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Website UCDR
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Belgium

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Employment (5)

Université libre de Bruxelles (ULB): 1050, Brussels, BE

Employment
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Université libre de Bruxelles

Université Libre de Bruxelles (ULB): Brussels, BE

2016-10-01 to present | Associate Professor (ULB Center for diabetes research. UCDR)
Employment
Source: Self-asserted source
Mariana Igoillo-Esteve

F.R.S-F.N.R.S: Brussels, BE

2015-10-01 to 2016-09-30 | FNRS scientific collaborator (ULB Center for diabetes research. UCDR)
Employment
Source: Self-asserted source
Mariana Igoillo-Esteve

Université Libre de Bruxelles: Bruxelles, BE

2007-10-01 to 2014-09-30 | Post Doctoral Fellow (ULB Center for diabetes research. UCDR)
Employment
Source: Self-asserted source
Mariana Igoillo-Esteve

Université Catholique de Louvain: Brussels, BE

2005-06-24 to 2007-09-30 | Post Doctoral Fellow ('Christian de Duve Institute of Cellular Pathology (ICP). Research Unit for Tropical Diseases . TROP)
Employment
Source: Self-asserted source
Mariana Igoillo-Esteve

Education and qualifications (2)

Universidad Nacional de San Martín: Buenos Aires, AR

2000-04-01 to 2005-04-29 | Ph.D. in Molecular Biology and Biotechnology (IIB/INTECH Conicet)
Education
Source: Self-asserted source
Mariana Igoillo-Esteve

Universidad de Buenos Aires: Buenos Aires, AR

1993-03-01 to 1999-02-20 | Biochemist (Facultad de Farmacia y Bioquimica )
Education
Source: Self-asserted source
Mariana Igoillo-Esteve

Professional activities (4)

EASD Islet Study Group and Beta-Cell Workshop: Oxford, GB

2019 | Best Oral presentation Award
Distinction
Source: Self-asserted source
Mariana Igoillo-Esteve

Belgian Endocrine Society: Brussels, BE

2018 | Investigator Award
Distinction
Source: Self-asserted source
Mariana Igoillo-Esteve

Belgian Endocrine Society: Brussels, BE

2013 | Young investigator award
Distinction
Source: Self-asserted source
Mariana Igoillo-Esteve

Belgian Endocrine Society: Brussels, BE

2011 | Young investigator award
Distinction
Source: Self-asserted source
Mariana Igoillo-Esteve

Works (43)

DNAJC3 deficiency induces β-cell mitochondrial apoptosis and causes syndromic young-onset diabetes.

European journal of endocrinology
2021-03-01 | Journal article
DOI: 10.1530/eje-20-0636
PMID: 33486469
Source: Self-asserted source
Mariana Igoillo-Esteve

tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors

International Journal of Molecular Sciences
2021-01-06 | Journal article
DOI: 10.3390/ijms22020496
Contributors: Maria Nicol Arroyo; Jonathan Alex Green; Miriam Cnop; Mariana Igoillo-Esteve
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

YIPF5 mutations cause neonatal diabetes and microcephaly through endoplasmic reticulum stress

Journal of Clinical Investigation
2020-11-09 | Journal article
DOI: 10.1172/JCI141455
Contributors: Elisa De Franco; Maria Lytrivi; Hazem Ibrahim; Hossam Montaser; Matthew N. Wakeling; Federica Fantuzzi; Kashyap Patel; Céline Demarez; Ying Cai; Mariana Igoillo-Esteve et al.
Source: check_circle
Crossref

Combined transcriptome and proteome profiling of the pancreatic β-cell response to palmitate unveils key pathways of β-cell lipotoxicity.

BMC genomics
2020-08-26 | Journal article
DOI: 10.1186/s12864-020-07003-0
PMID: 32847508
PMC: PMC7448506
Source: Self-asserted source
Mariana Igoillo-Esteve

Exenatide induces frataxin expression and improves mitochondrial function in Friedreich ataxia.

JCI insight
2020-01-30 | Journal article
DOI: 10.1172/jci.insight.134221
PMID: 31877117
PMC: PMC7098728
Source: Self-asserted source
Mariana Igoillo-Esteve

A Review of Mouse Models of Monogenic Diabetes and ER Stress Signaling.

Methods in molecular biology (Clifton, N.J.)
2020-01-01 | Journal article
DOI: 10.1007/978-1-0716-0385-7_4
PMID: 32180185
Source: Self-asserted source
Mariana Igoillo-Esteve

The tRNA Epitranscriptome and Diabetes: Emergence of tRNA Hypomodifications as a Cause of Pancreatic β-Cell Failure.

Endocrinology
2019-05-01 | Journal article
DOI: 10.1210/en.2019-00098
PMID: 30907926
Source: Self-asserted source
Mariana Igoillo-Esteve

Inflammatory stress in islet β-cells: therapeutic implications for type 2 diabetes?

Current Opinion in Pharmacology
2018-12 | Journal article
DOI: 10.1016/j.coph.2018.08.002
Contributors: Maria Lytrivi; Mariana Igoillo-Esteve; Miriam Cnop
Source: check_circle
Crossref

Pancreatic β-cell tRNA hypomethylation and fragmentation link TRMT10A deficiency with diabetes.

Nucleic acids research
2018-11-01 | Journal article
DOI: 10.1093/nar/gky839
PMID: 30247717
PMC: PMC6212784
Source: Self-asserted source
Mariana Igoillo-Esteve

Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

Molecular Metabolism
2017-09 | Journal article
DOI: 10.1016/j.molmet.2017.06.001
Contributors: Miriam Cnop; Sanna Toivonen; Mariana Igoillo-Esteve; Paraskevi Salpea
Source: check_circle
Crossref

JNK Activation of BIM Promotes Hepatic Oxidative Stress, Steatosis, and Insulin Resistance in Obesity.

Diabetes
2017-09-19 | Journal article
DOI: 10.2337/db17-0348
PMID: 28928277
Source: Self-asserted source
Mariana Igoillo-Esteve

Guanabenz Sensitizes Pancreatic β Cells to Lipotoxic Endoplasmic Reticulum Stress and Apoptosis.

Endocrinology
2017-06-01 | Journal article
DOI: 10.1210/en.2016-1773
PMID: 28323924
Source: Self-asserted source
Mariana Igoillo-Esteve

A Missense Mutation in PPP1R15B Causes a Syndrome Including Diabetes, Short Stature, and Microcephaly.

Diabetes
2015-07-09 | Journal article
DOI: 10.2337/db15-0477
PMID: 26159176
PMC: PMC4713904
Source: Self-asserted source
Mariana Igoillo-Esteve

Insulinoma Localization by Glucagon-Like Peptide-1 Receptor Imaging After 18 Years of Hypoglycemia

AACE Clinical Case Reports
2015-06 | Journal article
DOI: 10.4158/ep14427.cr
Part of ISSN: 2376-0605
Source: Self-asserted source
Mariana Igoillo-Esteve

Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms.

Diabetologia
2015-06-23 | Journal article
DOI: 10.1007/s00125-015-3669-6
PMID: 26099855
Source: Self-asserted source
Mariana Igoillo-Esteve

In vitro use of free fatty acids bound to albumin: A comparison of protocols.

BioTechniques
2015-05-01 | Journal article
DOI: 10.2144/000114285
PMID: 25967901
Source: Self-asserted source
Mariana Igoillo-Esteve

Unveiling a common mechanism of apoptosis in β-cells and neurons in Friedreich's ataxia

Human Molecular Genetics
2015-04-15 | Journal article
DOI: 10.1093/hmg/ddu745
Part of ISSN: 1460-2083
Part of ISSN: 0964-6906
Source: Self-asserted source
Mariana Igoillo-Esteve

RNA sequencing identifies dysregulation of the human pancreatic islet transcriptome by the saturated fatty acid palmitate.

Diabetes
2013-12-30 | Journal article
DOI: 10.2337/db13-1383
PMID: 24379348
Source: Self-asserted source
Mariana Igoillo-Esteve

tRNA methyltransferase homolog gene TRMT10A mutation in young onset diabetes and primary microcephaly in humans.

PLoS Genet
2013-10 | Journal article
PMID: 24204302
Source: Self-asserted source
Mariana Igoillo-Esteve

Diabetes in Friedreich Ataxia

Journal of Neurochemistry
2013-08 | Journal article
DOI: 10.1111/jnc.12216
Part of ISSN: 0022-3042
Source: Self-asserted source
Mariana Igoillo-Esteve

Central role and mechanisms of β-cell dysfunction and death in friedreich ataxia-associated diabetes

Annals of Neurology
2012-12 | Journal article
DOI: 10.1002/ana.23698
Part of ISSN: 0364-5134
Source: Self-asserted source
Mariana Igoillo-Esteve

Death Protein 5 and p53-Upregulated Modulator of Apoptosis Mediate the Endoplasmic Reticulum Stress-Mitochondrial Dialog Triggering Lipotoxic Rodent and Human  -Cell Apoptosis

Diabetes
2012-11-01 | Journal article
DOI: 10.2337/db12-0123
Part of ISSN: 0012-1797
Part of ISSN: 1939-327X
Source: Self-asserted source
Mariana Igoillo-Esteve

Pancreatic β-cells activate a JunB/ATF3-dependent survival pathway during inflammation

Oncogene
2012-03 | Journal article
DOI: 10.1038/onc.2011.353
Part of ISSN: 0950-9232
Part of ISSN: 1476-5594
Source: Self-asserted source
Mariana Igoillo-Esteve

DNA methylation profiling identifies epigenetic dysregulation in pancreatic islets from type 2 diabetic patients

The EMBO Journal
2012-03-21 | Journal article
DOI: 10.1038/emboj.2011.503
Part of ISSN: 0261-4189
Source: Self-asserted source
Mariana Igoillo-Esteve

The human pancreatic islet transcriptome: expression of candidate genes for type 1 diabetes and the impact of pro-inflammatory cytokines.

PLoS genetics
2012-03-08 | Journal article
DOI: 10.1371/journal.pgen.1002552
PMID: 22412385
PMC: PMC3297576
Source: Self-asserted source
Mariana Igoillo-Esteve

Longevity of human islet α- and β-cells

Diabetes, Obesity and Metabolism
2011-10 | Journal article
DOI: 10.1111/j.1463-1326.2011.01443.x
Part of ISSN: 1462-8902
Source: Self-asserted source
Mariana Igoillo-Esteve

Ubiquitin Fold Modifier 1 (UFM1) and Its Target UFBP1 Protect Pancreatic Beta Cells from ER Stress-Induced Apoptosis

PLoS ONE
2011-04-06 | Journal article
DOI: 10.1371/journal.pone.0018517
Part of ISSN: 1932-6203
Source: Self-asserted source
Mariana Igoillo-Esteve

Glucose-6-Phosphate Dehydrogenase of Trypanosomatids: Characterization, Target Validation, and Drug Discovery

Molecular Biology International
2011-04-04 | Journal article
DOI: 10.4061/2011/135701
Contributors: Shreedhara Gupta; Mariana Igoillo-Esteve; Paul A. M. Michels; Artur T. Cordeiro
Source: check_circle
Crossref

Glycosomal ABC transporters of Trypanosoma brucei: Characterisation of their expression, topology and substrate specificity

International Journal for Parasitology
2011-03 | Journal article
DOI: 10.1016/j.ijpara.2010.11.002
Part of ISSN: 0020-7519
Source: Self-asserted source
Mariana Igoillo-Esteve

STAT1 Is a Master Regulator of Pancreatic β-Cell Apoptosis and Islet Inflammation

Journal of Biological Chemistry
2011-01-14 | Journal article
DOI: 10.1074/jbc.m110.162131
Part of ISSN: 0021-9258
Part of ISSN: 1083-351X
Source: Self-asserted source
Mariana Igoillo-Esteve

The 6-Phosphogluconate Dehydrogenase of Leishmania (Leishmania) mexicana: Gene Characterization and Protein Structure Prediction

Journal of Molecular Microbiology and Biotechnology
2010 | Journal article
DOI: 10.1159/000320697
Part of ISSN: 1464-1801
Part of ISSN: 1660-2412
Source: Self-asserted source
Mariana Igoillo-Esteve

The transcription factor B-cell lymphoma (BCL)-6 modulates pancreatic {beta}-cell inflammatory responses.

Endocrinology
2010-12-29 | Journal article
DOI: 10.1210/en.2010-0790
PMID: 21190961
Source: Self-asserted source
Mariana Igoillo-Esteve

Genetic and Chemical Evaluation of Trypanosoma brucei Oleate Desaturase as a Candidate Drug Target

PLoS ONE
2010-12-06 | Journal article
DOI: 10.1371/journal.pone.0014239
Part of ISSN: 1932-6203
Source: Self-asserted source
Mariana Igoillo-Esteve

Causes and cures for endoplasmic reticulum stress in lipotoxic β-cell dysfunction

Diabetes, Obesity and Metabolism
2010-10 | Journal article
DOI: 10.1111/j.1463-1326.2010.01279.x
Part of ISSN: 1462-8902
Source: Self-asserted source
Mariana Igoillo-Esteve

Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes.

Diabetologia
2010-04-06 | Journal article
DOI: 10.1007/s00125-010-1707-y
PMID: 20369226
Source: Self-asserted source
Mariana Igoillo-Esteve

Enhanced Signaling Downstream of Ribonucleic Acid-Activated Protein Kinase-Like Endoplasmic Reticulum Kinase Potentiates Lipotoxic Endoplasmic Reticulum Stress in Human Islets

The Journal of Clinical Endocrinology & Metabolism
2010-03-01 | Journal article
DOI: 10.1210/jc.2009-2322
Part of ISSN: 0021-972X
Part of ISSN: 1945-7197
Source: Self-asserted source
Mariana Igoillo-Esteve

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

Diabetologia
2010-02 | Journal article
DOI: 10.1007/s00125-009-1562-x
Part of ISSN: 0012-186X
Part of ISSN: 1432-0428
Source: Self-asserted source
Mariana Igoillo-Esteve

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

Diabetes
2009-12 | Journal article
DOI: 10.2337/db09-0685
Part of ISSN: 0012-1797
Part of ISSN: 1939-327X
Source: Self-asserted source
Mariana Igoillo-Esteve

PTPN2, a candidate gene for type 1 diabetes, modulates interferon-gamma-induced pancreatic beta-cell apoptosis.

Diabetes
2009-03-31 | Journal article
DOI: 10.2337/db08-1510
PMID: 19336676
PMC: PMC2682688
Source: Self-asserted source
Mariana Igoillo-Esteve

An update on lipotoxic endoplasmic reticulum stress in pancreatic beta-cells.

Biochemical Society transactions
2008-10-01 | Journal article
DOI: 10.1042/bst0360909
PMID: 18793160
Source: Self-asserted source
Mariana Igoillo-Esteve

The pentose phosphate pathway in Trypanosoma cruzi: a potential target for the chemotherapy of Chagas disease.

Anais da Academia Brasileira de Ciencias
2007-12-01 | Journal article
DOI: 10.1590/s0001-37652007000400007
PMID: 18066434
Source: Self-asserted source
Mariana Igoillo-Esteve

The glucose-6-phosphate dehydrogenase from Trypanosoma cruzi: its role in the defense of the parasite against oxidative stress.

Molecular and biochemical parasitology
2006-06-19 | Journal article
DOI: 10.1016/j.molbiopara.2006.05.009
PMID: 16828178
Source: Self-asserted source
Mariana Igoillo-Esteve

The 6-phosphogluconate dehydrogenase from Trypanosoma cruzi: the absence of two inter-subunit salt bridges as a reason for enzyme instability.

Molecular and biochemical parasitology
2004-02-01 | Journal article
DOI: 10.1016/j.molbiopara.2003.10.007
PMID: 14698432
Source: Self-asserted source
Mariana Igoillo-Esteve
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