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Scopus Author ID: 8099960500

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Duke University: Durham, NC, US

2018-09-01 to present | Professor (Pharmacology)
Employment
Source: Self-asserted source
Andrew West

Works (50 of 151)

Items per page:
Page 1 of 4

Lewy body diseases and the gut

Molecular Neurodegeneration
2025-01-30 | Journal article
DOI: 10.1186/s13024-025-00804-5
Contributors: Timothy R. Sampson; Malú Gámez Tansey; Andrew B. West; Rodger A. Liddle
Source: check_circle
Crossref

Gut mucosal cells transfer α-synuclein to the vagus nerve

JCI Insight
2023-12-08 | Journal article
DOI: 10.1172/jci.insight.172192
Contributors: Rashmi Chandra; Arpine Sokratian; Katherine R. Chavez; Stephanie King; Sandip M. Swain; Joshua C. Snyder; Andrew B. West; Rodger A. Liddle
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Crossref

Gut mucosal cells transfer α-synuclein to the vagus nerve

2023-08-14 | Preprint
DOI: 10.1101/2023.08.14.553305
Contributors: Rashmi Chandra; Arpine Sokratian; Katherine R. Chavez; Stephanie King; Sandip M. Swain; Joshua C. Snyder; Andrew B. West; Rodger A. Liddle
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Crossref

The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease

Biochemical Society Transactions
2023-04-26 | Journal article
DOI: 10.1042/BST20201091
Contributors: Samuel Strader; Andrew B. West
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Crossref

LRRK2‐Targeting Therapies March Through the Valley of Death

Movement Disorders
2023-03 | Journal article
DOI: 10.1002/mds.29343
Contributors: Andrew B. West; Michael A. Schwarzschild
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Crossref

Identification of Novel α‐Synuclein Assemblies in Lewy Body Disease

Movement Disorders
2023-01 | Journal article
DOI: 10.1002/mds.29272
Contributors: Arpine Sokratian; Hjalte Gram; Poul H. Jensen; Andrew B. West
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Crossref

Who to Enroll in Parkinson Disease Prevention Trials?

Neurology
2022-08-16 | Journal article
DOI: 10.1212/WNL.0000000000200812
Contributors: Kellyann Niotis; Andrew B. West; Rachel Saunders-Pullman
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Crossref

Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease

Movement Disorders
2022-07 | Journal article
DOI: 10.1002/mds.29043
Contributors: Shijie Wang; Shakthi Unnithan; Nicole Bryant; Allison Chang; Liana S. Rosenthal; Alexander Pantelyat; Ted M. Dawson; Hussein R. Al‐Khalidi; Andrew B. West
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Crossref

Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration

Brain Communications
2022-03-01 | Journal article
DOI: 10.1093/braincomms/fcac042
Contributors: Lyndsay Hastings; Arpine Sokratian; Daniel J. Apicco; Christina M. Stanhope; Lindsey Smith; Warren D. Hirst; Andrew B. West; Kaela Kelly
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Crossref

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

2021-10-05 | Other
DOI: 10.1101/2021.10.04.463043
Contributors: Charlotte F. Brzozowski; Baraa A. Hijaz; Vijay Singh; Nolwazi Z. Gcwensa; Kaela Kelly; Edward S. Boyden; Andrew B. West; Deblina Sarkar; Laura A. Volpicelli-Daley
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Crossref

Sex-based differences in the activation of peripheral blood monocytes in early Parkinson disease

npj Parkinson's Disease
2021-04-13 | Journal article
DOI: 10.1038/s41531-021-00180-z
Contributors: Samantha M. Carlisle; Hongwei Qin; R. Curtis Hendrickson; Jordana E. Muwanguzi; Elliot J. Lefkowitz; Richard E. Kennedy; Zhaoqi Yan; Talene A. Yacoubian; Etty N. Benveniste; Andrew B. West et al.
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Crossref

Identification of LRRK2 Missense Variants in the Accelerating Medicines Partnership Parkinson’s Disease Cohort

Human Molecular Genetics
2021-02-27 | Journal article
DOI: 10.1093/hmg/ddab058
Contributors: Nicole Bryant; Nicole Malpeli; Julia Ziaee; Cornelis Blauwendraat; Zhiyong Liu; Andrew West
Source: check_circle
Crossref

Exosome markers of LRRK2 kinase inhibition

npj Parkinson's Disease
2020-11-13 | Journal article
DOI: 10.1038/s41531-020-00138-7
Contributors: Shijie Wang; Kaela Kelly; Jonathan M. Brotchie; James B. Koprich; Andrew B. West
Source: check_circle
Crossref

LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes

The EMBO Journal
2020-10-15 | Journal article
DOI: 10.15252/embj.2020104862
Contributors: Zhiyong Liu; Enquan Xu; Hien Tran Zhao; Tracy Cole; Andrew B West
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Crossref

LRRK2 and Rab10 Coordinate Macropinocytosis to Mediate Immunological Responses in Phagocytes

2020-01-31 | Preprint
DOI: 10.1101/2020.01.30.926840
Contributors: Zhiyong Liu; Enquan Xu; Hien Tran Zhao; Tracy Cole; Andrew B. West
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Crossref

Pharmacodynamic Markers of LRRK2 Inhibition in Biofluids

2020-01-29 | Preprint
DOI: 10.1101/2020.01.28.923557
Contributors: Shijie Wang; Kaela Kelly; Nathalie Schussler; Sylviane Boularand; Laurent Dubois; Frank Hsieh; Elizabeth Tengstrand; Jonathan M. Brotchie; James B. Koprich; Andrew B. West
Source: check_circle
Crossref

Caught in the act: LRRK2 in exosomes

Biochemical Society Transactions
2019-04-30 | Journal article
DOI: 10.1042/BST20180467
Contributors: Shijie Wang; Andrew B. West
Source: check_circle
Crossref

Finding useful biomarkers for Parkinson�s disease

Science translational medicine
2018 | Journal article
Source: Self-asserted source
Andrew West

Sensitivity and Specificity of Phospho-Ser129 $α$-Synuclein Monoclonal Antibodies

Journal of Comparative Neurology
2018 | Journal article
Source: Self-asserted source
Andrew West

The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition

Experimental Neurology
2018-11 | Journal article
DOI: 10.1016/j.expneurol.2018.07.012
Contributors: Kaela Kelly; Shijie Wang; Ravindra Boddu; Zhiyong Liu; Omar Moukha-Chafiq; Corinne Augelli-Szafran; Andrew B. West
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Crossref

Antisense Oligonucleotides to LRRK2 Ameliorate alpha-Synuclein Pathology and Behavioral Deficit Induced by Pre-Formed alpha-Synuclein Fibrils

ANNALS OF NEUROLOGY
2017 | Conference paper
Source: Self-asserted source
Andrew West

Biochemical characterization of purified mammalian ARL13B indicate that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF)

Journal of Biological Chemistry
2017 | Journal article
Source: Self-asserted source
Andrew West

Breathing new life into an old target: pulmonary disease drugs for Parkinson�s disease therapy

Genome medicine
2017 | Journal article
Source: Self-asserted source
Andrew West

Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

Acta neuropathologica communications
2017 | Journal article
Source: Self-asserted source
Andrew West

Exaggerated CpH methylation in the autism-affected brain

Molecular Autism
2017 | Journal article
DOI: 10.1186/s13229-017-0119-y
EID:

2-s2.0-85015167905
Contributors: Ellis, S.E.; Gupta, S.; Moes, A.; West, A.B.; Arking, D.E.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

Interplay Between LRRK2 Action in Neurons and Macrophages in Mediating $α$-Synuclein linked Neurodegeneration (P1. 003)

Neurology
2017 | Journal article
Source: Self-asserted source
Andrew West

LRRK2 Antisense Oligonucleotides Ameliorate $α$-Synuclein Inclusion Formation in a Parkinson�s Disease Mouse Model

Molecular Therapy-Nucleic Acids
2017 | Journal article
Source: Self-asserted source
Andrew West

LRRK2 levels in immune cells are increased in Parkinson�s disease

NPJ Parkinson's disease
2017 | Journal article
Source: Self-asserted source
Andrew West

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

Human molecular genetics
2017 | Journal article
Source: Self-asserted source
Andrew West

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program

Biomarkers in medicine
2017 | Journal article
Source: Self-asserted source
Andrew West

The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro

Biochimica et Biophysica Acta - Proteins and Proteomics
2017 | Journal article
DOI: 10.1016/j.bbapap.2016.12.001
EID:

2-s2.0-85007154231
Contributors: Liu, Z.; West, A.B.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

The dual enzyme LRRK2 hydrolyzes GTP in both its GTPase and kinase domains in vitro

Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics
2017 | Journal article
Source: Self-asserted source
Andrew West

Achieving neuroprotection with LRRK2 kinase inhibitors in Parkinson disease

Experimental Neurology
2017-12 | Journal article
DOI: 10.1016/j.expneurol.2017.07.019
Contributors: Andrew B. West
Source: check_circle
Crossref

α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration

Neurobiology of Disease
2017-09 | Journal article
DOI: 10.1016/j.nbd.2017.05.014
Contributors: Hisham Abdelmotilib; Tyler Maltbie; Vedad Delic; Zhiyong Liu; Xianzhen Hu; Kyle B. Fraser; Mark S. Moehle; Lindsay Stoyka; Nadia Anabtawi; Valentina Krendelchtchikova et al.
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Crossref

14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening

Human Molecular Genetics
2016 | Journal article
DOI: 10.1093/hmg/ddv453
EID:

2-s2.0-84962194804
Contributors: Lavalley, N.J.; Slone, S.R.; Ding, H.; West, A.B.; Yacoubian, T.A.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

G2019s-LRRK2 expression augments α-synuclein sequestration into inclusions in neurons

Journal of Neuroscience
2016 | Journal article
DOI: 10.1523/JNEUROSCI.3642-15.2016
EID:

2-s2.0-84978841976
Contributors: Volpicelli-Daley, L.A.; Abdelmotilib, H.; Liu, Z.; Stoyka, L.; Daher, J.P.L.; Milnerwood, A.J.; Unni, V.K.; Hirst, W.D.; Yue, Z.; Zhao, H.T. et al.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

Identification of bona-fide LRRK2 kinase substrates

Movement Disorders
2016 | Journal article
DOI: 10.1002/mds.26647
EID:

2-s2.0-84981164616
Contributors: West, A.B.; Cookson, M.R.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

LRRK2 autophosphorylation enhances its GTPase activity

FASEB Journal
2016 | Journal article
DOI: 10.1096/fj.15-277095
EID:

2-s2.0-84974784616
Contributors: Liu, Z.; Mobley, J.A.; Delucas, L.J.; Kahn, R.A.; West, A.B.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease

Movement Disorders
2016 | Journal article
DOI: 10.1002/mds.26686
EID:

2-s2.0-84991272394
Contributors: Fraser, K.B.; Rawlins, A.B.; Clark, R.G.; Alcalay, R.N.; Standaert, D.G.; Liu, N.; West, A.B.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

The NINDS Parkinson's disease biomarkers program

Movement Disorders
2016 | Journal article
DOI: 10.1002/mds.26438
EID:

2-s2.0-84949871151
Contributors: Rosenthal, L.S.; Drake, D.; Alcalay, R.N.; Babcock, D.; Bowman, F.D.; Chen-Plotkin, A.; Dawson, T.M.; Dewey, R.B.; German, D.C.; Huang, X. et al.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

Transcriptome analysis of cortical tissue reveals shared sets of downregulated genes in autism and schizophrenia

Translational psychiatry
2016 | Journal article
Source: Self-asserted source
Andrew West

Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers

Neurology
2016 | Journal article
DOI: 10.1212/WNL.0000000000002436
EID:

2-s2.0-84961266899
Contributors: Fraser, K.B.; Moehle, M.S.; Alcalay, R.N.; West, A.B.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019S LRRK2 carriers

Neurology
2016 | Journal article
Source: Self-asserted source
Andrew West

Leucine-rich repeat kinase 2 (LRRK2) pharmacological inhibition abates α-synuclein gene-induced neurodegeneration

Journal of Biological Chemistry
2015 | Journal article
DOI: 10.1074/jbc.M115.660001
EID:

2-s2.0-84939145610
Contributors: Daher, J.P.L.; Abdelmotilib, H.A.; Hu, X.; Volpicelli-Daley, L.A.; Moehle, M.S.; Fraser, K.B.; Needle, E.; Chen, Y.; Steyn, S.J.; Galatsis, P. et al.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury

Human Molecular Genetics
2015 | Journal article
DOI: 10.1093/hmg/ddv147
EID:

2-s2.0-84936758037
Contributors: Boddu, R.; Hull, T.D.; Bolisetty, S.; Hu, X.; Moehle, M.S.; Daher, J.P.L.; Kamal, A.I.; Joseph, R.; George, J.F.; Agarwal, A. et al.
Source: Self-asserted source
Andrew West via Scopus - Elsevier

Leucine-rich repeat kinase 2 deficiency is protective in rhabdomyolysis-induced kidney injury

Human molecular genetics
2015 | Journal article
Source: Self-asserted source
Andrew West

LRRK2 autophosphorylation enhances its GTPase activity

The FASEB Journal
2015 | Journal article
Source: Self-asserted source
Andrew West

LRRK2 pharmacological inhibition abates $α$-synuclein induced neurodegeneration

Journal of Biological Chemistry
2015 | Journal article
Source: Self-asserted source
Andrew West

M1 and M2 immune activation in Parkinson�s disease: foe and ally?

Neuroscience
2015 | Journal article
Source: Self-asserted source
Andrew West

pharmacological inhibition of Lrrk2 blocks alpha-synuclein induced neurodegeneration in rats: Wth06-06

Journal of Neurochemistry
2015 | Journal article
Source: Self-asserted source
Andrew West
Items per page:
Page 1 of 4

Peer review (4 reviews for 3 publications/grants)

Review activity for Nature (1)
Review activity for Nature communications (1)
Review activity for NPJ Parkinson's disease. (2)
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