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Direct evidence that the GPCR CysLTR2 mutant causative of uveal melanoma is constitutively active with highly biased signaling

Journal of Biological Chemistry
2021-01 | Journal article
DOI: 10.1074/jbc.RA120.015352
Contributors: Emilie Ceraudo; Mizuho Horioka; Jordan M. Mattheisen; Tyler D. Hitchman; Amanda R. Moore; Manija A. Kazmi; Ping Chi; Yu Chen; Thomas P. Sakmar; Thomas Huber
Source: check_circle
Crossref

Uveal Melanoma Oncogene CYSLTR2 Encodes a Constitutively Active GPCR Highly Biased Toward Gq Signaling

2019-06-06 | Other
DOI: 10.1101/663153
Contributors: Emilie Ceraudo; Mizuho Horioka; Jordan M. Mattheisen; Tyler D. Hitchman; Amanda R. Moore; Manija A. Kazmi; Ping Chi; Yu Chen; Thomas P. Sakmar; Thomas Huber
Source: check_circle
Crossref

GNA11 Q209L Mouse Model Reveals RasGRP3 as an Essential Signaling Node in Uveal Melanoma.

Cell reports
2018-02-01 | Journal article
DOI: 10.1016/j.celrep.2018.01.081
PMID: 29490280
PMC: PMC5854482
Source: Self-asserted source
Tyler Hitchman

Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair.

The Journal of pathology
2017-03-30 | Journal article
DOI: 10.1002/path.4883
PMID: 28188619
PMC: PMC5397343
Source: Self-asserted source
Tyler Hitchman
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