Personal information

Activities

Employment (8)

Keio University: Shinjuku, Tokyo, JP

2022-04-01 to present | Professor Emeritus
Employment
Source: Self-asserted source
Minoru Ko

Elixirgen Therapeutics: Baltimore, Maryland, US

2017-01-05 to present | Chief Scientific Officer
Employment
Source: Self-asserted source
Minoru Ko

School of Medicine, Keio University: Shinjuku, Tokyo, JP

2012-02-01 to 2022-01-31 | Professor and Chair (Systems Medicine)
Employment
Source: Self-asserted source
Minoru Ko

National Institute on Aging: Baltimore, Maryland, US

1998-09-01 to 2011-12-31 | Section Chief and Senior Investigator (Tenured) (Developmental Genomics and Aging Section, Laboratory of Genetics)
Employment
Source: Self-asserted source
Minoru Ko

Wayne State University: Detroit, Michigan, US

1996-09-01 to 1998-08-31 | Associate Professor (Tenured) (Center for Molecular Medicine and Genetics)
Employment
Source: Self-asserted source
Minoru Ko

Wayne State University: Detroit, Michigan, US

1992-09-01 to 1996-08-31 | Assistant Professor (Center for Molecular Medicine and Genetics)
Employment
Source: Self-asserted source
Minoru Ko

Japan Science and Technology Agency: Tsukuba, Ibaraki, JP

1991-08-01 to 1992-08-31 | Group Leader (ERATO, Furusawa MorphoGene Project)
Employment
Source: Self-asserted source
Minoru Ko

Japan Science and Technology Agency: Tsukuba, Ibaraki, JP

1988-04-01 to 1991-07-31 | Researcher (ERATO, Furusawa MorphoGene Project)
Employment
Source: Self-asserted source
Minoru Ko

Education and qualifications (2)

Keio University: Shinjuku, Tokyo, JP

1991 | Ph.D. (School of Medicine)
Education
Source: Self-asserted source
Minoru Ko

Keio University: Shinjuku, Tokyo, JP

1980-04-01 to 1986-03-31 | MD (School of Medicine)
Education
Source: Self-asserted source
Minoru Ko

Works (50 of 234)

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Page 1 of 5

ZSCAN4-binding motif—TGCACAC is conserved and enriched in CA/TG microsatellites in both mouse and human genomes

DNA Research
2024-02-01 | Journal article
Contributors: Tomohiko Akiyama; Kei-ichiro Ishiguro; Nana Chikazawa; Shigeru B H Ko; Masashi Yukawa; Minoru S H Ko
Source: check_circle
Crossref

A Phase I/II Clinical Trial of Intradermal, Controllable Self-Replicating Ribonucleic Acid Vaccine EXG-5003 against SARS-CoV-2

Vaccines
2023-11-27 | Journal article
Contributors: Takenao Koseki; Mayumi Teramachi; Minako Koga; Minoru S. H. Ko; Tomokazu Amano; Hong Yu; Misa Amano; Erica Leyder; Maria Badiola; Priyanka Ray et al.
Source: check_circle
Crossref
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A phase I/II clinical trial of intradermal, controllable self-replicating RNA vaccine EXG-5003 against SARS-CoV-2

2023-10-11 | Preprint
Contributors: Takenao Koseki; Mayumi Teramachi; Minako Koga; Minoru S.H. Ko; Tomokazu Amano; Hong Yu; Misa Amano; Erica Leyder; Maria Badiola; Priyanka Ray et al.
Source: check_circle
Crossref

Efficient differentiation of human pluripotent stem cells into skeletal muscle cells by combining RNA-based MYOD1-expression and POU5F1-silencing

Scientific Reports
2018-01-19 | Journal article
Contributors: Tomohiko Akiyama; Saeko Sato; Nana Chikazawa-Nohtomi; Atsumi Soma; Hiromi Kimura; Shunichi Wakabayashi; Shigeru B. H. Ko; Minoru S. H. Ko
Source: check_circle
Crossref

Correction of Down syndrome and Edwards syndrome aneuploidies in human cell cultures

DNA Research
2015 | Journal article
EID:

2-s2.0-84947793951

Contributors: Amano, T.; Jeffries, E.; Amano, M.; Ko, A.C.; Yu, H.; Ko, M.S.H.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

ExAtlas: An interactive online tool for meta-analysis of gene expression data

Journal of Bioinformatics and Computational Biology
2015 | Journal article
EID:

2-s2.0-84955262680

Contributors: Sharov, A.A.; Schlessinger, D.; Ko, M.S.H.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

Transient bursts of Zscan4 expression are accompanied by the rapid derepression of heterochromatin in mouse embryonic stem cells

DNA Research
2015 | Journal article
EID:

2-s2.0-84947790475

Contributors: Akiyama, T.; Xin, L.; Oda, M.; Sharov, A.A.; Amano, M.; Piao, Y.; Cadet, J.S.; Dudekula, D.B.; Qian, Y.; Wang, W. et al.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

A genetically engineered ovarian cancer mouse model based on fallopian tube transformation mimics human high-grade serous carcinoma development

Journal of Pathology
2014 | Journal article
EID:

2-s2.0-84902349728

Contributors: Sherman-Baust, C.A.; Kuhn, E.; Valle, B.L.; Shih, I.-M.; Kurman, R.J.; Wang, T.-L.; Amano, T.; Ko, M.S.; Miyoshi, I.; Araki, Y. et al.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

Chromatin properties of regulatory DNA probed by manipulation of transcription factors

Journal of Computational Biology
2014 | Journal article
EID:

2-s2.0-84905259973

Contributors: Sharov, A.A.; Nishiyama, A.; Qian, Y.; Dudekula, D.B.; Longo, D.L.; Schlessinger, D.; Ko, M.S.H.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

Efficient generation of integration-free human induced pluripotent stem cells from keratinocytes by simple transfection of episomal vectors

Stem Cells Translational Medicine
2014 | Journal article
EID:

2-s2.0-84903550641

Contributors: Piao, Y.; Hung, S.S.-C.; Lim, S.Y.; Wong, R.C.-B.; Ko, M.S.H.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

SOX9 accelerates ESC differentiation to three germ layer lineages by repressing SOX2 expression through P21 (WAF1/CIP1)

Development (Cambridge)
2014 | Journal article
EID:

2-s2.0-84908431266

Contributors: Yamamizu, K.; Schlessinger, D.; Ko, M.S.H.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

A conserved Oct4/POUV-dependent network links adhesion and migration to progenitor maintenance

Current Biology
2013 | Journal article
EID:

2-s2.0-84889085264

Contributors: Livigni, A.; Peradziryi, H.; Sharov, A.A.; Chia, G.; Hammachi, F.; Migueles, R.P.; Sukparangsi, W.; Pernagallo, S.; Bradley, M.; Nichols, J. et al.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

Developmental Arrest and Mouse Antral Not-Surrounded Nucleolus Oocytes

Biology of Reproduction
2013 | Journal article
WOSUID:

WOS:000314357700001

Contributors: Monti, Manuela; Zanoni, Mario; Calligaro, Alberto; Ko, Minoru S. H.; Mauri, Pierluigi; Redi, Carlo Alberto
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Identification of transcription factors for lineage-specific ESC differentiation

Stem Cell Reports
2013 | Journal article
EID:

2-s2.0-84890899156

Contributors: Yamamizu, K.; Piao, Y.; Sharov, A.A.; Zsiros, V.; Yu, H.; Nakazawa, K.; Schlessinger, D.; Ko, M.S.H.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas

American Journal of Physiology-Gastrointestinal and Liver Physiology
2013 | Journal article
WOSUID:

WOS:000320442300007

Contributors: Ko, Shigeru B. H.; Azuma, Sakiko; Yokoyama, Yukihiro; Yamamoto, Akiko; Kyokane, Kazuhiro; Niida, Shumpei; Ishiguro, Hiroshi; Ko, Minoru S. H.
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Repression of Global Protein Synthesis by Eif1a-Like Genes That Are Expressed Specifically in the Two-Cell Embryos and the Transient Zscan4-Positive State of Embryonic Stem Cells

DNA Res
2013 | Journal article
Contributors: Hung, S. S.; Wong, R. C.; Sharov, A. A.; Nakatake, Y.; Yu, H.; Ko, M. S.
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Role of iPSC-Producing Factors in Pre-Implantation Embryos

Principles of Cloning: Second Edition
2013 | Book
EID:

2-s2.0-84903221810

Contributors: Amano, T.; Ko, M.S.H.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells

Scientific Reports
2013 | Journal article
WOSUID:

WOS:000315695900001

Contributors: Nishiyama, Akira; Sharov, Alexei A.; Piao, Yulan; Amano, Misa; Amano, Tomokazu; Hoang, Hien G.; Binder, Bernard Y.; Tapnio, Richard; Bassey, Uwem; Malinou, Justin N. et al.
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Top3β is an RNA topoisomerase that works with fragile X syndrome protein to promote synapse formation

Nature Neuroscience
2013 | Journal article
EID:

2-s2.0-84883429403

Contributors: Xu, D.; Shen, W.; Guo, R.; Xue, Y.; Peng, W.; Sima, J.; Yang, J.; Sharov, A.; Srikantan, S.; Yang, J. et al.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

Totipotent Embryonic Stem Cells Arise in Ground-State Culture Conditions

Cell Reports
2013 | Journal article
WOSUID:

WOS:000321901200022

Contributors: Morgani, Sophie M.; Canham, Maurice A.; Nichols, Jennifer; Sharov, Alexei A.; Migueles, Rosa Portero; Ko, Minoru S. H.; Brickman, Joshua M.
Source: Self-asserted source
Minoru Ko via ResearcherID
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Zscan4 restores the developmental potency of embryonic stem cells

Nat Commun
2013 | Journal article
Contributors: Amano, T.; Hirata, T.; Falco, G.; Monti, M.; Sharova, L. V.; Amano, M.; Sheer, S.; Hoang, H. G.; Piao, Y.; Stagg, C. A. et al.
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Activation of JNK Triggers Release of Brd4 from Mitotic Chromosomes and Mediates Protection from Drug-Induced Mitotic Stress

Plos One
2012 | Journal article
WOSUID:

WOS:000305341500006

Contributors: Nishiyama, Akira; Dey, Anup; Tamura, Tomohiko; Ko, Minoru; Ozato, Keiko
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Forkhead transcription factor FoxA1 regulates sweat secretion through Best2 and Nkcc1 ion transporters

Journal of Investigative Dermatology
2012 | Journal article
WOSUID:

WOS:000302866900474

Contributors: Cui, C.; Childress, V.; Piao, Y.; Michel, M.; Johnson, A. A.; Kunisada, M.; Ko, M. S.; Kaestner, K. H.; Marmorstein, A. D.; Schlessinger, D.
Source: Self-asserted source
Minoru Ko via ResearcherID

Forkhead transcription factor FoxA1 regulates sweat secretion through Bestrophin 2 anion channel and Na-K-Cl cotransporter 1

Proceedings of the National Academy of Sciences of the United States of America
2012 | Journal article
WOSUID:

WOS:000299412600044

Contributors: Cui, Chang-Yi; Childress, Victoria; Piao, Yulan; Michel, Marc; Johnson, Adiv A.; Kunisada, Makoto; Ko, Minoru S. H.; Kaestner, Klaus H.; Marmorstein, Alan D.; Schlessinger, David
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Molecular mechanisms of pancreatic stone formation in chronic pancreatitis

Front Physiol
2012 | Journal article
Contributors: Ko, S. B.; Azuma, S.; Yoshikawa, T.; Yamamoto, A.; Kyokane, K.; Ko, M. S.; Ishiguro, H.
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Prenatal Arsenic Exposure Alters Gene Expression in the Adult Liver to a Proinflammatory State Contributing to Accelerated Atherosclerosis

PLoS ONE
2012 | Journal article
WOSUID:

WOS:000305350000021

Contributors: States, J. Christopher; Singh, Amar V.; Knudsen, Thomas B.; Rouchka, Eric C.; Ngalame, Ntube O.; Arteel, Gavin E.; Piao, Yulan; Ko, Minoru S. H.
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Silencing or amplification of endocannabinoid signaling in blastocysts via CB1 compromises trophoblast cell migration

Journal of Biological Chemistry
2012 | Journal article
EID:

2-s2.0-84866382236

Contributors: Xie, H.; Sun, X.; Piao, Y.; Jegga, A.G.; Handwerger, S.; Ko, M.S.H.; Dey, S.K.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier

Stochastic Modeling for the Expression of a Gene Regulated by Competing Transcription Factors

Plos One
2012 | Journal article
WOSUID:

WOS:000303198600016

Contributors: Yang, Hsih-Te; Ko, Minoru S. H.
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Transcriptional Activation by Oct4 Is Sufficient for the Maintenance and Induction of Pluripotency

Cell Reports
2012 | Journal article
WOSUID:

WOS:000309710200003

Contributors: Hammachi, Fella; Morrison, Gillian M.; Sharov, Alexei A.; Livigni, Alessandra; Narayan, Santosh; Papapetrou, Eirini P.; O'Malley, James; Kaji, Keisuke; Ko, Minoru S. H.; Ptashne, Mark et al.
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Zscan4 transiently reactivates early embryonic genes during the generation of induced pluripotent stem cells

Scientific Reports
2012 | Journal article
WOSUID:

WOS:000300568700001

Contributors: Hirata, Tetsuya; Amano, Tomokazu; Nakatake, Yuhki; Amano, Misa; Piao, Yulan; Hoang, Hien G.; Ko, Minoru S. H.
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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B-type lamins regulates neither their bound genes nor embryonic stem cells but are essential for organogenesis

Molecular Biology of the Cell
2011 | Journal article
WOSUID:

WOS:000305505500051

Contributors: Kim, Y.; Sharov, A.; Mcdole, K.; Cheng, M.; Hao, H.; Fan, C-M.; Gaiano, N.; Ko, M.; Zheng, Y.
Source: Self-asserted source
Minoru Ko via ResearcherID

Generation of mouse ES cell lines engineered for the forced induction of transcription factors

Scientific Reports
2011 | Journal article
WOSUID:

WOS:000300560100002

Contributors: Correa-Cerro, Lina S.; Piao, Yulan; Sharov, Alexei A.; Nishiyama, Akira; Cadet, Jean S.; Yu, Hong; Sharova, Lioudmila V.; Xin, Li; Hoang, Hien G.; Thomas, Marshall et al.
Source: Self-asserted source
Minoru Ko via ResearcherID
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Mouse B-Type Lamins Are Required for Proper Organogenesis But Not by Embryonic Stem Cells

Science
2011 | Journal article
WOSUID:

WOS:000298344000068

Contributors: Kim, Youngjo; Sharov, Alexei A.; McDole, Katie; Cheng, Melody; Hao, Haiping; Fan, Chen-Ming; Gaiano, Nicholas; Ko, Minoru S. H.; Zheng, Yixian
Source: Self-asserted source
Minoru Ko via ResearcherID
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Responsiveness of genes to manipulation of transcription factors in ES cells is associated with histone modifications and tissue specificity

Bmc Genomics
2011 | Journal article
WOSUID:

WOS:000287688300001

Contributors: Sharov, Alexei A.; Nishiyama, Akira; Piao, Yulan; Correa-Cerro, Lina S.; Amano, Tomokazu; Thomas, Marshall; Mehta, Samir; Ko, Minoru S. H.
Source: Self-asserted source
Minoru Ko via ResearcherID
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Salute to a giant ... Robert Geoffrey Edwards

Reproductive Biomedicine Online
2011 | Journal article
WOSUID:

WOS:000303047900001

Contributors: Ahuja, Kamal; Bennett, Fiona; Cohen, Jacques; Edwards, Ruth; Pritchard, Huw; Silver, Ann; Sirlin, Julio; Slee, John; Abse, Dannie; Ashwood-Smith, M. J. et al.
Source: Self-asserted source
Minoru Ko via ResearcherID

A Role for Borg5 During Trophectoderm Differentiation

Stem Cells
2010 | Journal article
WOSUID:

WOS:000279103500004

Contributors: Vong, QP; Liu, ZH; Yoo, JG; Chen, R; Xie, W; Sharov, AA; Fan, CM; Liu, CY; Ko, MSH; Zheng, YX
Source: Self-asserted source
Minoru Ko via ResearcherID
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Changes in Global Gene Expression During In Vitro Decidualization of Rat Endometrial Stromal Cells

JOURNAL OF CELLULAR PHYSIOLOGY
2010 | Journal article
WOSUID:

WOS:000272528300017

Contributors: VALLEJO, G; MASCHI, D; MESTRE-CITRINOVITZ, AC; AIBA, K; MARONNA, R; YOHAI, V; KO, MSH; BEATO, M; SARAGUETA, P
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Combinational differentiation by environmental manipulation and transgene with NIA ES cell bank

Developmental Biology
2010 | Journal article
WOSUID:

WOS:000280426400407

Contributors: Nakatake, Y; Ko, M
Source: Self-asserted source
Minoru Ko via ResearcherID

Dkk4 and Eda Regulate Distinctive Developmental Mechanisms for Subtypes of Mouse Hair

PLOS ONE
2010 | Journal article
WOSUID:

WOS:000276418200064

Contributors: CUI, CY; KUNISADA, M; PIAO, Y; CHILDRESS, V; KO, MSH; SCHLESSINGER, D
Source: Self-asserted source
Minoru Ko via ResearcherID
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Functional Heterogeneity of Embryonic Stem Cells Revealed through Translational Amplification of an Early Endodermal Transcript

Plos Biology
2010 | Journal article
WOSUID:

WOS:000278759600014

Contributors: Canham, MA; Sharov, AA; Ko, MSH; Brickman, JM
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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GENE EXPRESSION PROFILING OF MOUSE EMBRYOS WITH MICROARRAYS

Methods in Enzymology, Vol 477: Guide To Techniques in Mouse Development, Part B: Mouse Molecular Genetics, Second Edition
2010 | Book chapter
WOSUID:

WOS:000281776700025

Contributors: Sharov, AA; Piao, Y; Ko, MSH
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Zscan4 regulates telomere elongation and genomic stability in ES cells

NATURE
2010 | Journal article
WOSUID:

WOS:000276397300030

Contributors: ZALZMAN, M; FALCO, G; SHAROVA, LV; NISHIYAMA, A; THOMAS, M; LEE, SL; STAGG, CA; HOANG, HG; YANG, HT; INDIG, FE et al.
Source: Self-asserted source
Minoru Ko via ResearcherID
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Analysis of gene expression in mouse antral SN and NSN oocytes

16th Annual Conference of the International-Society-of-Development-Biologists
2009 | Conference paper
WOSUID:

WOS:000270034900985

Contributors: MONTI, M; KO, MSH; REDI, CA
Source: Self-asserted source
Minoru Ko via ResearcherID

Database for mRNA Half-Life of 19 977 Genes Obtained by DNA Microarray Analysis of Pluripotent and Differentiating Mouse Embryonic Stem Cells

DNA RESEARCH
2009 | Journal article
WOSUID:

WOS:000264002100004

Contributors: SHAROVA, LV; SHAROV, AA; NEDOREZOV, T; et al.
Source: Self-asserted source
Minoru Ko via ResearcherID
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Dax1 Binds to Oct3/4 and Inhibits Its Transcriptional Activity in Embryonic Stem Cells

MOLECULAR AND CELLULAR BIOLOGY
2009 | Journal article
WOSUID:

WOS:000268310000020

Contributors: SUN, CH; NAKATAKE, Y; AKAGI, T; URA, H; MATSUDA, T; NISHIYAMA, A; KOIDE, H; KO, MSH; NIWA, H; YOKOTA, T
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Defining Developmental Potency and Cell Lineage Trajectories by Expression Profiling of Differentiating Mouse Embryonic Stem Cells

DNA RESEARCH
2009 | Journal article
WOSUID:

WOS:000264002100006

Contributors: AIBA, L; NEDOREZOV, T; PIAO, Y; et al.
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Exhaustive Search for Over-represented DNA Sequence Motifs with CisFinder

DNA RESEARCH
2009 | Journal article
WOSUID:

WOS:000271610400002

Contributors: SHAROV, AA; KO, MSH
Source: Self-asserted source
Minoru Ko via ResearcherID
grade
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Functional heterogeneity of murine embryonic stem cells revealed through translational amplification in an early endoderm marker

16th Annual Conference of the International-Society-of-Development-Biologists
2009 | Conference paper
WOSUID:

WOS:000270034900826

Contributors: CANHAM, M; SHAROV, A; KO, M; BRICKMAN, J
Source: Self-asserted source
Minoru Ko via ResearcherID

Identification of evolutionarily conserved targets of the Oct4 transcription factor

16th Annual Conference of the International-Society-of-Development-Biologists
2009 | Conference paper
WOSUID:

WOS:000270034900844

Contributors: LIVIGNI, A; JONES, L; PERNAGALLO, S; HAMMACHI, F; SHAROV, A; MORRISON, G; KO, M; BRADLEY, M; BRICKMAN, J
Source: Self-asserted source
Minoru Ko via ResearcherID

Maintenance of undifferentiated mouse embryonic stem cells in suspension by the serum- and feeder-free defined culture condition (Developmental Dynamics 237, (2129-2138))

Developmental Dynamics
2009 | Journal article
EID:

2-s2.0-59649101440

Contributors: Tsuji, Y.; Yoshimura, N.; Aoki, H.; Sharov, A.A.; Ko, M.S.H.; Motohashi, T.; Kunisada, T.
Source: Self-asserted source
Minoru Ko via Scopus - Elsevier
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