Personal information

Cancer, lymphoma, immunotherapy, monoclonal antibody, transcription factor

Biography

Prof Alison Banham is currently Professor of Haemato-oncology and Head of the Nuffield Division of Clinical Laboratory Sciences, within the Radcliffe Department of Medicine at the University of Oxford.

Her academic qualifications include BA, MA and D.Phil. (PhD) degrees from the University of Oxford and Fellowship of the Royal College of Pathologists. Professor Banham is a member of the British Lymphoma Pathology Study Group and a founder member and currently Vice President of the European Network of Monoclonal Antibody Producing Laboratories.

Having originally studied Botany and then Biochemistry she was introduced to monoclonal antibody technology in 1990, through making antibodies for the detection of food spoilage fungi. Since 1995 her main research focus has been within the field of cancer, particularly lymphoma, focussing initially on the identification and characterisation of novel diagnostic and prognostic biomarkers and more recently, since 2009, expanding into novel antibody therapeutics.

Antibody therapeutics are focussed primarily of targeting the tumour vasculature, in particular the Notch signalling pathway and on the development of TCR mimic antibodies which recognise peptides from intracellular tumour proteins that are presented on the cell surface by MHC class I molecules. This work is supported by Cancer Research UK. Funding from Leukaemia and Lymphoma Research supports investigation into a family of forehead transcription factors that play a critical role in the pathogenesis of lymphoma and other types of cancer. These molecules play an important role in enabling tumour cells to evade the host immune response.

Prof Banham is happy to undertake outreach activities. She is a STEM Ambassador and a volunteer for the Inspiring the Future Campaign.

Activities

Employment (1)

University of Oxford: Oxford, Oxfordshire, GB

(RDM Clinical Laboratory Sciences; St Catherine's College)
Employment
Source: check_circle
ORCID Integration at the University of Oxford

Education and qualifications (5)

Royal College of Pathologists: London, London, GB

2007 | FRCPath
Education
Source: Self-asserted source
Alison Banham

Royal College of Pathologists: London, London, GB

2007 | FRCPath
Education
Source: Self-asserted source
Alison Banham

University of Oxford: Oxford, Oxfordshire, GB

1991 | MA (St Catherine's College)
Education
Source: Self-asserted source
Alison Banham

University of Oxford: Oxford, Oxfordshire, GB

1987 to 1990 | DPhil (Biochemistry) (St Catherine's College)
Education
Source: Self-asserted source
Alison Banham

University of Oxford: Oxford, Oxfordshire, GB

1983 to 1986 | BA (Botany) (St Catherine's College)
Education
Source: Self-asserted source
Alison Banham

Works (50 of 114)

Items per page:
Page 1 of 3

The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest.

2015 | Journal article
DOI:

10.1371/journal.pone.0128513

PMID:

26034982

Contributors: Gascoyne DM; Spearman H; Lyne L; Puliyadi R; Perez-Alcantara M; Coulton L; Fisher SE; Croucher PI; Banham AH
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Cancer/Testis Antigen PASD1 Silences the Circadian Clock.

2015-06 | Journal article
DOI:

10.1016/j.molcel.2015.03.031

PMID:

25936801

Contributors: Michael AK; Harvey SL; Sammons PJ; Anderson AP; Kopalle HM; Banham AH; Partch CL
Source: Self-asserted source
Alison Banham via Europe PubMed Central

A novel zinc finger gene, ZNF465, is inappropriately expressed in acute myeloid leukaemia cells.

2015-05 | Journal article
DOI:

10.1002/gcc.22242

PMID:

25706801

Contributors: Collin JF; Wells JW; Czepulkowski B; Lyne L; Duriez PJ; Banham AH; Mufti GJ; Guinn BA
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Pim-2 kinase influences Tregulatory cell function and stability by mediating Foxp3 N-terminal phosphorylation.

2015-05 | Journal article
DOI:

10.1074/jbc.M115.638221

PMID:

25987564

Contributors: Deng G; Nagai Y; Xiao Y; Li Z; Dai S; Ohtani T; Banham A; Li B; Wu SL; Hancock W et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Increased Expression of Phosphorylated FADD in Anaplastic Large Cell and Other T-Cell Lymphomas.

2014 | Journal article
DOI:

10.4137/BMI.S16553

PMID:

25232277

PMC:

PMC4159367

Contributors: Patel S; Murphy D; Haralambieva E; Abdulla ZA; Wong KK; Chen H; Gould E; Roncador G; Hatton CS; Anderson AP et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

The notch ligand JAGGED1 as a target for anti-tumor therapy.

2014 | Journal article
DOI:

10.3389/fonc.2014.00254

PMID:

25309874

PMC:

PMC4174884

Contributors: Li D; Masiero M; Banham AH; Harris AL
Source: Self-asserted source
Alison Banham via Europe PubMed Central

A review of ELTD1, a pro-angiogenic adhesion GPCR.

2014-12 | Journal article
DOI:

10.1042/BST20140216

PMID:

25399586

Contributors: Favara DM; Banham AH; Harris AL
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Elevated receptor for activated C kinase 1 expression is involved in intracellular Ca2+ influx and potentially associated with compromised regulatory T cell function in patients with asthma.

2014-09 | Journal article
DOI:

10.1111/cea.12375

PMID:

25048599

Contributors: Negoro T; Shimizu S; Narushima M; Banham AH; Wakabayashi H; Takayanagi R; Hagiwara T; Roncador G; Osabe T; Yanai T et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Quantification of hepatic FOXP3+ T-lymphocytes in HIV/hepatitis C coinfection.

2014-04 | Journal article
DOI:

10.1111/jvh.12141

PMID:

24597693

PMC:

PMC4159582

Contributors: Williams SK; Donaldson E; Van der Kleij T; Dixon L; Fisher M; Tibble J; Gilleece Y; Klenerman P; Banham AH; Howard M et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Reciprocal expression of the endocytic protein HIP1R and its repressor FOXP1 predicts outcome in R-CHOP-treated diffuse large B-cell lymphoma patients.

2014-02 | Journal article
DOI:

10.1038/leu.2013.224

PMID:

23884370

Contributors: Wong KK; Gascoyne DM; Brown PJ; Soilleux EJ; Snell C; Chen H; Lyne L; Lawrie CH; Gascoyne RD; Pedersen LM et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis.

2013-08 | Journal article
DOI:

10.1016/j.ccr.2013.06.004

PMID:

23871637

PMC:

PMC3743050

Contributors: Masiero M; Simões FC; Han HD; Snell C; Peterkin T; Bridges E; Mangala LS; Wu SY; Pradeep S; Li D et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor.

2013-03 | Journal article
DOI:

10.1074/jbc.M112.428854

PMID:

23339193

PMC:

PMC3591638

Contributors: Whiteman P; de Madrid BH; Taylor P; Li D; Heslop R; Viticheep N; Tan JZ; Shimizu H; Callaghan J; Masiero M et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

The transcription factor encyclopedia.

2012 | Journal article
DOI:

10.1186/gb-2012-13-3-r24

PMID:

22458515

PMC:

PMC3439975

Contributors: Yusuf D; Butland SL; Swanson MI; Bolotin E; Ticoll A; Cheung WA; Zhang XY; Dickman CT; Fulton DL; Lim JS et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

RNASET2--an autoantigen in anaplastic large cell lymphoma identified by protein array analysis.

2012-09 | Journal article
DOI:

10.1016/j.jprot.2012.06.009

PMID:

22732457

Contributors: Patel S; Chen H; Monti L; Gould E; Haralambieva E; Schmid J; Toomey D; Woessmann W; Roncador G; Hatton CS et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Identification and characterization of peripheral T-cell lymphoma-associated SEREX antigens.

2011 | Journal article
DOI:

10.1371/journal.pone.0023916

PMID:

21887344

PMC:

PMC3161784

Contributors: Cooper CD; Lawrie CH; Liggins AP; Collins GP; Hatton CS; Pulford K; Banham AH
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Impaired Ca²⁺ regulation of CD4⁺CD25⁺ regulatory T cells from pediatric asthma.

2011 | Journal article
DOI:

10.1159/000322845

PMID:

21576985

Contributors: Yamamoto Y; Negoro T; Hoshi A; Wakagi A; Shimizu S; Banham AH; Ishii M; Akiyama H; Kiuchi Y; Sunaga S et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Recruitment of regulatory T cells is correlated with hypoxia-induced CXCR4 expression, and is associated with poor prognosis in basal-like breast cancers.

2011 | Journal article
DOI:

10.1186/bcr2869

PMID:

21521526

PMC:

PMC3219210

Contributors: Yan M; Jene N; Byrne D; Millar EK; O'Toole SA; McNeil CM; Bates GJ; Harris AL; Banham AH; Sutherland RL et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

CD4-positive T-helper cell responses to the PASD1 protein in patients with diffuse large B-cell lymphoma.

2011-01 | Journal article
DOI:

10.3324/haematol.2010.028241

PMID:

20851862

PMC:

PMC3012768

Contributors: Ait-Tahar K; Liggins AP; Collins GP; Campbell A; Barnardo M; Cabes M; Lawrie CH; Moir D; Hatton C; Banham AH et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

A panel of cancer-testis genes exhibiting broad-spectrum expression in haematological malignancies.

2010 | Journal article
PMID:

20726502

PMC:

PMC2964014

Contributors: Liggins AP; Lim SH; Soilleux EJ; Pulford K; Banham AH
Source: Self-asserted source
Alison Banham via Europe PubMed Central

DNA vaccines to target the cancer testis antigen PASD1 in human multiple myeloma.

2010-11 | Journal article
DOI:

10.1038/leu.2010.196

PMID:

20861911

Contributors: Joseph-Pietras D; Gao Y; Zojer N; Ait-Tahar K; Banham AH; Pulford K; Rice J; Savelyeva N; Sahota SS
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Comparison of Choi and Hans' algorithms by immunohistochemistry and quantitative reverse transcriptase-PCR - letter.

2010-07 | Journal article
DOI:

10.1158/1078-0432.CCR-09-3216

PMID:

20628029

Contributors: Ballabio E; Chi J; Roncador G; Banham AH; Hatton CS; Lawrie CH
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Targeted phototherapy of plaque-type psoriasis using ultraviolet B-light-emitting diodes.

2010-07 | Journal article
DOI:

10.1111/j.1365-2133.2010.09763.x

PMID:

20302573

Contributors: Kemény L; Csoma Z; Bagdi E; Banham AH; Krenács L; Koreck A
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Aberrant expression of the neuronal transcription factor FOXP2 in neoplastic plasma cells.

2010-04 | Journal article
DOI:

10.1111/j.1365-2141.2009.08070.x

PMID:

20096010

Contributors: Campbell AJ; Lyne L; Brown PJ; Launchbury RJ; Bignone P; Chi J; Roncador G; Lawrie CH; Gatter KC; Kusec R et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Ribosome-associated nucleophosmin 1: increased expression and shuttling activity distinguishes prognostic subtypes in chronic lymphocytic leukaemia.

2010-02 | Journal article
DOI:

10.1111/j.1365-2141.2009.07979.x

PMID:

19961478

Contributors: Rees-Unwin KS; Faragher R; Unwin RD; Adams J; Brown PJ; Buckle AM; Pettitt A; Hutchinson CV; Johnson SM; Pulford K et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

FOXP3 expression in blood, synovial fluid and synovial tissue during inflammatory arthritis and intra-articular corticosteroid treatment.

2009-12 | Journal article
DOI:

10.1136/ard.2008.100768

PMID:

19066178

Contributors: Raghavan S; Cao D; Widhe M; Roth K; Herrath J; Engström M; Roncador G; Banham AH; Trollmo C; Catrina AI et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Immuno-fluorescence in situ hybridization index predicts survival in patients with diffuse large B-cell lymphoma treated with R-CHOP: a GELA study.

2009-11 | Journal article
DOI:

10.1200/JCO.2009.22.7058

PMID:

19786664

Contributors: Copie-Bergman C; Gaulard P; Leroy K; Briere J; Baia M; Jais JP; Salles GA; Berger F; Haioun C; Tilly H et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Expression of the forkhead box transcription factor FOXP1 is associated with oestrogen receptor alpha, oestrogen receptor beta and improved survival in familial breast cancers.

2009-10 | Journal article
DOI:

10.1136/jcp.2009.065169

PMID:

19622517

Contributors: Rayoo M; Yan M; Takano EA; Bates GJ; Brown PJ; Banham AH; Fox SB
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Immunophenotypic analysis of AIDS-related diffuse large B-cell lymphoma and clinical implications in patients from AIDS Malignancies Consortium clinical trials 010 and 034.

2009-10 | Journal article
DOI:

10.1200/JCO.2008.20.5450

PMID:

19752343

PMC:

PMC2799056

Contributors: Chadburn A; Chiu A; Lee JY; Chen X; Hyjek E; Banham AH; Noy A; Kaplan LD; Sparano JA; Bhatia K et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

A new immunostain algorithm classifies diffuse large B-cell lymphoma into molecular subtypes with high accuracy.

2009-09 | Journal article
DOI:

10.1158/1078-0432.CCR-09-0113

PMID:

19706817

Contributors: Choi WW; Weisenburger DD; Greiner TC; Piris MA; Banham AH; Delabie J; Braziel RM; Geng H; Iqbal J; Lenz G et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Cytolytic T-cell response to the PASD1 cancer testis antigen in patients with diffuse large B-cell lymphoma.

2009-08 | Journal article
DOI:

10.1111/j.1365-2141.2009.07761.x

PMID:

19552722

Contributors: Ait-Tahar K; Liggins AP; Collins GP; Campbell A; Barnardo M; Lawrie C; Moir D; Hatton C; Banham AH; Pulford K
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Prognostic impact of activated B-cell focused classification in diffuse large B-cell lymphoma patients treated with R-CHOP.

2009-08 | Journal article
DOI:

10.1038/modpathol.2009.73

PMID:

19448593

Contributors: Nyman H; Jerkeman M; Karjalainen-Lindsberg ML; Banham AH; Leppä S
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Therapeutic targeting of FOXP3-positive regulatory T cells using a FOXP3 peptide vaccine WO2008081581.

2009-07 | Journal article
DOI:

10.1517/13543770902785183

PMID:

19456276

Contributors: Banham AH; Pulford K
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Bcl-2 but not FOXP1, is an adverse risk factor in immunochemotherapy-treated non-germinal center diffuse large B-cell lymphomas.

2009-05 | Journal article
DOI:

10.1111/j.1600-0609.2009.01222.x

PMID:

19141121

Contributors: Nyman H; Jerkeman M; Karjalainen-Lindsberg ML; Banham AH; Enblad G; Leppä S
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Regulatory T cells in atopic dermatitis: epidermal dendritic cell clusters may contribute to their local expansion.

2009-05 | Journal article
DOI:

10.1111/j.1365-2133.2009.09035.x

PMID:

19222459

Contributors: Szegedi A; Baráth S; Nagy G; Szodoray P; Gál M; Sipka S; Bagdi E; Banham AH; Krenács L
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Disruption of neural progenitors along the ventricular and subventricular zones in periventricular heterotopia.

2009-02 | Journal article
DOI:

10.1093/hmg/ddn377

PMID:

18996916

PMC:

PMC2722192

Contributors: Ferland RJ; Batiz LF; Neal J; Lian G; Bundock E; Lu J; Hsiao YC; Diamond R; Mei D; Banham AH et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Immunomodulation of FOXP3+ regulatory T cells by the aromatase inhibitor letrozole in breast cancer patients.

2009-02 | Journal article
DOI:

10.1158/1078-0432.CCR-08-1507

PMID:

19188178

Contributors: Generali D; Bates G; Berruti A; Brizzi MP; Campo L; Bonardi S; Bersiga A; Allevi G; Milani M; Aguggini S et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Monoclonal antibodies raised to the human FOXP3 protein can be used effectively for detecting Foxp3(+) T cells in other mammalian species.

2009-02 | Journal article
DOI:

10.1016/j.vetimm.2008.10.328

PMID:

19084279

Contributors: Banham AH; Lyne L; Scase TJ; Blacklaws BA
Source: Self-asserted source
Alison Banham via Europe PubMed Central

FOXP3+ regulatory T cells as biomarkers in human malignancies.

2008-12 | Journal article
DOI:

10.1517/14712590802494022

PMID:

18990077

Contributors: Bignone PA; Banham AH
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Expression of the forkhead transcription factor FOXP1 is associated with that of estrogen receptor-beta in primary invasive breast carcinomas.

2008-10 | Journal article
DOI:

10.1007/s10549-007-9812-4

PMID:

18026833

Contributors: Bates GJ; Fox SB; Han C; Launchbury R; Leek RD; Harris AL; Banham AH
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Pathway activation patterns in diffuse large B-cell lymphomas.

2008-09 | Journal article
DOI:

10.1038/leu.2008.166

PMID:

18580954

Contributors: Bentink S; Wessendorf S; Schwaenen C; Rosolowski M; Klapper W; Rosenwald A; Ott G; Banham AH; Berger H; Feller AC et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

The presence of tumor-infiltrating FOXP3+ lymphocytes correlates with intratumoral angiogenesis in endometrial cancer.

2008-08 | Journal article
DOI:

10.1016/j.ygyno.2008.04.021

PMID:

18533240

Contributors: Giatromanolaki A; Bates GJ; Koukourakis MI; Sivridis E; Gatter KC; Harris AL; Banham AH
Source: Self-asserted source
Alison Banham via Europe PubMed Central

FOXP1 abnormalities in lymphoma: translocation breakpoint mapping reveals insights into deregulated transcriptional control.

2008-07 | Journal article
DOI:

10.1038/modpathol.2008.74

PMID:

18487996

Contributors: Goatly A; Bacon CM; Nakamura S; Ye H; Kim I; Brown PJ; Ruskoné-Fourmestraux A; Cervera P; Streubel B; Banham AH et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma.

2008-05 | Journal article
DOI:

10.1111/j.1365-2141.2008.07077.x

PMID:

18318758

Contributors: Lawrie CH; Gal S; Dunlop HM; Pushkaran B; Liggins AP; Pulford K; Banham AH; Pezzella F; Boultwood J; Wainscoat JS et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Translocations involving the immunoglobulin heavy chain gene locus predict better survival in gastric diffuse large B-cell lymphoma.

2008-05 | Journal article
DOI:

10.1158/1078-0432.CCR-07-4946

PMID:

18445693

Contributors: Nakamura S; Ye H; Bacon CM; Goatly A; Liu H; Kerr L; Banham AH; Streubel B; Yao T; Tsuneyoshi M et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Characterization of human FOXP1 isoform 2, using monoclonal antibody 4E3-G11, and intron retention as a tissue-specific mechanism generating a novel FOXP1 isoform.

2008-04 | Journal article
DOI:

10.1111/j.1365-2559.2008.02990.x

PMID:

18312343

Contributors: Brown PJ; Kagaya R; Banham AH
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Defense of the clone: antibody 259D effectively labels human FOXP3 in a variety of applications.

2008-04 | Journal article
DOI:

10.1182/blood-2008-01-134148

PMID:

18362214

Contributors: Fox BC; Bignone PA; Brown PJ; Banham AH
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Potentially oncogenic B-cell activation-induced smaller isoforms of FOXP1 are highly expressed in the activated B cell-like subtype of DLBCL.

2008-03 | Journal article
DOI:

10.1182/blood-2007-09-115113

PMID:

18077790

Contributors: Brown PJ; Ashe SL; Leich E; Burek C; Barrans S; Fenton JA; Jack AS; Pulford K; Rosenwald A; Banham AH
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Expression of BNIP3 correlates with hypoxia-inducible factor (HIF)-1alpha, HIF-2alpha and the androgen receptor in prostate cancer and is regulated directly by hypoxia but not androgens in cell lines.

2008-02 | Journal article
DOI:

10.1002/pros.20707

PMID:

18163427

Contributors: Shaida N; Launchbury R; Boddy JL; Jones C; Campo L; Turley H; Kanga S; Banham AH; Malone PR; Harris AL et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Is FOXP3 expressed in cutaneous T-cell lymphomas?

2008-01 | Journal article
DOI:

10.1111/j.1600-0609.2007.00990.x

PMID:

18036183

Contributors: Banham AH; Brown PJ; Lyne L; Schulze HJ; Hallermann C
Source: Self-asserted source
Alison Banham via Europe PubMed Central

Increased frequency of regulatory T cells in peripheral blood and tumour infiltrating lymphocytes in colorectal cancer patients.

2007 | Journal article
PMID:

17388261

PMC:

PMC2935744

Contributors: Ling KL; Pratap SE; Bates GJ; Singh B; Mortensen NJ; George BD; Warren BF; Piris J; Roncador G; Fox SB et al.
Source: Self-asserted source
Alison Banham via Europe PubMed Central
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