Personal information

Websites & social links

http://medchem.ciac.jl.cn/

Other IDs

ResearcherID: B-8126-2011

Keywords

Drug discovery, Pharmacology, TLR, Inflammasome, Caspases, Opioid, Innate immunity, Pain, Glia, Drug addiction, Biosensing, Nanomaterials, Bioinorganic chemistry, Chemical biology, Medicinal chemistry

Countries

China

Activities

Collapse all

Employment (2)

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences: Changchun, Jilin, CN

2015-02 to present | Principal Investigator (Professor) (Chemical Biology Laboratory)
Employment
Source: Self-asserted source
Xiaohui Wang

University of Colorado Boulder: Boulder, CO, US

2010-02 to 2015-02 | Post-Doc (Department of Chemistry & Biochemistry, The Biofrontiers Institute, Department of Psychology & Neuroscience, The Center for Neuroscience)
Employment
Source: Self-asserted source
Xiaohui Wang

Education and qualifications (2)

Changchun Institute of Applied Chemistry, Chinese Academy of Sciences: Changchun, CN

2004-09 to 2010-01 | Ph.D (Chemical Biology Laboratory)
Education
Source: Self-asserted source
Xiaohui Wang

Beijing Technology and Business University: Beijing, CN

2000-09 to 2004-07 | B.Eng. (Bioengineering)
Education
Source: Self-asserted source
Xiaohui Wang

Works (50 of 86)

Items per page:
Page 1 of 2

Chiral nanomaterials as vaccine adjuvants: a new horizon in immunotherapy

Nanoscale
2025 | Journal article
DOI: 10.1039/D4NR03542A
Contributors: Kaixuan Wang; Hongshuang Wang; Xiaohui Wang
Source: check_circle
Crossref

DMSO-promoted α-bromination of α-aryl ketones for the construction of 2-aryl-2-bromo-cycloketones

Organic & Biomolecular Chemistry
2025 | Journal article
DOI: 10.1039/D4OB01937G
Contributors: Haojiang Zhai; Penghui Li; Hongshuang Wang; Xiaohui Wang
Source: check_circle
Crossref

Temperature and steric hindrance-regulated selective synthesis of ketamine derivatives and 2-aryl-cycloketone-1-carboxamides via nucleophilic substitution and Favorskii rearrangement

Organic & Biomolecular Chemistry
2025 | Journal article
DOI: 10.1039/D4OB02039A
Contributors: Haojiang Zhai; Penghui Li; Hongshuang Wang; Xiaohui Wang
Source: check_circle
Crossref

Psychoactive Substances: Transforming the Paradigm for Treating Mental Health Disorders in the Post-Pandemic Era

Neuroscience Bulletin
2025-03 | Journal article
DOI: 10.1007/s12264-024-01341-9
Contributors: Haojiang Zhai; Yibo Wang; Xiaohui Wang
Source: check_circle
Crossref

Exploring End-of-Life Experiences and Consciousness through the Lens of Psychedelics

ACS Pharmacology & Translational Science
2025-03-14 | Journal article
DOI: 10.1021/acsptsci.5c00118
Contributors: Hongyuan Li; Xiaohui Wang
Source: check_circle
Crossref

Psychedelics and Pro-Social Behaviors: A Perspective on Autism Spectrum Disorders

ACS Pharmacology & Translational Science
2025-03-14 | Journal article
DOI: 10.1021/acsptsci.5c00034
Contributors: Xue Wang; Cong Lin; Xiaohui Wang
Source: check_circle
Crossref

Psychedelics and the Autonomic Nervous System: A Perspective on Their Interplay and Therapeutic Potential

ACS Pharmacology & Translational Science
2025-03-14 | Journal article
DOI: 10.1021/acsptsci.5c00005
Contributors: Hongyuan Li; Hongshuang Wang; Xiaohui Wang
Source: check_circle
Crossref

Utilizing Caenorhabditis Elegans as a Rapid and Precise Model for Assessing Amphetamine‐Type Stimulants: A Novel Approach to Evaluating New Psychoactive Substances Activity and Mechanisms

Advanced Science
2025-03-11 | Journal article
DOI: 10.1002/advs.202500808
Contributors: Yuanpeng Li; Hongyuan Li; Hongshuang Wang; Xiaohui Wang
Source: check_circle
Crossref

Psychedelics and Eating Disorders: Exploring the Therapeutic Potential for Anorexia Nervosa and Beyond

ACS Pharmacology & Translational Science
2025-03-07 | Journal article
DOI: 10.1021/acsptsci.5c00094
Contributors: Shuai Hu; Cong Lin; Hongshuang Wang; Xiaohui Wang
Source: check_circle
Crossref

Exploring the Therapeutic Potential of Psychedelics in Chronic Pain Management: A New Frontier in Medicine

Neuroscience Bulletin
2025-01-20 | Journal article
DOI: 10.1007/s12264-025-01351-1
Contributors: Cong Lin; Xue Wang; Xiaohui Wang
Source: check_circle
Crossref

Dissecting the chiral recognition of TLR4/MD2 with Neoseptin-3 enantiomers by molecular dynamics simulations

Physical Chemistry Chemical Physics
2024 | Journal article
DOI: 10.1039/D3CP06124H
Contributors: Cong Zhang; Siru Wu; Mingqi Li; Penghui Li; Xiubo Du; Yibo Wang; Xiaohui Wang
Source: check_circle
Crossref

A perspective on Alzheimer’s disease: exploring the potential of terminal/paradoxical lucidity and psychedelics

Molecular Neurodegeneration
2024-10-12 | Journal article
DOI: 10.1186/s13024-024-00761-5
Contributors: Cong Lin; Xiubo Du; Xiaohui Wang
Source: check_circle
Crossref

Dimethylsulfoniopropionate (DMSP) Increases Longevity and Mitochondrial Function in Caenorhabditis elegans: Implications for the Role of the Global Sulfur Cycle in Terrestrial Ecosystems

Environment & Health
2024-08-16 | Journal article
DOI: 10.1021/envhealth.3c00208
Contributors: Hongyuan Li; Peng Ji; Yue Cao; Zhitao Cui; Jingwei Gao; Hongshuang Wang; Cong Lin; Yibo Wang; Xiaohui Wang
Source: check_circle
Crossref

Exploring Dimethylsulfoniopropionate as a potential treatment for Alzheimer's disease: A study using the 3 × Tg-AD mouse model

Phytomedicine
2024-07 | Journal article
DOI: 10.1016/j.phymed.2024.155788
Contributors: Fanfan Sun; Xuelian Huang; Hongshuang Wang; Baoyi Lin; Hongyuan Li; Xiaohui Wang; Qiong Liu
Source: check_circle
Crossref

Sika Deer Velvet Antler Peptide Exerts Neuroprotective Effect in a Parkinson’s Disease Model via Regulating Oxidative Damage and Gut Microbiota

Pharmaceuticals
2024-07-22 | Journal article
DOI: 10.3390/ph17070972
Contributors: Ying Liu; Hongyuan Li; Min Yang; Jia Guo; Zepeng Sun; Shuyue Wang; Ru Li; Xin Pang; Yumi Kim; Xiaohui Wang et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

NMR-Based Chiral Discrimination of Bulky Amines with a 19F-Tagged NNO Pincer Complex

Analytical Chemistry
2024-07-16 | Journal article
DOI: 10.1021/acs.analchem.4c01748
Contributors: Wenjing Bao; Hongshuang Wang; Lixian Wen; Jian Wu; Yu-Cheng Gu; Xiaohui Wang; Yanchuan Zhao
Source: check_circle
Crossref

Protective Effects of Velvet Antler Methanol Extracts on Hypoxia-Induced Damage in Caenorhabditis elegans through HIF-1 and ECH-8 Mediated Lipid Accumulation

Nutrients
2024-07-13 | Journal article
DOI: 10.3390/nu16142257
Contributors: Ru Li; Hongyuan Li; Xiaohui Wang; Yinghua Peng
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Dissecting the Role of the Hydroxyl Moiety at C14 in (+)-Opioid-Based TLR4 Antagonists via Wet-Lab Experiments and Molecular Dynamics Simulations

Journal of Chemical Information and Modeling
2024-07-08 | Journal article
DOI: 10.1021/acs.jcim.4c00692
Contributors: Jingwei Gao; Cong Zhang; Hangyu Xu; Tianshu Zhang; Hongshuang Wang; Yibo Wang; Xiaohui Wang
Source: check_circle
Crossref

Nicotine Enantioselectively Targets Myeloid Differentiation Protein 2 and Inhibits the Toll-like Receptor 4 Signaling

Journal of Chemical Information and Modeling
2024-07-08 | Journal article
DOI: 10.1021/acs.jcim.4c00591
Contributors: Pu Jiang; Cong Zhang; Hongshuang Wang; Penghui Li; Xiubo Du; Yibo Wang; Ekaterina Lyukmanova; Cong Lin; Xiaohui Wang
Source: check_circle
Crossref

Microglia in neuroimmunopharmacology and drug addiction

Molecular Psychiatry
2024-06 | Journal article
DOI: 10.1038/s41380-024-02443-6
Contributors: Hongyuan Li; Linda R. Watkins; Xiaohui Wang
Source: check_circle
Crossref

O‐glycosylation in viruses: A sweet tango

mLife
2024-03 | Journal article
DOI: 10.1002/mlf2.12105
Contributors: Annan Ming; Jianxin Zhao; Yihan Liu; Yibo Wang; Xiaohui Wang; Jing Li; Leiliang Zhang
Source: check_circle
Crossref

Exploring the Function of (+)-Naltrexone Precursors: Their Activity as TLR4 Antagonists and Potential in Treating Morphine Addiction

Journal of Medicinal Chemistry
2024-02-22 | Journal article
DOI: 10.1021/acs.jmedchem.3c02316
Contributors: Jingwei Gao; Cong Lin; Cong Zhang; Xiaozheng Zhang; Yibo Wang; Hangyu Xu; Tianshu Zhang; Haohong Li; Hongshuang Wang; Xiaohui Wang
Source: check_circle
Crossref

Stereoselective recognition of morphine enantiomers by μ-opioid receptor

National Science Review
2024-02-01 | Journal article
DOI: 10.1093/nsr/nwae029
Contributors: Yibo Wang; Van A Ngo; Xiaohui Wang
Source: check_circle
Crossref

Psychedelics and Consciousness: Expanding the Horizons of Mind and Therapy

Research
2024-01 | Journal article
DOI: 10.34133/research.0495
Contributors: Miyuan Zhang; Yibo Wang; Tian-Ming Gao; Xiaohui Wang
Source: check_circle
Crossref

Dissecting the innate immune recognition of morphine and its metabolites by TLR4/MD2: an in silico simulation study

Physical Chemistry Chemical Physics
2023 | Journal article
DOI: 10.1039/D3CP03715K
Contributors: Xiaozheng Zhang; Ran Li; Haoran Xu; Guicai Wu; Siru Wu; Hongshuang Wang; Yibo Wang; Xiaohui Wang
Source: check_circle
Crossref

Dissecting the species-specific recognition of Neoseptin 3 by TLR4/MD2 via molecular dynamics simulations

Physical Chemistry Chemical Physics
2023 | Journal article
DOI: 10.1039/D3CP00949A
Contributors: Siru Wu; Cong Zhang; Yibo Wang; Penghui Li; Xiubo Du; Xiaohui Wang
Source: check_circle
Crossref

The pharmacology and therapeutic role of cannabidiol in diabetes

Exploration
2023-10 | Journal article
DOI: 10.1002/EXP.20230047
Contributors: Jin Zhang; Cong Lin; Sha Jin; Hongshuang Wang; Yibo Wang; Xiubo Du; Mark R. Hutchinson; Huiying Zhao; Le Fang; Xiaohui Wang
Source: check_circle
Crossref

Exploring the trimerization process of a transmembrane helix with an ionizable residue by molecular dynamics simulations: a case study of transmembrane domain 5 of LMP-1

Physical Chemistry Chemical Physics
2022 | Journal article
DOI: 10.1039/D2CP00102K
Contributors: Bo Zhang; Yinghua Peng; Yibo Wang; Xiaohui Wang
Source: check_circle
Crossref

Dissecting the Role of N-Glycan at N413 in Toll-like Receptor 3 via Molecular Dynamics Simulations

Journal of Chemical Information and Modeling
2022-11-14 | Journal article
DOI: 10.1021/acs.jcim.1c00818
Contributors: Yibo Wang; Siru Wu; Cong Zhang; Yushan Jin; Xiaohui Wang
Source: check_circle
Crossref

Ninety Years of Pentamidine: The Development and Applications of Pentamidine and its Analogs

Current Medicinal Chemistry
2022-08 | Journal article
DOI: 10.2174/0929867329666220314121446
Contributors: Bo Zhang; Yushan Jin; Lei Zhang; Hongshuang Wang; Xiaohui Wang
Source: check_circle
Crossref

Itaconate prolongs the healthy lifespan by activating UPRmt in Caenorhabditis elegans

European Journal of Pharmacology
2022-05 | Journal article
DOI: 10.1016/j.ejphar.2022.174951
Contributors: Qingqing Wang; Hongyuan Li; Gangwei Zhang; Xiaoguang Chen; Xiaohui Wang
Source: check_circle
Crossref

Cannabidiol protects against Alzheimer's disease in C. elegans via ROS scavenging activity of its phenolic hydroxyl groups

European Journal of Pharmacology
2022-03 | Journal article
DOI: 10.1016/j.ejphar.2022.174829
Contributors: Yue Zhang; Hongyuan Li; Sha Jin; Yuyuan Lu; Yinghua Peng; Lihui Zhao; Xiaohui Wang
Source: check_circle
Crossref

Nalmefene non-enantioselectively targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling: wet-lab techniques andin silicosimulations

Physical Chemistry Chemical Physics
2021 | Journal article
DOI: 10.1039/D1CP00237F
Contributors: Xiaozheng Zhang; Hongshuang Wang; Yibo Wang; Hongyuan Li; Siru Wu; Jingwei Gao; Tianshu Zhang; Jun Xie; Xiaohui Wang
Source: check_circle
Crossref

Peptide-based inhibitors of protein–protein interactions: biophysical, structural and cellular consequences of introducing a constraint

Chemical Science
2021 | Journal article
DOI: 10.1039/D1SC00165E
Contributors: Hongshuang Wang; Robert S. Dawber; Peiyu Zhang; Martin Walko; Andrew J. Wilson; Xiaohui Wang
Source: check_circle
Crossref

Engineered Exosomes-Based Photothermal Therapy with MRI/CT Imaging Guidance Enhances Anticancer Efficacy through Deep Tumor Nucleus Penetration

Pharmaceutics
2021-09 | Journal article | Author
DOI: 10.3390/pharmaceutics13101593
Contributors: Min Yang; Xiaohui Wang; Fang Pu; Ying Liu; Jia Guo; Shuzhuo Chang; Guoying Sun; Yinghua Peng
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Nicotine prevents in vivo Aβ toxicity in Caenorhabditis elegans via SKN-1

Neuroscience Letters
2021-09 | Journal article
DOI: 10.1016/j.neulet.2021.136114
Contributors: Xiaoda Lu; Yue Zhang; Hongyuan Li; Yushan Jin; Lihui Zhao; Xiaohui Wang
Source: check_circle
Crossref

Lessons Learned from the Explosion that Occurred during the Synthesis of Diaminomethanesulfonic Acid: Discussion and Preventative Strategies

ACS Chemical Health & Safety
2021-07-26 | Journal article
DOI: 10.1021/acs.chas.1c00021
Contributors: Bo Zhang; Lei Zhang; Hongshuang Wang; Xiaohui Wang
Source: check_circle
Crossref

Dissecting Role of Charged Residue from Transmembrane Domain 5 of Latent Membrane Protein 1 via In Silico Simulations and Wet-Lab Experiments

The Journal of Physical Chemistry B
2021-03-04 | Journal article
DOI: 10.1021/acs.jpcb.0c10708
Contributors: Yibo Wang; Bo Zhang; Cong Lin; Ying Liu; Min Yang; Yinghua Peng; Xiaohui Wang
Source: check_circle
Crossref

Velvet Antler Methanol Extracts Ameliorate Parkinson’s Disease by Inhibiting Oxidative Stress and Neuroinflammation: From C. elegans to Mice

Oxidative Medicine and Cellular Longevity
2021-01 | Journal article
DOI: 10.1155/2021/8864395
Contributors: Ying Liu; Hongyuan Li; Yunfei Li; Min Yang; Xiaohui Wang; Yinghua Peng; Gr gory Durand
Source: check_circle
Crossref

Exploring the Thermodynamics of 7-Amino Actinomycin D-Induced Single-Stranded DNA Hairpin by Spectroscopic Techniques and Computational Simulations

The Journal of Physical Chemistry B
2020-11-12 | Journal article
DOI: 10.1021/acs.jpcb.0c05593
Contributors: Yinghua Peng; Yibo Wang; Xiaohui Wang
Source: check_circle
Crossref

Exploring the Toxicology of Depleted Uranium with Caenorhabditis elegans

ACS Omega
2020-06-02 | Journal article
DOI: 10.1021/acsomega.0c00380
Contributors: Meiling Lu; Hongyuan Li; Yunfei Li; Yuyuan Lu; Hengshan Wang; Xiaohui Wang
Source: check_circle
Crossref

Small-Molecule Modulators of Toll-like Receptors

Accounts of Chemical Research
2020-05-19 | Journal article
DOI: 10.1021/acs.accounts.9b00631
Contributors: Yibo Wang; Shuting Zhang; Hongyuan Li; Hongshuang Wang; Tianshu Zhang; Mark R. Hutchinson; Hang Yin; Xiaohui Wang
Source: check_circle
Crossref

Exploring Methamphetamine Nonenantioselectively Targeting Toll-like Receptor 4/Myeloid Differentiation Protein 2 by in Silico Simulations and Wet-Lab Techniques

Journal of Chemical Information and Modeling
2020-03-23 | Journal article
DOI: 10.1021/acs.jcim.9b01040
Contributors: Xiaozheng Zhang; Yibo Wang; Hongshuang Wang; Hongyuan Li; Tianshu Zhang; Yinghua Peng; Xiaohui Wang
Source: check_circle
Crossref

Targeting trimeric transmembrane domain 5 of oncogenic latent membrane protein 1 using a computationally designed peptide

Chemical Science
2019 | Journal article
DOI: 10.1039/c9sc02474c
Part of ISSN: 2041-6520
Part of ISSN: 2041-6539
Source: Self-asserted source
Xiaohui Wang
grade
Preferred source (of 2)‎

Methamphetamine Activates Toll-Like Receptor 4 to Induce Central Immune Signaling within the Ventral Tegmental Area and Contributes to Extracellular Dopamine Increase in the Nucleus Accumbens Shell

ACS Chemical Neuroscience
2019-08-21 | Journal article
DOI: 10.1021/acschemneuro.9b00225
Contributors: Xiaohui Wang; Alexis L. Northcutt; Thomas A. Cochran; Xiaozheng Zhang; Timothy J. Fabisiak; Mackenzie E. Haas; Jose Amat; Hongyuan Li; Kenner C. Rice; Steven F. Maier et al.
Source: check_circle
Crossref

Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2019-06-04 | Journal article
DOI: 10.1096/fj.201900173rrr
PMID: 31162938
Source: Self-asserted source
Xiaohui Wang

Kineret protein solution survives ten years.

Journal of pharmaceutical and biomedical analysis
2018-08-10 | Journal article
DOI: 10.1016/j.jpba.2018.08.023
PMID: 30121556
Source: Self-asserted source
Xiaohui Wang

Near-Infrared Switchable Fullerene-Based Synergy Therapy for Alzheimer's Disease.

Small (Weinheim an der Bergstrasse, Germany)
2018-07-20 | Journal article
DOI: 10.1002/smll.201801852
PMID: 30028575
Source: Self-asserted source
Xiaohui Wang

Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists.

Journal of chemical information and modeling
2018-04-11 | Journal article
DOI: 10.1021/acs.jcim.7b00717
PMID: 29518316
Source: Self-asserted source
Xiaohui Wang

DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.

Experimental neurology
2018-03-09 | Journal article
DOI: 10.1016/j.expneurol.2018.03.005
PMID: 29530713
PMC: PMC5916033
Source: Self-asserted source
Xiaohui Wang
Items per page:
Page 1 of 2

Peer review (5 reviews for 4 publications/grants)

Review activity for ACS chemical biology. (1)
Review activity for ACS chemical neuroscience. (1)
Review activity for ACS medicinal chemistry letters. (1)
Review activity for Journal of chemical information and modeling. (2)
How many people are using ORCID?