOI: 10.1016/j.jalz.2016.08.012
EID:

2-s2.0-85007392964

Part of ISBN:

15525279 15525260
Contributors: Hamlett, E.D.; Goetzl, E.J.; Ledreux, A.; Vasilevko, V.; Boger, H.A.; LaRosa, A.; Clark, D.; Carroll, S.L.; Carmona-Iragui, M.; Fortea, J. et al.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Alpha-lipoic acid supplementation protects enzymes from damage by nitrosative and oxidative stress

Biochimica et Biophysica Acta - General Subjects
2016 | Journal article
DOI: 10.1016/j.bbagen.2015.09.001
EID:

2-s2.0-84946433994

Part of ISBN:

18728006 03044165
Contributors: Hiller, S.; DeKroon, R.; Hamlett, E.D.; Xu, L.; Osorio, C.; Robinette, J.; Winnik, W.; Simington, S.; Maeda, N.; Alzate, O. et al.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Cognitive impairment, neuroimaging, and Alzheimer neuropathology in mouse models of down syndrome

Current Alzheimer Research
2016 | Journal article
DOI: 10.2174/1567205012666150921095505
EID:

2-s2.0-84953439283

Part of ISBN:

18755828 15672050
Contributors: Hamlett, E.D.; Boger, H.A.; Ledreux, A.; Kelley, C.M.; Mufson, E.J.; Falangola, M.F.; Guilfoyle, D.N.; Nixon, R.A.; Patterson, D.; Duval, N. et al.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Neurodegeneration and memory loss in down syndrome: Perspectives on potential therapeutics

Research Progress in Alzheimer’s Disease and Dementia. Volume 6
2016 | Book chapter
EID:

2-s2.0-85022014103
Contributors: Ledreux, A.; Hamlett, E.D.; Lockrow, J.; Bharani, K.; Granholm, A.-C.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Neurodegeneration and memory loss in Down syndrome: Perspectives on potential therapeutics

Research Progress in Alzheimer's Disease and Dementia
2016-09 | Book chapter
Source: Self-asserted source
Eric D. Hamlett

Designer receptors enhance memory in a mouse model of down syndrome

Journal of Neuroscience
2015 | Journal article
DOI: 10.1523/JNEUROSCI.2658-14.2015
EID:

2-s2.0-84921930781

Part of ISBN:

15292401 02706474
Contributors: Fortress, A.M.; Hamlett, E.D.; Vazey, E.M.; Aston-Jones, G.; Cass, W.A.; Boger, H.A.; Granholm, A.-C.E.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Evidence of altered age-related brain cytoarchitecture in mouse models of down syndrome: A diffusional kurtosis imaging study

Magnetic Resonance Imaging
2015 | Journal article
DOI: 10.1016/j.mri.2014.12.008
EID:

2-s2.0-84927911157

Part of ISBN:

18735894 0730725X
Contributors: Nie, X.; Hamlett, E.D.; Granholm, A.-C.; Hui, E.S.; Helpern, J.A.; Jensen, J.H.; Boger, H.A.; Collins, H.R.; Falangola, M.F.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Identification and characterization of protein posttranslational modifications by differential fluorescent labeling

Neuromethods
2015 | Book chapter
DOI: 10.1007/7657_2015_91
EID:

2-s2.0-84978882325

Part of ISBN:

19406045 08932336
Contributors: Hamlett, E.D.; Osorio, C.; Alzate, O.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

nalysis of Proteins Using DIGE and MALDI Mass Spectrometry

2014 | Book chapter
DOI: DOI 10.1007/978-1-61779-573-2_5
Source: Self-asserted source
Eric D. Hamlett
grade
Preferred source (of 2)‎

Diggin′ on U(biquitin): A Novel Method for the Identification of Physiological E3 Ubiquitin Ligase Substrates

Cell Biochemistry and Biophysics
2013 | Journal article
DOI: 10.1007/s12013-013-9624-6
EID:

2-s2.0-84883446618

Part of ISBN:

10859195
Contributors: Rubel, C.E.; Schisler, J.C.; Hamlett, E.D.; DeKroon, R.M.; Gautel, M.; Alzate, O.; Patterson, C.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Analysis of protein posttranslational modifications using DIGE-based proteomics

Methods in Molecular Biology
2012 | Book
DOI: 10.1007/978-1-61779-573-2_9
EID:

2-s2.0-84858133658

Part of ISBN:

10643745
Contributors: Dekroon, R.M.; Robinette, J.B.; Osorio, C.; Jeong, J.S.Y.; Hamlett, E.; Mocanu, M.; Alzate, O.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Analysis of Protein Posttranslational Modifications Using DIGE-Based Proteomics

2012 | Book chapter
Source: Self-asserted source
Eric D. Hamlett

Proteomic analysis of mice expressing human ApoE demonstrates no differences in global protein solubility between APOE 3 and APOE 4 young mice

Electrophoresis
2012 | Journal article
DOI: 10.1002/elps.201200219
EID:

2-s2.0-84871438168

Part of ISBN:

01730835 15222683
Contributors: Londono, C.; Dekroon, R.M.; Mocanu, M.; Booe, J.; Winnik, W.M.; Swank, A.; Osorio, C.; Hamlett, E.D.; Alzate, O.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Wnt1/βcatenin injury response activates the epicardium and cardiac fibroblasts to promote cardiac repair

EMBO Journal
2012 | Journal article
DOI: 10.1038/emboj.2011.418
EID:

2-s2.0-84857192566

Part of ISBN:

02614189 14602075
Contributors: Duan, J.; Gherghe, C.; Liu, D.; Hamlett, E.; Srikantha, L.; Rodgers, L.; Regan, J.N.; Rojas, M.; Willis, M.; Leask, A. et al.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

High-accuracy peptide mass fingerprinting using peak intensity data with machine learning

Journal of Proteome Research
2008 | Journal article
DOI: 10.1021/pr070088g
EID:

2-s2.0-38649136585

Part of ISBN:

15353893
Contributors: Yang, D.; Ramkissoon, K.; Hamlett, E.; Giddings, M.C.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

Incorporating sequence information into the scoring function: A hidden Markov model for improved peptide identification

Bioinformatics
2008 | Journal article
DOI: 10.1093/bioinformatics/btn011
EID:

2-s2.0-40049086065

Part of ISBN:

13674803 14602059
Contributors: Khatun, J.; Hamlett, E.; Giddings, M.C.
Source: Self-asserted source
Eric D. Hamlett via Scopus - Elsevier

The Role of Tau Pathology in Alzheimer’s Disease and Down Syndrome
Source: check_circle
Multidisciplinary Digital Publishing Institute

Peer review (3 reviews for 3 publications/grants)

Review activity for Alzheimer's research & therapy (1)
Review activity for Journal of neuroinflammation (1)
Review activity for Molecular and cellular biochemistry. (1)
How many people are using ORCID?