Personal information

Other IDs

ResearcherID: L-6989-2014
Scopus Author ID: 56013209400

Countries

Germany

Activities

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Employment (8)

University of Duisburg-Essen: Essen, DE

2001 to present | Full Professor and Chair (Molecular Biology)
Employment
Source: Self-asserted source
Erich Gulbins

University of Cincinnati: Cincinnati, US

2011 to 2021 | Adjunct Professor (Dept. of Surgery)
Employment
Source: Self-asserted source
Erich Gulbins

St. Jude Children’s Research Hospital: Memphis, US

2000 to 2002 | Associate Professor (Immunology)
Employment
Source: Self-asserted source
Erich Gulbins

University of Tuebingen: Tuebingen , DE

1996 to 2000 | Assistant Professor (Dept. of Physiology)
Employment
Source: Self-asserted source
Erich Gulbins

University of Tuebingen: Tuebingen, DE

1994 to 1996 | Wissenschaftlicher Mitarbeiter, Independent Group Leader (Dept. of Physiology)
Employment
Source: Self-asserted source
Erich Gulbins

The Ohio State University: Columbus, OH, US

1994-03 to 1994-04 | Guest Scientist (Microbiology)
Employment
Source: Self-asserted source
Erich Gulbins

University of San Diego: San Diego, CA, US

1992 to 1994 | Physician (Rheumatology)
Employment
Source: Self-asserted source
Erich Gulbins

La Jolla Institute for Allergy and Immunology: San Diego, CA, US

1992 to 1994 | Postdoctoral Fellow
Employment
Source: Self-asserted source
Erich Gulbins

Education and qualifications (4)

Medical Faculty of the University of Tübingen: Tübingen, DE

1999 | Habilitation in Immunology (Immunology)
Education
Source: Self-asserted source
Erich Gulbins

Medical Faculty of the University of Tübingen: Tübingen, DE

1996 | Habilitation in Physiology (Physiology)
Education
Source: Self-asserted source
Erich Gulbins

University of Heidelberg: Heidelberg, DE

1992 | MD, PhD
Education
Source: Self-asserted source
Erich Gulbins

University of Heidelberg: Heidelberg, DE

1985 to 1991 | Medical School
Education
Source: Self-asserted source
Erich Gulbins

Professional activities (6)

National Academy of Sciences Leopoldina: Halle, DE

2011 to present | Member
Service
Source: Self-asserted source
Erich Gulbins

German Society for Microbiology and Hygiene: Muenster, DE

2011 to present
Membership
Source: Self-asserted source
Erich Gulbins

American Chemical Society: Washington D.C., District of Columbia, US

2011 to present
Membership
Source: Self-asserted source
Erich Gulbins

American Society for Microbiology: Washington, DC, US

1998 to present
Membership
Source: Self-asserted source
Erich Gulbins

German Physiological Society: Frankfurt, DE

1997 to present
Membership
Source: Self-asserted source
Erich Gulbins

American Association for the Advancement of Science: D.C., D.C., US

1994 to present
Membership
Source: Self-asserted source
Erich Gulbins

Funding (18)

A novel strategy to eradicate pancreatic ductal adenocarcinoma

2022-01 to 2024-12 | Grant
Worldwide Cancer Research (Edinburgh, GB)
Source: Self-asserted source
Erich Gulbins

Role of the acid ceramidase and sphingosine for the interplay of viral and bacterial pulmonary infections

2021-08 to 2024-07 | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
Source: Self-asserted source
Erich Gulbins

Subendothelial exosomes in coronary microvascular dysfunction

2021-05 to 2025-05 | Grant
National Institutes of Health (Md., Md., US)
Source: Self-asserted source
Erich Gulbins

Sphingosine inhalation as a novel treatment for bacterial pneumonia

2020-12 to 2023-11 | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
Source: Self-asserted source
Erich Gulbins

Molecular mechanisms of sphingosine-mediated killing of bacteria

2020-05 to 2023-04 | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
Source: Self-asserted source
Erich Gulbins

Regulation of the effects of antidepressants by sphingomyelin- and ceramide-controlled autophagy

2020-02 to 2023-03 | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
Source: Self-asserted source
Erich Gulbins

Biomedicine of the acid sphingomyelinase/acid ceramidase system

2015 to 2021 | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
Source: Self-asserted source
Erich Gulbins

Sphingolipid dynamics in infection control

2014 to 2020 | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
Source: Self-asserted source
Erich Gulbins

Sphingolipids-Signals and Disease

2007 to 2013 | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
Source: Self-asserted source
Erich Gulbins

Fellowship from BASF-AG

1992 to 1994 | Award
German Scholarship National Foundation (Berlin, DE)
Source: Self-asserted source
Erich Gulbins

Annika Liese Award on Major Depression

2014 | Award
Annika Liese Stiftung (Hannover, DE)
Source: Self-asserted source
Erich Gulbins

Du-Bois-Reymond Award

1999 | Award
German Physiological Society (Rostock, DE)
Source: Self-asserted source
Erich Gulbins

Eva and Klaus Grohe Award on Infectious Biology

2015 | Award
Berlin-Brandenburg Academy of Sciences (Berlin, DE)
Source: Self-asserted source
Erich Gulbins

Felowship

1994 | Grant
Leukemia and Lymphoma Society (NY, NY, US)
Source: Self-asserted source
Erich Gulbins

German Nephrology Society

1991 | Award
German Nephrology Society (Belin, DE)
Source: Self-asserted source
Erich Gulbins

Sandoz Prize for Young Investigators

1994 | Award
Sandoz (Berlin, DE)
Source: Self-asserted source
Erich Gulbins

Sphingosine inhalation as a novel treatment for bacterial pneumonia

Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
Source: Self-asserted source
Erich Gulbins

Travel Award from the International Society of Microcirculation

1991 | Award
International Society of Microcirculation (Pecs, HU)
Source: Self-asserted source
Erich Gulbins

Works (42)

Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells.

J Biol Chem
2021 | Journal article
Source: Self-asserted source
Erich Gulbins

Interferon regulatory factor 8 regulates expression of acid ceramidase and infection susceptibility in cystic fibrosis.

J Biol Chem
2021 | Journal article
Source: Self-asserted source
Erich Gulbins

The acid sphingomyelinase/ceramide system in COVID-19.

2021 | Journal article
Source: Self-asserted source
Erich Gulbins

Acid ceramidase of macrophages traps herpes simplex virus in multivesicular bodies and protects from severe disease.

Nature Communications
2020 | Journal article
Source: Self-asserted source
Erich Gulbins

Pharmacological inhibition of acid sphingomyelinase prevents uptake of SARS-CoV-2 by epithelial cells.

CELL Rep Med
2020 | Journal article
Source: Self-asserted source
Erich Gulbins

Recombinant acid ceramidase reduces inflammation and infection in cystic fibrosis.

Am J Respir Crit Care Med
2020 | Journal article
Source: Self-asserted source
Erich Gulbins

Sphingosine kills bacteria by binding to cardiolipin.

J Biol Chem
2020 | Journal article
Source: Self-asserted source
Erich Gulbins

Sphingosine prevents binding of SARS-CoV-2 spike to its cellular receptor ACE2.

J Biol Chem
2020 | Journal article
Source: Self-asserted source
Erich Gulbins

Antidepressants act by inducing autophagy controlled by sphingomyelin-ceramide.

Mol Psychiatry
2018 | Journal article
Source: Self-asserted source
Erich Gulbins

Sphingolipids as targets for inhalation treatment of cystic fibrosis.

Adv Drug Deliv Rev
2018 | Journal article
Source: Self-asserted source
Erich Gulbins

Direct pharmacological targeting of a mitochondrial ion channel selectively kills tumor cells in vivo.

Cancer Cell
2017 | Journal article
Source: Self-asserted source
Erich Gulbins

β1-Integrin accumulates in cystic fibrosis luminal airway epithelial membranes and decreases sphingosine, promoting bacterial infections.

Cell Host Microbe
2017 | Journal article
Source: Self-asserted source
Erich Gulbins

Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate.

J Hepatol
2016 | Journal article
Source: Self-asserted source
Erich Gulbins

Regulation of hematogenous tumor metastasis by acid sphingomyelinase.

EMBO Mol Med
2015 | Journal article
Source: Self-asserted source
Erich Gulbins

Mitochondrial ion channels as oncological targets

2014 | Journal article
DOI:

10.1038/onc.2013.578

EID:

2-s2.0-84892686676
Contributors: Leanza, L.; Zoratti, M.; Gulbins, E.; Szabo, I.
Source: Self-asserted source
Erich Gulbins via Scopus - Elsevier

Sphingoid long chain bases prevent lung infection by Pseudomonas aeruginosa.

EMBO Mol Med
2014 | Journal article
Source: Self-asserted source
Erich Gulbins

The ceramide system as a novel antidepressant target

2014 | Journal article
DOI:

10.1016/j.tips.2014.04.003

EID:

2-s2.0-84901774687
Contributors: Kornhuber, J.; Müller, C.P.; Becker, K.A.; Reichel, M.; Gulbins, E.
Source: Self-asserted source
Erich Gulbins via Scopus - Elsevier

Acid sphingomyelinase/ceramide system mediates effects of antidepressant drugs.

Nature Medicine
2013 | Journal article
Source: Self-asserted source
Erich Gulbins

Clofazimine, Psora 4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia.

Leukemia
2013 | Journal article
Source: Self-asserted source
Erich Gulbins

Clofazimine, Psora-4 and PAP-1, inhibitors of the potassium channel Kv1.3, as a new and selective therapeutic strategy in chronic lymphocytic leukemia

2013 | Journal article
DOI:

10.1038/leu.2013.56

EID:

2-s2.0-84881479922
Contributors: Leanza, L.; Trentin, L.; Becker, K.A.; Frezzato, F.; Zoratti, M.; Semenzato, G.; Gulbins, E.; Szabo, I.
Source: Self-asserted source
Erich Gulbins via Scopus - Elsevier

It Takes a CAD to Kill a Tumor Cell with a LMP

2013 | Journal article
DOI:

10.1016/j.ccr.2013.08.025

EID:

2-s2.0-84883631174
Contributors: Gulbins, E.; Kolesnick, R.N.
Source: Self-asserted source
Erich Gulbins via Scopus - Elsevier

Inhibitors of mitochondrial Kv1.3 channels induce Bax/Bak-independent death of cancer cells

2012 | Journal article
DOI:

10.1002/emmm.201200235

EID:

2-s2.0-84863473765
Contributors: Leanza, L.; Henry, B.; Sassi, N.; Zoratti, M.; Chandy, K.G.; Gulbins, E.; Szabò, I.
Source: Self-asserted source
Erich Gulbins via Scopus - Elsevier

Identification of novel functional inhibitors of acid sphingomyelinase

2011 | Journal article
DOI:

10.1371/journal.pone.0023852

EID:

2-s2.0-80052314330
Contributors: Kornhuber, J.; Muehlbacher, M.; Trapp, S.; Pechmann, S.; Friedl, A.; Reichel, M.; Mühle, C.; Terfloth, L.; Groemer, T.W.; Spitzer, G.M. et al.
Source: Self-asserted source
Erich Gulbins via Scopus - Elsevier

Kinase suppressor of Ras-1 protects against pulmonary Pseudomonas aeruginosa infections.

Nature Medicine
2011 | Journal article
Source: Self-asserted source
Erich Gulbins

Single-point mutations of a lysine residue change function of Bax and Bcl-xL expressed in Bax- and Bak-less mouse embryonic fibroblasts: Novel insights into the molecular mechanisms of Bax-induced apoptosis

2011 | Journal article
DOI:

10.1038/cdd.2010.112

EID:

2-s2.0-79951681014
Contributors: Szabò, I.; Soddemann, M.; Leanza, L.; Zoratti, M.; Gulbins, E.
Source: Self-asserted source
Erich Gulbins via Scopus - Elsevier

Lipids control mucus production in cystic fibrosis

2010 | Journal article
DOI:

10.1038/nm0310-267

EID:

2-s2.0-77749246125
Contributors: Gulbins, E.
Source: Self-asserted source
Erich Gulbins via Scopus - Elsevier

Lipids control mucus production in cystic fibrosis.

Nature Medicine
2010 | Journal article
Source: Self-asserted source
Erich Gulbins

Cystic fibrosis and innate immunity: how chloride channel mutations provoke lung disease.

Cell Microbiol
2009 | Journal article
Source: Self-asserted source
Erich Gulbins

Acid sphingomyelinase amplifies redox signaling in Pseudomonas aeruginosa-induced macrophage apoptosis.

Journal of Immunology
2008 | Journal article
Source: Self-asserted source
Erich Gulbins

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis.

Nature Medicine
2008 | Journal article
Source: Self-asserted source
Erich Gulbins

Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.

J Med Chem
2008 | Journal article
Source: Self-asserted source
Erich Gulbins

Mitochondrial potassium channel Kv1.3 mediates Bax-induced apoptosis in lymphocytes.

Proc Natl Acad Sci U S A
2008 | Journal article
Source: Self-asserted source
Erich Gulbins

Sphingolipids in the lungs.

Am J Respir Crit Care Med
2008 | Journal article
Source: Self-asserted source
Erich Gulbins

Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide.

Nature Medicine
2007 | Journal article
Source: Self-asserted source
Erich Gulbins

PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide.

Nature Medicine
2004 | Journal article
Source: Self-asserted source
Erich Gulbins

Host defense against Pseudomonas aeruginosa requires ceramide-rich membrane rafts.

Nature Medicine
2003 | Journal article
Source: Self-asserted source
Erich Gulbins

Raft ceramide in molecular medicine.

Oncogene
2003 | Journal article
Source: Self-asserted source
Erich Gulbins

CD95 signaling via ceramide-rich membrane rafts.

J Biol Chem
2001 | Journal article
Source: Self-asserted source
Erich Gulbins

Ceramide enables fas to cap and kill.

J. Biol. Chem.
2001 | Journal article
Source: Self-asserted source
Erich Gulbins

CD95/CD95 ligand interactions on epithelial cells in host defense to Pseudomonas aeruginosa.

Science
2000 | Journal article
Source: Self-asserted source
Erich Gulbins

CD66-mediated phagocytosis of Opa52 Neisseria gonorrhoeae requires a Src-like tyrosine kinase- and Rac1-dependent signalling pathway.

EMBO J.
1998 | Journal article
Source: Self-asserted source
Erich Gulbins

Acidic sphingomyelinase mediates entry of N. gonorrhoeae into nonphagocytic cells.

CELL
1997 | Journal article
Source: Self-asserted source
Erich Gulbins
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