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Other IDs

ResearcherID: AAJ-7192-2021

Biography

INSERM research director (DR2) working on the early molecular and cellular events driving chronic kidney disease (CKD) using microfluidic approaches

Activities

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Employment (3)

Institut Necker Enfants Malades: Paris, FR

2013-04-01 to present
Employment
Source: Self-asserted source
NICOLAS DUPONT

The University of New Mexico: Albuquerque, NM, US

2009-09-15 to 2013-03-01
Employment
Source: Self-asserted source
NICOLAS DUPONT

Institut Pasteur de Lille: Lille, Hauts-de-France, FR

2005-10-01 to 2009-09-15
Employment
Source: Self-asserted source
NICOLAS DUPONT

Education and qualifications (2)

Université de Paris: Paris, Île-de-France, FR

2018 to 2018 | HDR (Habilitation à Diriger des Recherches)
Education
Source: Self-asserted source
NICOLAS DUPONT

Université de Lille: Lille, Hauts-de-France, FR

2005 to 2009 | PhD
Education
Source: Self-asserted source
NICOLAS DUPONT

Funding (4)

Autophagy

2023 to present | Grant
Agence Nationale de la Recherche (paris, FR)
Source: Self-asserted source
NICOLAS DUPONT

Autophagy

2014-11 to 2016-08 | Contract
Fondation ARC pour la Recherche sur le Cancer (PARIS, FR)
Source: Self-asserted source
NICOLAS DUPONT

Autophagy

2013-04 to 2014-10 | Contract
Fondation pour la Recherche Médicale (PARIS, FR)
Source: Self-asserted source
NICOLAS DUPONT

Autophagy

Grant
Agence Nationale de la Recherche (PARIS, FR)
Source: Self-asserted source
NICOLAS DUPONT

Works (50 of 61)

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Simultaneous activation and blockade of autophagy to fight hepatocellular carcinoma

Autophagy Reports
2024-12-31 | Journal article
DOI: 10.1080/27694127.2024.2326241
Part of ISSN: 2769-4127
Contributors: Hala Shalhoub; Patrick Gonzalez; Alexandre Dos Santos; Julie Guillermet-Guibert; Nicolas Moniaux; Nicolas Dupont; Jamila Faivre
Source: Self-asserted source
NICOLAS DUPONT

TANGO2-related rhabdomyolysis symptoms are associated with abnormal autophagy functioning

Autophagy Reports
2024-12-31 | Journal article
DOI: 10.1080/27694127.2024.2306766
Part of ISSN: 2769-4127
Contributors: Hortense de Calbiac; Sebastian Montealegre; Marjolène Straube; Solène Renault; Hugo Debruge; Loïc Chentout; Sorana Ciura; Apolline Imbard; Edouard Le Guillou; Anca Marian et al.
Source: Self-asserted source
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Lipophagy and mitophagy in renal pathophysiology

Nephron
2024-08-23 | Review
DOI: 10.1159/000540688
Part of ISSN: 1660-8151
Part of ISSN: 2235-3186
Contributors: Nicolas Dupont; Fabiola Terzi
Source: Self-asserted source
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Yapping at the autophagy door? The answer is flowing in the kidney proximal tubule

Autophagy
2024-06-02 | Journal article
DOI: 10.1080/15548627.2024.2319023
Contributors: Aurore Claude-Taupin; Fabiola Terzi; Patrice Codogno; Nicolas Dupont
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PI3KCIIα-Dependent Autophagy Program Protects From Endothelial Dysfunction and Atherosclerosis in Response to Low Shear Stress in Mice

Arteriosclerosis, Thrombosis, and Vascular Biology
2024-03 | Journal article | Author
DOI: 10.1161/atvbaha.123.319978
Part of ISSN: 1079-5642
Part of ISSN: 1524-4636
Contributors: Mouin Nasr; Alexis Fay; Adrien Lupieri; Nicole Malet; Anne Darmon; Rana Zahreddine; Audrey Swiader; Amandine Wahart; Julien Viaud; Anne Negre-Salvayre et al.
Source: Self-asserted source
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To squeeze or not: Regulation of cell size by mechanical forces in development and human diseases

Biology of the Cell
2024-02 | Review
DOI: 10.1111/boc.202200101
Part of ISSN: 0248-4900
Part of ISSN: 1768-322X
Contributors: Aurore Claude-Taupin; Nicolas Dupont
Source: Self-asserted source
NICOLAS DUPONT

A historical perspective of macroautophagy regulation by biochemical and biomechanical stimuli

FEBS Letters
2024-01 | Review
DOI: 10.1002/1873-3468.14744
Part of ISSN: 0014-5793
Part of ISSN: 1873-3468
Contributors: Nicolas Dupont; Aurore Claude‐Taupin; Patrice Codogno
Source: Self-asserted source
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The AMPK-Sirtuin 1-YAP axis is regulated by fluid flow intensity and controls autophagy flux in kidney epithelial cells

Nature Communications
2023-12-05 | Journal article | Author
DOI: 10.1038/s41467-023-43775-1
Part of ISSN: 2041-1723
Contributors: Aurore Claude-Taupin; Pierre Isnard; Alessia Bagattin; Nicolas Kuperwasser; Federica Roccio; Biagina Ruscica; Nicolas GOUDIN; Meriem Garfa-Traoré; Alice Regnier; Lisa Turinsky et al.
Source: Self-asserted source
NICOLAS DUPONT

Fluid shear stress triggers cholesterol biosynthesis and uptake in inner medullary collecting duct cells, independently of nephrocystin-1 and nephrocystin-4

Frontiers in Molecular Biosciences
2023-10-17 | Journal article
DOI: 10.3389/fmolb.2023.1254691
Part of ISSN: 2296-889X
Contributors: Meriem Garfa Traoré; Federica Roccio; Caterina Miceli; Giulia Ferri; Mélanie Parisot; Nicolas Cagnard; Marie Lhomme; Nicolas Dupont; Alexandre Benmerah; Sophie Saunier et al.
Source: Self-asserted source
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Autophagy and the primary cilium in cell metabolism: What’s upstream?

Frontiers in Cell and Developmental Biology
2022-11-09 | Review
DOI: 10.3389/fcell.2022.1046248
Part of ISSN: 2296-634X
Contributors: Aurore Claude-Taupin; Nicolas Dupont; Patrice Codogno
Source: Self-asserted source
NICOLAS DUPONT

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Autophagy
2021 | Journal article
DOI: 10.1080/15548627.2020.1797280
WOSUID: WOS:000636121800001
Contributors: Klionsky, Daniel J.; Abdel-Aziz, Amal Kamal; Abdelfatah, Sara; Abdellatif, Mahmoud; Abdoli, Asghar; Abel, Steffen; Abeliovich, Hagai; Abildgaard, Marie H.; Abudu, Yakubu Princely; Acevedo-Arozena, Abraham et al.
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The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium

Cell Reports
2021 | Journal article
DOI: 10.1016/J.CELREP.2021.109045
WOSUID: WOS:000644709600019
Contributors: Boukhalfa, Asma; Roccio, Federica; Dupont, Nicolas; Codogno, Patrice; Morel, Etienne
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The lipid-kinase hidden behind PI3P A Specific Dialogue between the primary cilium and autophagic machinery

M S-Medecine Sciences
2021 | Journal article
WOSUID: WOS:000611354200002
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The menage a trois of autophagy, lipid droplets and liver disease

Autophagy
2021 | Journal article
DOI: 10.1080/15548627.2021.1895658
WOSUID: WOS:000636065400001
Contributors: Filali-Mouncef, Yasmina; Hunter, Catherine; Roccio, Federica; Zagkou, Stavroula; Dupont, Nicolas; Primard, Charlotte; Proikas-Cezanne, Tassula; Reggiori, Fulvio
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When the autophagy protein ATG16L1 met the ciliary protein IFT20

Autophagy
2021 | Journal article
DOI: 10.1080/15548627.2021.1935004
WOSUID: WOS:000656317800001
Contributors: Boukhalfa, Asma; Roccio, Federica; Dupont, Nicolas; Codogno, Patrice; Morel, Etienne
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Correction to: ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration

Cell Death & Differentiation
2021-11 | Journal article
DOI: 10.1038/s41418-021-00783-2
Contributors: Isaac Tamargo-Gómez; Gemma G. Martínez-García; María F. Suárez; Verónica Rey; Antonio Fueyo; Helena Codina-Martínez; Gabriel Bretones; Xurde M. Caravia; Etienne Morel; Nicolas Dupont et al.
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ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration

Cell Death & Differentiation
2021-09 | Journal article
DOI: 10.1038/s41418-021-00776-1
Contributors: Isaac Tamargo-Gómez; Gemma G. Martínez-García; María F. Suárez; Verónica Rey; Antonio Fueyo; Helena Codina-Martínez; Gabriel Bretones; Xurde M. Caravia; Etienne Morel; Nicolas Dupont et al.
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Links between autophagy and tissue mechanics

Journal of Cell Science
2021-09-01 | Journal article
DOI: 10.1242/jcs.258589
Contributors: Aurore Claude-Taupin; Patrice Codogno; Nicolas Dupont
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Fluid flow-induced shear stress controls the metabolism of proximal tubule kidney epithelial cells through primary cilium-dependent lipophagy and mitochondrial biogenesis

Autophagy
2020 | Journal article
DOI: 10.1080/15548627.2020.1823125
WOSUID: WOS:000571284900001
Contributors: Miceli, Caterina; Roccio, Federica; Penalva-Mousset, Lucille; Morel, Etienne; Codogno, Patrice; Dupont, Nicolas
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PI3KC2 alpha-dependent and VPS34-independent generation of PI3P controls primary cilium-mediated autophagy in response to shear stress

Nature Communications
2020 | Journal article
DOI: 10.1038/S41467-019-14086-1
WOSUID: WOS:000512534300005
Contributors: Boukhalfa, Asma; Nascimbeni, Anna Chiara; Ramel, Damien; Dupont, Nicolas; Hirsch, Emilio; Gayral, Stephanie; Laffargue, Muriel; Codogno, Patrice; Morel, Etienne
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Primary cilium-dependent autophagy drafts PIK3C2A to generate PtdIns3P in response to shear stress

Autophagy
2020 | Journal article
DOI: 10.1080/15548627.2020.1732687
WOSUID: WOS:000518260200001
Contributors: Boukhalfa, Asma; Nascimbeni, Anna Chiara; Dupont, Nicolas; Codogno, Patrice; Morel, Etienne
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The primary cilium and lipophagy translate mechanical forces to direct metabolic adaptation of kidney epithelial cells

Nature Cell Biology
2020 | Journal article
DOI: 10.1038/S41556-020-0566-0
WOSUID: WOS:000564510000005
Contributors: Miceli, Caterina; Roccio, Federica; Penalva-Mousset, Lucille; Burtin, Martine; Leroy, Christine; Nemazanyy, Ivan; Kuperwasser, Nicolas; Pontoglio, Marco; Friedlander, Gerard; Morel, Etienne et al.
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Monitoring of Autophagy and Cell Volume Regulation in Kidney Epithelial Cells in Response to Fluid Shear Stress

Methods in Molecular Biology
2019 | Journal article
DOI: 10.1007/978-1-4939-8873-0_22
WOSUID: WOS:000623746900023
Contributors: Lazari, Maria M.; Orhon, Idil; Codogno, Patrice; Dupont, Nicolas
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The primary cilium protein folliculin is part of the autophagy signaling pathway to regulate epithelial cell size in response to fluid flow

Cell Stress
2019 | Journal article
DOI: 10.15698/CST2019.03.180
WOSUID: WOS:000588300600003
Contributors: Zemirli, Naima; Boukhalfa, Asma; Dupont, Nicolas; Botti, Joelle; Codogno, Patrice; Morel, Etienne
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Interplay between primary cilia, ubiquitin-proteasome system and autophagy

Biochimie
2019-11 | Journal article
DOI: 10.1016/j.biochi.2019.06.009
Contributors: Asma Boukhalfa; Caterina Miceli; Yenniffer Ávalos; Etienne Morel; Nicolas Dupont
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Aspirin Recapitulates Features of Caloric Restriction

Cell Reports
2018 | Journal article
DOI: 10.1016/J.CELREP.2018.02.024
WOSUID: WOS:000426243000015
Contributors: Pietrocola, Federico; Castoldi, Francesca; Markaki, Maria; Lachkar, Sylvie; Chen, Guo; Enot, David P.; Durand, Sylvere; Bossut, Noelie; Tong, Mingming; Malik, Shoaib A. et al.
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Endothelial autophagic flux hampers atherosclerotic lesion development

Autophagy
2018 | Journal article
DOI: 10.1080/15548627.2017.1395114
WOSUID: WOS:000427049900014
Contributors: Kheloufi, Marouane; Vion, Anne-Clemence; Hammoutene, Adel; Poisson, Johanne; Lasselin, Juliette; Devue, Cecile; Pic, Isabelle; Dupont, Nicolas; Busse, Johanna; Stark, Konstantin et al.
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Autophagy is Required for Endothelial Atheroprotective Signaling Under Physiological Flow

Arteriosclerosis, Thrombosis, and Vascular Biology
2017 | Journal article
WOSUID: WOS:000408316600392
Contributors: Kheloufi, Marouane; Vion, Anne-Clemence; Hammoutene, Adel; Poisson, Johanne; Lasselin, Juliette; Devue, Cecile; Pic, Isabelle; Dupont, Nicolas; Busse, Johanna; Stark, Konstantin et al.
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Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

Proceedings of the National Academy of Sciences
2017 | Journal article
DOI: 10.1073/PNAS.1702223114
WOSUID: WOS:000412653900018
Contributors: Vion, Anne-Clemence; Kheloufi, Marouane; Hammoutene, Adel; Poisson, Johanne; Lasselin, Juliette; Devue, Cecile; Pic, Isabelle; Dupont, Nicolas; Busse, Johanna; Stark, Konstantin et al.
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Autophagy: A Druggable Process

Annual Review of Pharmacology and Toxicology
2017 | Journal article
DOI: 10.1146/ANNUREV-PHARMTOX-010716-104936
WOSUID: WOS:000396044800019
Contributors: Morel, Etienne; Mehrpour, Maryam; Botti, Joelle; Dupont, Nicolas; Hamai, Ahmed; Nascimbeni, Anna Chiara; Codogno, Patrice
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Cellular and molecular mechanism for secretory autophagy

Autophagy
2017 | Journal article
DOI: 10.1080/15548627.2017.1307486
WOSUID: WOS:000404150600012
Contributors: Kimura, Tomonori; Jia, Jingyue; Claude-Taupin, Aurore; Kumar, Suresh; Choi, Seong Won; Gu, Yuexi; Mudd, Michal; Dupont, Nicolas; Jiang, Shanya; Peters, Ryan et al.
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Dedicated SNAREs and specialized TRIM cargo receptors mediate secretory autophagy

The EMBO Journal
2017 | Journal article
DOI: 10.15252/EMBJ.201695081
WOSUID: WOS:000392428200005
Contributors: Kimura, Tomonori; Jia, Jingyue; Kumar, Suresh; Choi, Seong Won; Gu, Yuexi; Mudd, Michal; Dupont, Nicolas; Jiang, Shanya; Peters, Ryan; Farzam, Farzin et al.
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ER-plasma membrane contact sites contribute to autophagosome biogenesis by regulation of local PI3P synthesis

The EMBO Journal
2017 | Journal article
DOI: 10.15252/EMBJ.201797006
WOSUID: WOS:000405478400004
Contributors: Nascimbeni, Anna Chiara; Giordano, Francesca; Dupont, Nicolas; Grasso, Daniel; Vaccaro, Maria I.; Codogno, Patrice; Morel, Etienne
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Long-Lived Protein Degradation During Autophagy

Methods in Enzymology
2017 | Journal article
DOI: 10.1016/BS.MIE.2016.09.074
WOSUID: WOS:000410547900004
Contributors: Dupont, N.; Leroy, C.; Hamai, A.; Codogno, P.
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Molecular Mechanisms of Noncanonical Autophagy

International Review of Cell and Molecular Biology
2017 | Journal article
DOI: 10.1016/BS.IRCMB.2016.08.001
WOSUID: WOS:000403271800001
Contributors: Dupont, N.; Nascimbeni, A. C.; Morel, E.; Codogno, P.
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To be or not to be cell autonomous? Autophagy says both

Essays in Biochemistry
2017 | Journal article
DOI: 10.1042/EBC20170025
WOSUID: WOS:000450754800008
Contributors: Fenouille, Nina; Nascimbeni, Anna Chiara; Botti-Millet, Joelle; Dupont, Nicolas; Morel, Etienne; Codogno, Patrice
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Autophagy transduces physical constraints into biological responses

The International Journal of Biochemistry & Cell Biology
2016 | Journal article
DOI: 10.1016/J.BIOCEL.2016.08.021
WOSUID: WOS:000386985900046
Contributors: Dupont, Nicolas; Codogno, Patrice
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Fine-tuning autophagy: from transcriptional to posttranslational regulation.

2016 | Journal article
Source: Self-asserted source
NICOLAS DUPONT

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

2016 | Journal article
Source: Self-asserted source
NICOLAS DUPONT

Primary cilium and autophagy: The avengers of cell-size regulation

Autophagy
2016 | Journal article
DOI: 10.1080/15548627.2016.1212790
WOSUID: WOS:000387665000025
Contributors: Orhon, Idil; Dupont, Nicolas; Codogno, Patrice
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Primary-cilium-dependent autophagy controls epithelial cell volume in response to fluid flow

Nature Cell Biology
2016 | Journal article
DOI: 10.1038/NCB3360
WOSUID: WOS:000376750100012
Contributors: Orhon, Idil; Dupont, Nicolas; Zaidan, Mohamad; Boitez, Valerie; Burtin, Martine; Schmitt, Alain; Capiod, Thierry; Viau, Amandine; Beau, Isabelle; Kuehn, E. Wolfgang et al.
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Shear stress regulates endothelial autophagy: consequences on endothelial senescence and atherogenesis

Cardiovascular Research
2016 | Journal article
WOSUID: WOS:000379812500092
Contributors: Kheloufi, M.; Vion, A. C.; Hammoutene, A.; Poisson, J.; Dupont, N.; Souyri, M.; Tedgui, A.; Codogno, P.; Boulanger, C. M.; Rautou, P. E.
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Autophagy and regulation of cilia function and assembly

Cell Death and Differentiation
2015 | Journal article
DOI: 10.1038/CDD.2014.171
WOSUID: WOS:000349543600004
Contributors: Orhon, I.; Dupont, N.; Pampliega, O.; Cuervo, A. M.; Codogno, P.
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The Pro-apoptotic STK38 Kinase Is a New Beclin1 Partner Positively Regulating Autophagy

Current Biology
2015 | Journal article
DOI: 10.1016/J.CUB.2015.08.031
WOSUID: WOS:000362932800034
Contributors: Joffre, Carine; Dupont, Nicolas; Hoa, Lily; Gomez, Valenti; Pardo, Raul; Goncalves-Pimentel, Catarina; Achard, Pauline; Bettoun, Audrey; Meunier, Brigitte; Bauvy, Chantal et al.
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Unsaturated fatty acids induce non-canonical autophagy

The EMBO Journal
2015 | Journal article
DOI: 10.15252/EMBJ.201489363
WOSUID: WOS:000352997000007
Contributors: Niso-Santano, Mireia; Malik, Shoaib Ahmad; Pietrocola, Federico; Bravo-San Pedro, Jose Manuel; Marino, Guillermo; Cianfanelli, Valentina; Ben-Younes, Amena; Troncoso, Rodrigo; Markaki, Maria; Sica, Valentina et al.
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201st ENMC International Workshop: Autophagy in muscular dystrophies – Translational approach, 1–3 November 2013, Bussum, The Netherlands

2014 | Journal article
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Autophagy and Autophagic Flux in Tumor Cells

Methods in Enzymology
2014 | Journal article
DOI: 10.1016/B978-0-12-801329-8.00004-0
WOSUID: WOS:000341164600005
Contributors: Dupont, Nicolas; Orhon, Idil; Bauvy, Chantal; Codogno, Patrice
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Autophagy regulation: RNF2 targets AMBRA1

Cell Research
2014 | Journal article
DOI: 10.1038/CR.2014.105
WOSUID: WOS:000344992900005
Contributors: Morel, Etienne; Dupont, Nicolas; Codogno, Patrice
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Neutral Lipid Stores and Lipase PNPLA5 Contribute to Autophagosome Biogenesis

Current Biology
2014 | Journal article
DOI: 10.1016/J.CUB.2014.02.008
WOSUID: WOS:000333233300020
Contributors: Dupont, Nicolas; Chauhan, Santosh; Arko-Mensah, John; Castillo, Eliseo F.; Masedunskas, Andrius; Weigert, Roberto; Robenek, Horst; Proikas-Cezanne, Tassula; Deretic, Vojo
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Autophagy plays a WASHing game

The EMBO Journal
2013 | Journal article
DOI: 10.1038/EMBOJ.2013.202
WOSUID: WOS:000325714100002
Contributors: Dupont, Nicolas; Codogno, Patrice
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Peer review (2 reviews for 2 publications/grants)

Review activity for Cell research (1)
Review activity for EMBO reports. (1)
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