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Employment (1)

Tianjin University: Tianjin, CN

2018-11 to present (School of life science)
Employment
Source: Self-asserted source
Wang Yaxin

Education and qualifications (1)

Tsinghua University: Beijing, CN

Qualification
Source: Self-asserted source
Wang Yaxin

Funding (1)

EV71病毒复制机制及抗病毒抑制剂研究

2019-01-01 to 2021-12-01 | Grant
National Natural Science Foundation of China (Beijing, CN)
URL: https://app.dimensions.ai/details/grant/grant.8873149
GRANT_NUMBER:

81801998
Source: Self-asserted source
Wang Yaxin via DimensionsWizard

Works (29)

Etoposide targets 2A protease to inhibit enterovirus 71 replication

Microbiology Spectrum
2025-01-07 | Journal article
DOI: 10.1128/spectrum.02200-24
Contributors: Qinqin Liang; Sai Shi; Qingjie Zhang; Yaxin Wang; Sheng Ye; Binghong Xu; Bo Zhang
Source: check_circle
Crossref

Structure defining of ultrapotent neutralizing nanobodies against MERS-CoV with novel epitopes on receptor binding domain

PLOS Pathogens
2024-08-14 | Journal article
DOI: 10.1371/journal.ppat.1012438
Contributors: Sen Ma; Julie Overbaugh; Doudou Zhang; Qiwei Wang; Linjing Zhu; Xilin Wu; Sheng Ye; Yaxin Wang
Source: check_circle
Crossref

Host serine protease ACOT2 assists DENV proliferation by hydrolyzing viral polyproteins

mSystems
2024-01-23 | Journal article
DOI: 10.1128/msystems.00973-23
Contributors: Sen Ma; Sai Shi; Binghong Xu; Meijun Liu; Lei Xie; Yang Su; Jiachen Li; Qinqin Liang; Sheng Ye; Yaxin Wang et al.
Source: check_circle
Crossref

Computational and experimental studies of salvianolic acid A targets 3C protease to inhibit enterovirus 71 infection.

Frontiers in pharmacology
2023-03-02 | Journal article
DOI: 10.3389/fphar.2023.1118584
PMID: 36937869
PMC: PMC10017496
Contributors: Shi S; Xie L; Ma S; Binghong Xu; An H; Ye S; Wang Y
Source: Self-asserted source
Wang Yaxin

The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate.

European journal of medicinal chemistry
2022-05-13 | Journal article
DOI: 10.1016/j.ejmech.2022.114458
PMID: 35635946
PMC: PMC9098890
Contributors: Wang H; Pei R; Li X; Deng W; Xing S; Zhang Y; Zhang C; He S; Sun H; Xiao S et al.
Source: Self-asserted source
Wang Yaxin

Short-Term Instantaneous Prophylaxis and Efficient Treatment Against SARS-CoV-2 in hACE2 Mice Conferred by an Intranasal Nanobody (Nb22).

Frontiers in immunology
2022-03-17 | Journal article
DOI: 10.3389/fimmu.2022.865401
PMID: 35371009
PMC: PMC8967979
Contributors: Wu X; Wang Y; Cheng L; Ni F; Zhu L; Ma S; Huang B; Ji M; Hu H; Li Y et al.
Source: Self-asserted source
Wang Yaxin

Discovery of SARS-CoV-2 3CL<sup>Pro</sup> Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein-Ligand Interactions.

International journal of molecular sciences
2022-02-21 | Journal article
DOI: 10.3390/ijms23042392
PMID: 35216507
PMC: PMC8878928
Contributors: Wang Y; Binghong Xu; Ma S; Wang H; Shang L; Cheng Zhu; Sheng Ye
Source: Self-asserted source
Wang Yaxin

4-Iminooxazolidin-2-One as a Bioisostere of Cyanohydrin Suppresses EV71 Proliferation by Targeting 3C pro

Microbiology Spectrum
2021-12-22 | Journal article
DOI: 10.1128/Spectrum.01025-21
Contributors: Binghong Xu; Meijun Liu; Sen Ma; Yuying Ma; Si Liu; Luqing Shang; Cheng Zhu; Sheng Ye; Yaxin Wang; Daniel R. Perez
Source: check_circle
Crossref

Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease

Antiviral Research
2021-08 | Journal article
DOI: 10.1016/j.antiviral.2021.105102
Contributors: Meijun Liu; Binghong Xu; Yuying Ma; Luqing Shang; Sheng Ye; Yaxin Wang
Source: check_circle
Crossref

Activity-Based Protein Profiling Identifies ATG4B as a Key Host Factor for Enterovirus 71 Proliferation.

Journal of virology
2019-11 | Journal article
DOI: 10.1128/jvi.01092-19
PMID: 31554687
PMC: PMC6880168
Contributors: Sun Y; Zheng Q; Wang Y; Pang Z; Liu J; Yin Z; Lou Z
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors.

Journal of medicinal chemistry
2019-04-12 | Journal article
DOI: 10.1021/acs.jmedchem.9b00091
PMID: 30938999
Contributors: Yiqing Yang; Cao L; Gao H; Wu Y; Wang Y; Fang F; Tianlong Lan; Lou Z; yu rao
Source: Self-asserted source
Wang Yaxin

Site-Specific Incorporation of Chemical Fluorescence on Live Enterovirus-71 Virion by Using an Organometallic Palladium Reagent To Monitor Virus Entry.

Chembiochem : a European journal of chemical biology
2018-05 | Journal article
DOI: 10.1002/cbic.201800051
PMID: 29624826
Contributors: Wang Y; Liu J; Cao L; Wang W; Sun Y; Yin Z; Lou Z
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Identification of serotonin 2A receptor as a novel HCV entry factor by a chemical biology strategy.

Protein & cell
2018-03 | Journal article
DOI: 10.1007/s13238-018-0521-z
PMID: 29542010
PMC: PMC6338621
Contributors: Cao L; Chen J; Wang Y; Yang Y; Qing J; Rao Z; Chen X; Lou Z
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor.

Antimicrobial agents and chemotherapy
2017-06 | Journal article
DOI: 10.1128/aac.00298-17
PMID: 28461310
PMC: PMC5487676
Contributors: Wang Y; Cao L; Zhai Y; Yin Z; Sun Y; Shang L
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k.

Antiviral research
2017-01 | Journal article
DOI: 10.1016/j.antiviral.2017.01.002
PMID: 28063993
Contributors: Wang Y; Cao L; Zhai Y; Ma J; Nie Q; Li T; Yin Z; Sun Y; Shang L
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Structure-activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors.

European journal of medicinal chemistry
2016-08 | Journal article
DOI: 10.1016/j.ejmech.2016.08.064
PMID: 27614190
Contributors: Zhai Y; Ma Y; Ma F; Nie Q; Ren X; Wang Y; Shang L; Yin Z
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

The discovery of indole derivatives as novel hepatitis C virus inhibitors.

European journal of medicinal chemistry
2016-03 | Journal article
DOI: 10.1016/j.ejmech.2016.03.062
PMID: 27061978
Contributors: Han Z; Liang X; Wang Y; Qing J; Cao L; Shang L; Yin Z
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Synthesis and structure-activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors.

Bioorganic & medicinal chemistry letters
2016-02 | Journal article
DOI: 10.1016/j.bmcl.2016.02.039
PMID: 26916437
Contributors: Zeng D; Ma Y; Zhang R; Nie Q; Cui Z; Wang Y; Shang L; Yin Z
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Resistance analysis and characterization of NITD008 as an adenosine analog inhibitor against hepatitis C virus.

Antiviral research
2015-12 | Journal article
DOI: 10.1016/j.antiviral.2015.12.010
PMID: 26724382
Contributors: Qing J; Luo R; Wang Y; Nong J; Wu M; Shao Y; Tang R; Yu X; Yin Z; Sun Y
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

A Conserved Inhibitory Mechanism of a Lycorine Derivative against Enterovirus and Hepatitis C Virus.

Antimicrobial agents and chemotherapy
2015-11 | Journal article
DOI: 10.1128/aac.02274-15
PMID: 26596952
PMC: PMC4750679
Contributors: Guo Y; Wang Y; Cao L; Wang P; Qing J; Zheng Q; Shang L; Yin Z; Sun Y
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease.

Journal of medicinal chemistry
2015-11 | Journal article
DOI: 10.1021/acs.jmedchem.5b01013
PMID: 26571192
Contributors: Zhai Y; Zhao X; Cui Z; Wang M; Wang Y; Li L; Sun Q; Yang X; Zeng D; Liu Y et al.
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

A comprehensive procedure for antiviral inhibitor discovery using EV71 as an example.

Biophysics reports
2015-08 | Journal article
DOI: 10.1007/s41048-015-0006-z
PMID: 26942222
PMC: PMC4762143
Contributors: Cao L; Zhu S; Wang Y; Lou Z; Sun Y
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Peptidyl aldehyde NK-1.8k suppresses enterovirus 71 and enterovirus 68 infection by targeting protease 3C.

Antimicrobial agents and chemotherapy
2015-02 | Journal article
DOI: 10.1128/aac.00049-15
PMID: 25691647
PMC: PMC4394787
Contributors: Wang Y; Yang B; Zhai Y; Yin Z; Sun Y; Rao Z
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation.

Antiviral research
2014-10 | Journal article
DOI: 10.1016/j.antiviral.2014.10.009
PMID: 25446894
Contributors: Shang L; Wang Y; Qing J; Shu B; Cao L; Lou Z; Gong P; Sun Y; Yin Z
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Cyclophilin A associates with enterovirus-71 virus capsid and plays an essential role in viral infection as an uncoating regulator.

PLoS pathogens
2014-10 | Journal article
DOI: 10.1371/journal.ppat.1004422
PMID: 25275585
PMC: PMC4183573
Contributors: Qing J; Wang Y; Sun Y; Huang J; Yan W; Wang J; Su D; Ni C; Li J; Rao Z et al.
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Molecular mechanism of SCARB2-mediated attachment and uncoating of EV71.

Protein & cell
2014-07 | Journal article
DOI: 10.1007/s13238-014-0087-3
PMID: 24986489
PMC: PMC4145081
Contributors: Dang M; Wang X; Wang Q; Wang Y; Lin J; Sun Y; Li X; Zhang L; Lou Z; Wang J et al.
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Suramin inhibits EV71 infection.

Antiviral research
2013-12 | Journal article
DOI: 10.1016/j.antiviral.2013.12.008
PMID: 24374150
Contributors: Wang Y; Qing J; Sun Y; Rao Z
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation.

Journal of virology
2013-03 | Journal article
DOI: 10.1128/jvi.02733-12
PMID: 23487447
PMC: PMC3648134
Contributors: Chen C; Wang Y; Shan C; Sun Y; Xu P; Zhou H; Yang C; Shi PY; Rao Z; Zhang B et al.
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central

Enterovirus 71 VPg uridylation uses a two-molecular mechanism of 3D polymerase.

Journal of virology
2012-10 | Journal article
DOI: 10.1128/jvi.01712-12
PMID: 23055549
PMC: PMC3503026
Contributors: Sun Y; Wang Y; Shan C; Chen C; Xu P; Song M; Zhou H; Yang C; Xu W; Shi PY et al.
Source: Self-asserted source
Wang Yaxin via Europe PubMed Central
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