Personal information

Japan

Activities

Works (50 of 57)

Items per page:
Page 1 of 2

Discovery of gamma-mangostin from Garcinia mangostana as a potent and selective natural SIRT2 inhibitor

Bioorganic Chemistry
2020 | Journal article
EID:

2-s2.0-85075348216

Contributors: Yeong, K.Y.; Khaw, K.Y.; Takahashi, Y.; Itoh, Y.; Murugaiyah, V.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Drug discovery researches on modulators of lysine-modifying enzymes based on strategic chemistry approaches

Chemical and Pharmaceutical Bulletin
2020 | Journal article
EID:

2-s2.0-85077479971

Contributors: Itoh, Y.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl- l -methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols

Journal of the American Chemical Society
2020 | Journal article
EID:

2-s2.0-85077466803

Contributors: Ogihara, S.; Komatsu, T.; Itoh, Y.; Miyake, Y.; Suzuki, T.; Yanagi, K.; Kimura, Y.; Ueno, T.; Hanaoka, K.; Kojima, H. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Metalloprotein-Catalyzed Click Reaction for In Situ Generation of a Potent Inhibitor

ACS Catalysis
2020-04-23 | Journal article
Part of ISSN: 2155-5435
Part of ISSN: 2155-5435
Source: Self-asserted source
Yukihiro Itoh

Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site.

Journal of medicinal chemistry
2019-05-30 | Journal article
Source: Self-asserted source
Yukihiro Itoh
grade
Preferred source (of 2)‎

Identification of ortho-hydroxy anilide as a novel scaffold for lysine demethylase 5 inhibitors.

Bioorganic & medicinal chemistry letters
2019-03-21 | Journal article
Source: Self-asserted source
Yukihiro Itoh
grade
Preferred source (of 2)‎

Identification of novel lysine demethylase 5-selective inhibitors by inhibitor-based fragment merging strategy.

Bioorganic & medicinal chemistry
2019-02-04 | Journal article
Source: Self-asserted source
Yukihiro Itoh
grade
Preferred source (of 2)‎

N+-C-H···O Hydrogen bonds in protein-ligand complexes.

Scientific reports
2019-01-25 | Journal article
Source: Self-asserted source
Yukihiro Itoh
grade
Preferred source (of 2)‎

[Challenges of Young Chemists to Be Global].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
2019-01-01 | Journal article
Source: Self-asserted source
Yukihiro Itoh
grade
Preferred source (of 2)‎

Computational analysis for selectivity of histone deacetylase inhibitor by replica-exchange umbrella sampling molecular dynamics simulations

Journal of Chemical Physics
2018 | Journal article
EID:

2-s2.0-85044776916

Contributors: Tsukamoto, S.; Sakae, Y.; Itoh, Y.; Suzuki, T.; Okamoto, Y.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Design, synthesis and evaluation of γ-turn mimetics as LSD1-selective inhibitors

Bioorganic and Medicinal Chemistry
2018 | Journal article
EID:

2-s2.0-85040233617

Contributors: Ota, Y.; Miyamura, S.; Araki, M.; Itoh, Y.; Yasuda, S.; Masuda, M.; Taniguchi, T.; Sowa, Y.; Sakai, T.; Itami, K. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Histone H3 peptides incorporating modified lysine residues as lysine-specific demethylase 1 inhibitors

Bioorganic and Medicinal Chemistry Letters
2018 | Journal article
EID:

2-s2.0-85035753140

Contributors: Kakizawa, T.; Ota, Y.; Itoh, Y.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Design, Synthesis, and Biological Evaluation of a Conjugate of 5-Fluorouracil and an LSD1 Inhibitor.

Chemical & pharmaceutical bulletin
2018-10-24 | Journal article
Source: Self-asserted source
Yukihiro Itoh
grade
Preferred source (of 2)‎

Chemical Protein Degradation Approach and its Application to Epigenetic Targets.

Chemical record (New York, N.Y.)
2018-06-12 | Journal article
Source: Self-asserted source
Yukihiro Itoh
grade
Preferred source (of 2)‎

Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures

Molecules
2018-05 | Journal article
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Design, synthesis, and biological evaluation of novel ubiquitin-activating enzyme inhibitors.

Bioorganic & medicinal chemistry letters
2018-03-03 | Journal article
Source: Self-asserted source
Yukihiro Itoh
grade
Preferred source (of 2)‎

Chemical biology for pharmaceutical sciences (novel ideas for “drug” discovery)

Yakugaku Zasshi
2017 | Journal article
EID:

2-s2.0-85014080466

Contributors: Sohma, Y.; Itoh, Y.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Potent mechanism-based sirtuin-2-selective inhibition by an: In situ -generated occupant of the substrate-binding site, "selectivity pocket" and NAD<sup>+</sup>-binding site

Chemical Science
2017 | Journal article
EID:

2-s2.0-85027847133

Contributors: Mellini, P.; Itoh, Y.; Tsumoto, H.; Li, Y.; Suzuki, M.; Tokuda, N.; Kakizawa, T.; Miura, Y.; Takeuchi, J.; Lahtela-Kakkonen, M. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Targeted degradation of proteins localized in subcellular compartments by hybrid small molecules

Molecular Pharmacology
2017 | Journal article
EID:

2-s2.0-85012096156

Contributors: Okuhira, K.; Shoda, T.; Omura, R.; Ohoka, N.; Hattori, T.; Shibata, N.; Demizu, Y.; Sugihara, R.; Ichino, A.; Kawahara, H. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

“Drug” discovery with the help of organic chemistry

Yakugaku Zasshi
2017 | Journal article
EID:

2-s2.0-85014130166

Contributors: Itoh, Y.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

C-H activation enables a rapid structure-activity relationship study of arylcyclopropyl amines for potent and selective LSD1 inhibitors

Organic and Biomolecular Chemistry
2016 | Journal article
EID:

2-s2.0-84988504106

Contributors: Miyamura, S.; Araki, M.; Ota, Y.; Itoh, Y.; Yasuda, S.; Masuda, M.; Taniguchi, T.; Sowa, Y.; Sakai, T.; Suzuki, T. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide

Bioorganic and Medicinal Chemistry Letters
2016 | Journal article
EID:

2-s2.0-84958122821

Contributors: Kakizawa, T.; Mizukami, T.; Itoh, Y.; Hasegawa, M.; Sasaki, R.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

False HDAC inhibition by aurone compound

Chemical and Pharmaceutical Bulletin
2016 | Journal article
EID:

2-s2.0-84982699556

Contributors: Itoh, Y.; Suzuki, M.; Matsui, T.; Ota, Y.; Hui, Z.; Tsubaki, K.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Hippocampal microRNA-124 enhances chronic stress resilience in mice

Journal of Neuroscience
2016 | Journal article
EID:

2-s2.0-84977520803

Contributors: Higuchi, F.; Uchida, S.; Yamagata, H.; Abe-Higuchi, N.; Hobara, T.; Hara, K.; Kobayashi, A.; Shintaku, T.; Itoh, Y.; Suzuki, T. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Identification of SNAIL1 Peptide-Based Irreversible Lysine-Specific Demethylase 1-Selective Inactivators

Journal of Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-84959347787

Contributors: Itoh, Y.; Aihara, K.; Mellini, P.; Tojo, T.; Ota, Y.; Tsumoto, H.; Solomon, V.R.; Zhan, P.; Suzuki, M.; Ogasawara, D. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Molecular technology for controlling epigenetics: Regulation of histone acetylation and methylation by small molecules

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
2016 | Journal article
EID:

2-s2.0-84980383638

Contributors: Itoh, Y.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Targeting Cancer with PCPA-Drug Conjugates: LSD1 Inhibition-Triggered Release of 4-Hydroxytamoxifen

Angewandte Chemie - International Edition
2016 | Journal article
EID:

2-s2.0-85006817474

Contributors: Ota, Y.; Itoh, Y.; Kaise, A.; Ohta, K.; Endo, Y.; Masuda, M.; Sowa, Y.; Sakai, T.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Design, synthesis, and biological activity of N-alkylated analogue of NCL1, a selective inhibitor of lysine-specific demethylase 1

MedChemComm
2015 | Journal article
EID:

2-s2.0-84924418160

Contributors: Ahmed Khan, M.N.; Tsumoto, H.; Itoh, Y.; Ota, Y.; Suzuki, M.; Ogasawara, D.; Nakagawa, H.; Mizukami, T.; Miyata, N.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Histone H3 peptide based LSD1-selective inhibitors

Bioorganic and Medicinal Chemistry Letters
2015 | Journal article
EID:

2-s2.0-84937759882

Contributors: Kakizawa, T.; Ota, Y.; Itoh, Y.; Tsumoto, H.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells

ACS Medicinal Chemistry Letters
2015 | Journal article
EID:

2-s2.0-84931263762

Contributors: Itoh, Y.; Sawada, H.; Suzuki, M.; Tojo, T.; Sasaki, R.; Hasegawa, M.; Mizukami, T.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Strategies for the Discovery of Target-Specific or Isoform-Selective Modulators

Journal of Medicinal Chemistry
2015 | Journal article
EID:

2-s2.0-84943779677

Contributors: Zhan, P.; Itoh, Y.; Suzuki, T.; Liu, X.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylasea 8-selective inhibitors

ChemMedChem
2014 | Journal article
EID:

2-s2.0-84896738946

Contributors: Suzuki, T.; Muto, N.; Bando, M.; Itoh, Y.; Masaki, A.; Ri, M.; Ota, Y.; Nakagawa, H.; Iida, S.; Shirahige, K. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Identification of novel SIRT2-selective inhibitors using a click chemistry approach

Bioorganic and Medicinal Chemistry Letters
2014 | Journal article
EID:

2-s2.0-84897473979

Contributors: Tatum, P.R.; Sawada, H.; Ota, Y.; Itoh, Y.; Zhan, P.; Ieda, N.; Nakagawa, H.; Miyata, N.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Late-stage C-H coupling enables rapid identification of HDAC inhibitors: Synthesis and evaluation of NCH-31 analogues

ACS Medicinal Chemistry Letters
2014 | Journal article
EID:

2-s2.0-84900392663

Contributors: Sekizawa, H.; Amaike, K.; Itoh, Y.; Suzuki, T.; Itami, K.; Yamaguchi, J.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Recent advances in the structure-based rational design of TNKSIs

Molecular BioSystems
2014 | Journal article
EID:

2-s2.0-84907677397

Contributors: Zhan, P.; Song, Y.; Itoh, Y.; Suzuki, T.; Liu, X.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Synthesis, LSD1 inhibitory activity, and LSD1 Binding model of optically pure lysine-PCPA conjugates

Computational and Structural Biotechnology Journal
2014 | Journal article
EID:

2-s2.0-84902215175

Contributors: Itoh, Y.; Ogasawara, D.; Ota, Y.; Mizukami, T.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Target-guided synthesis: Medicinal chemistry strategy to allow target enzymes themselves to synthesize their own inhibitors

Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
2014 | Journal article
EID:

2-s2.0-84905711575

Contributors: Itoh, Y.; Miyata, N.; Suzuki, T.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Identification of Highly Selective and Potent Histone Deacetylase 3 Inhibitors Using Click Chemistry-Based Combinatorial Fragment Assembly

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84880715554

Contributors: Suzuki, T.; Kasuya, Y.; Itoh, Y.; Ota, Y.; Zhan, P.; Asamitsu, K.; Nakagawa, H.; Okamoto, T.; Miyata, N.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity

Journal of Medicinal Chemistry
2013 | Journal article
EID:

2-s2.0-84884997299

Contributors: Suzuki, T.; Ozasa, H.; Itoh, Y.; Zhan, P.; Sawada, H.; Mino, K.; Walport, L.; Ohkubo, R.; Kawamura, A.; Yonezawa, M. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Lysine-specific demethylase 1-selective inactivators: Protein-targeted drug delivery mechanism

Angewandte Chemie - International Edition
2013 | Journal article
EID:

2-s2.0-84882379526

Contributors: Ogasawara, D.; Itoh, Y.; Tsumoto, H.; Kakizawa, T.; Mino, K.; Fukuhara, K.; Nakagawa, H.; Hasegawa, M.; Sasaki, R.; Mizukami, T. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Search for a novel SIRT1 activator: Structural modification of SRT1720 and biological evaluation

Bioorganic and Medicinal Chemistry Letters
2013 | Journal article
EID:

2-s2.0-84881376738

Contributors: Matsuya, Y.; Kobayashi, Y.; Uchida, S.; Itoh, Y.; Sawada, H.; Suzuki, T.; Miyata, N.; Sugimoto, K.; Toyooka, N.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Small-molecular modulators of cancer-associated epigenetic mechanisms

Molecular BioSystems
2013 | Journal article
EID:

2-s2.0-84875867286

Contributors: Itoh, Y.; Suzuki, T.; Miyata, N.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Design, synthesis, and biological activity of a novel series of human sirtuin-2-selective inhibitors

Journal of Medicinal Chemistry
2012 | Journal article
EID:

2-s2.0-84863091432

Contributors: Suzuki, T.; Khan, M.N.A.; Sawada, H.; Imai, E.; Itoh, Y.; Yamatsuta, K.; Tokuda, N.; Takeuchi, J.; Seko, T.; Nakagawa, H. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Double protein knockdown of cIAP1 and CRABP-II using a hybrid molecule consisting of ATRA and IAPs antagonist

Bioorganic and Medicinal Chemistry Letters
2012 | Journal article
EID:

2-s2.0-84862170982

Contributors: Itoh, Y.; Ishikawa, M.; Kitaguchi, R.; Okuhira, K.; Naito, M.; Hashimoto, Y.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Rapid discovery of highly potent and selective inhibitors of histone deacetylase 8 using click chemistry to generate candidate libraries

Journal of Medicinal Chemistry
2012 | Journal article
EID:

2-s2.0-84870021564

Contributors: Suzuki, T.; Ota, Y.; Ri, M.; Bando, M.; Gotoh, A.; Itoh, Y.; Tsumoto, H.; Tatum, P.R.; Mizukami, T.; Nakagawa, H. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Design, synthesis and biological evaluation of nuclear receptor-degradation inducers

Bioorganic and Medicinal Chemistry
2011 | Journal article
EID:

2-s2.0-80054969919

Contributors: Itoh, Y.; Kitaguchi, R.; Ishikawa, M.; Naito, M.; Hashimoto, Y.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Development of target protein-selective degradation inducer for protein knockdown

Bioorganic and Medicinal Chemistry
2011 | Journal article
EID:

2-s2.0-79956220945

Contributors: Itoh, Y.; Ishikawa, M.; Kitaguchi, R.; Sato, S.; Naito, M.; Hashimoto, Y.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Specific degradation of CRABP-II via cIAP1-mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein

FEBS Letters
2011 | Journal article
EID:

2-s2.0-79954445413

Contributors: Okuhira, K.; Ohoka, N.; Sai, K.; Nishimaki-Mogami, T.; Itoh, Y.; Ishikawa, M.; Hashimoto, Y.; Naito, M.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors

Journal of Medicinal Chemistry
2010 | Journal article
EID:

2-s2.0-77955345001

Contributors: Hamada, S.; Suzuki, T.; Mino, K.; Koseki, K.; Oehme, F.; Flamme, I.; Ozasa, H.; Itoh, Y.; Ogasawara, D.; Komaarashi, H. et al.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier

Protein knockdown using methyl bestatin-ligand hybrid molecules: Design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins

Journal of the American Chemical Society
2010 | Journal article
EID:

2-s2.0-77952565704

Contributors: Itoh, Y.; Ishikawa, M.; Naito, M.; Hashimoto, Y.
Source: Self-asserted source
Yukihiro Itoh via Scopus - Elsevier
Items per page:
Page 1 of 2