Personal information

Hematopoiesis, Stem cells, DNA damage, Aging
Germany

Activities

Employment (6)

Heidelberg Institute for Stem Cell Technology and Experimental Medicine: Heidelberg, DE

2010-09-01 to present | Group Leader (Experimental Hematology Group)
Employment
Source: Self-asserted source
0000-0002-3567-254X

German Cancer Research Center: Heidelberg, DE

2010-09-01 to present | Division Head (Division of Experimental Hematology)
Employment
Source: Self-asserted source
0000-0002-3567-254X

Harvard Medical School: Boston, Massachusetts, US

2008-03-01 to 2010-08-31 | Instructor of Pediatrics (Hematology/Oncology)
Employment
Source: Self-asserted source
0000-0002-3567-254X

Boston Children's Hospital: Boston, Massachusetts, US

2008-03-01 to 2010-08-31 | Associate Research Scientist (Hematology/Oncology)
Employment
Source: Self-asserted source
0000-0002-3567-254X

Cincinnati Children's Hospital Medical Center: Cincinnati, OH, US

2005-04-01 to 2008-02-28 | Postdoctoral Research Associate (Division of Experimental Hematology)
Employment
Source: Self-asserted source
0000-0002-3567-254X

Cancer Research UK Manchester Institute: Manchester, Manchester, GB

2001-01-01 to 2005-03-31 | Postdoctoral Fellow (Gene Therapy Group)
Employment
Source: Self-asserted source
0000-0002-3567-254X

Education and qualifications (2)

University of Leeds: Leeds, West Yorkshire, GB

1996-10-01 to 2000-12-18 | PhD. (School of Biochemistry and Molecular Biology)
Education
Source: Self-asserted source
0000-0002-3567-254X

University of Leeds: Leeds, West Yorkshire, GB

1993-10-01 to 1996-06-30 | BSc. (hons) in Biochemistry and Molecular Biology (Department of Combined Studies)
Education
Source: Self-asserted source
0000-0002-3567-254X

Professional activities (16)

European Hematology Association: The Hague, NL

2020 to present | Section Chair, Molecular Hematopoiesis Workshop
Service
Source: Self-asserted source
0000-0002-3567-254X

American Society of Hematology: Washington, DC, US

2020 to present | Scientific Committee on Bone Marrow Failure
Service
Source: Self-asserted source
0000-0002-3567-254X

American Society of Hematology: Washington, DC, US

2018-12-01 to present | Editorial Board, Blood
Invited position
Source: Self-asserted source
0000-0002-3567-254X

German Stem Cell Network: Berlin, DE

2013 to present | Member
Membership
Source: Self-asserted source
0000-0002-3567-254X

European Hematology Association: The Hague, NL

2013 to present
Membership
Source: Self-asserted source
0000-0002-3567-254X

International Society for Experimental Hematology: Chicago, Illinois, US

2012 to present | Member
Membership
Source: Self-asserted source
0000-0002-3567-254X

American Society of Hematology: Washington, DC, US

2008 to present | Member
Membership
Source: Self-asserted source
0000-0002-3567-254X

International Society for Experimental Hematology: Chicago, Illinois, US

2019 to 2021-09 | Annual Meeting Scientific Program Committee
Service
Source: Self-asserted source
0000-0002-3567-254X

European Hematology Association: The Hague, NL

2017-01-01 to 2019-12-31 | Scientific Editorial Board, HemaSphere
Invited position
Source: Self-asserted source
0000-0002-3567-254X

International Society for Experimental Hematology: Chicago, Illinois, US

2016 to 2019 | Board of Directors
Service
Source: Self-asserted source
0000-0002-3567-254X

Fanconi Anemia Research Fund: Eugene, Oregon, US

2016-09 | David B. Frohnmayer Award
Distinction
Source: Self-asserted source
0000-0002-3567-254X

International Society for Experimental Hematology: Chicago, Illinois, US

2014 to 2016 | Chair of New Investigator Committee
Service
Source: Self-asserted source
0000-0002-3567-254X

Cancer Research UK Manchester Institute: Manchester, Manchester, GB

2004-12 | T. Michael Dexter Outstanding Young Investigator Award
Distinction
Source: Self-asserted source
0000-0002-3567-254X

University of Leeds: Leeds, West Yorkshire, GB

1996-10-01 | University Research Scholarship
Distinction
Source: Self-asserted source
0000-0002-3567-254X

University of Leeds: Leeds, West Yorkshire, GB

1996-06 | Shell Prize for outstanding undergraduate final year examination results (Department of Combined Studies)
Distinction
Source: Self-asserted source
0000-0002-3567-254X

University of Leeds: Leeds, West Yorkshire, GB

1994-06 | Crabtree Prize for outstanding undergraduate first year examination results (Department of Combined Studies)
Distinction
Source: Self-asserted source
0000-0002-3567-254X

Funding (7)

HSCs under acute and chronic inflammatory stress (B13*)

2018-01-01 to present | Grant
German Research Foundation (Bonn, DE)
GRANT_NUMBER: 407288266
Source: Self-asserted source
0000-0002-3567-254X via DimensionsWizard

Epigenetic Remodeling and Clonal Selection in a Murine Model of Accelerated Hematopoietic Stem Cell Aging.

2017-01-01 to present | Grant
German Research Foundation (Bonn, DE)
GRANT_NUMBER: 387740586
Source: Self-asserted source
0000-0002-3567-254X via DimensionsWizard

Aging and Metabolic Programming (AMPro)

2017 to 2021 | Grant
Helmholtz Association (Bonn, DE)
Source: Self-asserted source
0000-0002-3567-254X

Characterization of epigenetic plasticity and novel therapeutic targets in pre-leukemic hematopoiesis.

2017 to 2020 | Grant
Deutsche Krebshilfe (Bonn, DE)
Source: Self-asserted source
0000-0002-3567-254X

Effect of interferon-alpha on MPN stem cells.

2017 to 2020 | Grant
MPN Research Foundation (IL, IL, US)
Source: Self-asserted source
0000-0002-3567-254X

Dissecting the aetiology of bone marrow failure in Fanconi anemia.

2016 to 2019 | Grant
Fritz Thyssen Stiftung (Köln, DE)
Source: Self-asserted source
0000-0002-3567-254X

An investigation into the mechanism of acquisition of DNA mutations within hematopoietic stem cells under physiologic conditions.

2015 to 2017 | Grant
José Carreras Leukämie-Stiftung (München, DE)
Source: Self-asserted source
0000-0002-3567-254X

Works (50 of 65)

Items per page:
Page 1 of 2

Inflammatory exposure drives long-lived impairment of hematopoietic stem cell self-renewal activity and accelerated aging.

Cell stem cell
2022-07 | Journal article
Contributors: Bogeska R; Mikecin AM; Kaschutnig P; Fawaz M; Büchler-Schäff M; Le D; Ganuza M; Vollmer A; Paffenholz SV; Asada N et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Dynamic DNA methylation reveals novel <i>cis-</i>regulatory elements in murine hematopoiesis

2022-06 | Preprint
Contributors: Schönung M; Hartmann M; Krämer S; Stäble S; Hakobyan M; Kleinert E; Aurich T; Cobanoglu D; Heidel FH; Fröhling S et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Fast and high-fidelity <i>in situ</i> 3D imaging protocol for stem cells and niche components for mouse organs and tissues.

STAR protocols
2022-06 | Journal article
Contributors: Saçma M; Matteini F; Mulaw MA; Hageb A; Bogeska R; Sakk V; Vollmer A; Marka G; Soller K; Milsom MD et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Antigen presentation safeguards the integrity of the hematopoietic stem cell pool.

Cell stem cell
2022-05 | Journal article
Contributors: Hernández-Malmierca P; Vonficht D; Schnell A; Uckelmann HJ; Bollhagen A; Mahmoud MAA; Landua SL; van der Salm E; Trautmann CL; Raffel S et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Somatic mutation rates scale with lifespan across mammals.

Nature
2022-04-13 | Journal article
Source: Self-asserted source
0000-0002-3567-254X

IRON REGULATORY PROTEIN (IRP)-MEDIATED IRON HOMEOSTASIS IS CRITICAL FOR NEUTROPHIL DEVELOPMENT AND DIFFERENTIATION IN THE BONE MARROW

2022-03 | Preprint
Contributors: Bonadonna M; Altamura S; Tybl E; Palais G; Qatato M; Polycarpou-Schwarz M; Schneider M; Kalk C; Rüdiger W; Ertl A et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

An episomal DNA vector platform for the persistent genetic modification of pluripotent stem cells and their differentiated progeny.

Stem cell reports
2021-12-22 | Journal article
Source: Self-asserted source
0000-0002-3567-254X

DNMT1 Deficiency Impacts on Plasmacytoid Dendritic Cells in Homeostasis and Autoimmune Disease.

Journal of immunology (Baltimore, Md. : 1950)
2021-12-13 | Journal article
Source: Self-asserted source
0000-0002-3567-254X

Somatic mutation rates scale with lifespan across mammals

2021-08 | Preprint
Contributors: Cagan A; Baez-Ortega A; Brzozowska N; Abascal F; Coorens THH; Sanders MA; Lawson ARJ; Harvey LMR; Bhosle S; Jones D et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Hypersensitivity response has negligible impact on Hematopoietic Stem Cells.

Stem cell reports
2021-07-22 | Journal article
Source: Self-asserted source
0000-0002-3567-254X

Hotspot DNMT3A mutations in clonal hematopoiesis and acute myeloid leukemia sensitize cells to azacytidine via viral mimicry response

Nature Cancer
2021-05 | Journal article
Part of ISSN: 2662-1347
Source: Self-asserted source
0000-0002-3567-254X

A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification.

Haematologica
2021-05-01 | Journal article
Source: Self-asserted source
0000-0002-3567-254X

Hematopoietic stem cells fail to regenerate following inflammatory challenge

2020-08 | Other
OTHER-ID:

PPR195367

Contributors: Bogeska R; Kaschutnig P; Fawaz M; Mikecin A; Büchler-Schäff M; Paffenholz S; Asada N; Frauhammer F; Buettner F; Ball M et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

The role of the stem cell epigenome in normal aging and rejuvenative therapy.

Human molecular genetics
2020-08 | Journal article
Contributors: Jayarajan J; Milsom MD
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Continuous mitotic activity of primitive hematopoietic stem cells in adult mice.

The Journal of experimental medicine
2020-06 | Journal article
Contributors: Morcos MNF; Zerjatke T; Glauche I; Munz CM; Ge Y; Petzold A; Reinhardt S; Dahl A; Anstee NS; Bogeska R et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Haematopoietic stem cells in perisinusoidal niches are protected from ageing.

Nature cell biology
2019-11 | Journal article
Contributors: Saçma M; Pospiech J; Bogeska R; de Back W; Mallm JP; Sakk V; Soller K; Marka G; Vollmer A; Karns R et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations.

Leukemia
2019-11-15 | Journal article
Source: Self-asserted source
0000-0002-3567-254X

Ex Vivo Expansion of Functional Hematopoietic Stem Cells, Facilitating Transplantation in the Absence of Conditioning.

HemaSphere
2019-10-10 | Journal article
Source: Self-asserted source
0000-0002-3567-254X
grade
Preferred source (of 2)‎

Neutrophil Progenitors Function as a Mechanistic Link Between Sleep Disruption and Heart Disease.

HemaSphere
2019-08 | Journal article
Contributors: Milsom MD
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Proliferative behavior of hematopoietic stem cells revisited: No evidence for mitotic memory

2019-08 | Preprint
Contributors: Morcos MNF; Zerjatke T; Glauche I; Munz CM; Ge Y; Petzold A; Reinhardt S; Dahl A; Anstee N; Bogeska R et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer.

Nature medicine
2019-04 | Journal article
Contributors: Malehmir M; Pfister D; Gallage S; Szydlowska M; Inverso D; Kotsiliti E; Leone V; Peiseler M; Surewaard BGJ; Rath D et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Potential Pre-Leukemic Mutations in PPM1D Confer Chemotherapy Resistance to Aged HSC Clones.

HemaSphere
2019-01 | Journal article
Contributors: Milsom MD
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Identification of Embryonic Neural Plate Border Stem Cells and Their Generation by Direct Reprogramming from Adult Human Blood Cells.

Cell stem cell
2018-12 | Journal article
Contributors: Thier MC; Hommerding O; Panten J; Pinna R; García-González D; Berger T; Wörsdörfer P; Assenov Y; Scognamiglio R; Przybylla A et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

The Deconvolution of Human Hematopoiesis.

HemaSphere
2018-11 | Journal article
Contributors: Milsom MD
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity.

Cell stem cell
2018-05 | Journal article
Contributors: Haas S; Trumpp A; Milsom MD
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

RET-mediated autophagy suppression as targetable co-dependence in acute myeloid leukemia.

Leukemia
2018-03 | Journal article
Contributors: Rudat S; Pfaus A; Cheng YY; Holtmann J; Ellegast JM; Bühler C; Marcantonio DD; Martinez E; Göllner S; Wickenhauser C et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Stem Cells Spirited Away by Alcohol-Induced DNA Damage.

HemaSphere
2018-03 | Journal article
Contributors: Milsom MD
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

An Inflammatory Environment: Donor Granulocytes Mediate Endothelial Regeneration Following Transplantation.

HemaSphere
2018-01 | Journal article
Contributors: Milsom MD
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

The Roots of Neurodegenerative Disease Found in Developmental Hematopoiesis.

HemaSphere
2017-12 | Journal article
Contributors: Milsom MD
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Protein Kinase C Epsilon Is a Key Regulator of Mitochondrial Redox Homeostasis in Acute Myeloid Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research
2017-11 | Journal article
Contributors: Di Marcantonio D; Martinez E; Sidoli S; Vadaketh J; Nieborowska-Skorska M; Gupta A; Meadows JM; Ferraro F; Masselli E; Challen GA et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Enhancement of mouse hematopoietic stem/progenitor cell function via transient gene delivery using integration-deficient lentiviral vectors.

Experimental hematology
2017-09 | Journal article
Contributors: Alonso-Ferrero ME; van Til NP; Bartolovic K; Mata MF; Wagemaker G; Moulding D; Williams DA; Kinnon C; Waddington SN; Milsom MD et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Impact of DNA methylation programming on normal and pre-leukemic hematopoiesis.

Seminars in cancer biology
2017-09 | Journal article
Contributors: Langstein J; Milsom MD; Lipka DB
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

EDA-Fibronectin Originating from Osteoblasts Inhibits the Immune Response against Cancer.

PLoS biology
2016-09 | Journal article
Contributors: Rossnagl S; Altrock E; Sens C; Kraft S; Rau K; Milsom MD; Giese T; Samstag Y; Nakchbandi IA
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Lineage-specific BCL11A knockdown circumvents toxicities and reverses sickle phenotype.

The Journal of clinical investigation
2016-09 | Journal article
Contributors: Brendel C; Guda S; Renella R; Bauer DE; Canver MC; Kim YJ; Heeney MM; Klatt D; Fogel J; Milsom MD et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

The European Hematology Association Roadmap for European Hematology Research: a consensus document.

Haematologica
2016-01 | Journal article
Contributors: Engert A; Balduini C; Brand A; Coiffier B; Cordonnier C; Döhner H; de Wit TD; Eichinger S; Fibbe W; Green T et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.

Cell reports
2015-12 | Journal article
Contributors: Moehrle BM; Nattamai K; Brown A; Florian MC; Ryan M; Vogel M; Bliederhaeuser C; Soller K; Prows DR; Abdollahi A et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Clonal evolution of preleukemic hematopoietic stem cells in acute myeloid leukemia.

Experimental hematology
2015-10 | Journal article
Contributors: Sykes SM; Kokkaliaris KD; Milsom MD; Levine RL; Majeti R
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Inflammation-Induced Emergency Megakaryopoiesis Driven by Hematopoietic Stem Cell-like Megakaryocyte Progenitors.

Cell stem cell
2015-08 | Journal article
Contributors: Haas S; Hansson J; Klimmeck D; Loeffler D; Velten L; Uckelmann H; Wurzer S; Prendergast ÁM; Schnell A; Hexel K et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

The Fanconi anemia pathway is required for efficient repair of stress-induced DNA damage in haematopoietic stem cells.

Cell cycle (Georgetown, Tex.)
2015-07 | Journal article
Contributors: Kaschutnig P; Bogeska R; Walter D; Lier A; Huntscha S; Milsom MD
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

miRNA-embedded shRNAs for Lineage-specific BCL11A Knockdown and Hemoglobin F Induction.

Molecular therapy : the journal of the American Society of Gene Therapy
2015-06 | Journal article
Contributors: Guda S; Brendel C; Renella R; Du P; Bauer DE; Canver MC; Grenier JK; Grimson AW; Kamran SC; Thornton J et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells.

Nature
2015-02 | Journal article
Contributors: Walter D; Lier A; Geiselhart A; Thalheimer FB; Huntscha S; Sobotta MC; Moehrle B; Brocks D; Bayindir I; Kaschutnig P et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Identification of regulatory networks in HSCs and their immediate progeny via integrated proteome, transcriptome, and DNA methylome analysis.

Cell stem cell
2014-08 | Journal article
Contributors: Cabezas-Wallscheid N; Klimmeck D; Hansson J; Lipka DB; Reyes A; Wang Q; Weichenhan D; Lier A; von Paleske L; Renders S et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Early aberrant DNA methylation events in a mouse model of acute myeloid leukemia.

Genome medicine
2014-04 | Journal article
Contributors: Sonnet M; Claus R; Becker N; Zucknick M; Petersen J; Lipka DB; Oakes CC; Andrulis M; Lier A; Milsom MD et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Requirement for CDK6 in MLL-rearranged acute myeloid leukemia.

Blood
2014-04 | Journal article
Contributors: Placke T; Faber K; Nonami A; Putwain SL; Salih HR; Heidel FH; Krämer A; Root DE; Barbie DA; Krivtsov AV et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Identification of DNA methylation changes at cis-regulatory elements during early steps of HSC differentiation using tagmentation-based whole genome bisulfite sequencing.

Cell cycle (Georgetown, Tex.)
2014-01 | Journal article
Contributors: Lipka DB; Wang Q; Cabezas-Wallscheid N; Klimmeck D; Weichenhan D; Herrmann C; Lier A; Brocks D; von Paleske L; Renders S et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment.

Blood
2013-01 | Journal article
Contributors: Dorrance AM; De Vita S; Radu M; Reddy PN; McGuinness MK; Harris CE; Mathieu R; Lane SW; Kosoff R; Milsom MD et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Induction of histiocytic sarcoma in mouse skeletal muscle.

PloS one
2012-08 | Journal article
Contributors: Liu J; Hettmer S; Milsom MD; Hofmann I; Hua F; Miller C; Bronson RT; Wagers AJ
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Disrupted Signaling through the Fanconi Anemia Pathway Leads to Dysfunctional Hematopoietic Stem Cell Biology: Underlying Mechanisms and Potential Therapeutic Strategies.

Anemia
2012-05 | Journal article
Contributors: Geiselhart A; Lier A; Walter D; Milsom MD
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Overcoming reprogramming resistance of Fanconi anemia cells.

Blood
2012-02 | Journal article
Contributors: Müller LU; Milsom MD; Harris CE; Vyas R; Brumme KM; Parmar K; Moreau LA; Schambach A; Park IH; London WB et al.
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central

Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development.

Blood
2011-11 | Journal article
Contributors: Lane SW; De Vita S; Alexander KA; Karaman R; Milsom MD; Dorrance AM; Purdon A; Louis L; Bouxsein ML; Williams DA
Source: Self-asserted source
0000-0002-3567-254X via Europe PubMed Central
Items per page:
Page 1 of 2

Peer review (6 reviews for 4 publications/grants)

Review activity for Cell stem cell. (1)
Review activity for Nature (2)
Review activity for Nature aging. (1)
Review activity for The Journal of experimental medicine. (2)