Personal information

Websites & social links

Google Scholar Record
Website

Other IDs

ResearcherID: F-1721-2015
Scopus Author ID: 41961495700
Loop profile: 876390
Loop profile: 1019660

Keywords

circadian metabolism, exercise biology, obesity, physiology, endocannabinoid, lipid metabolism, O-GlcNAc glycosylation

Countries

China

Biography

A molecular physiologist aiming to elucidate how environmental cues, like light and food, reset the daily rhythms of metabolism and physiology, and translate this knowledge into better care and treatment for cardiometabolic diseases, including heart failure, diabetes, and visceral obesity. The research program applies molecular biology, metabolic/circadian phenotyping, and systems biology to pursue the aim, and collaborates with clinical research units.

Min-Dian Li grew up in Chengdu in the Southwest of China. His hometown is the home of Giant Pandas and enjoys a nation-wide fame for spicy cuisines, tourism, and living. He graduated Summa Cum Laude from Peking University College of Life Sciences, and received his PhD in Cellular and Molecular Physiology from Yale University under the mentorship of Dr. Xiaoyong Yang. He had been a Glenn/AFAR postdoctoral fellow in the laboratory of Dr. Gokhan Hotamisligil in Harvard University.

Activities

Collapse all

Employment (4)

Third Military Medical University Southwest Hospital: Chongqing, Chongqing, CN

2019 to present | Professor (Internal Medicine: Cardiovascular Medicine)
Employment
Source: Self-asserted source
Min-Dian Li

Harvard University T.H. Chan School of Public Health: Boston, MA, US

2016 to 2019 | Postdoctoral Fellow (Genetics and Complex Diseases)
Employment
Source: Self-asserted source
Min-Dian Li

Tsinghua University: Beijing, Beijing, CN

2017-04 to 2017-08 (School of Life Sciences)
Employment
Source: Self-asserted source
Min-Dian Li

Yale University: New Haven, CT, US

2015-07 to 2015-12 | Postdoctoral Associate (Comparative Medicine, School of Medicine)
Employment
Source: Self-asserted source
Min-Dian Li

Education and qualifications (2)

Yale University: New Haven, CT, US

2009-08-20 to 2015-05-31 | PhD (Cellular and Molecular Physiology)
Education
Source: Self-asserted source
Min-Dian Li

Peking University: Beijing, Beijing, CN

2005-08-31 to 2009-07-01 | B. Sc. (College of Life Sciences)
Education
Source: Self-asserted source
Min-Dian Li

Professional activities (6)

The Chinese Society of Biochemistry and Molecular Biology: Shanghai, CN

2021-12-01 to present | Deputy-Secretary (Division of Metabolism)
Membership
Source: Self-asserted source
Min-Dian Li

Chinese Society for Cell Biology: Shanghai, CN

2019 to present | Secretary - Permanent Member (Chinese Society for Biological Rhythms, CSCB)
Membership
Source: Self-asserted source
Min-Dian Li

Biophysical Society of China: Beijing, CN

2018 to present | Junior Board of Trustees (Metabolic Biology)
Membership
Source: Self-asserted source
Min-Dian Li

American Society for Biochemistry and Molecular Biology: Rockville, MD, US

2015-06-01 to present
Membership
Source: Self-asserted source
Min-Dian Li

American Federation for Aging Research: New York, NY, US

2017 | The Glenn Foundation for Medical Research Postdoctoral Fellowship in Aging Research
Distinction
Source: Self-asserted source
Min-Dian Li

American Federation for Aging Research : New York, NY, US

2014 | Glenn/AFAR Scholarship for Research in the Biology of Aging
Distinction
Source: Self-asserted source
Min-Dian Li

Funding (2)

Reprogramming of adipose tissue circadian biology by meal timing

2021-01 to 2023-12 | Grant
National Natural Science Foundation of China (Beijing, CN)
GRANT_NUMBER:

92057109
Source: Self-asserted source
Min-Dian Li

Adipocyte OGT signaling in diet-induced obesity

2020-01 to 2022-12 | Grant
National Natural Science Foundation of China (Beijing, CN)
GRANT_NUMBER:

81900776
Source: Self-asserted source
Min-Dian Li

Works (30)

Career pathways, part 16

Nature Metabolism
2025-01-07 | Journal article
DOI: 10.1038/s42255-024-01192-8
Contributors: Cholsoon Jang; Min-Dian Li
Source: check_circle
Crossref

Multi-omics profiling reveals rhythmic liver function shaped by meal timing

Nature Communications
2023-09-29 | Journal article | Author, Conceptualization, Investigation, Writing - original draft, Writing - review & editing, Funding acquisition
DOI: 10.1038/s41467-023-41759-9
Part of ISSN: 2041-1723
Contributors: Rongfeng Huang; Jianghui Chen; Meiyu Zhou; Haoran Xin; Sin Man Lam; Xiaoqing Jiang; Jie Li; Fang Deng; Guanghou Shui; Zhi-Hui Zhang et al.
Source: Self-asserted source
Min-Dian Li

Daytime-restricted feeding enhances running endurance without prior exercise in mice.

Nature metabolism
2023-06-26 | Journal article | Author, Conceptualization, Investigation, Writing - original draft, Writing - review & editing, Funding acquisition
DOI: 10.1038/s42255-023-00826-7
PMID: 37365376
Contributors: Xin H; Huang R; Zhou M; Chen J; Zhang J; Zhou T; Ji S; Liu X; He Tian; Sin Man Lam et al.
Source: Self-asserted source
Min-Dian Li

Temporal patterns of energy intake and cognitive function and its decline: a community-based cohort study in China

Life Metabolism
2022-11-03 | Journal article
DOI: 10.1093/lifemeta/loac011
Contributors: Hui Chen; Yang Tao; Min-Dian Li; Yuxuan Gu; Jiaxi Yang; You Wu; Dongmei Yu; Changzheng Yuan
Source: check_circle
Crossref

Circadian signatures of anterior hypothalamus in time-restricted feeding [version 1; peer review: 2 approved]

2022-09-22 | Journal article
DOI: 10.12688/f1000research.125368.1
Part of ISSN: 2046-1402
Funded by GRANT_NUMBER: 92057109
Contributors: Meiyu Zhou; Jianghui Chen; Rongfeng Huang; Haoran Xin; Xiaogen Ma; Lihua Li; Fang Deng; Zhihui Zhang; Min-Dian Li; Chen Jianghui et al.
Source: check_circle
F1000
grade
Preferred source (of 2)‎

Circadian signatures of adipose tissue in diet-induced obesity

Frontiers in Physiology
2022-08-31 | Journal article | Conceptualization, Funding acquisition, Investigation, Visualization, Writing - original draft, Writing - review & editing
DOI: 10.3389/fphys.2022.953237
Part of ISSN: 1664-042X
Contributors: Min-Dian Li
Source: Self-asserted source
Min-Dian Li

Regulation of the urea cycle by CPS1 O-GlcNAcylation in response to dietary restriction and aging

Journal of Molecular Cell Biology
2022-07-05 | Journal article
DOI: 10.1093/jmcb/mjac016
Contributors: Jing Wu; Jiayu Liu; Kalina Lapenta; Reina Desrouleaux; Min-Dian Li; Xiaoyong Yang; Feng Liu
Source: check_circle
Crossref

Clock-modulated checkpoints in time-restricted eating

Trends in Molecular Medicine
2022-01 | Journal article
DOI: 10.1016/j.molmed.2021.10.006
Contributors: Min-Dian Li
Source: check_circle
Crossref

Time to eat reveals the hierarchy of peripheral clocks

Trends in Cell Biology
2021-11 | Journal article
DOI: 10.1016/j.tcb.2021.08.003
Contributors: Zhihui Zhang; Guanghou Shui; Min-Dian Li
Source: check_circle
Crossref

Protocol for setup and circadian analysis of inverted feeding in mice

STAR Protocols
2021-09 | Journal article
DOI: 10.1016/j.xpro.2021.100701
Contributors: Haoran Xin; Rongfeng Huang; Meiyu Zhou; Xinyu Bao; Jianghui Chen; Fan Zeng; Xiaoqin Wan; Shifei Tong; Fang Deng; Min-Dian Li et al.
Source: check_circle
Crossref

Circadian Clock-Controlled Checkpoints in the Pathogenesis of Complex Disease

Frontiers in Genetics
2021-09-07 | Journal article
DOI: 10.3389/fgene.2021.721231
Part of ISSN: 1664-8021
Source: Self-asserted source
Min-Dian Li

A multi-tissue multi-omics analysis reveals distinct kinetics in entrainment of diurnal transcriptomes by inverted feeding.

iScience
2021-03-19 | Journal article
DOI: 10.1016/j.isci.2021.102335
PMID: 33889826
PMC: PMC8050734
Source: Self-asserted source
Min-Dian Li
grade
Preferred source (of 2)‎

Circadian Rhythm of Lipid Metabolism in Health and Disease

Small Methods
2020-07 | Journal article
DOI: 10.1002/smtd.201900601
Contributors: Zhihui Zhang; Haoran Xin; Min‐Dian Li
Source: check_circle
Crossref

O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity.

Nature communications
2020-01-10 | Journal article
DOI: 10.1038/s41467-019-13914-8
PMID: 31924761
PMC: PMC6954210
Source: Self-asserted source
Min-Dian Li

O-GlcNAcase targets pyruvate kinase M2 to regulate tumor growth

Oncogene
2019 | Journal article
DOI: 10.1038/s41388-019-0975-3
EID:

2-s2.0-85072049518
Contributors: Singh, J.P.; Qian, K.; Lee, J.-S.; Zhou, J.; Han, X.; Zhang, B.; Ong, Q.; Ni, W.; Jiang, M.; Ruan, H.-B. et al.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

O-GlcNAc transferase suppresses necroptosis and liver fibrosis

JCI Insight
2019-11-01 | Journal article
DOI: 10.1101/519975
Source: Self-asserted source
Min-Dian Li

Setting fire to fat

Journal of Biological Chemistry
2019-06 | Journal article
DOI: 10.1074/jbc.H119.009488
Contributors: Zhihui Zhang; Min-Dian Li
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Transcriptional regulation of O-GlcNAc homeostasis is disrupted in pancreatic cancer

Journal of Biological Chemistry
2018 | Journal article
DOI: 10.1074/jbc.RA118.004709
Part of ISBN: 2037371446
PMID: 30037904
Source: Self-asserted source
Min-Dian Li
grade
Preferred source (of 2)‎

Adipocyte OGT governs diet-induced hyperphagia and obesity

Nature Communications
2018-11-30 | Journal article
DOI: 10.1038/s41467-018-07461-x
Contributors: Min-Dian Li; Nicholas B. Vera; Yunfan Yang; Bichen Zhang; Weiming Ni; Enida Ziso-Qejvanaj; Sheng Ding; Kaisi Zhang; Ruonan Yin; Simeng Wang et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Mining Massive Amounts of Genomic Data: A Semiparametric Topic Modeling Approach

Journal of the American Statistical Association
2017 | Journal article
DOI: 10.1080/01621459.2016.1256812
EID:

2-s2.0-85032479953
Contributors: Fang, E.X.; Li, M.-D.; Jordan, M.I.; Liu, H.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

Uncoupling of Metabolic Health from Longevity through Genetic Alteration of Adipose Tissue Lipid-Binding Proteins

Cell Reports
2017 | Journal article
DOI: 10.1016/j.celrep.2017.09.051
EID:

2-s2.0-85030866687
Contributors: Charles, K.N.; Li, M.-D.; Engin, F.; Arruda, A.P.; Inouye, K.; Hotamisligil, G.S.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat

Cell
2014 | Journal article
DOI: 10.1016/j.cell.2014.09.010
EID:

2-s2.0-84916878247
Contributors: Ruan, H.-B.; Dietrich, M.O.; Liu, Z.-W.; Zimmer, M.R.; Li, M.-D.; Singh, J.P.; Zhang, K.; Yin, R.; Wu, J.; Horvath, T.L. et al.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

Cracking the O-GlcNAc code in metabolism

Trends in Endocrinology and Metabolism
2013 | Journal article
DOI: 10.1016/j.tem.2013.02.002
EID:

2-s2.0-84878235671
Contributors: Ruan, H.-B.; Singh, J.P.; Li, M.-D.; Wu, J.; Yang, X.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

O-GlcNAc signaling entrains the circadian clock by inhibiting BMAL1/CLOCK ubiquitination

Cell Metabolism
2013 | Journal article
DOI: 10.1016/j.cmet.2012.12.015
EID:

2-s2.0-84873362932
Contributors: Li, M.-D.; Ruan, H.-B.; Hughes, M.E.; Lee, J.-S.; Singh, J.P.; Jones, S.P.; Nitabach, M.N.; Yang, X.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

O-GlcNAc transferase is involved in glucocorticoid receptor-mediated transrepression

Journal of Biological Chemistry
2012 | Journal article
DOI: 10.1074/jbc.M111.303792
EID:

2-s2.0-84859772418
Contributors: Li, M.-D.; Ruan, H.-B.; Singh, J.P.; Zhao, L.; Zhao, T.; Azarhoush, S.; Wu, J.; Evans, R.M.; Yang, X.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1α stability

Cell Metabolism
2012 | Journal article
DOI: 10.1016/j.cmet.2012.07.006
EID:

2-s2.0-84864708480
Contributors: Ruan, H.-B.; Han, X.; Li, M.-D.; Singh, J.P.; Qian, K.; Azarhoush, S.; Zhao, L.; Bennett, A.M.; Samuel, V.T.; Wu, J. et al.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

The role of circadian clocks in metabolic disease.

The Yale journal of biology and medicine
2012 | Journal article
EID:

2-s2.0-84873474854
Contributors: Li, M.D.; Li, C.M.; Wang, Z.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

A retrospective on nuclear receptor regulation of inflammation: Lessons from GR and PPARs

PPAR Research
2011 | Journal article
DOI: 10.1155/2011/742785
EID:

2-s2.0-81555220924
Contributors: Li, M.-D.; Yang, X.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

Leptin and beyond: An odyssey to the central control of body weight

Yale Journal of Biology and Medicine
2011 | Journal article
EID:

2-s2.0-79959798820
Contributors: Li, M.-D.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I

PLoS ONE
2009 | Journal article
DOI: 10.1371/journal.pone.0005760
EID:

2-s2.0-66749142359
Contributors: Gao, D.; Yang, Y.-K.; Wang, R.-P.; Zhou, X.; Diao, F.-C.; Li, M.-D.; Zhai, Z.-H.; Jiang, Z.-F.; Chen, D.-Y.
Source: Self-asserted source
Min-Dian Li via Scopus - Elsevier

Peer review (28 reviews for 13 publications/grants)

Review activity for Cell metabolism. (3)
Review activity for Cell reports. (7)
Review activity for Communications biology. (1)
Review activity for Heliyon. (1)
Review activity for iScience. (4)
Review activity for Journal of Genetics and Genomics. (1)
Review activity for Lipids in health and disease (3)
Review activity for Nature communications (1)
Review activity for Nature metabolism. (2)
Review activity for Phenomics. (1)
Review activity for STAR protocols. (2)
Review activity for Trends in endocrinology and metabolism (1)
Review activity for UK Research and Innovation (1)
How many people are using ORCID?