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Structural Biology, Biochemistry, X-ray crystallography, Immunoglobulin receptors, Inflammation, Cell adhesion molecules, Receptor:ligand interactions, Host:pathogen interactions, Zebrafish model, Drug design
France

Activities

Employment (4)

Communauté d'Universités et Etablissements Languedoc-Roussillon Universités: Montpellier, Languedoc-Roussillon, FR

2016-01-01 to present | Permanent Researcher (CRCN) Inserm (LPHI UMR5294 - Team "Immunity, Inflammation and Bacterial Virulence")
Employment
Source: Self-asserted source
Laure YATIME

Aarhus Universitet: Aarhus, DK

2010-07-01 to 2015-11-30 | Senior Adviser (MBG - Group of Prof. Gregers Rom ANDERSEN)
Employment
Source: Self-asserted source
Laure YATIME

Aarhus Universitet: Aarhus, DK

2006-02-01 to 2010-06-30 | Post-doctoral fellow (MBG - Group of Prof. Poul NISSEN)
Employment
Source: Self-asserted source
Laure YATIME

Ecole Polytechnique: Palaiseau, FR

2002-02-01 to 2006-01-31 | Master/PhD student (Laboratoire de Biochimie, group of Prof. Sylvain BLANQUET)
Employment
Source: Self-asserted source
Laure YATIME

Education and qualifications (5)

University of Montpellier: Montpellier, Languedoc-Roussillon, FR

2016-11-28 to present | Habilitation à Diriger des Recherches (HDR)
Education
Source: Self-asserted source
Laure YATIME

University of Montpellier: Montpellier, Languedoc-Roussillon, FR

2016-05-30 to present | Formation de niveau 1 en Expérimentation Animale
Qualification
Source: Self-asserted source
Laure YATIME

Ecole Polytechnique: Palaiseau, FR

2002-09 to 2005-12 | PhD (Laboratoire de Biochimie)
Education
Source: Self-asserted source
Laure YATIME

Ecole Polytechnique: Palaiseau, FR

2001-09 to 2002-06 | Master (DEA) (Laboratoire de Biochimie)
Education
Source: Self-asserted source
Laure YATIME

Chimie ParisTech: Paris, Île-de-France, FR

1999-09 to 2002-06 | Engineer
Education
Source: Self-asserted source
Laure YATIME

Professional activities (4)

Societe Francaise de Biochimie et Biologie Moléculaire SFBBM: Paris, FR

2004 to present | Member
Membership
Source: Self-asserted source
Laure YATIME

Comité National du CNRS - section 20: Paris, FR

2021-09 to 2026-08 | Membre
Service
Source: Self-asserted source
Laure YATIME

Journal of Structural Biology: Amsterdam, NL

2013 | Paper of the Year
Distinction
Source: Self-asserted source
Laure YATIME

Ecole Polytechnique: Palaiseau, FR

2006 | PhD award 2005
Distinction
Source: Self-asserted source
Laure YATIME

Funding (3)

Towards the determination of the 3D-structure of invasin IbeA, a novel drug target for antibacterial strategies in Crohn’s disease – IbeAST

2022 to present | Grant
Instruct-ERIC (Oxford, GB)
Source: Self-asserted source
Laure YATIME

INFLANET

2021-03 to 2025-02 | Grant
H2020 Marie Skłodowska-Curie Actions (Montpellier, FR)
Source: Self-asserted source
Laure YATIME

Influence of divalent cations on S100A9 C-terminal region

2019 to 2020 | Grant
Instruct-ERIC (Oxford, GB)
Source: Self-asserted source
Laure YATIME

Works (35)

The IbeA protein from adherent invasive <i>Escherichia coli</i> is a flavoprotein sharing structural homology with FAD‐dependent oxidoreductases

The FEBS Journal
2023-10-03 | Journal article | Author
Part of ISSN: 1742-464X
Part of ISSN: 1742-4658
Contributors: Théo Paris; Agneta Kiss; Luca Signor; Georges Lutfalla; Mickael Blaise; Elisabetta Boeri Erba; Laurent Chaloin; Laure YATIME
Source: Self-asserted source
Laure YATIME

Molecular Actors of Inflammation and Their Signaling Pathways: Mechanistic Insights from Zebrafish

Biology
2023-01-19 | Review
Part of ISSN: 2079-7737
Contributors: Jade Leiba; Resul Özbilgiç; Liz Hernandez; Maria Demou; Georges Lutfalla; Laure Yatime; Mai Nguyen-Chi
Source: Self-asserted source
Laure YATIME

Les CEACAM épithéliales, plateformes d’ancrage des microorganismes pathogènes dans les muqueuses

médecine/sciences
2022-08 | Journal article
Part of ISSN: 0767-0974
Part of ISSN: 1958-5381
Contributors: Laure YATIME
Source: Self-asserted source
Laure YATIME

Characterization of a member of the CEACAM protein family as a novel marker of proton pump-rich ionocytes on the zebrafish epidermis

PLOS ONE
2021-07-12 | Journal article
Part of ISSN: 1932-6203
Source: Self-asserted source
Laure YATIME

Divalent cations influence the dimerization mode of murine S100A9 protein by modulating its disulfide bond pattern.

Journal of structural biology
2020-12-31 | Journal article
Source: Self-asserted source
Laure YATIME

The receptor for advanced glycation end products is a sensor for cell-free heme.

The FEBS journal
2020-12-12 | Journal article
Source: Self-asserted source
Laure YATIME

Structural Analysis of S100A8 Complex with Zinc and Calcium: A General Protocol for the Study of S100 Proteins in the Presence of Divalent Cations by X-Ray Crystallography

Methods in Molecular Biology
2019 | Book chapter
Source: Self-asserted source
Laure YATIME

A Single-Domain Antibody Targeting Complement Component C5 Acts as a Selective Inhibitor of the Terminal Pathway of the Complement System and Thus Functionally Mimicks the C-Terminal Domain of the Staphylococcus aureus SSL7 Protein

Frontiers in Immunology
2018-11-29 | Journal article
Source: Self-asserted source
Laure YATIME

L’hème, un nouveau ligand du récepteur des produits de glycation avancée (RAGE)

Néphrologie & Thérapeutique
2018-09 | Journal article
Part of ISSN: 1769-7255
Source: Self-asserted source
Laure YATIME

A cystein-dependent activation mechanism for the pro-inflammatory ligands of RAGE? | Un mécanisme d'activation cystéine-dépendant pour les ligands pro-inflammatoires de RAGE ?

Medecine/Sciences
2017 | Journal article
EID:

2-s2.0-85016978870

Contributors: Yatime, L.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Complement regulators and inhibitors in health and disease: a structural perspective

Nanomedicine
2016 | Book chapter
Source: Self-asserted source
Laure YATIME

Crystal structure of human S100A8 in complex with zinc and calcium

BMC Structural Biology
2016 | Journal article
EID:

2-s2.0-84975840818

Contributors: Lin, H.; Andersen, G.R.; Yatime, L.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

The Structure of the RAGE:S100A6 Complex Reveals a Unique Mode of Homodimerization for S100 Proteins

Structure
2016 | Journal article
EID:

2-s2.0-85002681347

Contributors: Yatime, L.; Betzer, C.; Jensen, R.K.; Mortensen, S.; Yatime, L.; Andersen, G.R.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structural basis for the targeting of complement anaphylatoxin C5a using a mixed L-RNA/L-DNA aptamer

Nature Communications
2015 | Journal article
EID:

2-s2.0-84928780593

Contributors: Yatime, L.; Maasch, C.; Hoehlig, K.; Klussmann, S.; Andersen, G.R.; Vater, A.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structures and characterization of digoxin- And bufalin-bound Na+,K+-ATPase compared with the ouabain-bound complex

Proceedings of the National Academy of Sciences of the United States of America
2015 | Journal article
EID:

2-s2.0-84922633960

Contributors: Laursen, M.; Gregersen, J.L.; Yatime, L.; Nissen, P.; Fedosova, N.U.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structural and functional characterization of human and murine C5a anaphylatoxins

Acta Crystallographica Section D: Biological Crystallography
2014 | Journal article
EID:

2-s2.0-84902472334

Contributors: Schatz-Jakobsen, J.A.; Yatime, L.; Larsen, C.; Petersen, S.V.; Klos, A.; Andersen, G.R.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

The specificity of DNA recognition by the RAGE receptor

Journal of Experimental Medicine
2014 | Journal article
EID:

2-s2.0-84899758628

Contributors: Yatime, L.; Andersen, G.R.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Crystal structure of the high-affinity Na+,K+-ATPase- ouabain complex with Mg2+ bound in the cation binding site

Proceedings of the National Academy of Sciences of the United States of America
2013 | Journal article
EID:

2-s2.0-84879701596

Contributors: Laursen, M.; Yatime, L.; Nissen, P.; Fedosova, N.U.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Human C3a and C3a desArg anaphylatoxins have conserved structures, in contrast to C5a and C5a desArg

Protein Science
2013 | Journal article
EID:

2-s2.0-84874050615

Contributors: Bajic, G.; Yatime, L.; Klos, A.; Andersen, G.R.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structural insight on the recognition of surface-bound opsonins by the integrin aI-domain of complement receptor 3

Frontiers in Immunology
2013 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Laure YATIME

Structural insight on the recognition of surface-bound opsonins by the integrin i domain of complement receptor 3

Proceedings of the National Academy of Sciences of the United States of America
2013 | Journal article
EID:

2-s2.0-84885333791

Contributors: Bajic, G.; Yatime, L.; Sim, R.B.; Vorup-Jensen, T.; Andersen, G.R.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structural insights into S100 proteins recognition and signal transduction by the RAGE receptor

Frontiers in Immunology
2013 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Laure YATIME

Structural insights into the oligomerization mode of the human receptor for advanced glycation end-products

FEBS Journal
2013 | Journal article
EID:

2-s2.0-84889651840

Contributors: Yatime, L.; Andersen, G.R.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structural basis for activation of the complement system by component C4 cleavage

Proceedings of the National Academy of Sciences of the United States of America
2012 | Journal article
EID:

2-s2.0-84866558185

Contributors: Kidmose, R.T.; Laursen, N.S.; Dobó, J.; Kjaer, T.R.; Sirotkina, S.; Yatime, L.; Sottrup-Jensen, L.; Thiel, S.; Gál, P.; Andersen, G.R.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

HiLiDe-systematic approach to membrane protein crystallization in lipid and detergent

Crystal Growth and Design
2011 | Journal article
EID:

2-s2.0-79958013764

Contributors: Gourdon, P.; Andersen, J.L.; Hein, K.L.; Bublitz, M.; Pedersen, B.P.; Liu, X.-Y.; Yatime, L.; Nyblom, M.; Nielsen, T.T.; Olesen, C. et al.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structural insights into the high affinity binding of cardiotonic steroids to the Na+,K+-ATPase

Journal of Structural Biology
2011 | Journal article
EID:

2-s2.0-79954415607

Contributors: Yatime, L.; Laursen, M.; Morth, J.P.; Esmann, M.; Nissen, P.; Fedosova, N.U.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structure of the RACK1 dimer from saccharomyces cerevisiae

Journal of Molecular Biology
2011 | Journal article
EID:

2-s2.0-79960717195

Contributors: Yatime, L.; Hein, K.L.; Nilsson, J.; Nissen, P.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Exploring the Na+/K+-ATPase:Src kinase complex

Acta Crystallographica Section A Foundations of Crystallography
2011-08-22 | Journal article
Part of ISSN: 0108-7673
Source: Self-asserted source
Laure YATIME

A systematic approach to membrane protein crystallization in bilayers

Acta Crystallographica Section A Foundations of Crystallography
2010-08-29 | Journal article
Part of ISSN: 0108-7673
Source: Self-asserted source
Laure YATIME

P-type ATPases as drug targets: Tools for medicine and science

Biochimica et Biophysica Acta - Bioenergetics
2009 | Journal article
EID:

2-s2.0-61349128572

Contributors: Yatime, L.; Buch-Pedersen, M.J.; Musgaard, M.; Morth, J.P.; Winther, A.-M.L.; Pedersen, B.P.; Olesen, C.; Andersen, J.P.; Vilsen, B.; Schiøtt, B. et al.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Protection-Based Assays to Measure Aminoacyl-tRNA Binding to Translation Initiation Factors

Methods in Enzymology
2007 | Book
EID:

2-s2.0-38449087034

Contributors: Mechulam, Y.; Guillon, L.; Yatime, L.; Blanquet, S.; Schmitt, E.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structure of an archaeal heterotrimeric initiation factor 2 reveals a nucleotide state between the GTP and the GDP states

Proceedings of the National Academy of Sciences of the United States of America
2007 | Journal article
EID:

2-s2.0-36749037829

Contributors: Yatime, L.; Mechulam, Y.; Blanquet, S.; Schmitt, E.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structural switch of the γ subunit in an archaeal aIF2αγ heterodimer

Structure
2006 | Journal article
EID:

2-s2.0-33644790001

Contributors: Yatime, L.; Mechulam, Y.; Blanquet, S.; Schmitt, E.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Structure - Function relationships of the intact aIF2α subunit from the archaeon Pyrococcus abyssi

Biochemistry
2005 | Journal article
EID:

2-s2.0-20544464681

Contributors: Yatime, L.; Schmitt, E.; Blanquet, S.; Mechulam, Y.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier

Functional Molecular Mapping of Archaeal Translation Initiation Factor 2

Journal of Biological Chemistry
2004 | Journal article
EID:

2-s2.0-1942437572

Contributors: Yatime, L.; Schmitt, E.; Blanquet, S.; Mechulam, Y.
Source: Self-asserted source
Laure YATIME via Scopus - Elsevier