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Employment (1)

Chugai Pharmaceutical: Gotemba, JP

2015-04-01 to present | Research Scientist (Pharmaceutical Science Dept.)
Employment
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Sotaro Naoi

Education and qualifications (1)

University of Tokyo: Tokyo, JP

Education
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Sotaro Naoi

Works (26)

Data from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.c.7267968
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Data from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.c.7267968.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

Cancer Immunology Research
2024-06-04 | Journal article
DOI: 10.1158/2326-6066.CIR-23-0638
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S1 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964682
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S1 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964682.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S2 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964679
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S2 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964679.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S3 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964673
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S3 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964673.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S4 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964670.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S4 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964670
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S5 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964667.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S5 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964667
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S6 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964664
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S6 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964664.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S7 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964661
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S7 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964661.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S8 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964658
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S8 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964658.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S9 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964655.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Figure S9 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964655
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Supplementary Methods from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964652
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Supplementary Methods from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964652.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Table S1 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964649.v1
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Table S1 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer

2024-06-04 | Preprint
DOI: 10.1158/2326-6066.25964649
Contributors: Hirofumi Mikami; Shu Feng; Yutaka Matsuda; Shinya Ishii; Sotaro Naoi; Yumiko Azuma; Hiroaki Nagano; Kentaro Asanuma; Yoko Kayukawa; Toshiaki Tsunenari et al.
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Physiologically based pharmacokinetic (PBPK) model that describes enhanced FcRn-dependent distribution of monoclonal antibodies (mAbs) by pI-engineering in mice

Drug Metabolism and Pharmacokinetics
2023-12 | Journal article
DOI: 10.1016/j.dmpk.2023.100506
Contributors: Sotaro Naoi; Mizuki Yamane; Takayuki Nemoto; Motohiro Kato; Ryoichi Saito; Tatsuhiko Tachibana
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