Personal information

Computational analysis, Leishmania genome, Trypanosome genome, computational physics

Activities

Employment (4)

Vrije Universiteit Brussel: Brussels, BE

Employment
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Vrije Universiteit Brussel

Universitair Ziekenhuis Brussel: Brussel, Brussel, BE

2020-01-01 to present (Medical genetics)
Employment
Source: Self-asserted source
Hideo Imamura

Institute of Tropical Medicine Antwerp: Antwerp, BE

2009-02 to 2019-12-31
Employment
Source: Self-asserted source
Hideo Imamura

Boston College: Chestnut Hill, MA, US

2006-02 to 2009-01
Employment
Source: Self-asserted source
Hideo Imamura

Education and qualifications (1)

University of Waterloo Faculty of Science: Waterloo, ON, CA

2001-01-01 to 2005-12-31 | Ph.D. (Physics)
Education
Source: Self-asserted source
Hideo Imamura

Professional activities (1)

Wellcome Sanger Institute: Hinxton, Cambridgeshire, GB

2009-02 to 2019-12 | visiting bioinformatician (Pathogen)
Invited position
Source: Self-asserted source
Hideo Imamura

Works (50 of 51)

Items per page:
Page 1 of 2

Long-term hematopoietic stem cells trigger quiescence in Leishmania parasites

PLOS Pathogens
2024-04-24 | Journal article
Part of ISSN: 1553-7374
Contributors: Laura Dirkx; Sara Van Acker; Yasmine Nicolaes; João Luís Reis Cunha; Rokaya Ahmad; Rik Hendrickx; Ben Caljon; Hideo Imamura; Didier G. Ebo; Daniel C. Jeffares et al.
Source: Self-asserted source
Hideo Imamura

Molecular surveillance of Plasmodium falciparum drug-resistance markers in Vietnam using multiplex amplicon sequencing (2000–2016)

Scientific Reports
2023-08-25 | Journal article
Part of ISSN: 2045-2322
Contributors: Eduard Rovira-Vallbona; Johanna Helena Kattenberg; Nguyen Van Hong; Pieter Guetens; Hideo Imamura; Pieter Monsieurs; Driss Chiheb; Annette Erhart; Bui Quang Phuc; Nguyen Xuan Xa et al.
Source: Self-asserted source
Hideo Imamura

Immunovirological and environmental screening reveals actionable risk factors for fatal COVID-19 during post-vaccination nursing home outbreaks

Nature Aging
2023-05-22 | Journal article
Part of ISSN: 2662-8465
Contributors: Lize Cuypers; Els Keyaerts; Samuel L. Hong; Sarah Gorissen; Soraya Maria Menezes; Marick Starick; Jan Van Elslande; Matthias Weemaes; Tony Wawina-Bokalanga; Joan Marti-Carreras et al.
Source: Self-asserted source
Hideo Imamura

Core Genome Sequencing Analysis of E. coli O157:H7 Unravelling Genetic Relatedness among Strains from Cattle, Beef, and Humans in Bishoftu, Ethiopia

Microbiology Research
2023-01-25 | Journal article
Part of ISSN: 2036-7481
Contributors: Fanta Gutema; Lieven De Zutter; DEnis Piérard; Bruno Bremer Hinckel; Hideo Imamura; Geertrui Rasschaert; Reta Duguma; Getahun Agga; Florence Crombe
Source: Self-asserted source
Hideo Imamura

Healthcare-Associated SARS-CoV-2 Reinfection after 3 Months with a Phylogenetically Distinct Omicron Variant: A Case Report

Viruses
2022-08-23 | Journal article
Contributors: Kim Callebaut; Anke Stoefs; Dimitri Stylemans; Oriane Soetens; Florence Crombé; Ellen Vancutsem; Hideo Imamura; Ingrid Wybo; Deborah De Geyter; Denis Piérard et al.
Source: check_circle
Crossref
grade
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Genomic and Phenotypic Characterization of Experimentally Selected Resistant Leishmania donovani Reveals a Role for Dynamin-1-Like Protein in the Mechanism of Resistance to a Novel Antileishmanial Compound

mBio
2022-02-22 | Journal article
Part of ISSN: 2150-7511
Contributors: Aya Hefnawy; Gabriel Negreira; Marlene Jara; James A. Cotton; Ilse Maes; Erika D’Haenens; Hideo Imamura; Bart Cuypers; Pieter Monsieurs; Christina Mouchtoglou et al.
Source: Self-asserted source
Hideo Imamura

High throughput single-cell genome sequencing gives insights into the generation and evolution of mosaic aneuploidy in<i>Leishmania donovani</i>

Nucleic Acids Research
2022-01-11 | Journal article
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Gabriel H. Negreira; Pieter Monsieurs; Hideo Imamura; Ilse Maes; Nada Kuk; Akila Yagoubat; Frederik Van den Broeck; Yvon Sterkers; Jean-Claude Dujardin; Malgorzata A Domagalska
Source: Self-asserted source
Hideo Imamura

Transcriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models

Microorganisms
2022-01-03 | Journal article
Contributors: Marlene Jara; Michael Barrett; Ilse Maes; Clement Regnault; Hideo Imamura; Malgorzata Anna Domagalska; Jean-Claude Dujardin
Source: check_circle
Crossref
grade
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Ecological divergence and hybridization of Neotropical <i>Leishmania</i> parasites

Proceedings of the National Academy of Sciences
2020-10-06 | Journal article | Author
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Frederik Van den Broeck; Nicholas Savill; Hideo Imamura; Mandy Sanders; Ilse Maes; Sinclair Cooper; David Mateus; Marlene Jara; Vanessa Adaui Sicheri; Jorge Arevalo et al.
Source: Self-asserted source
Hideo Imamura
grade
Preferred source (of 2)‎

Evaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level

Scientific Reports
2020-09-14 | Journal article
Part of ISSN: 2045-2322
Contributors: Hideo Imamura; Pieter Monsieurs; Marlene Jara; Mandy Sanders; Ilse Maes; Manu Vanaerschot; Matthew Berriman; James A. Cotton; Jean-Claude Dujardin; Malgorzata A. Domagalska
Source: Self-asserted source
Hideo Imamura

Global genome diversity of the Leishmania donovani complex

eLife
2020-03-25 | Journal article
Contributors: Susanne U Franssen; Caroline Durrant; Olivia Stark; Bettina Moser; Tim Downing; Hideo Imamura; Jean-Claude Dujardin; Mandy J Sanders; Isabel Mauricio; Michael A Miles et al.
Source: check_circle
Crossref

A Guide to Next Generation Sequence Analysis of Leishmania Genomes

2019 | Book chapter
Part of ISBN: 9783531162218
Part of ISBN: 9783531913292
Part of ISSN: 2524-3225
Part of ISSN: 2524-3233
Source: Self-asserted source
Hideo Imamura
grade
Preferred source (of 2)‎

Genomes of Leishmania parasites directly sequenced from patients with visceral leishmaniasis in the Indian subcontinent

PLOS Neglected Tropical Diseases
2019-12-12 | Journal article
Contributors: Malgorzata A. Domagalska; Matthew Brian Rogers; Hideo Imamura; Mandy Sanders; Frederik Van den Broeck; Narayan Raj Bhattarai; Manu Vanaerschot; Ilse Maes; Erika D’Haenens; Keshav Rai et al.
Source: check_circle
Crossref

Tracking of quiescence in Leishmania by quantifying the expression of GFP in the ribosomal DNA locus

Scientific Reports
2019-12-12 | Journal article
Contributors: Marlene Jara; Ilse Maes; Hideo Imamura; Malgorzata A. Domagalska; Jean Claude Dujardin; Jorge Arevalo
Source: check_circle
Crossref

Meiotic sex in Chagas disease parasite Trypanosoma cruzi

Nature Communications
2019-09-03 | Journal article
Contributors: Philipp Schwabl; Hideo Imamura; Frederik Van den Broeck; Jaime A. Costales; Jalil Maiguashca-Sánchez; Michael A. Miles; Bjorn Andersson; Mario J. Grijalva; Martin S. Llewellyn
Source: check_circle
Crossref

Major changes in chromosomal somy, gene expression and gene dosage driven by SbIII in Leishmania braziliensis and Leishmania panamensis

Scientific Reports
2019-07-01 | Journal article
Contributors: Luz H. Patino; Hideo Imamura; Lissa Cruz-Saavedra; Paula Pavia; Carlos Muskus; Claudia Méndez; Jean Claude Dujardin; Juan David Ramírez
Source: check_circle
Crossref

Refining wet lab experiments with in silico searches: A rational quest for diagnostic peptides in visceral leishmaniasis

PLOS Neglected Tropical Diseases
2019-05-06 | Journal article
Part of ISSN: 1935-2735
Contributors: Bruno Bremer Hinckel; Tegwen Marlais; Stephanie Airs; Tapan Bhattacharyya; Hideo Imamura; Jean-Claude Dujardin; Sayda El-Safi; Om Prakash Singh; Shyam Sundar; Andrew Keith Falconar et al.
Source: Self-asserted source
Hideo Imamura
grade
Preferred source (of 2)‎

Genomic Analysis of Colombian Leishmania panamensis strains with different level of virulence

Scientific Reports
2018 | Journal article
EID:

2-s2.0-85057203724

Contributors: Urrea, D.A.; Duitama, J.; Imamura, H.; Álzate, J.F.; Gil, J.; Muñoz, N.; Villa, J.A.; Dujardin, J.-C.; Ramirez-Pineda, J.R.; Triana-Chavez, O.
Source: Self-asserted source
Hideo Imamura via Scopus - Elsevier

Genomic insights into virulence mechanisms of Leishmania donovani: Evidence from an atypical strain

BMC Genomics
2018 | Journal article
EID:

2-s2.0-85057547972

Contributors: Samarasinghe, S.R.; Samaranayake, N.; Kariyawasam, U.L.; Siriwardana, Y.D.; Imamura, H.; Karunaweera, N.D.
Source: Self-asserted source
Hideo Imamura via Scopus - Elsevier

Genomic and transcriptomic alterations in Leishmania donovani lines experimentally resistant to antileishmanial drugs

International Journal for Parasitology: Drugs and Drug Resistance
2018-08 | Journal article
Contributors: Alberto Rastrojo; Raquel García-Hernández; Paola Vargas; Esther Camacho; Laura Corvo; Hideo Imamura; Jean-Claude Dujardin; Santiago Castanys; Begoña Aguado; Francisco Gamarro et al.
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Crossref
grade
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Integrated genomic and metabolomic profiling of ISC1, an emerging Leishmania donovani population in the Indian subcontinent.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
2018-04 | Journal article
Contributors: Cuypers B; Berg M; Imamura H; Dumetz F; De Muylder G; Domagalska MA; Rijal S; Bhattarai NR; Maes I; Sanders M et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
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Molecular Preadaptation to Antimony Resistance in Leishmania donovani on the Indian Subcontinent.

mSphere
2018-04 | Journal article
Contributors: Dumetz F; Cuypers B; Imamura H; Zander D; D'Haenens E; Maes I; Domagalska MA; Clos J; Dujardin JC; De Muylder G
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Discovery and genomic analyses of hybridization between divergent lineages of Trypanosoma congolense, causative agent of Animal African Trypanosomiasis.

Molecular ecology
2017-12 | Journal article
Contributors: Tihon E; Imamura H; Dujardin JC; Van Den Abbeele J; Van den Broeck F
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Genomic analysis of Isometamidium Chloride resistance in Trypanosoma congolense.

International journal for parasitology. Drugs and drug resistance
2017-12 | Journal article
Contributors: Tihon E; Imamura H; Van den Broeck F; Vermeiren L; Dujardin JC; Van Den Abbeele J
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
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Haplotype selection as an adaptive mechanism in the protozoan pathogen Leishmania donovani.

Nature ecology & evolution
2017-12 | Journal article
Contributors: Prieto Barja P; Pescher P; Bussotti G; Dumetz F; Imamura H; Kedra D; Domagalska M; Chaumeau V; Himmelbauer H; Pages M et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Evidence for viable and stable triploid Trypanosoma congolense parasites.

Parasites & vectors
2017-10 | Journal article
Contributors: Tihon E; Imamura H; Dujardin JC; Van Den Abbeele J
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
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Multiplexed Spliced-Leader Sequencing: A high-throughput, selective method for RNA-seq in Trypanosomatids.

Scientific reports
2017-06 | Journal article
Contributors: Cuypers B; Domagalska MA; Meysman P; Muylder G; Vanaerschot M; Imamura H; Dumetz F; Verdonckt TW; Myler PJ; Ramasamy G et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Modulation of Aneuploidy in Leishmania donovani during Adaptation to Different In Vitro and In Vivo Environments and Its Impact on Gene Expression.

mBio
2017-05 | Journal article
Contributors: Dumetz F; Imamura H; Sanders M; Seblova V; Myskova J; Pescher P; Vanaerschot M; Meehan CJ; Cuypers B; De Muylder G et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Single locus genotyping to track Leishmania donovani in the Indian subcontinent: Application in Nepal.

PLoS neglected tropical diseases
2017-03 | Journal article
Contributors: Rai K; Bhattarai NR; Vanaerschot M; Imamura H; Gebru G; Khanal B; Rijal S; Boelaert M; Pal C; Karki P et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.

PloS one
2016 | Journal article
Contributors: Mondelaers A; Sanchez-Cañete MP; Hendrickx S; Eberhardt E; Garcia-Hernandez R; Lachaud L; Cotton J; Sanders M; Cuypers B; Imamura H et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Species- and Strain-Specific Adaptation of the HSP70 Super Family in Pathogenic Trypanosomatids.

Genome biology and evolution
2016-07 | Journal article
Contributors: Drini S; Criscuolo A; Lechat P; Imamura H; Skalický T; Rachidi N; Lukeš J; Dujardin JC; Späth GF
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Apolipoprotein L1 Variant Associated with Increased Susceptibility to Trypanosome Infection.

mBio
2016-04 | Journal article
Contributors: Cuypers B; Lecordier L; Meehan CJ; Van den Broeck F; Imamura H; Büscher P; Dujardin JC; Laukens K; Schnaufer A; Dewar C et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent.

eLife
2016-03 | Journal article
Contributors: Imamura H; Downing T; Van den Broeck F; Sanders MJ; Rijal S; Sundar S; Mannaert A; Vanaerschot M; Berg M; De Muylder G et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

In vitro selection of miltefosine resistance in promastigotes of Leishmania donovani from Nepal: genomic and metabolomic characterization.

Molecular microbiology
2016-03 | Journal article
Contributors: Shaw CD; Lonchamp J; Downing T; Imamura H; Freeman TM; Cotton JA; Sanders M; Blackburn G; Dujardin JC; Rijal S et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Genome and phylogenetic analyses of Trypanosoma evansi reveal extensive similarity to T. brucei and multiple independent origins for dyskinetoplasty.

PLoS neglected tropical diseases
2015-01 | Journal article
Contributors: Carnes J; Anupama A; Balmer O; Jackson A; Lewis M; Brown R; Cestari I; Desquesnes M; Gendrin C; Hertz-Fowler C et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Genomic confirmation of hybridisation and recent inbreeding in a vector-isolated Leishmania population.

PLoS genetics
2014-01 | Journal article
Contributors: Rogers MB; Downing T; Smith BA; Imamura H; Sanders M; Svobodova M; Volf P; Berriman M; Cotton JA; Smith DF
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Molecular mechanisms of drug resistance in natural Leishmania populations vary with genetic background.

PLoS neglected tropical diseases
2012 | Journal article
Contributors: Decuypere S; Vanaerschot M; Brunker K; Imamura H; Müller S; Khanal B; Rijal S; Dujardin JC; Coombs GH
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Adaptive mechanisms in pathogens: universal aneuploidy in Leishmania.

Trends in parasitology
2012-09 | Journal article
Contributors: Mannaert A; Downing T; Imamura H; Dujardin JC
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent.

The Journal of infectious diseases
2012-09 | Journal article
Contributors: Vanaerschot M; Decuypere S; Downing T; Imamura H; Stark O; De Doncker S; Roy S; Ostyn B; Maes L; Khanal B et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Genome-wide SNP and microsatellite variation illuminate population-level epidemiology in the Leishmania donovani species complex.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
2012-01 | Journal article
Contributors: Downing T; Stark O; Vanaerschot M; Imamura H; Sanders M; Decuypere S; de Doncker S; Maes I; Rijal S; Sundar S et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.

Genome research
2011-12 | Journal article
Contributors: Rogers MB; Hilley JD; Dickens NJ; Wilkes J; Bates PA; Depledge DP; Harris D; Her Y; Herzyk P; Imamura H et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.

Genome research
2011-12 | Journal article
Contributors: Downing T; Imamura H; Decuypere S; Clark TG; Coombs GH; Cotton JA; Hilley JD; de Doncker S; Maes I; Mottram JC et al.
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

The effect of Plasmodium falciparum Sir2a histone deacetylase on clonal and longitudinal variation in expression of the var family of virulence genes

International Journal for Parasitology
2010-01 | Journal article
Part of ISSN: 0020-7519
Contributors: Catherine J. Merrick; Ron Dzikowski; Hideo Imamura; Jeffrey Chuang; Kirk Deitsch; Manoj T. Duraisingh
Source: Self-asserted source
Hideo Imamura via Crossref Metadata Search
grade
Preferred source (of 2)‎

Weak preservation of local neutral substitution rates across mammalian genomes.

BMC evolutionary biology
2009 | Journal article
Contributors: Imamura H; Karro JE; Chuang JH
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Sequences conserved by selection across mouse and human malaria species.

BMC genomics
2007 | Journal article
Contributors: Imamura H; Persampieri JH; Chuang JH
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Minimum model for the alpha-helix-beta-hairpin transition in proteins.

Proteins
2007-05 | Journal article
Contributors: Imamura H; Chen JZ
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Dependence of folding dynamics and structural stability on the location of a hydrophobic pair in beta-hairpins.

Proteins
2006-05 | Journal article
Contributors: Imamura H; Chen JZ
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Conformational conversion of proteins due to mutation

Europhysics Letters (EPL)
2004-08 | Journal article
Part of ISSN: 0295-5075
Contributors: H Imamura; J. Z. Y Chen
Source: Self-asserted source
Hideo Imamura via Crossref Metadata Search
grade
Preferred source (of 2)‎

Self-assembly of the ionic peptide EAK16: the effect of charge distributions on self-assembly.

Biophysical journal
2004-08 | Journal article
Contributors: Jun S; Hong Y; Imamura H; Ha BY; Bechhoefer J; Chen P
Source: Self-asserted source
Hideo Imamura via Europe PubMed Central
grade
Preferred source (of 2)‎

Universal model for α-helix and β-sheet structures in protein

Physica A: Statistical Mechanics and its Applications
2003-04 | Journal article
Part of ISSN: 0378-4371
Contributors: Jeff Z.Y. Chen; Hideo Imamura
Source: Self-asserted source
Hideo Imamura via Crossref Metadata Search
grade
Preferred source (of 2)‎
Items per page:
Page 1 of 2

Peer review (4 reviews for 2 publications/grants)

Review activity for Heliyon. (3)
Review activity for Nature communications (1)